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| 1 | Transient elastography compared to liver biopsy and morphometry for predicting fibrosis in pediatric chronic liver disease: Does etiology matter?显示文摘AIM: To evaluate transient elastography(TE) as a noninvasive tool in staging liver fibrosis compared with liver biopsy and morphometry in children with different chronic liver diseases.METHODS: A total of 90 children [50 with chronic hepatitis C virus(HCV), 20 with autoimmune hepatitis(AIH) and 20 with Wilson disease] were included in the study and underwent liver stiffness measurement(LSM) using TE. Liver biopsies were evaluated for fibrosis, qualitatively, by Ishak score and quantitatively by fibrosis area fraction(FAF) using digital image analysis(morphometry). LSM was correlated with fibrosis and other studied variables using spearman correlation. A stepwise multiple regression analysis was alsoperformed to examine independent factors associated with LSM. Different cut-off values of LSM were calculated for predicting individual fibrosis stages using receiveroperating characteristic curve. Cut-off values with optimal clinical performance(optimal sensitivity and specificity simultaneously) were selected.RESULTS: The majority of HCV group had minimal activity(80%) and no/mild fibrosis(72%). On the other hand, the majority of AIH group had mild to moderate activity(70%) and moderate to severe fibrosis(95%) and all Wilson disease group had mild to moderate activity(100%) and moderate to severe fibrosis(100%). LSM correlated significantly with both FAF and Ishak scores and the correlation appeared better with the latter(r = 0.839 vs 0.879, P < 0.0001 for both). LSM discriminated individual stages of fibrosis with high performance. Sensitivity ranged from 81.4% to 100% and specificity ranged from 75.0% to 97.2%. When we compared LSM values for the same stage of fibrosis, they varied according to the different etiologies. Higher values were in AIH(16.15 ± 7.23 k Pa) compared to Wilson disease(8.30 ± 0.84 k Pa) and HCV groups(7.43 ± 1.73 k Pa). Multiple regression analysis revealed that Ishak fibrosis stage was the only independent variable associated with higher LSM(P < 0.0001).CONCLUSION: TE appears reliable in distinguishing different stages of liver fibrosis in children. However, its values vary according to the disease type. For that, a disease-specific estimation of cut-off values for fibrosis staging is worthy. | Behairy El-Sayed Behairy Mostafa Mohamed Sira Khaled Refat Zalata El-Sayed Ebrahem Salama Mohamed Ahmed Abd-Allah | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 2 | 302例显微根尖手术的回顾性研究显示文摘目的探讨显微根尖手术的疗效及影响因素,并评估Kim和Kratchman显微根尖手术病例分类对疗效判断的价值。方法收集显微根尖手术病例(回访时间至少为1年)的临床资料及影像资料,并参照Kimand Kratchman显微根尖手术病例分类标准对病例进行分类,分析显微根尖手术的疗效及影响因素。结果研究共纳入302例患者的400颗患牙,显微根尖手术的成功率为94.25%。不同病损类型显微根尖手术疗效的差异有统计学意义(P<0.05),B、C类病例的显微根尖手术疗效优于D、E、F类病例(P<0.05)。不同牙位显微根尖手术疗效的差异有统计学意义(P<0.05)。前牙的疗效优于后牙,上颌牙的疗效优于下颌牙。根管充填质量及根尖再手术均对显微根尖手术的疗效无影响(P>0.05)。结论显微根尖手术具有较好的临床疗效,是保留患牙的有效方法;牙位和病损类型是显微根尖手术疗效的影响因素;KimandKratchman显微根尖手术病例分类可以帮助预测显微根尖手术的治疗效果。 | 陈益燕 Siras Prasad Pradan 杨锦波 | 2021 | 华西口腔医学杂志2021，39，4： | 5 |
| 3 | Serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C显示文摘AIM:To evaluate serum complement C4a and its relation to liver fibrosis in children with chronic hepatitis C virus(HCV)infection.METHODS:The study included 30 children with chronic HCV infection before receiving antiviral therapy.Chronic HCV infection was defined by positive anti-HCV,a positive polymerase chain reaction for HCV-RNA for more than 6 mo with absence of any associated liver disease.A second group of 30 age-and sex-matched healthy children served as controls.Serum C4a levels were measured by enzyme-linked immunosorbent assay.Liver fibrosis stage and inflammatory grade were assessed using Ishak scoring system.Serum C4a levels were compared according to different clinical,laboratory and histopathological parameters.Statistical significance for quantitative data was tested by MannWhitney U non-parametric tests.For qualitative data,significance between groups was tested by 2test.Correlation was tested by Spearman’s test.Results were considered significant if P value≤0.05.RESULTS:The age of the patients ranged from 3.5to 18 years and that of controls ranged from 4 to 17years.C4a mean levels were merely lower in patients(153.67±18.69 mg/L)than that in the controls(157.25±11.40 mg/L)with no statistical significance(P=0.378).It did not differ significantly in patients with elevated vs those with normal transaminases(152.25±16.62 vs 155.36±21.33;P=0.868)or with different HCV viremia(P=0.561).Furthermore,there was no statistical significant difference in serum levels between those with no/mild fibrosis and those with moderate fibrosis(154.65±20.59 vs 152.97±17.72;P=0.786)or minimal and mild activity(155.1±21.93 vs 152.99±17.43;P=0.809).Though statistically not significant,C4a was highest in fibrosis score 0(F0),decreasing in F1 and F2 to be the lowest in F3.When comparing significant fibrosis(Ishak score≥3)vs other stages,C4a was significantly lower in F3 compared to other fibrosis scores(143.55±2.33 mg/L vs 155.26±19.64 mg/L;P=0.047)and at a cutoff value of less than 144.01 mg/L,C4a could discriminate F3 with 76.9%sensitivity and75%specificity from other stages of fibrosis.CONCLUSION:Serum complement C4a did not correlate with any of transaminases,HCV viremia or with the histopathological scores.Although C4a decreased with higher stages of fibrosis,this change was not significant enough to predict individual stages of fibrosis.Yet,it could predict significant fibrosis with acceptable clinical performance. | Behairy E Behairy Ghada M El-Mashad Ragab S Abd-Elghany Enas M Ghoneim Mostafa M Sira | 2013 | World Journal of Hepatology2013，5，8： | 4 |
| 4 | 慢性宫颈炎的发生因素分析显示文摘慢性宫颈炎是妇科最常见的疾病,与宫颈癌的发生关系十分密切,但该病的发病原因至今尚欠明确.为了进一步探讨慢性宫颈炎发病的相关因京,尤其是其配偶男方包皮切除(包皮垢)对慢性宫颈炎发病的影响,我们在马里共和国对成年妇女进行了有关慢性宫颈炎病因学的调查,现将结果报道如下. | 姜仙姣 Sira Diarra | 2004 | 医学研究通讯2004，33，12： | 4 |
| 5 | SOX9 in biliary atresia: New insight for fibrosis progression显示文摘Background:Liver fibrosis is a hallmark determinant of morbidity in biliary atresia(BA)even in successfully operated cases.Responsible factors for this rapid progression of fibrosis are not completely defined.Aberrant expression of the transcription factor SOX9 and hepatic progenitor cells(HPCs)proliferation have roles in fibrogenesis in cholestatic disorders.However,they were not investigated sufficiently in BA.We aimed to delineate the relation of SOX9 and HPCs to fibrosis and its progression in BA.Methods:Forty-eight patients with BA who underwent an initial diagnostic liver biopsy(LB)and consequent intraoperative LB were recruited and compared to 28 cases with non-BA cholestasis that had an LB in their diagnostic workup.Liver fibrosis,tissue SOX9 and HPC expressions were studied in both BA and non-BA-cholestasis cases.Liver fibrosis,SOX9,and HPCs’dynamic changes in BA cases were assessed.Relation of fibrosis and its progression to SOX9 and HPCs in BA was assessed.Results:SOX9 and HPCs in ductular reaction(DR)form were expressed in 100%of BA and their grades increased significantly in the second biopsy.The rapidly progressive fibrosis in BA,represented by fibrosis grade of the intraoperative LB,correlated significantly to SOX9-DR and HPC-DR at the diagnostic(r=0.420,P=0.003 and r=0.405,P=0.004,respectively)and the intraoperative(r=0.460,P=0.001 and r=0.467,P=0.001,respectively)biopsy.On the other hand,fibrosis,SOX9-DR,and HPC-DR were significantly lower in non-BA cases at a comparable age(P<0.001,P=0.006,and P=0.014,respectively).Conclusions:Fibrosis in BA is rapidly progressive within a short time and is significantly correlated to SOX9 and HPCs.Assessment of targeting SOX9 and HPCs on fibrosis progression is warranted. | Hanaa Ahmed El-Araby Magdy Anwar Saber Noha Mohamed Radwan Doha Maher Taie Nermin Mohamed Adawy Ahmad Mohamed Sira | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，2： | 3 |
| 6 | Serum Inter-Alpha-Trypsin Inhibitor Heavy Chain 4 (ITIH4) in Children with Chronic Hepatitis C: Relation to Liver Fibrosis and Viremia显示文摘 | Mostafa M. Sira Behairy E. Behairy Azza M. Abd-Elaziz Sameh A. Abd Elnaby Ehab E. Eltahan Piero Luigi Almasio | 2014 | Hepatitis Research and Treatment2014，，： | 2 |
| 7 | Safety and efficacy of Hansenula-derived PEGylated-interferon alpha-2a and ribavirin combination in chronic hepatitis C Egyptian children显示文摘AIM:To investigate the safety and efficacy of a Hansenula-derived PEGylated(polyethylene glycol)interferon(IFN)-alpha-2a(Reiferon Retard)plus ribavirin customized regimen in treatment-na?ve and previously treated(non-responders and relapsers)Egyptian children with chronic hepatitis C infection.METHODS:Forty-six children with chronic hepatitis C virus(HCV)infection were selected from three tertiary pediatric hepatology centers.Clinical and laboratory evaluations were undertaken.Quantitative polymerase chain reaction(PCR)for HCV-RNA was performed before starting treatment,and again at 4,12,24,48,72wk during treatment and 6 mo after treatment cessation.All patients were assigned to receive a weekly subcutaneous injection of PEG-IFN-alpha-2a plus daily oral ribavirin for 12 wk.Thirty-four patients were treatment-na?ve and 12 had a previous treatment trial.Patients were then divided according to PCR results into two groups.GroupⅠincluded patients who continued treatment on a weekly basis(7-d schedule),while groupⅡincluded patients who continued treatment on a 5-d schedule.Patients from either group who were PCR-negative at week 48,but had at least one PCRpositive test during therapy,were assigned to have an extended treatment course up to 72 wk.The occurrence of adverse effects was assessed during treatment and follow up.The study was registered at www.ClinicalTrials.gov(NCT02027493).RESULTS:Only 11 out of 46(23.9%)patients showed a sustained virological response(SVR),two patients were responders at the end of treatment;however,they were lost to follow up at 6 mo post treatment.Breakthrough was seen in 18(39.1%)patients,one patient(2.17%)showed relapse and 14(30.4%)were non-responders.Male gender,short duration of infection,low viral load,mild activity,and mild fibrosis were the factors related to a better response.On the other hand,patients with high viral load and absence of fibrosis failed to respond to treatment.Before treatment,liver transaminases were elevated.After commencing treatment,they were normalized in all patients at week 4 and were maintained normal in responders till the end of treatment,while they increased again significantly in non-responders(P=0.007 and 0.003 at week 24 and 72 respectively).The 5-d schedule did not affect the response rate(1/17 had SVR).Treatment duration(whether 48 wk or extended course to 72 wk)gave similar response rates(9/36 vs 2/8 respectively;P=0.49).Type of previous treatment(short acting IFN vs PEG-IFN)did not affect the response to retreatment.On the other hand,SVR was significantly higher in previous relapsers than in previous non-responders(P=0.039).Only mild reversible adverse effects were observed and children tolerated the treatment well.CONCLUSION:Reiferon Retard plus ribavirin combined therapy was safe.Our customized regimen did not influence SVR rates.Further trials on larger numbers of patients are warranted. | Suzan El Naghi Tawhida Y Abdel-Ghaffar Hanaa El-Karaksy Elham F Abdel-Aty Mona S El-Raziky Aleef A Allam Heba Helmy Hanaa A El-Araby Behairy E Behairy Mohamed A El-Guindi Hatem El-Sebaie Aisha Y Abdel-Ghaffar Nermin A Ehsan Ahmed M El-Hennawy Mostafa M Sira | 2014 | World Journal of Gastroenterology2014，20，16： | 2 |
| 8 | Sliding mode control of DC - to - DC power converters via extend linearization 显示文摘 | Sira - Ramfrez H Rios - Bolfvar M | 1994 | IEEE Transactions on Circuits and Systems1994，41，10： | 1 |
| 9 | Surface modification of poly- carbonate in homogeneous atmospheric pressure discharge显示文摘 | Sira M Trunec D Stahel P | 2008 | Journal of Physics D: Applied Physics2008，41，01： | 1 |
| 10 | Sliding motions in bilinear switched networks显示文摘 | Sira Ramirez H | 1987 | IEEETrans on Circuit System1987，34，8： | 1 |
| 11 | Putting humpty dumpty together again:the importance of integrating cognitive and emotional interventions显示文摘 | Mateer CA Sira CS O'Connell ME | | 0，，01： | 1 |
| 12 | Pattern of occurrence and treatment of impacted teeth at the Muhimbili National Hospital, Dares Salaam, Tanzania显示文摘 | Farizana M Elison NM Sira O | 2013 | BMC Oral Health2013，13，： | 1 |
| 13 | Adaptive waveform design for improved detection of iow-RCS targets in heavy sea clutter 显示文摘 | Sandeep P Sira Douglas Cachran Darry Morrell | 2007 | IEEE journal of selected topics in signal processing2007，1，1： | 1 |
| 14 | Dynamic configuration of time-varying waveforms for agile sensing and tracking in clutter显示文摘 | Sira S P Papandreou-Suppappola A and Morrell D | 2007 | IEEE Transactions on Signal Processing2007，55，7： | 1 |
| 15 | Titanium dioxide-graphene composite electrochemical sensor for detection of hexavalent chromium显示文摘Hexavalent chromium(Cr(VI))compound is useful to various industries but is toxic and carcinogenic.In this research work,we fab-ricate an amperometric sensor for the determination of Cr(VI),using a titanium dioxide(TiO2)-reduced graphene oxide(rGO)composite as the sensing element.The composite was synthesized following sol−gel chemistry,yielding TiO2 nanoparticles of~50 nm in size,immobilized on chemically exfoliated rGO sheets.The composite was employed in a 3-electrode electrochemical cell and operated in an amperometric mode,exhibiting good responses to the 50 to 500 ppb Cr(VI).Our best result from pH 3 Mcilvane’s buffer medium reveals the sensitivity of 9.12×10−4 ppb−1 and a detection limit of 6 ppb with no signal interference from 200 ppm Ca(II),150 ppm Mg(II),and 50 ppb Pb(II).The excellent results of the TiO2-rGO sensor can be attributed to synergic effects between TiO2 and rGO,resulting from the presence of n-p heterojunctions and the formation of the TiO2 nanoparticles on rGO. | Natpichan Pienutsa Krittamet Yannawibut Jetthana Phattharaphongmanee Oukrit Thonganantakul Sira Srinives | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，3： | 1 |
| 16 | Waveform- agile sensing for tracking显示文摘 | Sira S P Li Y Papandreou-Suppappola A | 2009 | IEEE Signal Processing Maga- zine2009，26，1： | 1 |
| 17 | Dynamic configuration of time-varying waveforms for agile sensing and tracking in clutter 显示文摘 | Sira S P Li Y Papandreou-Suppappola A | 2007 | IEEE Signal Processing Magazine2007，55，7： | 1 |
| 18 | Cognitive and emotional consequences of TBI:intervention strategies for vocational rehabilitation显示文摘 | Ateer CA Sira CS | 2006 | Neuro Re-hab2006，21，： | 1 |
| 19 | Serological mark- ers of autoimmunity in children with hepatitis A:relation to a- cute and fulminant presentation显示文摘 | Abdel-Ghaffar TY Sira MM Sira AM | 2015 | Eur J Gastroenterol Hep- atol2015，27，10： | 1 |
| 20 | Natural history of hepatitis B in perinatally infected carriers显示文摘 | Boxall EH Sira J Standish RA | 2004 | Arch Dis Child Fetal Neonatal Ed2004，89，5： | 1 |
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