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| 1 | Human ESC-derived expandable hepatic organoids enable therapeutic liver repopulation and pathophysiological modeling of alcoholic liver injury显示文摘We report the generation of human ESC-derived,expandable hepatic organoids(hEHOs)using our newly established method with wholly defined(serum-free,feeder free)media.The hEHOs stably maintain phenotypic features of bipotential liver stem/progenitor cells that can differentiate into functional hepatocytes or cholangiocytes.The hEHOs can expand for 20 passages enabling large scale expansion to cell numbers requisite for industry or clinical programs.The cells from hEHOs display remarkable repopulation capacity in injured livers of FRG mice following transplantation,and they differentiate in vivo into mature hepatocytes.If implanted into the epididymal fat pads of immune-deficient mice,they do not generate non-hepatic lineages and have no tendency to form teratomas.We further develop a derivative model by incorporating human fetal liver mesenchymal cells(hFLMCs)into the hEHOs,referred to as hFLMC/hEHO,which can model alcoholic liver disease-associated pathophysiologic changes,including oxidative stress generation,steatosis,inflammatory mediators release and fibrosis,under ethanol treatment.Our work demonstrates that the hEHOs have considerable potential to be a novel,ex vivo pathophysiological model for studying alcoholic liver disease as well as a promising cellular source for treating human liver diseases. | Shuyong Wang Xuan Wang Zuolong Tan Yuxin Su Juan Liu Mingyang Chang Fang Yan Jie Chen Tao Chen Chuanjiang Li Jie Hu Yunfang Wang | 2019 | Cell Research2019，29，12： | 20 |
| 2 | ANALYSIS OF MECHANICS IN BALL SPINNING OF THIN-WALLED TUBE显示文摘Ball spinning is applied to manufacturing thin-walled tube with high precision and high mechanical properties. On the basis of plastic mechanics,by simplifying ball spinning of thin-walled tube as plane strain problem,slab method is used for the purpose of calculating the contact deformation pressure. The spinning force components,the torsional moment,the deformation power and the deformation work are calculated further as well. The influence of the two important process parameters such as the feed ratio and the ball diameter on the spinning force components is analyzed in order to further control the spinning force components by regulating the two process variables during the ball spinning process. The stress and strain state in deformable zone as well as mechanics boundary conditions in ball spinning are obtained. The effect of the three spinning force components on the formability of the spun part is analyzed and validated through the ball spinning experiments. The theoretical and experimental results show that the radial spinning component plays a significant role in ball spinning of thin-walled tube,and the mechanics situation in backward ball spinning contributes to enhancing the plasticity of the metal material,but that in forward ball spinning contributes to advancing the axial flow of the metal material. | JIANG Shuyong REN Zhengyi | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 18 |
| 3 | An innovative flake graphite upgrading process based on HPGR,stirred grinding mill, and nanobubble column flotation显示文摘Physical upgrading of graphite is typically achieved with many stages of grinding and flotation to produce a concentrate with approximately 95% carbon grade.An innovative grinding and column flotation process has been developed for efficient graphite upgrading to substantially simplify the process flowsheet and reduce operating costs.In this process,a high-pressure grinding roller(HPGR) and a stirred mill were employed as primary comminution techniques and a nanobubble flotation column as a key separation process.The results obtained with a crystalline flake graphite sample with a carbon grade of 11.15% show that the novel process can produce a concentrate with 94.82% carbon grade and 97.89% recovery from an open circuit of one rougher and two cleaner flotation stages.Scanning electron microscope(SEM)microphotographs indicate that HPGR offers the advantage of more effective protection of graphite flakes during crushing.Grinding test results show that stirred mill could not only protect graphite flakes but also promote the efficient liberation of graphite.Compared with the traditional flotation process,nanobubble flotation can effectively recover ultrafine graphite.The new process possesses a number of important advantages over the traditional method,including substantially higher graphite recovery,greatly simplified process flowsheet,better protection of flake size,reduced reagent consumption and process costs,etc. | Fangyuan Ma Dongping Tao Youjun Tao Shuyong Liu | 2021 | International Journal of Mining Science and Technology2021，31，6： | 9 |
| 4 | Ni-Co/Mg-Al catalyst derived from hydrotalcite-like compound prepared by plasma for dry reforming of methane显示文摘Ni-Co bimetallic catalysts with different Ni/Co content were derived from cold plasma jet decomposition and reduction of hydrotalcite-like compounds containing Ni,Co,Mg and Al,and their catalytic performance was investigated with dry reforming of methane.Experimental results showed that the hydrotalcite-like precursors could be completely decomposed and partly reduced by cold plasma jet,and the Nicontained catalysts exhibited much higher activity than the catalyst without Ni.Especially,the catalyst with Ni/Co ratio of 8/2 achieved not only the highest conversions of 80.3%and 69.3%for CH4 and CO2,respectively,but also the best stability in 100 h testing.The catalysts were characterized by XRD,XPS,TEM and N2 adsorption techniques,and the results showed that the better performance of the 8Ni2Co bimetallic catalyst was attributed to its higher metal dispersion,smaller metal particle size,as well as the interaction effect between Ni and Co,which were brought by the special catalyst preparation method. | Huali Long Yan Xu Xiaoqing Zhang Shijing Hu Shuyong Shang Yongxiang Yin Xiaoyan Dai | 2013 | Journal of Energy Chemistry2013，22，5： | 8 |
| 5 | A Tracing Algorithm of Thevenin Equivalent Parameters for Power Systems With Large Disturbance显示文摘 | SUN huadong CHEN Shuyong CHANG Xiaopeng LIN Weifang | 2012 | 中国电机工程学报2012，32，22： | 5 |
| 6 | Capillary blood flow in patients with dysmenorrhea treated with acupuncture显示文摘OBJECTIVE: To observe capillary blood flow at acupoints during acupuncture treatment of primary dysmenorrhea and gain new insights into its analgesic mechanism. METHODS: Patients with primary dysmenorrhea were enrolled and randomly assigned to a treatment or control group. Subjects' symptoms were differentiated into variousTraditional Chinese Medicine(TCM) syndromes and treated for 10 sessions with puncturing acupuncture or self-pressing right-hand Hegu(LI 4), adding other acupoints based on syndrome. Laser speckle was used to compare the change in the vasomotor amplitude and perfusion of the capillaries in Hegu(LI 4) before and during the treatment. Each subject was required to finish the period pain symptoms observation form, verbal rating scales, numerical rating scale, pain rating index, face rating scale, Zung self-rating depression scale, Zung self-rating anxiety scale, and numerical rating scale before and after treatments. RESULTS: After 10 sessions, the symptom scores, pain index(PI), and visual analog scale(VAS) decreased significantly in treatment group. The volume of blood flow in Hegu(LI 4) declined slightly. No significant evidence supported that needling caused capillary contraction, but the capillary vasomotor amplitude at Hegu(LI 4) increased remarkably. CONCLUSION: Acupuncture can increase the capillary blood flow, thus promoting the flow of Qi and blood in terms of TCM theory, which facilitates pain relief. | Tao Huang Lijian Yang Shuyong Jia Xiang Mu Mozheng Wu Hang Ye Weizhe Liu Xinnong Cheng | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 5 |
| 7 | Effects of drought stress on the photosynthetic physiological parameters of Populus 3 euramericana ‘‘Neva''显示文摘Populus 9 euramericana ‘‘Neva'' is the main poplar species in China, where drought stress is becoming extremely urgent. We carried out this research to study the effects of drought stress on the photosynthesis of Populus 9 euramericana ‘‘Neva''. Drought stress was induced by 58–62%(light), 48–52%(moderate), and 38–42%(severe) relative soil moisture content(RSMC). The effects of drought stress on photosynthetic rate, chlorophyll fluorescence parameters, and other related physiological parameters were investigated during treatment. Net photosynthetic rate(PN), and stomatal conductance decreased significantly and intercellular CO_2 concentration initially increased and then declined, whereas the stomatal limitation factors showed opposite trends in the light under moderate drought stress. Photosystem II(PSII) maximum photochemical efficiency, actual photochemical efficiency,and photochemical quenching decreased gradually under drought stress, whereas nonphotochemical quenching initially increased and then declined. Superoxide dismutase,peroxidase, and catalase activities initially increased and then decreased as RSMC was reduced, whereas malondialdehyde(MDA) content and relative electric conductivity(REC) increased gradually. These results suggest that stomatal factors accounted for the decline in PNunder light and moderate drought stress, whereas leaf PNdecreased mainly due to non-stomatal factors under severe drought stress. PSII was damaged; thus, photosynthetic electron transfer was restricted, indicating that heat dissipation is important for the light protection mechanism of plants.Antioxidant enzymes increased at the beginning of treatment, and the increased MDA and REC led to cell membrane damage. These results suggest that poplar seedlings stabilized their photosynthetic apparatus by reducing the light trapping ability under light and moderate drought stress conditions. This helped dissipate heat and enhance antioxidant enzyme activity. Stomatal factors accounted for the decline in P_N, whereas damage to PSII and antioxidant enzymes under severe drought stress suggested that the decline in P_N was caused by non-stomatal restrictive factors. | Guoting Liang Jianwen Bu Shuyong Zhang Guo Jing Guangcan Zhang Xia Liu | 2019 | Journal of Forestry Research2019，30，2： | 3 |
| 8 | Ni/MgO catalyst prepared using atmospheric high-frequency discharge plasma for CO_2 reforming of methane显示文摘A new type of Ni/MgO catalyst was prepared using atmospheric high-frequency discharge cold plasma. The influences of conventional method, plasma method, and plasma plus calcination method on the catalytic activity were studied and the CO2 reforming of methane was chosen as the probe reaction. The catalysts were characterized by X-ray diffraction (XRD), transmission electron microscope (TEM), X-ray photoelectron spectroscopy, and CO2 temperature-programmed surface reaction techniques. The results suggested that the nickel-based catalyst prepared by plasma plus calcination method possessed a smaller particle size and a higher dispersion of active component, better low-temperature activity and enhanced anti-coking ability. The conversion of CO2 and CH4 was 90.70% and 89.37%, respectively, and the reaction lasted for 36 h without obvious deactivation under 101.325 kPa and 750°C with CO2/CH4 = 1/1. | Pan Qin Huiyuan Xu Huali Long Yi Ran Shuyong Shang Yongxiang Yin Xiaoyan Dai | 2011 | Journal of Natural Gas Chemistry2011，20，5： | 3 |
| 9 | Remote Sensing Image Classification Based on Decision Tree in the Karst Rocky Desertification Areas: A Case Study of Kaizuo Township显示文摘Karst rocky desertification is a phenomenon of land degradation as a result of affection by the interaction of natural and human factors.In the past,in the rocky desertification areas,supervised classification and unsupervised classification are often used to classify the remote sensing image.But they only use pixel brightness characteristics to classify it.So the classification accuracy is low and can not meet the needs of practical application.Decision tree classification is a new technology for remote sensing image classification.In this study,we select the rocky desertification areas Kaizuo Township as a case study,use the ASTER image data,DEM and lithology data,by extracting the normalized difference vegetation index,ratio vegetation index,terrain slope and other data to establish classification rules to build decision trees.In the ENVI software support,we access the classification images.By calculating the classification accuracy and kappa coefficient,we find that better classification results can be obtained,desertification information can be extracted automatically and if more remote sensing image bands used,higher resolution DEM employed and less errors data reduced during processing,classification accuracy can be improve further. | Shuyong MA Xinglei ZHU Yulun AN | 2014 | Asian Agricultural Research2014，6，7： | 2 |
| 10 | Thermal evolution effects on the properties of converting Cs-polluted soil into pollucite-base glass-ceramics for radioactive cesium immobilization显示文摘The Fukushima nuclear accident in Japan on March 11,2011,produced large amounts of Cs-polluted soil which must be controlled to prevent the spread of hazardous Cs into the environment.In this paper,the effects of heat treatment on the structure and properties of Cs-containing glass-ceramics,as a simulated nuclear waste form,were systematically investigated.Cesium atoms are chemically bonded in the pollucite structure,and the amorphous phase further encapsulates the pollucite crystals in the glassceramics,thus providing an extra protective layer for the immobilized Cs.XRD analysis,Raman and FT-IR studies on the glass-ceramics synergistically indicated that the optimum crystallization temperature for pollucite is around 1000℃.The pollucite is predominantly the main crystalline phase with a narrow crystal size distribution between 0.5 and 2 mm.Standard leaching test results show that the leaching rate of Cs was very low(3.0×10^(-3) g/(m^(2)·d)).The study offers a practical method for immobilizing Cs in pollucite-base glass-ceramics.Moreover,the experimentally obtained data may provide some important references for converting Cs-polluted soil into pollucite-base glass-ceramics waste form. | Yong Yang Xin Cao Lifen Shi Zhengyi Zhang Pingping Wang Jinwei Li Yangshan Sun Shuyong Chen Tianhe Wang Liyun Ma Shou Peng | 2021 | Journal of Materiomics2021，7，6： | 2 |
| 11 | Stannous oxalate: An efficient catalyst for poly(trimethylene terephthalate) synthesis显示文摘A complete study on the catalytic activity of stannous oxalate for poly(trimethylene terephthalate) (PTT) synthesis via esterification method is carried out by comparison to the well known catalysts (tetrabutyl titanate (TBT), dibutyltin oxide (Bu2SnO), and stannous octoate (SOC)). Their catalytic activity in the esterification process is monitored by measuring the amount of water generated, while intrinsic viscosity (IV) and content of terminal carboxyl groups (CTCG) are used as the index in the polycondensation process. Stannous oxalate shows higher activity than the other catalysts. Decrease in reaction time and improvements in PTT property are observed. The higher catalytic activity of stannous oxalate is attributed to its chelate molecular structure. | JIA ShuYong REN YuRong ZHANG Dan HU Jing ZENG Yi WANG GongYing | 2008 | Science China Chemistry2008，51，3： | 2 |
| 12 | Numerical Simulation of Microporosity Evolution of Aluminum Alloy Castings显示文摘A mathematical model to calculate the size and distribution of microporosities was studied and coupled with a stochastic microstructure evolution model. The model incorporates various solidification phenomena such as grain structure evolution,solidification shrinkage, interdendritic fluid flow and formation and growth of pores during solidification processes. The nucleation and growth of grains were modeled with a cellular automaton method that utilizes the results from a macro scale modeling of the solidification process. Experiments were made to validate the proposed models. The calculated results of aluminum alloy castings agreed with the experimental measurements. | Shuyong DONG, Shoumei XIONG and Baicheng LIUDepartment of Mechanical Engineering, Tsinghua University, Beijing 100084, China | 2004 | Journal of Materials Science & Technology2004，20，1： | 2 |
| 13 | A new approach of proration-injection allocation for water-flooding mature oilfields显示文摘This paper presents a new method of injection-production allocation estimation for water-flooding mature oilfields.The suggested approach is based on logistic growth rate functions and several type-curve matching methods.Using the relationship between these equations,oil production and water injection rate as well as injection-production ratio can be easily forecasted.The calculation procedure developed and outlined in this paper requires very few production data and is easily implemented.Furthermore,an oilfield case has been analyzed.The synthetic and field cases validate the calculation procedure,so it can be accurately used in forecasting production data,and it is important to optimize the whole injection-production system. | Shuyong Hu Yongkai Li Ziwei Wang Guoqiang Hu | 2015 | Petroleum2015，1，1： | 2 |
| 14 | The effects of phenolic acid on nitrogen metabolism in Populus 3 euramericana ‘Neva’显示文摘The declines in soil fertility and productivity in continuously cropped poplar plantations are related to phenolic acid accumulation in the soil.Nitrogen is a vital life element for poplar and whether the accumulation of phenolic acid could influence nitrogen metabolism in poplar and thereby hinder continuous cropping is not clear.In this study, poplar cuttings of Populus × euramericana‘Neva’ were potted in vermiculite, and phenolic acids at three concentrations(0 X, 0.5 X and 1.0 X) were added according to the actual content(1.0 X) in the soil of a second-generation poplar plantation.Each treatment had eight replicates.We measured gas exchange parameters and the activities of key enzymes related to nitrogen metabolism in the leaves.Leaf photosynthetic parameters varied with the concentration of phenolic acids.The net photosynthetic rate(P_N) significantly decreased with increasing phenolic acid concentration, and non-stomatal factors might have been the primary limitation for P_N.The activities of nitrate reductase(NR), glutamine synthetase(GS) and glutamate synthase(GOGAT), as well as the contents of nitrate nitrogen, ammonium nitrogen, and total nitrogen in the leaves decreased with increasing phenolic acid concentration.This was significantly and positively related to P_N(P<0.05).The low concentration of phenolic acids mainly affected the transformation process of NO_3^- to NO_2^-, while the high concentration of phenolic acids affected both processes, where NO_3^- was transferred to NO_2^- and NH_4^+ was transferred to glutamine(Gln).Overall, phenolic acid had significant inhibitory effects on the photosynthetic productivity of Populus × euramericana‘Neva’.This was probably due to its influence on the activities of nitrogen assimilation enzymes, which reduced the amount of amino acids that were translated into protein and enzymes.Improving the absorption and utilization of nitrogen by plants could help to overcome the problems caused by continuous cropping. | Hui Li Huicheng Xie Zilong Du Xianshuang Xing Jie Zhao Jing Guo Xia Liu Shuyong Zhang | 2018 | Journal of Forestry Research2018，29，4： | 2 |
| 15 | Influence of MgO contents on silica supported nano-size gold catalyst for carbon monoxide total oxidation显示文摘A series of nano-size gold catalysts were prepared by deposition-precipitation method using silica material promoted with different amounts of MgO as the carrier. The influences of MgO addition on the structure and property of the nano-size gold catalysts were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), O2 temperature-programmed desorption (O2-TPD), and inductively coupled with plasma atomic emission spectroscopy (ICP-AES) techniques. The total oxidation of CO was chosen as the probe reaction. The results suggest that for the gold catalysts supported on the silica material after MgO modification, the size of the gold particles is pronouncedly reduced, the oxygen mobility is enhanced, and the catalytic activity for low-temperature CO oxidation is greatly improved. The gold catalyst modified by 6 wt% MgO (Mg/SiO2 weight ratio) shows higher CO oxidation activity, over which the temperature of CO total oxidation is lower about 150 K than that over the silica directly supported gold catalyst. | Huiyuan Xu Weiyi Li Shuyong Shang Chunrong Yan | 2011 | Journal of Natural Gas Chemistry2011，20，5： | 2 |
| 16 | A recommended rate for application of Chaetomium globosum ND35 fungus fertilizer on poplar plantations in China显示文摘Previous studies showed that Chaetomium globosum ND35 fungus fertilizer can improve the microbial community structure and enzyme activities of replanted soil.However, it remains unclear whether can improve the physiological and ecological characteristics of plants under successive rotation.In this study, we investigated the photosynthetic, physiological, and biochemical indexes including photosynthetic parameters, chlorophyll fluorescence, and chlorophyll content of 1-year-old poplar seedlings under seven different doses(range from 0 to1.67 g kg^(-1)) of C.globosum ND35 fungus fertilizer to study the effects of fungus fertilizer on photosynthesis of Poplar.Our results showed that:(1) With increasing application of fungus fertilizer in replanted soil, chlorophyll content of poplar leaves(Chl) increased, while physiological indexes such as electron transport rate(ETR),net photosynthetic rate(P_n), quantum efficiency(U),nitrate reductase(NR) activity and root vigor initially increased and then declined.Meanwhile, heat dissipation that depended on the xanthophyll cycle declined and nonphotochemical quenching(NPQ) initially increased and then decreased.When the dose of C.globosum ND35 fungus fertilizer was 0.67 g kg^(-1)(T3) and 1.00 g kg^(-1)(T4), excess light energy of photosynthetic apparatus was reduced, and photosynthetic apparatus distributed more light energy to the direction of photochemical reactions,which improved the efficiency of energy use.Plant height and biomass of leaves, stems, and roots were maximum at T3.We conclude that applying appropriate amounts of C.globosum ND35 fungus fertilizer can improve root physiological activity and capacity for use of light by poplar leaves.This can improve the operating states of the photosynthetic apparatus and lead to increased photosynthetic efficiency of poplar leaves and accumulation of dry matter.This suggests a strategy to alleviate the successive rotation obstacle of soil nutrient depletion. | Xuanxuan Xia Kexiang Gao Xianshuang Xing Rui Yang Shuyong Zhang Zilong Du Jing Guo Xia Liu | 2018 | Journal of Forestry Research2018，29，4： | 2 |
| 17 | Role of ball size in backward ball spinning of thin-walled tubular part with longitudinal inner ribs 显示文摘 | JIANG Shuyong REN Zhengyi LI Chunfeng | 2009 | Journal of Materials Processing Technology2009，209，4： | 1 |
| 18 | The electrochemical behavior of PbSO 4 with different structures on Pb显示文摘 | Yonglang Guo Lin Niu Shuyong Zhang Shenhao Chen | 2000 | Journal of Power Sources2000，，1： | 1 |
| 19 | Effect of compound Guizhu capsule on phosphate and tension homology deleted on chromsome ten and murine double mimute 2 gene expression in lung cancer of mice显示文摘OBJECTIVE: To observe the inhibitory effect of the Chinese herbal compound Guizhu capsule(CGZC)on lung cancer and explore the possible mechanism underlying its actions by evaluating its effects on the expression of phosphate and tension homology deleted on chromsome ten(PTEN) and murine double mimute 2(MDM2) in lung cancer model mice.METHODS: A mouse model of transplanted lung cancer was established by subcutaneous inoculation of cancer cells into the axillae of mice. Twenty-four hours later, the mice were weighed and randomly divided into the model control group, cisplatin group(DDP group), and high, moderate and low dosage CGZC groups, with ten mice in each group. The control mice received an equal volume of distilled water. DDP was intraperitoneally injected at 1 mg/kg in the DDP group, once a day for 3days. CGZC diluted with distilled water was admin-istered at 20 g/kg(10 times the clinical adult dosage) in the high-dose group, 10 g/kg(5 times the clinical adult dosage) in the moderate-dose group and 5 g/kg(2.5 times the clinical adult dosage) in the low-dose group once a day for 10 days. On the11 th day, the mice were weighed and killed. The tumor tissues were weighed and the tumor inhibition rate was calculated. PTEN and MDM2 protein expression were detected by immunohistochemical analysis of tumor tissues.RESULTS: The CGZC high-and moderate-dose groups showed a significant inhibitory effect on tumor growth(P < 0.05); there was no significant difference between the high dose group and the DDP group(P > 0.05). The CGZC high-dose group also showed enhanced expression of PTEN protein(P <0.01) and decreased expression of MDM2 protein(P < 0.01) in lung cancer cells of the mice. There was no significant difference between the high dose group and the DDP group.CONCLUSION: CGZC has a significant inhibitory effect on transplanted lung cancer in mice. The mechanism may involve reducing expression of PTEN and decreasing the expression of MDM2 in the lung cancer tissues of the mice. | Cao Yong Zhang Shuyong Zhang Ge Zhang Na Zhang Lixia Huang Yuanliang Yuan Naijun Tang Xiaojuan Du Jiajin Fang Jiuyun | 2017 | Journal of Traditional Chinese Medicine2017，37，4： | 1 |
| 20 | Effects of pulse flow and leading edge sweep on mixed flow turbines for engine exhaust heat recovery显示文摘Recovery of heat energy from internal combustion engine exhaust will achieve significant road transportation CO2 reduction. Turbocharging and turbogenerating are most commonly used technologies to recover engine exhaust heat energy.Engine exhaust pulse flow can significantly affect the turbine performance of turbocharging and turbogenerating systems,and it is necessary to consider the pulse flow effects in turbine design and performance analysis.An investigation was carried out by numerical simulation on the mixed flow turbine pulse flow performance and flow fields.Results showed that the variations of the turbine efficiency and flowfiled under pulsating flow conditions demonstrate significant unsteady effects.The effect of blade leading edge sweep on turbine pulse flow performance was studied.It is shown that increasing of the leading edge sweep angle can improve the turbine average instantaneous efficiency by about 2 percent under pulsating flow conditions. | ZHANG YangJun CHEN Li ZHUGE WeiLin ZHANG ShuYong | 2011 | Science China(Technological Sciences)2011，54，2： | 1 |
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