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| 1 | SHRIMP zircon U-Pb ages of Kalatongke No.1 and Huangshandong Cu-Ni-bearing mafic-ultramafic complexes,North Xinjiang,and geological implications显示文摘The SHRIMP zircon U-Pb dating was carried out and yielded 287±5 Ma (MSWD = 0.34) and 274±3 Ma (MSWD = 1.35) for the Kalatongke No. 1 and Huangshan- dong Cu-Ni-bearing mafic-ultramafic complexes. These ages are much more precise than pre-existing rock-mineral Rb-Sr, Sm-Nd and Re-Os isochron ages for the two complexes and constrain the timing of not only the complexes but also the magmatic Cu-Ni sulfide deposits more reliably. It is neces- sary to carefully reevaluate the previous chronological data for the complexes. The Cu-Ni-bearing mafic-ultramafic com- plexes have the ages similar to those of postcollisional A-type granites in the same area, implying that they could be related to the delamination of lithospheric mantle and upwelling and partial melting of asthenospheric mantle in postcollisional setting. Therefore, the Cu-Ni-bearing mafic-ultramafic com- plexes are a direct indicator of vertical growth of the conti- nental crustal in the Central Asian Orogenic Belt. | HANBaofu JIJianqing SONGBiao CHENLihui LIZonghuai | 2004 | Chinese Science Bulletin2004，49，22： | 104 |
| 2 | SHRIMP Geochronology of Volcanics of the Zhangjiakou and Yixian Formations, Northern Hebei Province, with a Discussion on the Age of the Xing'anling Group of the Great Hinggan Mountains and Volcanic Strata of the Southeastern Coastal Area of China显示文摘A zircon U-Pb geochronological study on the volcanic rocks reveals that both of the Zhangjiakou and Yixian Formations, northern Hebei Province, are of the Early Cretaceous, with ages of 135-130 Ma and 129-120 Ma, respectively. It is pointed out that the ages of sedimentary basins and volcanism in the northern Hebei -western Liaoning area become younger from west to east, i. e. the volcanism of the Luanping Basin commenced at c. 135 Ma, the Luotuo Mount area of the Chengde Basin c. 130 Ma, and western Liaoning c. 128 Ma. With a correlation of geochronological stratigraphy and biostratigraphy, we deduce that the Xing'anling Group, which comprises the Great Hinggan Mountains volcanic rock belt in eastern China, is predominantly of the early-middle Early Cretaceous, while the Jiande and Shimaoshan Groups and their equivalents, which form the volcanic rock belt in the southeastern coast area of China, are of the mid-late Early Cretaceous, and both the Jehol and Jiande Biotas are of the Early Cretaceous, not Late Jurassic or Late Jurassic-Early Cretaceous. Combining the characteristics of the volcanic rocks and, in a large area, hiatus in the strata of the Late Jurassic or Late Jurassic-early Early Cretaceous between the formations mentioned above and the underlying sequences, we can make the conclusion that, in the Late Jurassic-early Early Cretaceous, the eastern China region was of high relief or plateau, where widespread post-orogenic volcanic series of the Early Cretaceous obviously became younger from inland in the west to continental margin in the east. This is not the result of an oceanward accretion of the subduction belt between the Paleo-Pacific ocean plate and the Asian continent, but rather reflects the extension feature, i.e. after the closure of the Paleo-Pacific ocean, the Paleo-Pacific ancient continent collided with the Asian continent and reached the peak of orogenesis, and then the compression waned and resulted in the retreating of the post-orogenic extension from outer orogenic zone to inner part (or collision zone). The determination of the eruption age of the volcanics of the Zhangjiakou Formation definitely constrains the switch period, which began in the Indosinian and finished in the Yanshanian, that is, 140-135 Ma. The switch is concretely the change from the approximate E-W Paleo-Asian tectonic system to the NE to NNE Pacific system, and the period is also the apex of a continent-continent collision and orogenesis of subduction, being consumed and eventually disappearing of the Paleo-Pacific ancient continent, and all the processes commenced in the Indosinian. While the following post-orogenic large-scale eruption in the Early Cretaceous marks the final completeness of the Paleo-Pacific structure dynamics system. | NIUBaogui HEZhengjun SONGBiao RENJishun XIAOLiwei | 2004 | Acta Geologica Sinica(English Edition)2004，78，6： | 63 |
| 3 | Zircon SHRIMP U-Pb dating for the Cangshuipu volcanic rocks and its implications for the lower boundary age of the Nanhua strata in South China显示文摘The continental volcanic rocks and volcaniclastic sedimentary conglomerates of the Cangshuipu Formation occur well in Yiyang of Hunan Province, consisting of a wedge-shaped succession of Neoproterozoic strata that overlie with high-angle unconformity the flysch turbidites of the Lengjiaxi Group in the Upper Mesoproterozoic Eonothem. SHRIMP zircon U-Pb dating gives a weighted mean age of 814 ( 12 Ma for the dacitic volcanic agglomerates from the lowest part of the volcanic rocks in the Cangshuipu Formation. This age is younger than previously reported values of 921-933 Ma for the volcanic rocks from the Cangshuipu Formation. Our new dating represents the lower boundary age of the Neoproterozoic System in the studied area. The younger age for the Cangshuipu volcanic rocks is supported by the following observations: (1) Lower Neoproterozoic strata (814-1000 Ma) are missing in the studied area; (2) the Nanhua rift system was initiated at about 820 Ma; and (3) an age of ~820 Ma may be taken as the lower boundary timing of the Nanhua System (even Neoproterozoic) in South China. | WANGJian LIXianhua DUANTaizhong LIUDunyi SONGBiao LIZhongxiong GAOYonghua | 2003 | Chinese Science Bulletin2003，48，16： | 55 |
| 4 | Zircon U-Pb SHRIMP ages of eclogites from the North Qilian Mountains in NW China and their tectonic implication显示文摘Cathodoluminescence (CL) imaging and ion microprobe (SHRIMP) U-Pb dating were carried out for zircons from eclogites in the North Qilian Mountains. The results show weighted mean ages of 463 6 Ma and 468 13 Ma for two samples, respectively. These ages are the earliest record of Caledonian high-pressure metamorphism in the North Qilian Mountains, and they may represent the timing of eclogite-facies metamorphism when the oceanic crust was subducted to mantle depths in this orogenic belt. | SONGShuguang ZHANGLifei NIUYaoling SONGBiao ZHANGGuibing WANGQianjie | 2004 | Chinese Science Bulletin2004，49，8： | 45 |
| 5 | SHRIMP U-Pb zircon age of the Jinchuan ultramafic intrusion and its geological significance显示文摘 | LIXianhua SULi SONGBiao LIUDunyi | 2004 | Chinese Science Bulletin2004，49，4： | 41 |
| 6 | SHRIMP Age and Geochemistry of the Bikou Volcanic Terrane:Implications for Neoproterozoic Tectonics on the Northern Margin of the Yangtze Craton显示文摘The Bikou volcanic terrane is predominated by subalkaline tholeiitic lavas. Rock samples display lower initialratios of Sr and Nd, 0.701248-0.704413 and 0.511080-0.512341 respectively. 207pb and 208pb are significantly enriched inthe lavas. Most samples have positive εNd, which indicates that the magma was derived from EM-type mantle source,while a few samples with negative εNd indicate that there was contamination in the magma evolution. Magmadifferentiation is demonstrated by variations of LREE and LILE from depletion to enrichment. Additionally, normalizedREE patterns and trace elements showed that lavas from the Bikou volcanic terrane have similar characteristics to those ofbasalts in arc settings caused by subduction and collision. Analyses showed that the Bikou volcanic terrane is a volcanicarc. New evidence proved that the Hengdan Group, north of the Bikou arc, is a turbidite terrane filling a forearc basin.Consequently, the Bikou volcanic terrane and the Hengdan turbidite terrane construct an arc-basin system. New SHRIMPages showed that this arc-basin system developed on the northern margin of the Yangtze craton in the Neoproterozoic(846-776 Ma), and this arc-basin system is in agreement with the tectonic processes of Rodinia in the Neoproterzoic. | YANQuanren WANGZongqi A.D.HANSON P.A.DRUSCHKE YANZhen LIUDunyi JIANPing SONGBiao WANGTao JIANGChunfa | 2003 | Acta Geologica Sinica(English Edition)2003，77，4： | 32 |
| 7 | SHRIMP zircon U-Pb ages of garnet pyroxenite and Fushui gabbroic complex in Song-shugou region and constraints on tectonic evolution of Qinling Orogenic Belt显示文摘 | SULi SONGShuguang SONGBiao ZHOUDingwu HAOJianrong | 2004 | Chinese Science Bulletin2004，49，12： | 30 |
| 8 | SHRIMP U-Pb zircon dating of the uppermost Cretaceous Furao Formation near the Heilong River: An age closest to the K/T boundary显示文摘 | LIXianhua LIWuxian CHENPeiji WANXiaoqiao LIGang SONGBiao JIANGJianhong LIUJicai YINDeshun YANWei | 2004 | Chinese Science Bulletin2004，49，8： | 5 |
| 9 | Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke:the first multicentre,phase III trial in China显示文摘background and purpose Data on the efficacy and safety of alteplase for acute ischaemic stroke(AIS)administered 3-4.5 hours after the onset of stroke symptoms in Chinese patients is limited.We sought to determine whether AIS patients would benefit from thrombolysis with alteplase between 3 and 4.5 hours after the onset of stroke symptoms in a prospective,multicentre,single-arm trial in China.Materials and methods Eligible AIS patients were given 0.9 mg/kg alteplase intravenously.The primary efficacy endpoint was a favourable outcome at 3 months,defined as a score of 0 or 1 on the modified Rankin Scale.Thresholds for the primary efficacy endpoint were determined to be 40%based on the literature review.The primary safety endpoint was symptomatic intracranial haemorrhage(sICH)according to the European Cooperative Acute Stroke Study III(ECASS III)trial definition.Post hoc analysis between this study and the ECASS III trial were compared using the propensity score matching(PSM)method.results A total of 120 eligible AIS patients from 11 sites in China received thrombolysis therapy in this study.The median time from onset of symptoms to needle was 3 hours 54 min.The percentage of patients with a favourable outcome was 63.3%(95%CI 54.4 to 71.4),significantly higher than the predefined threshold(p<0.0001).Three patients(2.5%,95%CI 0.5 to 7.1)had sICH,including two fatal sICH.Six patients died within 3 months after treatment.The post hoc PSM analysis showed a numerically higher rate of the primary efficacy endpoint in this study(63.3%)than the matched placebo arm(56.7%)in the ECASS III trial.Conclusions Intravenous alteplase with a standard dose administered between 3 and 4.5 hours after onset of symptoms is effective and safe for Chinese AIS patients. | Huaguang Zheng Yi Yang Huisheng Chen Chuanling Li Yangkun Chen Fu-Dong Shi Li Yang Xiaoping Cui Zuneng Lu Yanling Liang Songbiao Cui Anding Xu Yiqing Wu Yaqing Sun Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，3： | 4 |
| 10 | Effects of metal ions and heat shock on the expression of a metallothionein-like gene htMT2 in Helianthus tuberosus显示文摘The expression of htMT2 in tissues of Helianthus tuberosus treated with metal ions and heat shock is studied by Northern blot hybridization. The results indicate that htMT2 is not expressed in roots. The expression in leaves and stems can be reduced by Cu2+ and induced by low concentration of Zn2+. However, the expression of htMT2 can be suppressed by Zn2+ when its concentrations are above 500 μmol/L. The effects of Ca2+ on the expression of htMT2 in leaves are similar to that of Zn2+. But Ca2+ induces the expression of htMT2 in stems. The expression levels of htMT2 in various tissues are not significantly affected by heat shock. The results above demonstrate that the expression of htMT2 can be regulated by metal ions and confirm that htMT2 is a new metallothionein-like gene. | CHANG Tuanjie, CHEN Lei, CHEN Wanxin, LU Zixian, CHEN Songbiao and ZHU Zhen(Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China) | 2002 | Progress in Natural Science:Materials International2002，12，7： | 3 |
| 11 | Cloning and Functional Analysis of the Bifunctional Agglutinin/Trypsin Inhibitor from Helianthus tuberosus L.显示文摘以便发现新抗虫性基因,四相应 cDNAs, hta -- 一,有一些 775, 718, 784 和 752 bp 的 hta-b, hta-c 和 hta-d,分别地(GenBank 就职数字 AF477031-AF477034 ) ,从 Helianthustuberosus L 的一个 tuber cDNA 表示图书馆被孤立。顺序分析表明所有四 cDNAs 包含 444 bp 的一个开的读物框架,编码 147 氨基酸残余的多肽,并且 cDNAs 的序列很类似于 jacalin 相关的家庭的甘露糖绑定凝集素基因的那些。Inhemagglutination 反应和幸运十抑制试金,从表示 GST-HTA 的导致的 Escherichia 关口 i BL21 (DE3 ) 的净化亲密关系的 HTA (向日葵 tuberosusagglutinin ) 比另外的测试的糖为甘露糖显示出红血球凝聚能力和一个更高的糖类绑定能力。Trypsininhibitory 活动在导致的 E 的粗略的摘录被检测。表示 HTA 的关口 i BL21 (DE3 ) ,并且被胰岛素进一步验证禁止的活动在本国的聚丙烯酰胺上染色胶化。在 HTA 和胰岛素之间的相互作用的 Themechanism 被分子的建模学习。我们发现很多的氢契约和静电的相互作用能在 HTA-b 的建议有约束力的地点和胰岛素的活跃地点之间被形成,并且稳定的 HTA/trypsin 建筑群能被形成。上面的结果暗示 HTA 可能是一个双性人有糖类绑定活动和胰岛素的功能的蛋白质禁止的活动。而且,北弄污分析证明 hta 主要在 H 的澡盆 ers 被表示。tuberosus,很微弱地在茎表示了,然而并非根本在另外的纸巾表示了。南部的弄污分析显示那 hta 被编码由一 multi-genefamily。抗虫性特点在另一份报纸被描述了。 | Tuanjie Chang Hongli Zhai Songbiao Chen Guisheng Song Honglin Xu Xiaoli Wei Zhen Zhu | 2006 | Journal of Integrative Plant Biology2006，48，8： | 2 |
| 12 | Green fluorescent protein as a vital elimination marker to easily screen marker-free transgenic progeny derived from plants co-transformed with a double T-DNA binary vector system显示文摘 | Songbiao Chen Xugang Li Xiang Liu Hongling Xu Kun Meng Guifang Xiao Xiaoli Wei Feng Wang Zhen Zhu | 2005 | Plant Cell Reports2005，，9： | 1 |
| 13 | High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells显示文摘Clear cell renal cell carcinoma(ccRCC)is a frequently occurring renal cancer.The Von Hippel-Lindau disease tumor suppressor VHL,a known tumor suppressor gene,is frequently mutated in about 50%of patients with ccRCC.However,it is unclear whether VHL influences the progression of ccRCC tumors expressing wild-type VHL.In the present study,we found that higher expression of VHL was correlated with the better disease-free survival(DFS)in ccRCC patients using The Cancer Genome Atlas(TCGA)datasets.We revealed that VHL overexpression in ccRCC cells inhibited epithelial-mesenchymal transition(EMT),sterol regulatory elementbinding protein 1(SREBP1)-regulated triglyceride synthesis,and cell proliferation.Proteomic analysis provided us a global view that VHL regulated four biological processes,including metabolism,immune regulation,apoptosis,and cell movement.Importantly,we found that VHL overexpression led to up-regulated expression of proteins associated with antigen processing and interferonresponsive proteins,thus rendering ccRCC cells more sensitive to interferon treatment.We defined an interferon-responsive signature(IRS)composed of ten interferon-responsive proteins,whose m RNA expression levels were positively correlated with DFS in ccRCC patients.Taken together,our results propose that the subset of ccRCC patients with high VHL expression benefit from immunotherapy. | Songbiao Zhu Wenxi Ding Yuling Chen Weixuan Wang Renhua Xu Chongdong Liu Xiaohui Liu Haiteng Deng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，4： | 1 |
| 14 | A versatile zero background T-Vector systemfor gene cloning and functional genomics显示文摘 | SONGBIAO C PATrAVIPHA S JIANLI L | 2000 | Plant Physiology2000，150，： | 1 |
| 15 | A metallothionein-like gene htMT2 strongly expressed in internodes and nodes of Helianthus tuberosus and effects of metal ion treatment on its expression显示文摘 | Tuanjie Chang Xiang Liu Honglin Xu Kun Meng Songbiao Chen Zhen Zhu | 2004 | Planta2004，，3： | 1 |
| 16 | Green fluorescent protein as a vital elimination marker to easily screen marker-free transgenic progeny derived from plants co-transformed with a double T-DNA binary vector system显示文摘 | Songbiao Chen Xugang Li Xiang Liu Hongling Xu Kun Meng Guifang Xiao Xiaoli Wei Feng Wang Zhen Zhu | 2005 | Plant Cell Reports2005，，9： | 1 |
| 17 | Green fluorescent protein as a vital elimination marker to easily screen marker-free transgenic progeny derived from plants co-transformed with a double T-CAN binary vector system显示文摘 | Songbiao Chen Xugang Li Xiang Liu | 2005 | Plant Cell Rep2005，23，： | 1 |
| 18 | A rersatile zero background T-rector system for gene coning and func-tional genomics显示文摘 | Songbiao C Pattavipha S Jianli L | | 0，，： | 1 |
| 19 | Changes of Aroma Components in 'Keitt' Mango during the Postharvest Period显示文摘[Objective]This study aimed to investigate the changes of aroma components in mango fruit at different post-harvest stages.[Method]The aroma components in‘Keitt'mango fruit at 3,6,9 and 13 d postharvest were extracted using head-space solid phase microextraction( HS-SPME) and analyzed by gas chromatograph-mass spectrophotometer( GC-MS).[Result]The results showed that a total of 42 aroma compounds were identified from the mango samples at four stages. To be specific,monoterpene and sesquiterpene were the major components; at 3,6,9 and 13 d postharvest,the relative contents of terpene were 94. 24%,98. 91%,55. 32% and 95. 97%,respectively.[Conclusion]1S-( +)-3-carene is the characteristic aroma component in ripe fruit of‘Keitt'mango. The aroma of mango fruit is also affected by ester,alcohol and aldehyde compounds. | Yigang ZHOU Hongxia WU Quansheng YAO Songbiao WANG Changbin WEI Xiaowei MA | 2014 | Agricultural Biotechnology2014，3，2： | 1 |
| 20 | The Magna- porthe oryzae effector AvrPizt targets the RING E3 ubiquitin ligase APIP6 to suppress pathogen-associated molecular pat- tern-triggered immunity in rice 显示文摘 | Park C H Chen Songbiao Shiraekar G | 2012 | Plant Cell2012，24，11： | 1 |
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