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5篇 您的检索式：作者名="Sterndorff"

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		题名	作者	年代	出处	被引量
	1	Grounding experiments on soft bottoms显示文摘	M. J. Sterndorff P. Terndrup Pedersen	1996	Journal of Marine Science and Technology1996，，3：	1
	2	Grounding experiments on soft bottoms显示文摘	STERNDORFF M J PEDERSEN P T	1996	Journal of Marine Science and Technology1996，1，3：	1
	3	Design of fixed offshore platforms to dynamic ship impact loads显示文摘	Sterndorff M J Waegter J Eilersen C	1992	ASME Journal of Offshore Mechanics and Arctic Engineering1992，114，：	1
	4	Grounding experi- ments on soft bottoms显示文摘	STERNDORFF M J PENDERSEN P T	1996	Journal of Marine Science and Technology1996，1，3：	1
	5	Identification and heterologous expression of the globomycin biosynthetic gene cluster显示文摘Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens.Its mode of action is based on the competitive inhibition of the lipoprotein signal peptidase II(LspA),which is absent in eukaryotes and considered an attractive target for the development of new antibiotics.Despite its interesting biological properties,the gene cluster encoding its biosynthesis has not yet been identified.In this study we employed a genome-mining approach in the globomycin-producing Streptomyces sp.CA-278952 to identify a candidate gene cluster responsible for its biosynthesis.A null mutant was constructed using CRISPR base editing where production was abolished,strongly suggesting its involvement in the biosynthesis.The putative gene cluster was then cloned and heterologously expressed in Streptomyces albus J1074 and Streptomyces coelicolor M1146,therefore unambigu-ously linking globomycin and its biosynthetic gene cluster.Our work paves the way for the biosynthesis of new globomycin derivatives with improved pharmacological properties.	Daniel Oves-Costales Tetiana Gren Eva Baggesgaard Sterndorff Jesús Martín Francisco Javier Ortiz-Lopez Tue S.Jørgensen Xinglin Jiang Fernando Roman-Hurtado Fernando Reyes Olga Genilloud Tilmann Weber	2023	Synthetic and Systems Biotechnology2023，8，2：	0

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