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| 1 | Effects of iron and oxygen on chlorophyll biosynthesis in vivo observations on iron and oxygen-defieient plants 显示文摘 | Spiller S C Castelfranco A M Castelfranco P A | 1982 | Plant Physiol1982，69，1： | 1 |
| 2 | Regional differences in quinine absorption from the undisturbed human colon assessed using a timed release delivery system显示文摘 | John M Hebden Clive G Wilson Robin C Spiller | 1999 | Pharm Res1999，16，7： | 1 |
| 3 | 查看详情显示文摘 | Losi P Briganti E Magera A Spiller D Ristori C Battolla B Balderi M Kull S Balbarini A Stefano R D Soldani G | | 0，，： | 1 |
| 4 | Nodal/Cripto signaling in fetal male germ cell development: implications for testicu lar germ cell tumors显示文摘 | Spiller C M Bowles J Koopman P | 2013 | Int J Develop Biol2013，57，24： | 1 |
| 5 | Effects of iron and oxygen on chlorophyll biosynthesis I In vivo ob- servations on iron and oxygen-deficient plants显示文摘 | SPILLER S C CASTELFRANCO A M CASTELFRANCO P A | 1982 | Plant Physiology1982，69，1： | 1 |
| 6 | Effect of purified cellulose, pectin, and a low-residue diet on fecal volatile fatty acids, transit time, and fecal weight in humans 显示文摘 | SPILLER G A CHERNOFF M C HILL R A | 1980 | The American Journal of Clini- cal Nutrtion1980，33，4： | 1 |
| 7 | Interactive Segmentation of Clustered Cells via Geodesic Com- mute Distance and Constrained Density Weighted Nystrom Method显示文摘 | Du C J Marcello M Spiller D G | 2010 | Cytometry Part A2010，，12： | 1 |
| 8 | Disruption of colonic barrier function and induction of mediator release by strains of Campylobacter jejuni that invade epithelial cells显示文摘AIM: To study the mechanisms by which Campylobacter jejuni (C. jejuni) causes inflammation and diarrhea. In particular, direct interactions with intestinal epithelial cells and effects on barrier function are poorly under- stood. METHODS: To model the initial pathogenic effects of C. jejuni on intestinal epithelium, polarized human colonic HCA-7 monolayers were grown on permeabilized filters and infected apically with clinical isolates of C. jejuni. Integrity of the monolayer was monitored by changes in monolayer resistance, release of lactate dehydrogenase, mannitol fluxes and electron microscopy. Invasion of HCA-7 cells was assessed by a modified gentamicin protection assay, translocation by counting colony forming units in the basal chamber, stimulation of mediator release by immunoassays and secretory responses in monolayers stimulated by bradykinin in an Ussing chamber. RESULTS: All strains translocated across monolayers but only a minority invaded HCA-7 cells. Strains that invaded HCA-7 cells destroyed monolayer resistance over 6 h, accompanied by increased release of lactate dehydrogenase, a four-fold increase in permeability to [3H] mannitol, and ultrastructural disruption of tight junctions, with rounding and lifting of cells off the filter membrane. Synthesis of interleukin (IL)-8 and prostaglandin E2 was increased with strains that invaded the monolayer but not with those that did not. CONCLUSION: These data demonstrate two distinct effects of C. jejuni on colonic epithelial cells and provide an informative model for further investigation of initial host cell responses to C. jejuni. | Johannes Beltinger Jo del Buono Maeve M Skelly John Thornley Robin C Spiller William A Stack Christopher J Hawkey | 2008 | World Journal of Gastroenterology2008，14，48： | 1 |
| 9 | Measurement of gastric meal and secretion volumes using magnetic resonance imaging显示文摘 | C L Hoad H Parker N Hudders C Costigan E F Cox A C Perkins P E Blackshaw L Marciani R C Spiller M R Fox P A Gowland | 2015 | Physics in Medicine and Biology2015，，3： | 1 |
| 10 | The MACH2 study:role of omeprazole in eradication of Helicobacter pylori with i-week triple therapies显示文摘 | Lind T Megraud F Unge P Bayerdorffer E OMorain C Spiller R Velduyzen van Zanten S Bardhan KD Hellblom M Wrangstadh M Zeijlon L Cederberg C | | 0，，： | 1 |
| 11 | Phosphoramidate oligonucle- otides as potent antisense molecules in cells and in vivo 显示文摘 | Faria M Spiller D G Dubertret C | 2001 | Nat Bio- technol2001，19，1： | 1 |
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