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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Embryo- growth rate and duration in sunflower as affected by tem- perature显示文摘 | CHIMENTI C A Hall A J SOL LOAPEZ M | 2001 | Field Crops Research2001，69，： | 1 |
| 3 | Hallux valgus in heritance:pedigree research in 350 patients with bunion deformity显示文摘 | Piqu-vidal C Sol MT Antich J | 2007 | J Foot Ankle Surg2007，46，3： | 1 |
| 4 | Effect of drainage area on hypsometry from an analysis of small-scale drainage basins in the Siwalik Hills (central Nepal)显示文摘 | Hurtrez J E Sol C Lucazeau F | | 0，，： | 1 |
| 5 | Hallux valgus in-heritance:pedigree research in 350 patients with bunion deformity显示文摘 | Piqu-Vidal C Sol MT Antich J | 2007 | J Foot Ankle Surg2007，46，3： | 1 |
| 6 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 7 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Clin Microbiol1990，28，3： | 1 |
| 8 | The role of self - efficacy in vascular risk factor management: a ran- domized controlled trial显示文摘 | SOL B G VAN I)ER GRAAF Y VAN DER BIJL J J et at | 2008 | Patient Educ Couns2008，71，2： | 1 |
| 9 | Effect and drainage area on hypsornetry from an analysis of small-scale drainage basins in the Siwalik hills( Central Nepal)显示文摘 | HURTREZ J E SOL C LUCAZEAU F | 1999 | Earth Surface Processes and Landforms1999，24，9： | 1 |
| 10 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R Sol C J Salimans M M | 1990 | J Cli Microbiol1990，28，3： | 1 |
| 11 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R C J A Sol M M M Salimans | 1990 | Journal of Clinical Microbiology1990，28，： | 1 |
| 12 | Rapid and simple methods for purification ofnucleic acid 显示文摘 | Boom R Sol C J A Salimans M M M | 1990 | J Clin Microbiol1990，28，： | 1 |
| 13 | Design of optical wide-band log-periodic nanoantennas using surface integral equation techniques 显示文摘 | SOL TABOADA J M ARA~O G | 2013 | Optics Communications2013，，8： | 1 |
| 14 | Rapid and simple method for purification of nucleic acids显示文摘 | Boom R C J Sol M M Salimans | 1990 | J Clin Microbiol1990，28，： | 1 |
| 15 | Effect of drainage area on hypsometry from an analysis of small-scale drainage basins in the Siwalik Hills(central Nepal)显示文摘 | Hurtrez J E Sol C Lucazeau F | 1999 | Earth Surface Processes and Landorms1999，328，： | 1 |
| 16 | A mixed numerical/experimentaltechnique for the nondestructive identification of the stiffnessproperties of fibre reinforced composite materials显示文摘 | H Sol H Hua J De Visscher | 1997 | NDT&EInternational(S0963-8695)1997，2，30： | 1 |
| 17 | Measurements of the Dynamic Rail Pad Properties 显示文摘 | MAES J SOL H GUILLAUME P | 2006 | Journal of Sound and Vibration2006，，293： | 1 |
| 18 | Paraneoplastic pemphigus:a case of long-term survival associated with systemic lupus erythematosus and polymyositis显示文摘 | Mascaró JM Jr Ferrando J Solé MT | 1999 | Dermatology1999，199，1： | 1 |
| 19 | The Program for the Prevention of Childhood Asthma:a specialized care program for children with wheezing or asthma in Brazil显示文摘 | Urrutia-Pereira M Avila J SoléD | 2016 | J Bras Pneumol2016，42，1： | 1 |
| 20 | Social interaction, co-worker altruism and incentives 显示文摘 | Dur R Sol J | 2010 | Games and Economic Behavior2010，69，2： | 1 |
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