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| 1 | Portal hemodynamics as predictors of high risk esophageal varices in cirrhotic patients显示文摘AIM: To evaluate portal hypertension parameters in liver cirrhosis patients with and without esophageal varices (EV). METHODS: A cohort of patients with biopsy confirmed liver cirrhosis was investigated endoscopically and with color Doppler ultrasonography as a possible non-invasive predictive tool. The relationship between portal hemodynamics and the presence and size of EV was evaluated using uni-and multivariate approaches. RESULTS: Eighty five consecutive cirrhotic patients (43 men and 42 women) were enrolled. Mean age (± SD) was 47.5 (± 15.9). Portal vein diameter (13.88 ± 2.42 vs 12.00 ± 1.69, P < 0.0005) and liver vascular index (8.31 ± 2.72 vs 17.8 ± 6.28, P < 0.0005) were found to be significantly higher in patients with EV irrespective of size and in patients with large varices (14.54 ± 1.48 vs 13.24 ± 2.55, P < 0.05 and 6.45 ± 2.78 vs 10.96 ± 5.05, P < 0.0005, respectively), while portal vein flow velocity (13.25 ± 3.66 vs 20.25 ± 5.05, P < 0.0005), congestion index (CI) (0.11 ± 0.03 vs 0.06 ± 0.03, P < 0.0005), portal hypertensive index (2.62 ± 0.79 vs 1.33 ± 0.53, P < 0.0005), and hepatic (0.73 ± 0.07 vs 0.66 ± 0.07, P < 0.001) and splenic artery resistance index (RI) (0.73 ± 0.06 vs 0.62 ± 0.08, P < 0.0005) were significantly lower. A logistic regression model confirmed spleen size (P = 0.002, AUC 0.72) and portal hypertensive index (P = 0.040, AUC 0.79) as independent predictors for the occurrence of large esophageal varices (LEV). CONCLUSION: Our data suggest two independent situations for beginning endoscopic evaluation ofcompensated cirrhotic patients: Portal hypertensive index > 2.08 and spleen size > 15.05 cm. These factors may help identifying patients with a low probability of LEV who may not need upper gastrointestinal endoscopy. | Mohammad K Tarzamni Mohammad H Somi Sara Farhang Morteza Jalilvand | 2008 | World Journal of Gastroenterology2008，14，12： | 15 |
| 2 | Personality factors and profiles in variants of irritable bowel syndrome显示文摘AIM: To study the association between irritable bowel syndrome (IBS) variants (constipation,diarrhea,or both) and personality traits in non-psychiatric patients. METHODS: IBS was diagnosed using the Rome Ⅱ diagnostic criteria after exclusion of organic bowel pathology. The entry of each patient was confirmed following a psychiatric interview. Personality traits and the score of each factor were evaluated using the NEO Five Factor Inventory. RESULTS: One hundred and fifty patients were studied. The mean age (± SD) was 33.4 (± 11.0) year (62% female). Subjects scored higher in neuroticism (26.25 ± 7.80 vs 22.92 ± 9.54,P < 0.0005),openness (26.25 ± 5.22 vs 27.94 ± 4.87,P < 0.0005) and conscientiousness (32.90 ± 7.80 vs 31.62 ± 5.64,P < 0.01) compared to our general population derived from universities of Iran. Our studied population consisted of 71 patients with Diarrhea dominant-IBS,33 with Constipation dominant-IBS and 46 with Altering type-IBS. Scores of conscientiousness and neuroticism were significantly higher in C-IBS compared to D-IBS and A-IBS (35.79 ± 5.65 vs 31.95 ± 6.80,P = 0.035 and 31.97 ± 9.87,P = 0.043,respectively). Conscientiousness was the highest dimension of personality in each of the variants. Patients with C-IBS had almost similar personality profiles,composed of higher scores for neuroticism and conscientiousness,with low levels of agreeableness,openness and extraversion that were close to those of the general population. CONCLUSION: Differences were observed between IBS patients and the general population,as well as between IBS subtypes,in terms of personality factors. Patients with constipation-predominant IBS showed similar personality profiles. Patients with each subtype of IBS may benefit from psychological interventions,which can be focused considering the characteristics of each subtype. | Alireza Farnam Mohammad H Somi Firouz Sarami Sara Farhang Sanaz Yasrebinia | 2007 | World Journal of Gastroenterology2007，13，47： | 10 |
| 3 | Lactobacillus plantarum B7 inhibits Helicobacter pylori growth and attenuates gastric inflammation显示文摘AIM:To determine the anti-Helicobacter property of Lactobacillus plantarum B7(L.plantarum)B7 supernatants in vitro and the protective effects of L.plantarum B7 on serum tumor necrosis factor-alpha(TNF-?),gastric malondialdehyde(MDA)level,apoptosis,and histopathology in Helicobacter pylori(H.pylori)-induced gastric inflammation in rats. METHODS:In vitro,the inhibition of H.pylori growth was examined using L.plantarum B7 supernatants at pH 4 and pH 7 and at the concentration of 1×,5×and 10×on plates inoculated with H.pylori.The inhibitory effect of H.pylori was interpreted by the size of the inhibition zone.In vitro,male Sprague-Dawley rats were randomly divided into four groups including group 1(control group),group 2(H.pylori infected group), group 3(H.pylori infected with L.plantarum B7 106 CFUs/mL treated group)and group 4(H.pylori infected with L.plantarum B7 1010 CFUs/mL treated group).One week after H.pylori inoculation,L.plantarum B7 106 CFUs/mL or 10 10 CFUs/mL were fed once daily to group 3 and group 4,respectively,for one week.Blood and gastric samples were collected at the end of the study. RESULTS:In vitro,at intact pH 4,mean inhibitory zone diameters of 8.5 mm and 13 mm were noted at concentrations of 5×and 10×of L.plantarum B7 supernatant disks,respectively.At adjusted pH 7, L.plantarum B7 supernatants at concentrations of 5 ×and 10×yielded mean inhibitory zone diameters of 6.5 mm and 11 mm,respectively.In the in vitro study, in group 2,stomach histopathology revealed mild to moderate H.pylori colonization and inflammation.The level of gastric MDA and epithelial cell apoptosis were significantly increased compared with group 1.The serum TNF-??level was significant decreased in group 3 compared with group 2(P<0.05).In addition,L.plantarum B7 treatments resulted in a significant improvement in stomach pathology,and decreased gastric MDA level and apoptotic epithelial cells. CONCLUSION:L.plantarum B7 supernatant inhibits H.pylori growth.This inhibition was dose-dependent and greater at pH 4.Moreover,L.plantarum B7 attenuated H.pylori-induced gastric inflammation. | Chompoonut Sunanliganon Duangporn Thong-Ngam Somying Tumwasorn Naruemon Klaikeaw | 2012 | World Journal of Gastroenterology2012，18，20： | 6 |
| 4 | Role of international criteria in the diagnosis of autoimmune hepatitis显示文摘AIM: To study the clinical and laboratory characteristics of autoimmune hepatitis (AIH), and compare them with International Autoimmune Hepatitis Group (IAHG) criteria. METHODS: Sixty consecutive patients with AIH attended the University Clinic at Tabriz University of Medical Sciences, Iran for a 12mo period and were assessed in a case series study. Serological and biochemical evaluations were carried out in all patients. Autoantibodies, such as antinuclear antibody (ANA), anti-smooth muscle antibody (ASMA), anti-liver-kidney microsomal antibody (ALKM-1) type 1, and perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCA) were evaluated in these patients. A liver biopsy was performed after diagnosis of the disease. Patients were evaluated in terms of their signs and symptoms, and laboratory results and the degree to which they corresponded with the diagnostic criteria of IAHG. In this study, both a comprehensive diagnostic scoring system and a simplified diagnostic scoring system were employed for AIH.RESULTS: Sixty patients, 2-0 male, 40 female, mean age 39.45 ± 17.50 years, participated in the study. Treatment began immediately after enrolment into the study. The percent distribution of the study population into definite and probable did not change after the treatment. The most common symptoms in descending order were fatigue (100%), icter (66.7%), abdominal discomfort (33.3%), abdominal distension (2-8.3%), dark urine (2-3.3%), edema (2-3.3%), hematemesis (2-0.0%), pruritus (2-0.0%), melena (11.7%) and pale stool (10.0%). At the physical examination, splenomegaly, ascites, hepatomegaly, epigastric tenderness and an abdominal mass were found in 50.0%, 16.7%, 13.3%, 5.0% and 3.3% of patients, respectively. Hypergammaglobulinemia was detected in 95.0% of cases. ALKM-1, P-ANCA, ANA and ASMA were positive in 71.4%, 66.7%, 42-.4% and 19.4% of cases, respectively. Portal hypertensive gastropathy (45.0%), esophageal varices (41.7%) and cirrhosis (40.0%) were the most prevalent complications of AIH, and there was no evidence of primary sclerosing cholangitis, ulcerative colitis and overlap syndrome in these patients. According to IAHG criteria, 80.0% of cases had a definite diagnosis, 15.0% had a probable diagnosis and 5.0% had no AIH. The percent distribution of the study population into definite, probable and no AIH did not change after using the simplified diagnostic scoring system for AIH. CONCLUSION: This research showed that the majority of cases in our study were appropriately diagnosed according to the IAHG criteria and simplified scoring system. Thus, these criteria are very useful. | Mohammad Reza Abdollahi Mohammad Hossein Somi Esmaeil Faraji | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 5 | Induction of desiccation tolerance in desiccation sensitive Citrus limon seeds显示文摘Many economically important perennial species bear recalcitrant seeds, including tea, coffee, cocoa, mango,citrus, rubber, oil palm and coconut. Orthodox seeds can be dried almost completely without losing viability, but so-called recalcitrant seeds have a very limited storage life and die upon drying below a higher critical moisture content than orthodox seeds. As a result, the development of longterm storage methods for recalcitrant seeds is compromised.Lowering this critical moisture content would be very valuable since dry seed storage is the safest, most convenient and cheapest method for conserving plant genetic resources.Therefore, we have attempted to induce desiccation tolerance(DT) in the desiccation sensitive seeds of Citrus limon. We show that DT can be induced by paclobutrazol(an inhibitor of gibberellin biosynthesis) and we studied its associated transcriptome to delineate the molecular mechanisms underlying this induction of DT. Paclobutrazol not only interfered with gibberellin related gene expression but also caused extensive changes in expression of genes involved in the biosynthesis and signaling of other hormones. Paclobutrazol induced a transcriptomic switch encompassing suppression of biotic-and induction of abiotic responses.We hypothesize that this is the main driver of the induction of DT by paclobutrazol in C. limon seeds. | Alexandre Marques Harm Nijveen Charles Somi Wilco Ligterink Henk Hilhorst | 2019 | Journal of Integrative Plant Biology2019，61，5： | 5 |
| 6 | Tacrolimus and mycophenolate mofetil as second-line treatment in autoimmune hepatitis:Is the evidence of sufficient quality to develop recommendations?显示文摘BACKGROUND The standard management of autoimmune hepatitis(AIH)is based on corticosteroids,alone or in combination with azathioprine.Second-line treatments are needed for patients who have refractory disease.However,high-quality data on the alternative management of AIH are scarce.AIM To evaluate the efficacy and safety of tacrolimus and mycophenolate mofetil(MMF)and the quality of evidence by using the Grading of Recommendations Assessment,Development and Evaluation approach(GRADE).METHODS A systematic review and meta-analysis of the available data were performed.We calculated pooled event rates for three outcome measures:Biochemical remission,adverse events,and mortality,with their corresponding 95%confidence intervals(CI).RESULTS The pooled biochemical remission rate was 68.9%(95%CI:60.4-76.2)for tacrolimus,and 59.6%(95%CI:54.8-64.2)for MMF,and rates of adverse events were 25.5%(95%CI:12.4-45.3)for tacrolimus and 24.1%(95%CI:15.4-35.7)for MMF.The pooled mortality rate was estimated at 11.5%(95%CI:7.1-18.1)for tacrolimus and 9.01%(95%CI:6.2-12.8)for MMF.Pooled biochemical remission rates for tacrolimus and MMF in patients with intolerance to standard therapy were 56.6%(CI:43.4-56.6)vs 73.5%(CI:58.1-84.7),and among non-responders were 59.1%(CI:48.7-68.8)vs 40.8%(CI:32.3-50.0),respectively.Moreover,the overall quality assessments using GRADE proved to be very low for all our outcomes in both treatment groups.CONCLUSION Tacrolimus and MMF are in practice considered effective for patients with AIH who are non-responders or intolerant to first-line treatment,but we found no high-quality evidence to support this statement. | Mohammadreza Abdollahi Neda Khalilian Ekrami Morteza Ghojazadeh H Marike Boezen Mohammadhossein Somi Behrooz Z Alizadeh | 2020 | World Journal of Gastroenterology2020，26，38： | 5 |
| 7 | Influence of tool material and rotational speed on mechanical properties of friction stir welded AZ31B magnesium alloy显示文摘In this investigation,the effect of friction stir welding(FSW)parameters such as tool material rotational speed,and welding speed on the mechanical properties of tensile strength,hardness and impact energy of magnesium alloy AZ31B was studied.The experiments were carried out as per Taguchi parametric design concepts and an L9 orthogonal array was used to study the influence of various combinations of process parameters.Statistical optimization technique,ANOVA,was used to determine the optimum levels and to find the significance of each process parameter.The results indicate that rotational speed(RS)and traverse speed(TS)are the most significant factors,followed by tool material(TM),in deciding the mechanical properties of friction stir processed magnesium alloy.In addition,mathematical models were developed to establish relationship between different process variables and mechanical properties. | Ugender Singarapu Kumar Adepu Somi Reddy Arumalle | 2015 | Journal of Magnesium and Alloys2015，3，4： | 2 |
| 8 | Corrosion Behavior of AZ31 Magnesium Alloy in Highly Alkaline Environment显示文摘Industrial components made with a magnesium-aluminum alloy AZ31 are often used in diverse engineering applications where component weight,strength,and durability are critical.Similarly as other Mg alloys,however,the AZ31 is susceptible to corrosion in alkaline environments.In this work,corrosion of commercial grade AZ31 alloy plate was examined in potassium hydroxide(KOH) using immersion and potentiodynamic studies.The results suggest that the concentration of Al and Mn in the alloy may govern the kinetics of micro-galvanic corrosion and the initiation of corrosion pits.Further,trace amounts of Ni in the AZ31 alloy were seen to enable formation of Ni(OH)2 surface layer,which may have further accelerated alloy corrosion due to its cracking and void coalescence.The effect of pH on the corrosion behavior of AZ31 was studied with reference to Pourbaix diagrams. | Somi Doja Lukas Bichler Simon Fan | 2017 | Acta Metallurgica Sinica(English Letters)2017，30，4： | 2 |
| 9 | The status of antimicrobial resistance of Helicobacter pylori in Eastern Azerbaijan, Iran: comparative study according to demographics显示文摘 | Morteza Milani Reza Ghotaslou Mohammad T. Akhi Mohammad R. Nahaei Alka Hasani Mohammad H. Somi Mandana Rafeey Yaeghob Sharifi | 2012 | Journal of Infection and Chemotherapy2012，，6： | 2 |
| 10 | Effects of probiotic yo- gurt consumption on metabolic factors in individuals with nonal- coholic fatty liver disease显示文摘 | Nabavi S Rafraf M Somi MH | 2014 | J Dairy Sci2014，97，12： | 1 |
| 11 | Thromibin inhibition attenuates neurodegeneration and cerebral edema formation following transient forebrain ischemia显示文摘 | Ohyama H Ho somi N Takahashi T | 2001 | Brain Res2001，902，2： | 1 |
| 12 | BMP and FGF regulate the differentiation of muhipotential pericardial mesoderm into the myocardial or epicardial lineage显示文摘 | Kruithof BP van Wijk B Somi S | 2006 | Dev Biol2006，295，2： | 1 |
| 13 | Adsorption of carbon dioxide using impregnated activated carbon promoted by zinc显示文摘 | Somy A Mehrnia M R Amrei H D | 2009 | Int J Greenhouse Gas Control2009，3，3： | 1 |
| 14 | Greenhouse gas emissions from reservoirs of the western United States显示文摘 | SOMIS N DUCHEMIN E CANUEL R | 2004 | Global Biogeochemical Cycles2004，18，： | 1 |
| 15 | BMP and FGF regulate the differenti- ation of multipotential pericardial mesoderm into the myocardial or epicardial lineage 显示文摘 | Kruithof BP van Wijk B Somi S | 2006 | Dev Biol2006，295，2： | 1 |
| 16 | Evaluation of the My-coDot test in patients with suspected tuberculosis in a field settingin Tanzania显示文摘 | Somi GR O'Brien RJ Mfinanga GS | 1999 | Int J Tuberc Lung Dis1999，3，3： | 1 |
| 17 | Some early results related to electrical impedance of normal and abnormal gastric tissue 显示文摘 | Keshtkar A Salehnia Z Somi MH | 2012 | Phys Med2012，28，1： | 1 |
| 18 | Cytokines during early pregnancy of mam- mals : a review 显示文摘 | Schafer - Somi S | 2003 | Animal Reprod Sei2003，75，12： | 1 |
| 19 | Cytokines during early pregnancy mammals显示文摘 | Somi S S | 2003 | Anim Reprod Sci2003，75，： | 1 |
| 20 | Cytokines during early pregnancy of mammals: a review显示文摘 | Somi SS | 2003 | Animal Reproduction Science2003，75，12： | 1 |
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