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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | 定期运动有助于改善高血压患者蛋白质稳态、炎症和血管活性显示文摘体育锻炼是一种公认的非药物控制血压的策略,除了降低血压外,运动还能对高血压患者的炎症特征、自主功能、内皮功能和抗氧化状态产生积极的影响。但其对高血压患者的蛋白质稳态的影响尚不清楚。已有动物研究表明,运动训练干预可以改善蛋白质质量控制机制,但在动物模型中报告的积极作用仍有待于在人类身上得到证实。本研究旨在根据报告的运动习惯,评估患高血压成年人的蛋白质稳态,生活质量以及炎症、氧化应激和血管活性生物标记物状态。 | Teixeira M Gouveia M Duarte A Ferreira M Simões MI Conceição M Silva G Magalhães S Ferreira R Nunes A Vieira SI Ribeiro F 周卫(译) 叶鹏(审校) | 2020 | 中华高血压杂志2020，28，12： | 2 |
| 3 | Age-dependent reductions in the level of glial fibrillary acidic protein in the prefrontal cortex in major depression显示文摘 | Si X Miguel-Hidalgo J J O′Dwyer G | 2004 | Neuropsychopharmacology2004，29，： | 1 |
| 4 | Oestrogen receptor genotypes and litter size in Hungarian Large White pigs显示文摘 | HOROGH G ZSOLNAI A KOMI(O)si I | 2005 | J Anim Breed Genet2005，122，1： | 1 |
| 5 | Growth-stimulatory and transcriptional activation properties of raloxffene in human endometrial Ishikawa cells显示文摘 | Barsalou A Dayan G Anghel SI | 2002 | Mol Cell Endocrinol2002，190，12： | 1 |
| 6 | Effects of misalignment between transmission and emission scans on attenuation-corrected cardiac显示文摘 | Matsunari I Boning G Ziegler SI | 1998 | J Nucl Med1998，39，： | 1 |
| 7 | Role of the IL-23/IL-17 axis in Crohn's disease 显示文摘 | Siakavellas SI Bamias G | 2012 | Discov Med2012，14，77： | 1 |
| 8 | Numerical simulationof the NOx emissions in a 1,000,MW tangentially firedpulverized-coal boiler:Influence of the multi-group arrangementof the separated over fire air 显示文摘 | Zhou H Mo G Y Si D B | 2011 | Energy &Fuels2011，25，5： | 1 |
| 9 | Analytic solutions of a second - order functional differential equation with a state derivative dependent delay 显示文摘 | Si J G Wang X | 1999 | Colloquium Math1999，，79： | 1 |
| 10 | A comparative study of 3-D and axisymmetric magnetizer assemblies used in magnetic flux leakage inspection of pipelines显示文摘 | Katragadda G Si JT Lord W | 1996 | IEEE Transaction on Magnetics1996，32，3： | 1 |
| 11 | Solitary thyroid nodule as presenting syndrome of pendred syndrome caused by a novel splice-site mutation in intron-8 of the SLC26A4gene显示文摘 | Massa G Jaenen N de Varebeke SI | 2003 | Eur J Pediatr2003，162，10： | 1 |
| 12 | Co2P: A facile solid state synthesis and its applications in alkalinerechargeable batteries 显示文摘 | PENG W X JIAO L F HUAN Q N LI L YANG J Q ZHAO Q Q WANG Q H DU H M L|U G SI Y C WANG Y J YUAN H T | 2012 | J Alloys Compd2012，511，： | 1 |
| 13 | Locations of the beta1 transmembrane helices in the BK potassium channel显示文摘 | Liu G Zakharov SI Yang L | 2008 | Proc Natl Acad Sci U S A2008，105，10： | 1 |
| 14 | Analytic solutions of a second - order iterative functional differential equation 显示文摘 | Si J G Wang X | 2000 | J Comput Appl Math2000，126，： | 1 |
| 15 | 显示文摘 | Gao Z W Si G Zhao X P | 2001 | Chinese Journal of Chemical Physics2001，14，5： | 1 |
| 16 | Investigations into the time- and dose-dependent effect of fumonisin B 1 in order to determine tolerable limit values in pigs显示文摘 | M Zomborszky-Kovács F Kovács P Horn F Vetési I Repa G Tornyos á Tóth | 2002 | Livestock Production Science2002，，3： | 1 |
| 17 | Analytic solutions of a second - order functional differential equation with a state dependent delay 显示文摘 | Si J G Wang X | 2001 | Result Math2001，，39： | 1 |
| 18 | Competition and Multiscaling in Evolving Networks显示文摘 | BARABáSI A L | 2001 | Europhysics Letters2001，54，： | 1 |
| 19 | Minocycline promotes axonal regeneration through suppression of RGMa in ratMCAO/ reperfusion model显示文摘 | Tao T Xu G Si Chen C | 2013 | Synapse2013，67，： | 1 |
| 20 | 查看详情显示文摘 | T(o)r(o)k B Balázsik K Sz(o)ll(o)si G Felf(o)ldi K | | 0，，： | 1 |
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