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| 1 | 不同提取方法山苍子油的化学成分与抗氧化活性分析显示文摘【目的】比较不同提取方法对山苍子油提取效率与抗氧化活性的影响,通过GC-MS分析,研究山苍子油成分构成与抗氧化活性的内在关联,分析山苍子油抗氧化活性的主要物质基础。【方法】采用液液萃取(分别加以超声波与磁化辅助处理)、二氧化碳超临界萃取以及水蒸气蒸馏法提取山苍子油,DPPH法比较不同提取方式对山苍子油抗氧化活力的影响,GC-MS分析山苍子油的主要成分,并以1,4-二溴苯为内标,采用面积归化法解析主要成分的相对含量。【结果】山苍子油具有显著的抗氧化活性。液液萃取法的提取效率与山苍子油抗氧化活性最高,超声波辅助处理油得率最高,为26.3%,磁化辅助处理抗氧化活性最优,达到31.22 mg·mL^-1(IC50),二氧化碳超临界萃取法次之,抗氧化活性为56.95 mg·mL^-1(IC50),水蒸气蒸馏法抗氧化活性最弱,为64.95 mg·mL^-1(IC50);GC-MS分析检测出122种以上的化合物,包括12种脂肪酸,16种萜烯,18种含氧萜烯以及其他微量化合物包括烯烃、醇、酮类与烷烃等。GC-MS分析结果表明:山苍子干果主要成分为饱和脂肪酸(月桂酸等)、不饱和脂肪酸(9,12-十八碳二烯酸、9-十八碳烯酸等)以及α蒎烯、β蒎烯、柠檬烯等萜烯、氧化萜烯类物质。液液萃取法得到的山苍子油脂肪酸含量(53.51%-66.61%)明显高于二氧化碳超临界萃取(17.64%)与水蒸气蒸馏法(8.1%),而二氧化碳超临界萃取与水蒸气蒸馏法得到的萜烯、氧化萜烯类含量分别达到29.37%和17.69%,明显高于液液萃取法(6.49%-9.75%)。【结论】磁化辅助处理有利于抗氧化活性物质的提取,且不饱和脂肪酸的含量最高;超声波辅助处理可以提升油的得率;水蒸气蒸馏法和超临界流体萃取法更有利于萜烯类化合物的获取;联系到水蒸气蒸馏法得到的山苍子油富含萜烯化合物却显示较低的抗氧化活性(64.95 mg·mL^-1),色谱级的柠檬醛抗氧化活性最低(74.33 mg·mL^-1),因此推测脂肪酸成分(特别是不饱和脂肪酸)是山苍子油抗氧化活性的主要物质基础。 | 李芳 Yaru Song Howard Holness Kevin O’Shea | 2015 | 林业科学2015，51，3： | 14 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Power flow in the coupled dynamic system of machinery and building floor显示文摘The transmision mechanism of vibrational power flow in the complex flekible coupled system of machinery mouned on a multi-storey plant building via isolators are studied in this paper from the viewpoint of energy. In view of practical isolation designs in engineering,an asymmetric isolation system with mtiltiple isolators on a fiekible foundation is modeled, in which the interactions between the machine and the floor, and among different mouating points are taken illto account. Moreover, the transmission characteristics of power flow in the system concerned are analyzed with the use of subsystem mobility synthetic techaique. Further more,the power flow spectra of the asymmetric system are calculated and compared with those of symmetric one to reveal the effects of asymmetricity and system parameters on the power flow.Finally, new approaches to the control of structural vibration and acoustics for this kin of problems are proposed. | XIONG Yeping Song K.J. and Wang C.(Institute o, Engineerng Medanics, Sandong University of Technology, Jinan, 250014) | 1996 | Chinese Journal of Acoustics1996，15，1： | 3 |
| 4 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 5 | RNA编辑介导了COPA的功能转换显示文摘【据Journal of Hepatology 2021年1月报道】RNA编辑介导了COPA的功能转换--最新发现的肝细胞癌发生机制(作者Song Y等)RNA编辑与RNA序列中的核苷酸变化相关。近期有研究报道了异常腺苷和肌苷的RNA编辑与癌症相关。目前为止,很少发现具有重要功能的蛋白质编辑靶点与肝癌相关。来自新加坡国立大学的Song等研究了蛋白质的编辑靶点COPA(coatomer亚基α)在肝细胞癌(HCC)中的作用。 | SONG Y AN O REN X 张海玲 胡玉琳 | 2021 | 临床肝胆病杂志2021，37，2： | 2 |
| 6 | Phosphodiesterase 4D polymorphisms and the risk of cerebral infarction in a biracial population:the stroke prevention in young women study显示文摘 | Cole JW O'Connell JR | 2006 | Hum Mol Genet2006，15，： | 1 |
| 7 | Availability, reliability and downtime of systems with repairable components显示文摘 | KIUREGHIAN A D DITLEVSEN O D SONG J | 2007 | Reliability Engineering and System Safety2007，92，2： | 1 |
| 8 | Direct competitive enzyme-linked immunosorbent assay for sulfamethazlne显示文摘 | Euna K O Song H Park J H | 2000 | J Vet Med Sci2000，62，： | 1 |
| 9 | Effects of pretwist and presetting on coupled bending vibrations of rotating thin-walled composite beams显示文摘 | Oh S Y Song O Librescu L | 2003 | International Journal of Solids and Structures2003，40，5： | 1 |
| 10 | A novel genetic system to detect protein-protein interactions显示文摘 | Fields S Song O | 1989 | Nature1989，340，6230： | 1 |
| 11 | Physical properties of gelidium corneum-gelatin blend films containing grapefruit seed extract or green tea extract and its application in the packaging of pork loins显示文摘 | HONG Y H LIM G O SONG K B | 2009 | Food Science2009，74，1： | 1 |
| 12 | A Novel Genetic System to Detect Protein-Protein Interactions 显示文摘 | FIELDS S SONG O | 1989 | Nature1989，340，6230： | 1 |
| 13 | Apreliminary design study for the HYPER system显示文摘 | PARK W S SONG T Y LEE B O | 2002 | Nuclear Engineering and Design2002，219，3： | 1 |
| 14 | Gender differences in mortality after mitral valve operation : evidence for higher mortality in perimenopausal women 显示文摘 | Song HK Grab JD O'Brien SM | 2008 | Ann Thorac Surg2008，85，： | 1 |
| 15 | Uitrasonicallyinduced degradation of 2-meth-ylisoborneol and geosmin 显示文摘 | Song W H Sheake O | 2007 | Water Research2007，41，： | 1 |
| 16 | Stable but nondissipative water显示文摘 | Song O Y Shin H Ko H S | 2005 | ACM Transactions on Graphics2005，24，1： | 1 |
| 17 | Synthesis of methane gas hydrate in porous sediments and its dissociation by depressurizing显示文摘 | KONO H O NARASIMHAN S SONG F | 2002 | Powder Technology2002，122，23： | 1 |
| 18 | lntestinal Npt 2b Plays a Major Role in Phosphate Absorption and Homeostasis显示文摘 | Sabbagh Y Brien S P O Song W | 2009 | Journal of the American So- ciety of Nephrology2009，20，11： | 1 |
| 19 | A novel genetic system to detect pro- tein-protein interactions 显示文摘 | Fields S Song O | 1989 | Nature1989，340，6230： | 1 |
| 20 | Apoptotic pathways in tumor progression and therapy显示文摘 | Melet A Song K Bucur O | 2008 | Adv Exp Med Biol2008，615，： | 1 |
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