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| 1 | SKIP Confers Osmotic Tolerance during Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis显示文摘译解位于下面的机制种回答到不能生活的应力为改进植物压力抵抗是关键的。大部分在 transcriptional 水平响应盐应力对基因表示的规定被知道;然而,很少在 posttranscriptional 水平对这个过程被知道。最近,我们证明那个翻斗车是与钟基因 pre-mRNAs 交往并且为调整他们拼接的选择和 mRNA 成熟是必要的 spliceosome 的一个部件。在这研究,我们发现 skip-1 植物对盐和渗透的压力过分敏感,并且那个翻斗车为拼接的选择和几咸忍耐的基因的 mRNA 成熟被要求,包括 NHX1, CBL1, P5CS1, RCI2A,和 PAT10。染色体宽的分析表明那个翻斗车调停在咸压力的条件下面许多基因拼接的选择,和在 skip-1 的其他的拼接事件的那个大多数包含 intron 保留和罐头 generatea 在抄录 mRNA 的早熟的结束 codon。翻斗车也控制由 modulating 的其他的拼接 5 和 3 的识别或劈开拼接在咸压力的条件下面的施主和领受人地点。因此,这研究探讨的基本问题拼接的 mRNA 在植物的机械在 posttranscriptional 水平贡献咸压力的回答,并且提供在其他的拼接和盐忍耐之间的一个连接。 | Jinlin Feng dingjing Li Zhaoxu Gao Yaru Lu Junya Yu Qian Zheng Shuning Yan Wenjiao Zhang Hang He Ligeng Ma Zhengge Zhu | 2015 | Molecular Plant2015，8，7： | 10 |
| 2 | ARIMA and Facebook Prophet Model in Google Stock Price Prediction显示文摘We use the Autoregressive Integrated Moving Average(ARIMA)model and Facebook Prophet model to predict the closing stock price of Google during the COVID-19 pandemic as well as compare the accuracy of these two models’predictions.We first examine the stationary of the dataset and use ARIMA(0,1,1)to make predictions about the stock price during the pandemic,then we train the Prophet model using the stock price before January 1,2021,and predict the stock price after January 1,2021,to present.We also make a comparison of the prediction graphs of the two models.The empirical results show that the ARIMA model has a better performance in predicting Google’s stock price during the pandemic. | Beijia Jin Shuning Gao Zheng Tao | 2022 | Proceedings of Business and Economic Studies2022，5，5： | 2 |
| 3 | Exome sequencing identifies rare mutations of LDLR and QTRT1 conferring risk for early-onset coronary artery disease in Chinese显示文摘Despite the advances made over the past decades,the known loci for coronary artery disease(CAD)still only explain<20%of the genetic variation in risk[1,2].The known loci with the strongest effects usually confer a 20%-37%increased CAD risk and the most loci modulate risk by≤10%[1].While most of the current data are from European populations,the use of trans-ethnic analyses could be helpful to identify additional loci.Genetic inheritance may impose a high burden on early-onset coronary artery disease(EOCAD). | Kang Yao Yuxiang Dai Juan Shen Yi Wang Huanjie Yang Runda Wu Qijun Liao Hongyi Wu Xiaodong Fang Shalaimaiti Shali Lili Xu Meng Hao Chenhao Lin Zhonghan Sun Yilian Liu Mengxin Li Zhen Wang Qiang Gao Shuning Zhang Chenguang Li Wei Gao Lei Ge Yunzeng Zou Aijun Sun Juying Qian Li Jin Shangyu Hong Yan Zheng Junbo Ge | 2022 | National Science Review2022，9，8： | 1 |
| 4 | MAGUS:machine learning and graph theory assisted universal structure searcher显示文摘Crystal structure predictions based on first-principles calculations have gained great success in materials science and solid state physics.However,the remaining challenges still limit their applications in systems with a large number of atoms,especially the complexity of conformational space and the cost of local optimizations for big systems.Here,we introduce a crystal structure prediction method,MAGUS,based on the evolutionary algorithm,which addresses the above challenges with machine learning and graph theory.Techniques used in the program are summarized in detail and benchmark tests are provided.With intensive tests,we demonstrate that on-the-fly machine-learning potentials can be used to significantly reduce the number of expensive first-principles calculations,and the crystal decomposition based on graph theory can efficiently decrease the required configurations in order to find the target structures.We also summarized the representative applications of this method on several research topics,including unexpected compounds in the interior of planets and their exotic states at high pressure and high temperature(superionic,plastic,partially diffusive state,etc.);new functional materials(superhard,high-energy-density,superconducting,photoelectric materials),etc.These successful applications demonstrated that MAGUS code can help to accelerate the discovery of interesting materials and phenomena,as well as the significant value of crystal structure predictions in general. | Junjie Wang Hao Gao Yu Han Chi Ding Shuning Pan Yong Wang Qiuhan Jia Hui-Tian Wang Dingyu Xing Jian Sun | 2023 | National Science Review2023，10，7： | 1 |
| 5 | FOXP3 inhibits NF-κB activity and hence COX2 expression in gastric cancer cells显示文摘 | Qiang Hao Cun Zhang Yuan Gao Shuning Wang Jialin Li Meng Li Xiaochang Xue Weina Li Wei Zhang Yingqi Zhang | 2014 | Cellular Signalling2014，，3： | 1 |
| 6 | Gut microbe-derived metabolite indole-3-carboxaldehyde alleviates atherosclerosis显示文摘DearEditor,Indole-3-carboxaldehyde(ICA)is a gut microbe-derived tryptophan metabolite.Here,we explored the role of ICA in atherosclerosis.Plasma tryptophan metabolites were measured in healthy individuals and patients with atherosclerosis(Supplementary Table S1).The latter group showed disturbed tryptophan metabolism,while no difference was observed in tryptophan levels between the two groups(Fig.1a).ICA concentration is lower in the patients group(Fig.1b),consistent with previous clinical studies.1 The concentration of other metabolites of kynurenine or serotonin pathway showed no variations between the control and the patients(Supplementary Fig.1a). | Yijing Lu Wenlong Yang Zhiyong Qi Rifeng Gao Jing Tong Tingwen Gao Yin Zhang Aijun Sun Shuning Zhang Junbo Ge | 2023 | Signal Transduction and Targeted Therapy2023，8，11： | 0 |
| 7 | Effect of Na^(+)and Sr^(2+)Substitution on the Formation of the Oxygen Vacancies in Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+)Phosphor显示文摘The low-valence cations Na^(+)and Sr^(2+)were selected as the co-dopants to increase the vacancies concentration in the Y_(2.982)Ce_(0.018)Al_(2)Ga_(3)O_(12)phosphor.The successful incorporation of Na^(+)and Sr^(2+)was confirmed by the X-Ray Difiraction(XRD)results.All the samples show 5d-4f green persistent luminescence of Ce^(3+)after 450 nm excitation.The decay curves demonstrate that the persistent luminescence is efiectively enhanced with Na+and Sr2+doping.The thermoluminescence glow curves also show not only does the trap concentration increase,but also the distribution of trap depths is broadened.In addition,the air-and H_(2)/Ar-annealing treatments were conducted on every as-made sample.The experimental results prove that the increased traps after the Na^(+)/Sr^(2+)doping are mainly attributed to the oxygen vacancies,and the traps have a continuous and broad distribution of trap depths.We hope this work could give new inspiration for designing a high-performance persistent phosphor. | YANG Ting JIANG Hongyi DONG Ye GAO Shuai LIU Shuning | 2023 | Journal of Wuhan University of Technology(Materials Science)2023，38，5： | 0 |
| 8 | Ultra-lightweight ceramic scaffolds with simultaneous improvement of pore interconnectivity and mechanical strength显示文摘The high porosity and interconnectivity of scaffolds are critical for nutrient transmission in bone tis-sue engineering but usually lead to poor mechanical properties.Herein,a novel method that combines acid etching(AE)with selective laser sintering(SLS)and reaction bonding(RB)of Al particles is pro-posed to realize highly improved porosity,interconnectivity,mechanical strength,and in vitro bioactivity in 3D Al_(2)O_(3) scaffolds.By controlling the oxidation and etching behaviors of Al particles,a tunable hol-low spherical feature can be obtained,which brings about the distinction in compressive response and fracture path.The prevention of microcrack propagation on the in situ formed hollow spheres results in unique near elastic buckling rather than traditional brittle fracture,allowing an unparalleled compressive strength of 3.72±0.17 MPa at a high porosity of 87.7%±0.4%and pore interconnectivity of 94.7%±0.4%.Furthermore,scaffolds with an optimized pore structure and superhydrophilic surface show excellent cell proliferation and adhesion properties.Our findings offer a promising strategy for the coexistence of out-standing mechanical and biological properties,with great potential for tissue engineering applications. | Ye Dong Annan Chen Ting Yang Shuai Gao Shuning Liu Hongyi Jiang Yusheng Shi Chenglong Hu | 2023 | Journal of Materials Science & Technology2023，，6： | 0 |
| 9 | Ultrasmall iron-quercetin metal natural product nanocomplex with antioxidant and macrophage regulation in rheumatoid arthritis显示文摘Oxidative stress,due to the disruption of the balance between reactive oxygen species(ROS)generation and the antioxidant defense system,plays an important role in the pathogenesis of rheumatoid arthritis(RA).Excessive ROS leads to the loss of biological molecules and cellular functions,release of many inflammatory mediators,stimulate the polarization of macrophages,and aggravate the inflammatory response,thus promoting osteoclasts and bone damage.Therefore,foreign antioxidants would effectively treat RA.Herein,ultrasmall iron-quercetin natural coordination nanoparticles(Fe-Qur NCNs)with excellent anti-inflammatory and antioxidant properties were constructed to effectively treat RA.Fe-Qur NCNs obtained by simple mixing retain the inherent ability to remove ROS of quercetin and have a better water-solubility and biocompatibility.In vitro experiments showed that Fe-Qur NCNs could effectively remove excess ROS,avoid cell apoptosis,and inhibit the polarization of inflammatory macrophages by reducing the activation of the nuclear factor-κ-gene binding(NF-κB)pathways.In vivo experiments showed that the swollen joints of mice with rheumatoid arthritis treated with Fe-Qur NCNs significantly improved,with Fe-Qur NCNs largely reducing inflammatory cell infiltration,increasing antiinflammatory macrophage phenotypes,and thus inhibiting osteoclasts,which led to bone erosion.This study demonstrated that the new metal-natural coordination nanoparticles could be an effective therapeutic agent for the prevention of RA and other diseases associated with oxidative stress. | Zhihui Han Xiang Gao Yuanjie Wang Shuning Cheng Xiaoyan Zhong Yong Xu Xiaozhong Zhou Zengli Zhang Zhuang Liu Liang Cheng | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
| 10 | Biodegradable interference distraction implant:a promising replacement for conventional implant in patients with insufficient alveolar bone height显示文摘Background Dental implants have been widely used in the last few decades.However,patients with insufficient bone height need reconstructive surgeries before implant insertion.Distraction implant(Dl)has been invented to simplify the treatment procedure,but the shortcomings of Dl have limited its clinical use.We introduced biodegradable polyester to a novel Dl,called biodegradable interference distraction implant(BIDI).The purpose of this study was to assess the radiological,histological,and biomechanical properties of BIDI in animal models.Methods BIDIs were manufactured and inserted into the atrophied mandibles of 6 dogs. | Yongfeng Li Tao Li Bo Shao Yingying Sun Yuan Gao Yongqiang Zhang Qi Gao Shuning Shen Qiang Niu Mingming Shen Liang Kong | 2013 | 医用生物力学2013，28，S1： | 0 |
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