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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | Non-pulmonary allergic diseases and inflammatory bowel disease: A qualitative review显示文摘While the etiological underpinnings of inflammatory bowel disease(IBD) are highly complex, it has been not-ed that both clinical and pathophysiological similarities exist between IBD and both asthma and non-pulmonary allergic phenomena. In this review, several key points on common biomarkers, pathophysiology, clinical manifesta-tions and nutritional and probiotic interventions for both IBD and non-pulmonary allergic diseases are discussed.Histamine and mast cell activity show common behav-iors in both IBD and in certain allergic disorders. IgE also represents a key immunoglobulin involved in both IBD and in certain allergic pathologies, though these links require further study. Probiotics remain a critically important intervention for both IBD subtypes as well as multiple allergic phenomena. Linked clinical phenomena, especially sinonasal disease and IBD, are discussed. In addition, nutritional interventions remain an underuti-lized and promising therapy for modification of both al-lergic disorders and IBD. Recommending new mothers breastfeed their infants, and increasing the duration of breastfeeding may also help prevent both IBD and al-lergic diseases, but requires more investigation. While much remains to be discovered, it is clear that non-pulmonary allergic phenomena are connected to IBD in a myriad number of ways and that the discovery of com-mon immunological pathways may usher in an era of vastly improved treatments for patients. | David S Kotlyar Mili Shum Jennifer Hsieh Wojciech Blonski David A Greenwald | 2014 | World Journal of Gastroenterology2014，20，32： | 5 |
| 3 | The effect of music on preprocedure anxiety in Hong Kong Chinese day patients显示文摘 | David Lee Amanda Henderson David Shum | 2004 | J Clinical Nursing2004，13，3： | 1 |
| 4 | Mediating effects of coping, personal belief, and social support on the relationship among stress, depression, and smoking behaviour in university students显示文摘 | Jing Sun Nicholas Buys Donald Stewart David Shum | 2011 | Health Education2011，，2： | 1 |
| 5 | Prospective Memory and Pediatric Traumatic Brain Injury: Effects of Cognitive Demand显示文摘 | Ward Heather Shum David McKinlay Lyn | 2007 | Child Neuropsychology2007，13，3： | 1 |
| 6 | 前瞻记忆和警觉性的关系:来自ERP研究的证据显示文摘前瞻记忆指记住将来的计划或意图的能力;警觉性是指在一段相对长的时间内保持注意的能力.一般来说,前瞻记忆都包含有警觉性成分.在一般的前瞻记忆任务中,被试先形成一个前瞻记忆的意图,在形成意图之后,不是立即实现这个意图, | 王亚 李雪冰 黄佳 曹筱燕 崔吉芳 赵晴 王玉娜 David H K SHUM 陈楚侨 | 2012 | 科学通报2012，57，21： | 1 |
| 7 | The development of prospective memory in typically developing children显示文摘 | TIAN-XIAO YANG RAYMOND C K CHAN DAVID SHUM | | 0，，03： | 1 |
| 8 | Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis显示文摘 | Chuan Shi Xin Yu Eric F.C. Cheung David H.K. Shum Raymond C.K. Chan | 2013 | Psychiatry Research2013，，： | 1 |
| 9 | Relationship between prospective memory and vigilance: Evidence from ERP显示文摘Event-related potentials (ERPs) were used in this study to investigate the neural correlates of prospective memory (PM) and vigilance. Twenty college or graduate students participated in this study. They were administered a PM and a vigilance task and physiological data were collected at the same time. Behavioral results showed that the RT associated with PM cues was longer than those associated with vigilance targets. ERP results showed that PM cues and vigilance targets did not show significant difference in the N2 but PM cues evoked greater N300 than vigilance targets, and vigilance targets evoked greater parietal positivity/P3 than PM cues, suggesting vigilance and PM have similar but also distinctive neural basis. | WANG Ya LI XueBing HUANG Jia CAO XiaoYan CUI JiFang ZHAO Qing WANG YuNa SHUM David H K CHAN Raymond C K | 2012 | Chinese Science Bulletin2012，57，31： | 0 |
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