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| 1 | 实体瘤CART治疗面临的挑战显示文摘嵌合性抗原受体T细胞疗法在CD19表达阳性的血液系统恶性肿瘤中取得了惊人的效果。靶向CD19的CART细胞(CART CD19)可使急性淋巴细胞白血病的缓解率提高。然而,CART疗法对实体肿瘤的疗效近几年一直未有实质性的突破。实体肿瘤免疫治疗中存在诸多亟待解决的问题,如CART如何进入实体瘤微环境并在其中保持活力、怎样更加快速准确的识别肿瘤细胞、如何克服免疫抑制发挥作用等。本文主要探讨CART细胞治疗实体瘤所面临的挑战。 | 丁烁 赵磊 Rojina Shilpakar 魏云巍 | 2018 | 中国免疫学杂志2018，34，4： | 7 |
| 2 | MRI differential diagnosis of intrahepatic biloma from subacute hematoma显示文摘 | T. Shigemura F. Yamamoto S. K. Shilpakar T. Kojima S. Yamamoto Y. Pu | 1995 | Abdominal Imaging1995，，3： | 1 |
| 3 | MRIdifferential diagnosis of intrahepatic biloma from subacute hematoma显示文摘 | Shigemura T Yamamto F Shilpakar K | 1995 | Abdom Imaging1995，20，3： | 1 |
| 4 | MRI differential diagnosis of intrahepatic biloma from subacute hematoma显示文摘 | T. Shigemura F. Yamamoto S. K. Shilpakar T. Kojima S. Yamamoto Y. Pu | 1995 | Abdominal Imaging1995，，3： | 1 |
| 5 | Genetics of Schiz- ophrenia显示文摘 | Roofeh D Tumuluru D Shilpakar S | 2013 | Int J Mental Hea:th2013，42，1： | 1 |
| 6 | Vohage and Frequency Control of Parallel Operated Synchronous Generator and Induction Generator With STATCOM in Micro Hydro Scheme显示文摘 | I Tamrakar L B Shilpakar B G Femandes | 2007 | Generation Transmission & Dis- tribution IET2007，1，5： | 1 |
| 7 | Analysis of a novel solid state voltage regulator for a self-excited induction generator显示文摘 | SINGH B SHILPAKAR L B | 1998 | IEEE Proceedings Generator Transactions Distribution1998，145，6： | 1 |
| 8 | Dynamic Behavior of a Three Phase Self-excited Induction Generator for Single-phase Power Generation 显示文摘 | SHILPAKAR L B SINGH B P | 1998 | Electric Power Systems Research1998，48，1： | 1 |
| 9 | MRI differential diagnosis of intrahepatic biloma from subacute hematoma显示文摘 | Shigemura T Yamamto F Shilpakar K | 1995 | Abdom imaging1995，20，3： | 1 |
| 10 | Analysis of a novel solid state voltage regulator for a self-excited induction generator显示文摘 | Shilpakar L B | 1998 | IEE Proceeding Generation Transmission Distribu-tion1998，145，6： | 1 |
| 11 | Analysis of a novel solid state voltage regulator for a self-excited induction genera- tor显示文摘 | SINGH B SHILPAKAR L B | 1998 | IEEE Proceedings Gneneating Trasactions Distri- buction1998，145，6： | 1 |
| 12 | Management of acute odontoid fractures: operative techniques and complication avoidance显示文摘 | Shilpakar S McLaughlin MR Haid RW Jr | 2000 | Neurosurg Focus2000，8，6： | 1 |
| 13 | Structural and Magnetic Properties in Nd_(0.7)Sr_(0.3)MnO_3 Manganite显示文摘The temperature evolution of the crystal structure for Nd_(0.5)Sr_(0.5)MnO_3 has been investigated by powder XRD between 125 Kand 725K.The structure can be described with a monoclinic symmetry(space group P21/m)in the temperature range of 125—175 K,while with the increase in temperature between 175 Kand 575 Kthe structure involves a higher orthorhombic symmetry(space group Imma).The rhombohedral structure with space group R-3cis observed at high temperature region of 575—725K.The increase in the magnetization at low temperatures can be ascribed to the field-induced short-range magnetic order of the Nd3+ions.The dc and ac susceptibility data show some anomalies around the FM-PM transition region which can be attributed to the glass behavior and magnetic relaxation. | Feng Xiaomei Chen Jiankun Shen Yifu Unisha Shilpakar Wang Ding Huang Guoqiang | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 0 |
| 14 | 微波消融与无水乙醇消融治疗单纯性甲状腺囊肿的效果比较显示文摘目的比较两种消融方法治疗单纯性甲状腺囊肿的疗效。方法回顾性比较我院2014年8月~2017年3月超声引导下分别应用无水乙醇消融(无水乙醇组,n=30)或微波消融方法(微波消融组,n=30)治疗60例单纯性甲状腺囊肿患者的临床资料。比较两组患者术后临床疗效、治疗前后甲状腺激素水平变化及术中术后并发症。结果术中自觉颈部疼痛者21例,其中无水乙醇组16例,微波消融组5例,差异有统计学意义(χ^2=8.864,P=0.003);术中穿刺后发生较明显出血者3例,其中无水乙醇组2例,微波消融组1例,差异无统计学意义(χ^2=0.351,P=0.554);术后无水乙醇组出现声音嘶哑者2例,微波消融组0例,差异无统计学意义(χ^2=2.069,P=0.150)。术后随访3~5个月,两组远期临床效果无差异(Z=-3.611,P=0.718),两组治疗前后甲状腺激素水平均在正常范围内。结论微波消融术与无水乙醇消融术治疗单纯性甲状腺囊肿疗效相似,但前者术中疼痛发生率低;两种方法治疗单纯性甲状腺囊肿对甲状腺内分泌功能均无明显影响。 | 刘鲁嘉 张健 Shilpakar Rojina 李爱东 | 2020 | 哈尔滨医科大学学报2020，54，2： | 0 |
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