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| 1 | 用酵母双杂交体系筛选与FMRP相作用蛋白的cDNA显示文摘目的采用酵母双杂交体系寻找与脆性X智力低下蛋白(Fragile X men-tal retadation protein,FMRP)相互作用的蛋白,探讨FMRP的生物医学功能。方法以编码FMRP_(Pro327-Thr518)肽段的cDNA序列与pBTM116质粒DNA结合结构域重组作为'钓饵',从小鼠胚胎cDNA文库中筛选与之相互作用蛋白的cDNA。结果筛选出13个与FMRP_(Pro327-Thr518)肽段特异性地相互作用的克隆,其中12个为小鼠泛素转运酶9(UBC9),1个是在GenBank中无高同源序列的未知cDNA序列。结论小鼠UBC9与人UBC9的氨基酸序列完全相同,且FMRP与UBC9蛋白表达的时空特征相似,因此认为人UBC9是与FMRP相互作用的蛋白,其相互作用的生物学意义有待进一步研究。本工作表明酵母双杂交体系是研究蛋白质相互作用的有效方法。 | 陈雨亭 Anne Sittler 余珉 Barbara Bardoni 吴冠芸 Jean Louis Mandel 沈岩 | 1998 | 中国医学科学院学报1998，20，3： | 4 |
| 2 | A multivariate analysis of clinicopathologie factors for predictiving outcome in uterine sarcomas显示文摘 | Wolfson AH Wolfson DJ Sittler SY | 1994 | Gynecol Oncol1994，52，1： | 1 |
| 3 | Unfiltered sulfur colloidand sentinel node biopsy for breast cancer technical and kinetic con-siderations 显示文摘 | Moffat Jr FL Gulec SA Sittler SY | 1999 | Annals of Surgical Oncology1999，6，8： | 1 |
| 4 | A multivariate analysis of clinicopathologic factors for predictiving outercome in uterine sarcomas显示文摘 | Wolfson AH Wolfson DJ Sittler SY | 1994 | Gynecol Oncol1994，52，： | 1 |
| 5 | Unfiltered sulfur colloid and sentinel node biopsy for breast cancer: technical and kinetic considerations显示文摘 | Moffat FL Jr Gulec SA Sittler SY | 1999 | Ann Surg Oncol1999，6，8： | 1 |
| 6 | A metagenomic analy- sis of pandemic influenza A (2009 H1N1 ) infection in patients from North America显示文摘 | Greninger AL Chen EC Sittler T | 2010 | PLoS One2010，5，13： | 1 |
| 7 | Alternative splicing of exon 14 determines nuclear or cytoplasmic localisation of fmrl protein isoforms 显示文摘 | Sittler A Devys D Weber C | 1996 | Hum Mol Genet1996，5，1： | 1 |
| 8 | A multivariate analysis of clinicopathologie factors for predicting outcome in uterine sarcomas显示文摘 | Wolfson AH Wolfson DJ Sittler SY | 1994 | Gynecol Oncol1994，52，1： | 1 |
| 9 | Alternative splicing of exon 14 determines nuclear or cytoplasmic localization of fmr I protein isoforms显示文摘 | Sittler A Devys D Weber C | 1996 | Hum Mol Genet1996，5，1： | 1 |
| 10 | An optimal data association problem in surveillance theory 显示文摘 | SITTLER R W | 1964 | IEEE Military Electronics1964，8，2： | 1 |
| 11 | An Optimal Data Association Problem in Surveillance Theory 显示文摘 | Sittler R W | 1964 | IEEE Transactions on Military Electronics1964，8，： | 1 |
| 12 | An Optimal Data Association Problem in Surveillance Theory 显示文摘 | Sittler R W | 1964 | IEEE Military Electronics1964，8，2： | 1 |
| 13 | Magnetic loop behind an interplanetary shock: Voyager, Helios, and IMP 8 observations 显示文摘 | Burlaga L F Sittler E Mariani F | 1981 | J Geophys Res1981，86，： | 1 |
| 14 | An optimal data association problem in surveillance theory 显示文摘 | Sittler R W | 1964 | IEEE Transactions on Military Electronics1964，8，2： | 1 |
| 15 | The plasmodium protein network diverges from those of other eukaryotes 显示文摘 | Suthram S Sittler T Ideker T | 2005 | Nature2005，438，7064： | 1 |
| 16 | The Plasmodium protein network diverges from those of other eukaryotes显示文摘 | Suthram S Sittler T Ideker T | | 0，，7064： | 1 |
| 17 | An optimal data association problem in surveil- lance theory显示文摘 | Sittler R W | | 0，，02： | 1 |
| 18 | A metagenomie analysis of pandemic influenza A (2009H1N1) Infection in patients from North America显示文摘 | Greninger A L Chen E C Sittler T | 2010 | PLos One2010，185，13： | 1 |
| 19 | Gastric cancer:classification,histology and application of molecular pathology显示文摘 | Hu B El Hajj N Sittler S | | 0，，03： | 1 |
| 20 | A multivariate analysis of clinicopathological factors for predicting outcome in uterine sarcomas显示文摘 | Wolfson AH Wolfson DJ Sittler SY | 1994 | Gynecol Oncol1994，52，1： | 1 |
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