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| 1 | What will the future hold for artificial organs in the service of assisted reproduction: prospects and considerations显示文摘Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)practices.This special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in management.Cutting edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction.Extrapolation on clinical application leads to the future use of infertility management in humans.To date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials.The application of these artificial organs could provide a solution to infertility cases with no other options.This manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in humans.This paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments. | Mara Simopoulou Konstantinos Sfakianoudis Petroula Tsioulou Anna Rapani Polina Giannelou Nikolaos Kiriakopoulos Agni Pantou Nikolaos Vlahos George Anifandis Stamatis Bolaris Konstantinos Pantos Michael Koutsilieri | 2019 | Frontiers of Medicine2019，13，6： | 2 |
| 2 | Lipid metabolism and osteoar- thritis : lessons from atherosclerosis 显示文摘 | Gkretsi V Simopoulou T Tsezou A | 2011 | Prog Lipid Res2011，50，： | 1 |
| 3 | Endothelial dysfunction in conduit arteries and in microcirculation. Novel therapeutic approaches显示文摘 | Dimitris Tousoulis Chryssa Simopoulou Nikos Papageorgiou Evangelos Oikonomou George Hatzis Gerasimos Siasos Eleftherios Tsiamis Christodoulos Stefanadis | 2014 | Pharmacology and Therapeutics2014，，3： | 1 |
| 4 | Lectin - like oxidized low density lipoprotein receptor 1 ( LOX - 1 ) expression in human articu- lar chondrocytes显示文摘 | Simopoulou T Malizos KN Tsezou A | 2007 | Clin Exp Rheumato12007，25，： | 1 |
| 5 | Differen-tial expression of leptin and leptin's receptor isoform(Ob-Rb) mR-NA between advanced and minimally affected osteoarthri-tic carti-lage;effect on cartilage metabolism显示文摘 | SIMOPOULOU T MALIZOS K N ILIOPOULOS D | | 0，，08： | 1 |
| 6 | Differential expression of leptin and leptin' s receptor isoform ( Ob-Rb )mRNA between advanced and minimally affected osteoar-thritic cartilage ; effect on cartilage metabolism 显示文摘 | Simopoulou T Malizos K N lliopoulos D | 2007 | Osteo Arthritis and Cartilage2007，15，8： | 1 |
| 7 | Cell adhesion molecules and in vitro fertilization显示文摘 | Simopoulou M Nikolopoulou E Dimakakos A | 2014 | In Vivo2014，28，5： | 1 |
| 8 | Symposium:Role of poultry products in enriching the human diet with n-3PUFA human requirement for n-3 polyunsaturated fatty acid显示文摘 | Simopoulous AP | 2000 | Poul Sci2000，79，22： | 1 |
| 9 | Acute renal failure : a rare presentation of hypothyroidism 显示文摘 | LIAKOPOULOS V DOVAS S SIMOPOULOU T | 2009 | Ren Fail2009，31，4： | 1 |
| 10 | Acute renal failure: a rare presentation of hypothyroidism显示文摘 | Liakopoulos V Dovas S Simopoulou T | 2009 | Ren Fail2009，31，4： | 1 |
| 11 | A borderline form of empty follicle syndrome: ease report显示文摘 | Nikolettos N Asimakopoulos B Simopoulou M | 2004 | Clin Exp Obstet Gyneeol2004，31，1： | 1 |
| 12 | Omega-3 fatty acids in health and disease and in growth and development显示文摘 | Artemis | 1991 | Am J Clinl Nutr1991，54，3： | 1 |
| 13 | Impaired expression of genes regulating cholesterol efflux in human osteoarthritic chondrocytes显示文摘 | Tsezou A Iliopoulos D Malizos KN Simopoulou T | 2010 | J Orthop Res2010，28，8： | 1 |
| 14 | Oocyte and embryo vitrification in the IVF laboratory:a comprehensive review 显示文摘 | Simopoulou M Asimakopoulos B Bakas P | 2014 | Folia Med(Plovdiv)2014，56，3： | 1 |
| 15 | Tuberculous py- omyositis: a re-emerging entity of many faces显示文摘 | Simopoulou T Varna A Dailiana Z | 2016 | Clin Rheumatol2016，35，4： | 1 |
| 16 | Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism显示文摘 | Simopoulou T Malizos KN Iliopoulos D Stefanou N Papatheodorou L Ioannou M | 2007 | Osteoarthritis Cartilage2007，15，8： | 1 |
| 17 | Oocyte and embryo vitrification in the IVF laboratory: a comprehensive review显示文摘 | Simopoulou M Asimakopoulos B Bakas P | 2014 | Folia Medica2014，56，3： | 1 |
| 18 | Differential expression of leptin and leptin's receptor isoform (Ob-Rb) mRNA between advanced and minimally affected osteoarthritic cartilage; effect on cartilage metabolism显示文摘 | Simopoulou T Malizos KN Iliopoulos D | 2007 | Osteoarthritis Cartilage2007，15，8： | 1 |
| 19 | Dif-ferential expression of leptin and leptin's receptor isoform(Ob-Rb)mRNA between advanced and minimally affected osteoarthriticcartilage;effect on cartilage metabolism显示文摘 | SIMOPOULOU T MALIZOS K N ILIOPOULOS D | 2007 | Osteoarthritis Carti-lage2007，15，8： | 1 |
| 20 | A borderline form of empty follicle syndrome : case report 显示文摘 | Nikolettos N Asimakopoulos B Simopoulou M | 2004 | Clin Exp Obstet Gyneco12004，31，1： | 1 |
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