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| 1 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 2 | Correlation of transient elastography with hepatic venous pressure gradient in patients with cirrhotic portal hypertension: A study of 326 patients from India显示文摘AIM To study the diagnostic accuracy of transient elastography(TE) for detecting clinically significant portal hypertension(CSPH) in Indian patients with cirrhotic portal hypertension.METHODS This retrospective study was conducted at the Institute of Liver, Gastroenterology, and Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, on consecutive patients with cirrhosis greater than 15 years of age who underwent hepatic venous pressure gradient(HVPG) and TE from July 2011 to May 2016. Correlation between HVPG and TE was analyzed using the Spearman's correlation test. Receiver operating characteristic ( ROC) curves were prepared for determining the utility of TE in predicting various stages of portal hypertension. The best cut-off value of TE forthe diagnosis of CSPH was obtained using the Youden index.RESULTS The study included 326 patients [median age 52(range 16-90) years; 81% males]. The most common etiology of cirrhosis was cryptogenic(45%) followed by alcohol(34%). The median HVPG was 16.0(range 1.5 to 30.5) mm Hg. Eighty-five percent of patients had CSPH. A significant positive correlation was noted between TE and HVPG(rho 0.361, P < 0.001). The area under ROC curve for TE in predicting CSPH was 0.740(95%CI: 0.662-0.818)(P < 0.01). A cut-off value of TE of 21.6 k Pa best predicted CSPH with a positive predictive value(PPV) of 93%.CONCLUSION TE has a fair positive correlation with HVPG; thus, TE can be used as a non-invasive modality to assess the degree of portal hypertension. A cut-off TE value of 21.6 k Pa identifies CSPH with a PPV of 93%. | Ashish Kumar Noor Muhammad Khan Shrihari Anil Anikhindi Praveen Sharma Naresh Bansal Vikas Singla Anil Arora | 2017 | World Journal of Gastroenterology2017，23，4： | 8 |
| 3 | Delayed migration of K-wire into popliteal fossa used for tension band wiring of patellar fracture显示文摘被用于破裂固定的 K 电线和不锈钢电线的破裂不是不平常的,但是移植是稀罕的。我们报导为髌紧张乐队配线使用到腿弯部的窝的破 K 电线的移植的一个案例。破硬件通过手术被移开。我们想建议那 K 电线和电线固定使用了因为膝盖骨的破裂的治疗能移居进膝的以后的分隔空间并且引起临床的症状。在曾经,骨折统一了识别电线的硬件破裂或运动和移动的存在的内部固定以后的近临床、放射学的后续能避免如此的复杂并发症。 | Sanjay Meena Hira Lal Nag Senthil Kumar Nilesh Barwar Samarth Mittal Amit Singla | 2013 | Chinese Journal of Traumatology2013，16，3： | 7 |
| 4 | Genetic polymorphism in CD14 gene, a co-receptor of TLR4 associated with non-alcoholic fatty liver disease显示文摘AIM To evaluate the pathogenic role of toll-like receptor(TLR) gene polymorphisms in patients with nonalcoholic fatty liver disease(NAFLD).METHODS Two hundred and fifty subjects(NAFLD = 200, healthy volunteers = 50) underwent polymerase chain reaction and restriction fragment length polymorphism to assess one polymorphism in the toll-like receptor 2(TLR2) gene(A753G), two polymorphisms in the TLR4 gene(TLR4 Asp299 Gly and Thr399 Ile allele), and two polymorphisms in the cluster of differentiation 14(CD14)(C-159 T and C-550T) gene, a co-receptor of TLR4. Association of TLR gene polymorphisms with NAFLD and its severity was evaluated by genetic models of association.RESULTS On both multiplicative and recessive models of gene polymorphism association, there was significant association of CD14 C(-159) T polymorphism with NAFLD; patients with TT genotype had a 2.6 fold increased risk of developing NAFLD in comparison to CC genotype. There was no association of TLR2 Arg753 Gln, TLR4 Asp299 Gly, Thr399 Ile, and CD14 C(-550) T polymorphisms with NAFLD. None of the TLR gene polymorphisms had an association with histological severity of NAFLD.CONCLUSION Patients with CD14 C(-159) T gene polymorphism, a co-receptor of TLR4, have an increased risk of NAFLD development. | Shweta Kapil Ajay Duseja Bal Krishan Sharma Bhupesh Singla Anuradha Chakraborti Ashim Das Pallab Ray Radha K Dhiman Yogesh Chawla | 2016 | World Journal of Gastroenterology2016，22，42： | 7 |
| 5 | Surgical treatment of Lenke 5 adolescent idiopathic scoliosis: Comparison of anterior vs posterior approach显示文摘AIM To compare the posterior vs anterior approaches for fusion of Lenke 5 adolescent idiopathic scoliosis curves,matched for curve magnitude and for the distal level of fixation(dLOF) standardized to the third lumbar vertebrae(L3).METHODS A prospectively collected multicenter database was used for this retrospective comparative study. Our dependent variables included sagittal and coronal radiographic measurements, number of fused vertebrae, estimated blood loss, length of hospitalization and SRS total and individual domain scores at the two-year follow-up. Subject demographics were similar for all group comparisons.Independent t-test was used to compare groups for all analyses at P < 0.01.RESULTS For all matched cases of Lenke 5 curves, a selective approach was used only 50% of the time in cases undergoing a posterior fusion. When comparing a posterior selective approach to an anterior selective approach,surgeons utilizing a posterior approach fused significantly more levels than surgeons using an anterior approach with no other significant differences in radiographic or SRS outcomes(Ant = 4.8 ± 1.0 levels vs post = 6.1 ± 1.0 levels, P < 0.0001). When the dLOF was standardized to L3, the anterior approached provided significantly greater lumbar Cobb percent correction than the posterior approach(Ant = 69.1% ± 12.6% vs post =54.6% ± 16.4%, P = 0.004), with no other significant radiographic or SRS score differences between approaches.CONCLUSION Surgeons treating Lenke 5c curves with a posterior instrumentation and fusion vs an anterior approach include more motion segments, even with a selective fusion. When controlled for the distal level of fixation,the anterior approach provides greater correction of the thoracolumbar curve. | Mark F Abel Anuj Singla Mark A Feger Lindsay D Sauer Wendy Novicoff | 2016 | World Journal of Orthopedics2016，7，9： | 6 |
| 6 | Metabolic effects of obesity:A review显示文摘With the many recent advances in the biomedical world,vast changes are taking place in our growing knowledge of the physiological aspects of almost all the tissues and organs of the human body.One of the most prevalent topics of discussion is the question of obesity and its effect on the metabolic changes in the human body.The original classical role of adipose tissue as an energy storage organ has been greatly modified.We now know that it is an endocrine organ,producing adipokines like leptin,adiponectin,visfatin,resistin,apelin,etc,which modulate metabolic processes in the body.Since obesity is associated with an increase in the adipose tissue mass,these hormones may be expected to be produced in increased concentrations and may thus have a significant impact on the macronutrient metabolism.Further,these adipokines may interact with long term energy modulators like insulin.Even though the scientific community has started unravelling the mysteries of the close linkage between obesity,its hormones and their physiological effects,a lot still remains to be discovered.The present discussion makes an attempt to trace the basic modern day concepts of the role of obesity in various metabolic processes. | Parul Singla Animesh Bardoloi Anuj A Parkash | 2010 | World Journal of Diabetes2010，1，3： | 5 |
| 7 | All ileo-cecal ulcers are not Crohn's:Changing perspectives of symptomatic ileocecal ulcers显示文摘AIM To investigated clinical,endoscopic and histopathological parameters of the patients presenting with ileocecal ulcers on colonoscopy.METHODS Consecutive symptomatic patients undergoing colonoscopy,and diagnosed to have ulcerations in the ileocecal(I/C) region,were enrolled.Biopsy was obtained and theirclinical presentation and outcome were recorded.RESULTS Out of 1632 colonoscopies,104 patients had ulcerations in the I/C region and were included in the study.Their median age was 44.5 years and 59% were males.The predominant presentation was lower GI bleed(55,53%),pain abdomen ± diarrhea(36,35%),fever(32,31%),and diarrhea alone(9,9%).On colonoscopy,terminal ileum was entered in 96(92%) cases.The distribution of ulcers was as follows:Ileum alone 40%(38/96),cecum alone 33%(32/96),and both ileum plus cecum 27%(26/96).The ulcers were multiple in 98% and in 34% there were additional ulcers elsewhere in colon.Based on clinical presentation and investigations,the etiology of ulcers was classified into infective causes(43%) and noninfective causes(57%).Fourteen patients(13%) were diagnosed to have Crohn's disease(CD).CONCLUSION Non-specific ileocecal ulcers are most common ulcers seen in ileo-cecal region.And if all infections are clubbed together then infection is the most common(> 40%) cause of ulcerations of the I/C region.Cecal involvement and fever are important clues to infective cause.On the contrary CD account for only 13% cases as a cause of ileo-cecalulcers.So all symptomatic patients with I/C ulcers on colonoscopy are not Crohn's. | Jay Toshniwal Romesh Chawlani Amit Thawrani Rajesh Sharma Anil Arora Hardik L Kotecha Mohan Goyal Vijendra Kirnake Pankaj Jain Pankaj Tyagi Naresh Bansal Munish Sachdeva Piyush Ranjan Mandhir Kumar Praveen Sharma Vikas Singla Rinkesh Bansal Vineet Shah Sunita Bhalla Ashish Kumar | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，7： | 5 |
| 8 | Optimization of Distributed Solar Photovoltaic Power Generation in Day-ahead Electricity Market Incorporating Irradiance Uncertainty显示文摘This paper proposes a simple and practical approach to model the uncertainty of solar irradiance and determines the optimized day-ahead(DA)schedule of electricity mar-ket.The problem formulation incorporates the power output of distributed solar photovoltaic generator(DSPVG)and forecasted load demands with a specified level of certainty.The proposed approach determines the certainty levels of the random variables(solar irradiance and forecasted load demand)from their probability density function curves.In this process of optimization,the energy storage system(ESS)has also been mod-eled based on the fact that the energy stored during low locational marginal price(LMP)periods and dispatched during high LMP periods would strengthen the economy of DA schedule.The objective of the formulated non-linear optimization problem is to maximize the social welfare of market participants,which incorporates the assured generation outputs of DSPVG,subject to real and reactive power balance and transmission capability constraints of the system and charging/dis-charging and energy storage constraints of ESS.The simulation has been performed on the Indian utility 62-bus system.The results are presented with a large number of cases to demonstrate the effectiveness of the proposed approach for the efficient,economic and reliable operation of DA electricity markets. | Anu Singla Kanwardeep Singh Vinod Kumar Yadav | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，3： | 4 |
| 9 | Biomedical applications of collagen显示文摘 | Chi H. Lee Anuj Singla Yugyung Lee | 2001 | International Journal of Pharmaceutics2001，，1： | 3 |
| 10 | Effect of Biogas Digested Liquid on CH_4 and N_2O Flux in Paddy Ecosystem显示文摘Biogas production generates digested slurry as a byproduct. It can be used as a fertilizer especially after its conversion into digested liquid. A pot based study was conducted in order to evaluate the effect of the application of digested liquid on CH 4 and N 2 O flux, and plant biomass in paddy. Analysis revealed that digested liquid treated soils released more CH 4 compared to ammonium sulphate and the control. Ammonium sulphate treated soil emitted the highest N 2 O whereas digested liquid application decreased its emission significantly. Further, the cumulative emission over 101 d of the experiment was found to be higher for CH 4(16.9 to 29.9 g m-2) compared to N 2 O(-49.3 to 18.9 mg m-2) for all treatments. Digested liquid application had positive impact on plant variables such as panicle number and weight of panicles. This study suggests that digested liquid application significantly decrease N 2 O emission and increase CH 4 emission possibly due to affecting the availability of organic C in the soil to microbial activity for methanogenesis. Another possibility for enhancing CH 4 emission by following biogas digested liquid could be attributed to the increase in plant biomass. | Ankit Singla Kazuyuki Inubushi | 2014 | Journal of Integrative Agriculture2014，13，3： | 3 |
| 11 | Baastrup's disease: The kissing spine显示文摘A 67-year-old male presented with a gradually progressive low back pain of 2 years duration. The patient was leading a retired life and there was no history of chronic fever or significant trauma. There was no radiation of pain or any features suggestive of claudication. There was no history of any comorbidity. The pain was aggravated with extension of the spine and relieved with flexion. There was no swelling or neurological deficit, but muscle spasm was present. Radiographs of the spine revealed degenerative changes in the lumbosacral spine, along with articulation of spinous processes at in lumbar spine at all levels level suggestive of Baastrup's disease, commonly known as 'kissing spine'. Routine blood investigations were within normal limits. The patient was managed conservatively. He was given a week's course of analgesics and muscle relaxants and then started on spinal flexion exercises, with significant improvement being noted at 6 months follow up. | Amit Singla Vivek Shankar Samarth Mittal Abhinav Agarwal Bhavuk Garg | 2014 | World Journal of Clinical Cases2014，2，2： | 2 |
| 12 | Hepatitis C eradication with sofosbuvir leads to significant metabolic changes显示文摘AIM To assess the effect of sofosbuvir(SOF) based regimens on glycemic and lipid control.METHODS This is a retrospective analysis of hepatitis C virus(HCV)-infected patients treated and cured with a SOF regimen [SOF/ribavirin/interferon, SOF/simeprevir, or SOF/ledipasvir(LDV) ± ribavirin] from January 2014 to March 2015. Patients with hemoglobin A1C(HbA1C) and lipid panels within six months before and six months after therapy were identified and included in our study. Due to the known hemolytic effect of ribavirin, HbA1C was obtained a minimum of three months post-treatment for the patients treated with a ribavirin regimen. Medical history, demographics, HCV genotype, pre-therapy RNA, and liver biopsies were included in our analysis. The patients who started a new medication or had an adjustment of baseline medical management for hyper-lipidemia or diabetes mellitus(DM) were excluded from our analysis.RESULTS Two hundred and thirty-four patients were reviewed, of which 60 patients met inclusion criteria. Sixty-three point three percent were male, 26.7% were Caucasian, 41.7% were African American and 91.7% were infected with hepatitis C genotype 1. Mean age was 60.6 ± 6.7 years. Thirty-nine patients had HbA1C checked before and after treatment, of which 22 had the diagnosis of DM type 2. HbA1C significantly decreased with treatment of HCV(pretreatment 6.66% ± 0.95% vs posttreatment 6.14% ± 0.65%, P < 0.005). Those treated with SOF/LDV had a lower HbA1C response than those treated with other regimens(0.26% ± 0.53% vs 0.71% ± 0.83%, P = 0.070). Fifty-two patients had pre- and post-treatment lipid panels; there was a significant increase in low-density lipoprotein(LDL) and total cholesterol(TC) after treatment(LDL: 99.5 ± 28.9 mg/dL vs 128.3 ± 34.9 mg/dL, P < 0.001; TC: 171.6 ± 32.5 mg/dL vs 199.7 ± 40.0 mg/dL, P < 0.001). Pretreatment body-mass index(BMI) did not differ from post-treatment BMI(P = 0.684). CONCLUSION Eradication of HCV with a SOF regimen resulted in a significant drop in HbA1C and an increase in LDL and TC post therapy. | Amilcar L Morales Zachary Junga Manish B Singla Maria Sjogren Dawn Torres | 2016 | World Journal of Hepatology2016，8，35： | 2 |
| 13 | Complications of Pedicle Screw Fixation in Scoliosis Surgery: A Systematic Review显示文摘 | John M. Hicks Amit Singla Francis H. Shen Vincent Arlet | 2010 | Spine2010，，11： | 2 |
| 14 | Aggressive Approach to Staghorn Calculi—Safety and Efficacy of Multiple Tracts Percutaneous Nephrolithotomy显示文摘 | Manish Singla Aneesh Srivastava Rakesh Kapoor Nitin Gupta Mohd S. Ansari Deepak Dubey Anant Kumar | 2008 | Urology2008，，6： | 2 |
| 15 | Coexistence of pneumothorax and chilaiditi sign:A case report显示文摘We present a case of 50 year old male patient with coexistence of Pneumothorax and Chilaiditi sign.Chilaiditi sign is an incidental radiographic finding of a usually asymptomatic condition in which a part of intestine is located between the liver and diaphragm;however,the term'Chilaiditi syndrome'is used for symptomatic hepatodiaphragmatic interposition.The patient had no symptoms of abdominal pain,constipation,diarrhea,or emesis.Incidentally,Chilaiditi sign was diagnosed on chest radiography.Pneumothorax is defined as air in the pleural space.Pneumothoraces are classified as spontaneous or traumatic.Spontaneous pneumothorax is labelled as primary when no underlying lung disease is present,or secondary,when it is associated with pre-existing lung disease.Our case is the rare in the literature indicating the coexistence of Chilaiditi sign and pneumothorax. | Tangri Nitin Singhal Sameer Sharma Priyanka Mehta Dinesh Bansal Sachin Bhushan Neeraj Singla Sulbha Singh Puneet | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 16 | Automatic License Plate Recognition System for Vehicles Using a CNN显示文摘Automatic License Plate Recognition(ALPR)systems are important in Intelligent Transportation Services(ITS)as they help ensure effective law enforcement and security.These systems play a significant role in border surveillance,ensuring safeguards,and handling vehicle-related crime.The most effective approach for implementing ALPR systems utilizes deep learning via a convolutional neural network(CNN).A CNN works on an input image by assigning significance to various features of the image and differentiating them from each other.CNNs are popular for license plate character recognition.However,little has been reported on the results of these systems with regard to unusual varieties of license plates or their success at night.We present an efficient ALPR system that uses a CNN for character recognition.A combination of pre-processing and morphological operations was applied to enhance input image quality,which aids system efficiency.The system has various features,such as the ability to recognize multi-line,skewed,and multifont license plates.It also works efficiently in night mode and can be used for different vehicle types.An overall accuracy of 98.13%was achieved using the proposed CNN technique. | Parneet Kaur Yogesh Kumar Shakeel Ahmed Abdulaziz Alhumam Ruchi Singla Muhammad Fazal Ijaz | 2022 | Computers, Materials & Continua2022，，4： | 2 |
| 17 | Retrospective Study of clinical and hematological aspects associated with dogs naturally infected by Hepatozoon canis in Ludhiana,Punjab,India显示文摘Objective:To evaluate clinical and hematological aspects of dogs naturally infected with Hepatozoon canis(H.canis)presented at the Small Animal Clinics of Guru Angad Dev Veterinary and Animal Sciences University,Ludhiana.Methods:Blood films of 34 naturally infected dogs were examined for haematological alterations and parasitaemia.Signalment and clinical signs were recorded from the animals.Clinical histories were filled oul during the consultation.Results:Of the 34 positive dogs by Giemsa stained peripheral blood films.88.23%presented parasilaemia by H.canis only,while 11.77%had the combination of H.canis,Babesia sp.and Ehrlichia sp.Young male dogs less than oue-year-old,of nondescript breed,were the most commonly affected.And 26.47%were presented with anorexia/inappetence as the only clinical symptom.Other clinical symptoms were mild to moderate fever,pale mucosae and lethargy;a few were also showing the signs of vomiting and diarrhoea.Haematological alterations showed mainly normochromic-normocytic anaemia,leukocytosis and neutrophilia.Conclusions:The findings of this study substantiate that H.canis caused clinical and haematological alterations of the varied intensity in dogs,even with low parasilaemia.should he taken into consideration. | Sushma Chhabra Sanjeev Kumar Uppal Lachhman Das Singla | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，6： | 2 |
| 18 | A comparison of the clinical and experimental characteristics of four acute surgical pain models: Dental extraction, bunionectomy, joint replacement, and soft tissue surgery显示文摘 | Neil K. Singla Paul J. Desjardins Phoebe D. Chang | 2014 | Pain2014，，3： | 2 |
| 19 | 显示文摘 | Sinha V R Singla A K Wadhawan S | 2004 | International Journal of Pharmaceutics2004，274，12： | 1 |
| 20 | Ultrasonographic evaluation of gallbladder volume in diabetics显示文摘 | Agarwal AK Miglani S Singla S | 2004 | J Aseoc Physicians India2004，52，： | 1 |
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