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| 1 | Low-temperature formation of photocatalytic Pt-anatase film by magnetron sputtering 显示文摘 | J Sheng L Shivalingappa J Karasawa | 1999 | J Mat Sci1999，34，10： | 1 |
| 2 | Myocardial infarction in the elderly显示文摘 | Chaturvedi NC Shivalingappa G Shanks B | 1972 | Lancet1972，1，： | 1 |
| 3 | Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia?显示文摘 | Yuval Bdolah Chun Lam Augustine Rajakumar Venkatesha Shivalingappa Walter Mutter Benjamin P. Sachs Kee Hak Lim Tali Bdolah-Abram Franklin H. Epstein S. Ananth Karumanchi | 2008 | American Journal of Obstetrics and Gynecology2008，，4： | 1 |
| 4 | Digital mixer for quartz crystal thickness monitor显示文摘 | Shivalingappa L Srinivasan M P Mohan S | 1996 | Vacuum1996，47，1： | 1 |
| 5 | Preparation and photocatalysis evaluation of anatase film on Pt-buffered polyimide 显示文摘 | Sheng J Shivalingappa L Karasawa J | 1998 | Vacuum1998，51，4： | 1 |
| 6 | Soluble endoglin contributes to the pathogenesis of preeclampsia 显示文摘 | Shivalingappa V Mourad T Chun L | 2006 | Nature Med2006，6，12： | 1 |
| 7 | Digital mixer for quartz crystal thickness monitor显示文摘 | L Shivalingappa M P Srinivasan S Mohan | 1996 | Vacuum1996，47，1： | 1 |
| 8 | Comparison between Conventional Mechanical Fixation and Use of Autologous Platelet Rich Plasma (PRP) in Wound Beds Prior to Resurfacing with Split Thickness Skin Graft显示文摘 | P Walker V Shivalingappa S | 2015 | World J Plast Surg2015，4，1： | 1 |
| 9 | Photocatalytic effect in platinum doped titanium dioxide films 显示文摘 | Shivalingappa L Sheng J Fukami T | 1997 | Vacuum1997，48，5： | 1 |
| 10 | Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing Preeclampsia显示文摘 | Sarosh Rana S Ananth Karumanchi Richard J. Levine Shivalingappa Venkatesha Jose Alejandro Rauh-Hain Hector Tamez Ravi Thadhani | 2007 | Hypertension2007，，1： | 1 |
| 11 | Effect of Nylon-66 nano-fiber interleaving on impact damageresistance of epoxy/carbon fiber composite laminates 显示文摘 | Paul Akangah Shivalingappa Lingaiah Kunigal Shivakumar | 2010 | Compos Struct2010，92，6： | 1 |
| 12 | Preparation and photocatalysis evaluation of anatase film on Pt-buffered polyamide显示文摘 | Sheng J Shivalingappa L Karasawa J | 1998 | Vacuum1998，51，4： | 1 |
| 13 | Chlorogenic acid may be a potent inhibitor of dimeric SARS-CoV-2 main protease 3CLpro: an in silico study显示文摘Background:Since the emergence of coronavirus disease 2019 to date,there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection,and the identification of novel hits against therapeutic targets has become a global emergency.Echinacea purpurea is a traditional herb utilized to treat cough,fever,sore throat,respiratory tract infection,and so on as an immune stimulant.In this study,in silico molecular docking approach was used to screen phytocompounds from E.purpurea against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease(3CLpro)and severe acute respiratory syndrome coronavirus main peptidase(96%sequence similarity)to blunt the viral gene expression and viral replication.Methods:Initially,we screened phytocompounds for their druggability and ADMET property.Furthermore,x-ray crystallographic structures of main proteases 3CLpro and main peptidase having Protein Data Bank ID 6LU7 and 2GTB were used as protein targets for the identification of potential drug candidates.We performed docking using AutoDock Vina by PyRx 0.8 software.BIOVIA Discovery Studio Visualizer v2019 was used to analyze ligand-protein complex.The probable protein targets of the selected compound were predicted by BindingDB(P≥0.7).STRING and Kyoto Encyclopedia of Genes and Genomes pathways are utilized to identify the molecular pathways modulated by the predicted targets(FDR≤0.05),and the network interaction between compounds and protein pathways was constructed by Cytoscape 3.6.1.Results:Among all the compounds,chlorogenic acid showed druggable characteristics and scored the lowest binding energy with main protease and main peptidase via interacting with active site 1 domain amino acid residues.Interestingly,chlorogenic acid interacted with Phe140 main protease 3CLpro,which is potentially involved in the dimerization.Enrichment analysis identified chlorogenic acid to modulate insulin resistance,necroptosis,interleukin-17,tumor necrosis factor signaling pathway,legionellosis,T helper 17 cell differentiation,advanced glycation end products and receptor for advanced glycation end products,mitogen-activated protein kinase,Ras,estrogen,vascular endothelial growth factor,B-cell receptor,nuclear factor kappa B,Rap1,hypoxia inducible factor-1,phosphatidylinositide 3-kinase-Akt,insulin,mechanistic target of rapamycin,p53,retinoic acid inducible gene I like receptor,and ErbB signaling pathways.Conclusion:Chlorogenic acid may act as a potent main protease 3CLpro inhibitor and may also inhibit the severe acute respiratory syndrome coronavirus 2 dimerization,viral gene expression,and replication within the lung epithelium.Chlorogenic acid may go a long way in finding one of the multipronged solutions to tackle coronavirus disease 2019 viral infection in the future. | Rajkumar Sanjay Patil Nayeem A.Khatib Vishal Shivalingappa Patil Shailendra Sanjay Suryawanshi | 2021 | Traditional Medicine Research2021，6，2： | 0 |
| 14 | Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera显示文摘Objective:To identify the safe and effective natural inhibitors of spike glycoprotein and main protease 3CLpro using potential natural antiviral compounds which are studied under various animal models and viral cell lines.Methods:First,compounds were retrieved from the Pub Chem database and predicted for their druggability using the Mol Soft web server,and compounds having drug-like property were predicted for major adverse drug reactions like cardiotoxicity,hepatotoxicity,arrhythmia,myocardial infarction,and nephrotoxicity using ADVERpred.Docking of nontoxic antiviral compounds with spike glycoprotein and main protease 3CLpro was performed using Auto Dock vina by PyRx 0.8 version.The stability of compoundprotein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond software.Results:Based on the druggable and nontoxic profile,nine compounds were selected.Among them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of spike glycoprotein(glycosylation site)and main protease 3CLpro via interacting with active site amino acid residues before and after MD simulation at 50 ns.Withanone,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral replication.Conclusion:The current study reports Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a potential lead hit for further experimental validation. | Vishal Shivalingappa Patil Vrushabh B.Hupparage Ajay P.Malgi Sanjay H.Deshpande Sathgowda A.Patil Shamanand P.Mallapur | 2021 | Chinese Herbal Medicines2021，13，3： | 0 |
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