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| 1 | UGT1A1 gene polymorphism: Impact on toxicity and efficacy of irinotecan-based regimens in metastatic colorectal cancer显示文摘AIM: To investigate the correlation between uridine diphosphate glucuronosyl transferase 1A1 (UGT1A1) gene polymorphisms and irinotecan-associated side effects and parameters of drug efficacy in patients with metastatic colorectal cancer (mCRC) receiving a low-dose weekly irinotecan chemotherapeutic regimen. METHODS: Genotypes were retrospectively evaluated by gene scan analysis on the ABI 310 sequencer of the TATAA box in the promoter region of the UGT1A1 gene in blood samples from 105 patients who had received 1st line irinotecan-based chemotherapy for mCRC. RESULTS: The distribution of the genotypes was as follows: wild type genotype (WT) (6/6 ) 39.0%, heterozygous genotype (6/7) 49.5%, and homozygous genotype (7/7) 9.5%. The overall response rate (OR) was similar between patients carrying the (6/7, 7/7) or the WT genotype (6/6) (44.3% vs 43.2%, P = 0.75). Neither time to progression [(TTP) 8.1 vs 8.2 mo, P = 0.97] nor overall survival [(OS) 21.2 vs 18.9 mo, P = 0.73] differed significantly in patients who carried the(6/6) when compared to the (6/7, 7/7) genotype. No significant differences in toxicity were observed: Grade 3 and 4 delayed diarrhoea [(6/7, 7/7) vs (6/6); 13.0% vs 6.2%, P =0.08], treatment delays [(6/7, 7/7) vs (6/6); 25.1% vs 19.3%, P = 0.24] or dose reductions [(6/7, 7/7) vs (6/6); 21.5% vs 27.2%, P = 0.07].CONCLUSION: This analysis demonstrates the non-significant influence of the UGT1A1 gene polymorphism on efficacy and rate of irinotecan-associated toxicity in mCRC patients receiving low-dose irinotecan based chemotherapy. | Christoph Schulz Volker Heinemann Andreas Schalhorn Nikolas Moosmann Thomas Zwingers Stefan Boeck Clemens Giessen Hans-Joachim Stemmler | 2009 | World Journal of Gastroenterology2009，15，40： | 31 |
| 2 | Truncating mutations in Peutz-Jeghers syndrome are associated with more polyps, surgical interventions and cancers显示文摘 | Heidi Salloch Anke Reinacher-Schick Karsten Schulmann Christian Pox J?rg Willert Andrea Tannapfel Stefan Heringlake Timm O. Goecke Stefan Aretz Susanne Stemmler Wolff Schmiegel | 2010 | International Journal of Colorectal Disease2010，，1： | 2 |
| 3 | Stationary-frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X M MERK W STEMMLER H | 2002 | IEEE Transaction on Industry Applications2002，38，2： | 1 |
| 4 | Stationary frame gene- ralized integrators for current control of active power filters with zero steady state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X MERK W STEMMLER H | 2002 | IEEE Trans on Industry Applications2002，38，2： | 1 |
| 5 | Stationary- frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions显示文摘 | YUAN X MERK W STEMMLER H | 2002 | IEEE Trans on IA2002，38，2： | 1 |
| 6 | Dual-phase 3D MDCT angiography for evaluation of the liver before hepatic resection显示文摘 | Stemmler BJ Paulson EK Thornton FJ | 2004 | AJR2004，183，6： | 1 |
| 7 | Anthracycline-induced cardiotoxi- city : cardiac monitoring by continuous wave-Dopp|er ultrasound cardiac output monitoring and correlation to echocardiography显示文摘 | Geiger S Stemmler HJ Suh| P | 2012 | Onkologie Epub2012，35，5： | 1 |
| 8 | Stationary- frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions 显示文摘 | YUAN Xiaoming MERK W STEMMLER H | 2002 | IEEE Trans on Industry Application2002，38，2： | 1 |
| 9 | Vibrio species associated with mortality of sharks held in captivity显示文摘 | D. J. Grimes J. Stemmler H. Hada E. B. May D. Maneval F. M. Hetrick R. T. Jones M. Stoskopf R. R. Colwell | 1984 | Microbial Ecology1984，，3： | 1 |
| 10 | Mechanical ventilation with positive end-expiratory pressure in critically ill patients:comparisonof CW-Doppler ultrasound cardiac output monitoring(USCOM)and thermodilution(PiCCO)显示文摘 | Horster S Stemmler HJ Sparrer J | 2012 | Acta Cardiol2012，67，2： | 1 |
| 11 | Cadhefins in development and cancer 显示文摘 | Stemmler MP | 2008 | Mol Biosyst2008，，8： | 1 |
| 12 | Self-balancing of the Clamping-capacitor-voltages in the Multilevel Capacitor- clamping-inverter under Sub-harmonic PWM Modulation 显示文摘 | Yuang Xiaoming Stemmler H Barbi I | 2001 | IEEE Transactions on Power Electronics2001，16，2： | 1 |
| 13 | Cadherins in development and cancer显示文摘 | Stemmler MP | 2008 | Mol Biosyst2008，28，8： | 1 |
| 14 | Randomised phase 1I trim of gemcitabine plus vinorelbine vs gemcitabine plus cisplatin vs gemcitabine pluscapecitabine in patients with pretreated meta- static breast cancer显示文摘 | Stemmler H J diGioia D Freier W | 2011 | Br J Cancer2011，104，7： | 1 |
| 15 | Stationary -frame generalized integrators for current control of active power filters with zero steady-state error for current harmonics of concern under unbalanced and distorted operating conditions 显示文摘 | YUAN Xiaoming MERK W STEMMLER H | 2002 | IEEE Transactions on Industry Applications2002，38，2： | 1 |
| 16 | Weekly docetaxel (Taxotere) in patients with metastatic breast cancer 显示文摘 | Stemmler HJ Gutschow K Sommer H | 2001 | Ann Oncol2001，12，10： | 1 |
| 17 | High efficacy of gemcitabine and cisplatin in patients with predominantly anthracycline- and taxane-pretreated metastatic breast cancer显示文摘 | V. Heinemann H. J. Stemmler A. Wohlrab D. Bosse C. Losem S. Kahlert G. Rauthe | 2006 | Cancer Chemotherapy and Pharmacology2006，，5： | 1 |
| 18 | Cardiac output measurements in septic patients: comparing the accuracy of USCOM to PiCCO显示文摘 | Horster S Stemmler HJ Strecker N | 2012 | Crit Care Res Pract2012，2012，27： | 1 |
| 19 | Self-balancing of the clamping-capacitor-voltages in the multilevel capacitor clamping inverter under sub-harmonic PWM modulation显示文摘 | YUAN Xiao-ming STEMMLER H BARBI I | 2001 | IEEE Trans on Power Electronics2001，16，2： | 1 |
| 20 | Stationary Frame Generalized Integrators for Current Control of Active Power Filters With Zero Steady-state Error for Current Harmonics of Concern under Unbalanced and Distorted Operating Conditions显示文摘 | Yuan X Merk W Stemmler H | | 0，，02： | 1 |
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