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| 1 | 高级别软组织肉瘤:肿瘤治疗反应的评估——应用RECIST和Choi标准探讨影像与病理间治疗反应相关性的初步研究显示文摘目的根据实性肿瘤治疗反应的评估标准(RECIST)和应用于胃肠道间质瘤新的Choi评估标准,比较高级别软组织肉瘤进行术前放化疗后的影像变化和病理反应。方法本研究包括37例罹患局灶性高级别软组织肉瘤并进行术前放化疗病人(男21例,女16例,平均年龄4412岁),所有病人均经机构伦理委员会批准并签署知情同意书,采用随机对比试验,并进行回顾分析。在CT和MR影像上,应用RECIST和Choi标准评价肿瘤对术前治疗的反应, | S. Stacchiotti P. Collini A. Messina C. Morosi M. Barisella R. Bertulli 展影(译) 雷新玮(校) | 2009 | 国际医学放射学杂志2009，32，4： | 7 |
| 2 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 3 | Stress proteins in ex- perimental nephrotoxicity: A ten year experience 显示文摘 | Stacchiotti A Bonomini F Favero G | 2010 | Ital J Anat Embryol2010，115，12： | 1 |
| 4 | Imatinib mesylate inchordoma显示文摘 | Casali PG Messina A Stacchiotti S | 2004 | Cancer2004，101，9： | 1 |
| 5 | Extraskeletal myxoid chondrosarcoma: tumor response to sunitinib 显示文摘 | Stacchiotti S Dagrada GP Morosi C | 2012 | Clin Sarcoma Res2012，2，1： | 1 |
| 6 | Morphological and bio-chemical studies on aging and autophagy显示文摘 | Rezzani R Stacchiotti A Rodella LF | 2012 | Ageing ResRev2012，11，1： | 1 |
| 7 | Sunitinib in advanced alveolar soft part sarcoma:evidence of a direct antitumor effect显示文摘 | Stacchiotti S Negri T Zaffaroni N | | 0，，07： | 1 |
| 8 | Response toimatinib plus sirolimus in advanced chordoma 显示文摘 | Stacchiotti S Marrari A Tamborini E | 2009 | Ann Oncol2009，20，11： | 1 |
| 9 | Gemcitabine in advanced angiosarcoma:a retrospective case series analysis from the Italian Rare Cancer Network显示文摘 | Stacchiotti S Palassini E Sanfilippo R | 2012 | Ann Oncol2012，23，2： | 1 |
| 10 | ER signaling regulation drives the switch between autophagy and apoptosis in NRK-52E cells exposed to cisplatin显示文摘 | Rovetta F Stacchiotti A Consiglio A | 2012 | Exp Cell Res2012，318，3： | 1 |
| 11 | Different role of schisandrin B on mercury-induced renal damage in vivo and in vitro显示文摘 | Stacchiotti A Volti G L Lavazza A | 2011 | Toxicology2011，286，1： | 1 |
| 12 | Dose-dependent mercuric chloride tubular injury in rat kidney显示文摘 | Stacchiotti A Borsani E Rodella L | 2003 | Ultrastruct Pathol2003，27，： | 1 |
| 13 | Imafinib mesylate in chordoma显示文摘 | Casali PG Messina A Stacchiotti S | 2004 | Cancer2004，101，9： | 1 |
| 14 | Phase II study of imatinib in advanced chordoma显示文摘 | Stacchiotti S Longhi A Ferraresi V | | 0，，09： | 1 |
| 15 | Response to sunitinib malate in Mvanced alveolar soft part sarcoma显示文摘 | STACCHIOTTI S TAMBORINI E MARRARI A | 2009 | Clin Cancer Res2009，15，： | 1 |
| 16 | Imatinib mesylate in advanced chordoma:A multicenter phase II study显示文摘 | Stacchiotti S Ferrari S Ferraresi V | | 0，，18： | 1 |
| 17 | 显示文摘 | Casali PG Messina A Stacchiotti S | 2004 | Cancer2004，101，9： | 1 |
| 18 | ER signaling regula- tion drives the switch between autophagy and apoptosis in NRK- 52E cells exposed to cisplatin显示文摘 | Rovetta F Stacchiotti A Consiglio A | 2012 | Exp Cell Res2012，318，3： | 1 |
| 19 | Response to imatinib mesylate (IM) in flbrosarcoma(FS) arising in dermatoflbrosarcoma protuberans(DFSP)显示文摘 | Gronchi A Stacchiotti S Pedeutour F | 2008 | J Clin Oncol2008，26，10： | 1 |
| 20 | Chordoma of the mobile spine and sacrum: a retrospective analysis of a series of patients surgically treated at two referral centers显示文摘 | Stacchiotti S Casali PG Lo Vullo S | 2010 | Ann Surg Oncol2010，17，1： | 1 |
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