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| 1 | Microproteinuria in patients with inflammatory bowel disease:Is it associated with the disease activity or the treatment with 5-aminosalicylic acid?显示文摘瞄准:调查在有煽动性的肠疾病(IBD ) 的病人的 microproteinuria 是否与 5-aminosalicylic 酸(5-ASA ) 与疾病活动或治疗被联系。方法:我们有希望地与 IBD 在 86 个连续病人学习了 microproteinuria, 61 与 ulcerative (UC ) 并且 25 与 Crohn 的疾病(CD ) ,以前象在他们在学习的包括以后的 2 和 6 个月一样。46 个病人为 28.8 个月(范围 1-168 瞬间) 的一个时期收到了 5-ASA。Microalbuminuria (妈磅) 和尿肾的管状的蛋白质 beta2-microglobulin (beta2mGLB ) 和 beta-N-acetyl-D-glucosamidase 铺平(贝它 -- 唠叨) 一夜间在 12-h 象 creatinine 一样被决定尿收集。肿瘤坏死 factor-alpha (TNF-alpha ) 浆液层次也被测量。结果:277 大小的一个总数(194 在 UC 病人并且 83 在 CD 病人) 被执行。在 UC 和 CD 病人的反常 microproteinuria 的流行为妈磅是 12.9% 和 6.0% , 22.7% 和 27.7% 为 beta2mGLB,并且 11.3% 和 8.4% 为贝它 -- 分别地唠叨。妈磅没与 IBD 活动被联系。Beta2mGLB 和贝它 -- 唠叨尿层次被相关到 UC 活动(UCAI:P<0.01;UCEI:P<0.005 ) 。在 UC 病人和贝它的妈磅 -- 在 CD 病人唠叨尿层次与 TNF-alpha 浆液层次有关。一个协会在 microproteinuria 和吸烟习惯之间被注意。有 5-ASA 的治疗没被相关到 microproteinuria 的严厉或到 creatinine 的变化。结论:Microproteinuria 主要与 UC 和它的活动被联系然而并非由 5-ASA 影响了。 | Androniki C Poulou Konstantinos E Goumas Dimitrios C Dandakis Ioannis Tyrmpas Maria Panagiotaki Androniki Georgouli Dimitrios C Soutos Athanasios Archimandritis | 2006 | World Journal of Gastroenterology2006，12，5： | 126 |
| 2 | Hepatic encephalopathy:An approach to its multiple pathophysiological features显示文摘Hepatic encephalopathy(HE)is a neuropsychiatric complex syndrome,ranging from subtle behavioral abnormalities to deep coma and death.Hepatic encephalopathy emerges as the major complication of acute or chronic liver failure.Multiplicity of factors are involved in its pathophysiology,such as central and neuromuscular neurotransmission disorder,alterations in sleep patterns and cognition,changes in energy metabolism leading to cell injury,an oxidative/nitrosative state and a neuroinflammatory condition.Moreover,in acute HE,a condition of imminent threat of death is present due to a deleterious astrocyte swelling.In chronic HE,changes in calcium signaling,mitochondrial membrane potential and long term potential expression,N-methyl-D-aspartate-cGMP and peripheral benzodiazepine receptors alterations,and changes in the mRNA and protein expression and redistribution in the cerebral blood flow can be observed.The main molecule indicated as responsible for all these changes in HE is ammonia.There is no doubt that ammonia,a neurotoxic molecule,triggers or at least facilitates most of these changes.Ammonia plasma levels are increased two-to three-fold in patients with mild to moderate cirrhotic HE and up to ten-fold in patients with acute liver failure. Hepatic and inter-organ trafficking of ammonia and its metabolite,glutamine(GLN),lead to hyperammonemic conditions.Removal of hepatic ammonia is a differentiated work that includes the hepatocyte,through the urea cycle,converting ammonia into GLN via glutamine synthetase.Under pathological conditions,such as liver damage or liver blood bypass,the ammonia plasma level starts to rise and the risk of HE developing is high. Knowledge of the pathophysiology of HE is rapidly expanding and identification of focally localized triggers has led the development of new possibilities for HE to be considered.This editorial will focus on issues where, to the best of our knowledge,more research is needed in order to clarify,at least partially,controversial topics. | Juan Carlos Perazzo Silvina Tallis Amalia Delfante Pablo Andrés Souto Abraham Lemberg Francisco Xavier Eizayaga Salvador Romay | 2012 | World Journal of Hepatology2012，4，3： | 16 |
| 3 | Infiltrative xanthogranulomatous cholecystitis mimicking aggressive gallbladder carcinoma: A diagnostic and therapeutic dilemma显示文摘Xanthogranulomatous cholecystitis(XGC) is an uncommon variant of chronic cholecystitis. The perioperative findings in aggressive cases may be indistinguishable from those of gallbladder or biliary tract carcinomas. Three patients presented mass lesions that infiltrated the hepatic hilum,provoked biliary dilatation and jaundice,and were indicative of malignancy. Surgical excision was performed following oncological principles and included extirpation of the gallbladder,extrahepatic bile duct,and hilar lymph nodes,as well as partial hepatectomy. Postoperative morbidity was minimal. Surgical pathology demonstrated XGC and absence of malignancy in all three cases. All three patients are alive and well after years of follow-up. XGC may have such an aggressive presentation that carcinoma may only be ruled out on surgical pathology. In such cases,the best option may be radical resection following oncological principles performed by expert surgeons,in order that postoperative complications may be minimized if not avoided altogether. | Lucas Souto Nacif Amelia Judith Hessheimer Sonia Rodríguez Gómez Carla Montironi Constantino Fondevila | 2017 | World Journal of Gastroenterology2017，23，48： | 13 |
| 4 | Hepatic encephalopathy: Ever closer to its big bang显示文摘Hepatic encephalopathy(HE) is a neuropsychiatric disorder that commonly complicates the course of patients with liver disease. Despite the fact that the syndrome was probably first recognized hundreds of years ago, the exact pathogenesis still remains unclear. Minimal hepatic encephalopathy(MHE) is the earliest form of HE and is estimated to affect more that 75% of patients with liver cirrhosis. It is characterized by cognitive impairment predominantly attention, reactiveness and integrative function with very subtle clinical manifestations. The development of MHE is associated with worsen in driving skills, daily activities and the increase of overall mortality. Skeletal muscle has the ability to shift from ammonia producer to ammonia detoxifying organ. Due to its large size, becomes the main ammonia detoxifying organ in case of chronic liver failure and muscular glutaminesynthase becomes important due to the failing liver and brain metabolic activity. Gut is the major glutamine consumer and ammonia producer organ in the body. Hepatocellular dysfunction due to liver disease, results in an impaired clearance of ammonium and in its interorgan trafficking. Intestinal bacteria, can also represent an extra source of ammonia production and in cirrhosis, small intestinal bacterial overgrowth and symbiosis can be observed. In the study of HE, to get close to MHE is to get closer to its big bang; and from here, to travel less transited roads such as skeletal muscle and intestine, is to go even closer. The aim of this editorial is to expose this road for further and deeper work. | Pablo A Souto Ariel R Marcotegui Lisandro Orbea Juan Skerl Juan Carlos Perazzo | 2016 | World Journal of Gastroenterology2016，22，42： | 6 |
| 5 | High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula显示文摘to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice Age.These proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface wetness.Analysis:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[cal.yr BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier conditions.The Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet phases.The LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification index.However,four different climate phases were differentiated in this period.High-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global models.The study provides new information and a detailed chronology of climatic events that will help to refine local modulation of the climate evolution model in the still quite unexplored region of the NW Iberian Peninsula,a key area for understanding the paleoclimatic dynamics in SW Europe. | Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja Sebastian Perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal | 2020 | Geoscience Frontiers2020，11，5： | 2 |
| 6 | Spectral classification of water masses under the influence of the Amazon River plume显示文摘The large amount of dissolved and particulate material discharged by the Amazon River into the Equatorial Atlantic Ocean cause distinct spectral response of its waters as compared to the nearby ocean waters. This paper shows the application of K-means clustering algorithm for classifying water masses in the region under the Amazon River plume influence according to their spectral behavior. Salinity and temperature data from 67 oceanographic stations were related to Sea-viewing Wide Field-of-view Sensor (SeaWiFS) remote sensing reflectances values and the following bio-optical products: (i) chlorophyll-a concentration, (ii) water attenuation coefficient and (iii) absorption coefficient for dissolved and detrital material. Four different water masses were identified such as: (1) oceanic water, (2) intermediate oceanic water, (3) intermediate river plume water and (4) Amazon River plume water. The spectral behavior of these water masses allowed concluding that the main active optical component of the waters in the region is the colored dissolved organic matter originated mostly from the Amazon River. | Gustavo Souto Fontes Molleri Milton Kampel Evlyn Mrcia Leo de Moraes Novo | 2010 | Acta Oceanologica Sinica2010，29，3： | 2 |
| 7 | Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines显示文摘 | Jácomo R H Melo R A Souto F R | 2007 | Haematologica2007，92，10： | 1 |
| 8 | Influence of amino acids on okadaic acid production显示文摘 | SOUTO M L FERNA′NDEZA J J NORTE M | 2001 | Toxicon2001，，39： | 1 |
| 9 | Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection显示文摘 | Alves-Filho JC S6nego F Souto FO | 2010 | Nat Med2010，16，： | 1 |
| 10 | Lumbosacral angiolipoma:case report显示文摘 | do Souto AA Domingnes IS Chimelli L | 2003 | Arq Neuropsiquiatr2003，61，2： | 1 |
| 11 | Free-response receiver op- erating characteristic evaluation of lossy JPEG2000 and object- based set partitioning in hierarchical trees compression of digitized mammograms显示文摘 | Penedo M Souto M Tahoces P G | 2005 | Radiology2005，237，2： | 1 |
| 12 | Simulation of anti-roll tanks and sloshing type problems with Smoothed Particle Hydrodynamics 显示文摘 | Souto Iglesias A | 2004 | Ocean Engineering2004，31，： | 1 |
| 13 | On the existence and con- centration behaviour of ground state solutions for a class of problems with critical growth 显示文摘 | Alves C O Souto M A S | 2002 | Comm Pure Appl Anal2002，3，： | 1 |
| 14 | Dyeing mechanism and optimization of polyamide 6,6 functionalized with double barrier discharge (DBD) plasma in air显示文摘 | Oliveira F R Zille A Souto A P | 2014 | Applied Sur- face Science2014，293，： | 1 |
| 15 | Analytical matched filter hound for M- QAM hierarchical constellations with diversity lception in multipath rayleigh fading channels 显示文摘 | Souto N Dinis R Silva J C | 2010 | IEEE Trans on Communications2010，58，3： | 1 |
| 16 | The role of antibiotic prophylaxis on wound infection after mesh hernia repair under local anesthesia on an ambulatory basis显示文摘 | Angel Celdrán Octavio Frieyro Juan C. Pinta José L. Souto Jaime Esteban José M. Rubio José F. Se?arís | 2004 | Hernia2004，，1： | 1 |
| 17 | Immune mediators in idiopathic nephrotic syndrome:evidence for a relation between interleukin 8 and proteinuria显示文摘 | Souto MF Teixeira AL Rasso RC | 2008 | Pediatr Res2008，64，： | 1 |
| 18 | Liquid moment amplitude assessment in sloshing type problems with Smooth Paritcle Hydrodynamics显示文摘 | Souto Iglesias A | 2006 | Ocean Eengineering2006，33，： | 1 |
| 19 | Actinomyces species, streptococci, and Enterococcus faecdis in primary root canal in- fections显示文摘 | Siqueira JF Jr R6~as IN Souto R | 2002 | J Endod2002，28，3： | 1 |
| 20 | Allelopathic effects ofhumus phenolics on growth and respiration of myeorrhizal fungi显示文摘 | SOUTO C PELLISSIER F CHIAPUSIO G | 2000 | Journal of Chemical Ecology2000，26，9： | 1 |
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