2篇
您的检索式：作者名="Slama Aida"
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| 1 | Vogt-Koyanagi-Harada综合征与克罗恩病:一种独特的关系显示文摘Vogt-Koyanagi-Harada disease(VKH)is a rare,multisystem disease of melanocyte-containing organs.It is characterized by diffuse,granulomatous inflammation involving various organs.It has been reported to occur in association with other autoimmune disorders.We report the case of a female patient who was diagnosed with VKH at the age of 4 years and who was treated with corticosteroids until the age of 16.Twenty years later,Crohn’s disease was diagnosed,with a severe flare-up.Three cases of VKH associated with ulcerative colitis have previously been reported anecdotally but,to our knowledge,this is the first case occurring in association to Crohn’s disease. | Ahlem Souguir Aya Hammami Wafa Dahmeni Hanene Jaziri Imed Ben Mansour Ahlem Zayene Aida Ben Slama Mehdi Ksiaa Ahlem Brahem Salem Ajmi Ali Jmaa | 2018 | Gastroenterology Report2018，6，1： | 0 |
| 2 | Severe hemorrhagic colitis in a patient with chronic myeloid leukemia in the blastic phase after dasatinib use显示文摘Dasatinib is a second-line tyrosine kinase inhibitor used in patients with imatinib resistant or intolerant chronic myeloid leukemia (CML) and Philadelphia chromosomepositive acute leukemia. Gastrointestinal bleeding may occur in up to 7% of patients using dasatinib, although, severe dasatinib-related acute colitis had rarely been reported. Here, we present the case of a 36-year-old female who progressed to acute myeloid leukemia after fourteen months of receiving imatinib for CML in the chronic phase and was treated with a dasatinib-containing chemotherapy regimen. On day 34 of treatment, the patient developed moderate abdominal pain and bloody diarrhea with mucous. Analyses of stool specimens were negative for parasites, Clostridium difficile , and other pathogenic bacteria. The cytomegalovirus pp65 antigen was negative in her blood leukocytes. A colonoscopy revealed acute colitis, and a mucosal biopsy showed nonspecific colitis. The patient was treated with broad-spectrum antibiotics, bowel rest and hydration, and dasatinib treatment was stopped. Her bloody diarrhea improved within 72 h. After confirming cytological remission, the patient received initial course of consolidation, and dasatinib treatment was reinstated. However, hemorrhagic colitis recurred. After discontinuing dasatinib, herhemorrhagic colitis drastically improved and did not recur following the administration of nilotinib. The characteristics of our patient suggest that dasatinib treatment can lead to hemorrhagic colitis, which typically resolves after discontinuation of the drug. | Zahra Kmira Ben Sayed Nesrine Zaghouani Houneida Ben Fredj Wafa Slama Aida Ben Youssef Yosra Zaier Monia Badreddine Sriha Khelif Abderrahim | 2013 | World Journal of Gastrointestinal Pathophysiology2013，4，3： | 0 |
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