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| 1 | Mechanism insight into the formation of H_(2)S from thiophene pyrolysis: A theoretical study显示文摘Pyrolysis is an efficient and economical method for the utilization of waste rubber,but the high sulfur content limits its industrial application.Currently,the migration and transformation of the element S during pyrolysis of waste rubber is far from well known.In this work,a density functional theory(DFT)method was employed to explore the possible formation pathways of H_(2)S and its precursors(radicals HS·and S·)during the pyrolysis of thiophene,which is an important primary pyrolytic product of rubber.In particular,the influence of reactive hydrogen radicals was carefully investigated in the thiophene pyrolysis process.The calculation results indicate that the decomposition of thiophene tends to be initiated by hydrogen transfer between adjacent carbon atoms,which needs to overcome an energy barrier of 312.4 kJ/mol.The optimal pathway to generate H_(2)S in thiophene pyrolysis involves initial H migration and S-C bond cleavage,with an overall energy barrier of 525.8 kJ/mol.In addition,a thiol intermediate that bears unsaturated C-C bonds is essential for thiophene pyrolysis to generate H_(2)S,which exists in multiple critical reaction pathways.Moreover,the presence of hydrogen radicals significantly changes the decomposition patterns and reduces the energy barriers for thiophene decomposition,thus promoting the formation of H_(2)S.The current work on H_(2)S formation from thiophene can provide some theoretical support to explore clean utilization technologies for waste rubber. | Shiguan Yang Xinrui Fan Ji Liu Wei Zhao Bin Hu Qiang Lu | 2021 | Frontiers of Environmental Science & Engineering2021，15，6： | 1 |
| 2 | Characterization of Spartina altemiflora as feedstock for anaerobic digestion 显示文摘 | Yang Shiguan Li Jihong Zheng Zheng | 2009 | Biomass and Bioenergy2009，33，： | 1 |
| 3 | Anaerobic batch digestion of Spartina alterniflora aloneand co-digestion with cow feces显示文摘 | Chen Guangyin Zheng Zheng Yang Shiguan | 2010 | Fuel Processing Technology2010，91，11： | 1 |
| 4 | Experimental co-digestion of corn stalk and vermicompost to improve biogas production 显示文摘 | Chen Guangyin Zheng Zheng Yang Shiguan | 2010 | Waste Management2010，30，10： | 1 |
| 5 | Application of Serial Section Method to Determine the Radiotherapy Target Volume for Esophageal Squamous Carcinoma显示文摘 | Yipeng Song Yemin Liang Rukun Zang Likuan Hu Shiguan Zhu | 2013 | Cell Biochemistry and Biophysics2013，，： | 1 |
| 6 | The e / a values of ideal metallic glasses in relation to cluster formulae显示文摘 | Guang Han Jianbing Qiang Fengwei Li Liang Yuan Shiguan Quan Qing Wang Yingmin Wang Chuang Dong Peter H?ussler | 2011 | Acta Materialia2011，，15： | 1 |
| 7 | THE SOLUBILITY OF FERROALLOYED NEODYMIUM IN MOLTEN SALT CONTAINING NEODYMIUM TRICHLORIDE显示文摘The solubility of ferroalloyed neodymium in molten salt containing neodymium trichloride and the de-pendence of solubility on temperature and composition of the melt are determined by means of electrochemicalmethod.The data obtained are in good agreement with result of chemical analysis of the quenched molten saltsamples. | Chen Shiguan Lu Qingtao Yu Ronglin Li Xiaohua(Department of Metallurgical Engineering,Shanghai University of Technology,Shanghai 200072,P.R.China) | 1990 | Journal of Rare Earths1990，8，1： | 0 |
| 8 | IL13Rα1 prevents a castration resistant phenotype of prostate cancer by targeting hexokinase 2 for ubiquitin-mediated degradation显示文摘Objective:Androgen deprivation therapy(ADT)is still the principal treatment option for prostate cancer(PCa).In addition to reactivation of androgen receptor signaling,the resistance of PCa to apoptosis during ADT also contributes to castration resistant PCa(CRPC).A previous study reported that gene transfer of IL-13Rα2 into PCa cells sensitized the cells to the IL-13R-targeted cytotoxin IL13Rα1,leading to apoptosis.Compared with IL-13Rα2,IL13Rα1 is more constitutively expressed in PCa cells,but its function in PCa remains to be established.Methods:We determined the role and expression of IL13Rα1 in PCa cancer cells using western blotting,flow cytometry,and cell proliferation assays.Co-immunoprecipitation and mass spectrometry were used to identify the proteins that interacted with IL13Rα1,to elucidate its function.Results:In this study,we showed that IL13Rα1 was selectively suppressed in androgen-deprived PCa cells and that its suppression tended to be associated with poor prognoses of PCa patients.IL13Rα1 overexpression promoted apoptosis and inhibited tumor growth under androgen-deprived or castrated conditions(P<0.01).Mechanistically,IL13Rα1 recruited and facilitated ubiquitin protein ligase E3C-mediated ubiquitination and degradation of hexokinase 2(HK2),resulting in glycolytic inhibition and eventually leading to PCa cell apoptosis.Furthermore,our data revealed that mutated ataxia-telangiectasia kinase phosphorylated and facilitated the selective ubiquitin proteasome-mediated degradation of HK2.Notably,IL13Rα1-overexpressing PCa cells were more susceptible to apoptosis and exhibited reduced tumor growth after exposure to the HK2 inhibitor,2-deoxy-D-glucose(P<0.01).Conclusions:Our data identified a tumor suppressor role for IL13Rα1 in preventing the resistance of PCa cells to apoptosis during androgen deprivation by inhibiting glycolysis.IL13Rα1-mediated signaling involving HK2 may therefore provide a novel treatment target and strategy for CRPC. | Tingting Feng Jing Wang Kai Cheng Qiqi Lu Ru Zhao Shiguan Wang Qingyun Zhang Luna Ge Jihong Pan Guanhua Song Lin Wang | 2022 | Cancer Biology & Medicine2022，19，7： | 0 |
| 9 | The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure显示文摘Environmental stresses,such as temperature,disease and altitude could induce systematic changes of biological systems which manifests as concerted responses across multiple systems within a certain period of time[1].High altitude acclimatization(HAA)refers to a series of adaptive physiological responses to hypoxic stress. | Yi Li Meng Hao Zixin Hu Yanyun Ma Kun Wang Xiaoyu Liu Xianhong Yin Menghan Zhang Yi Wang Meng Liang Yuan Guo Lei Bao Shixuan Zhang Shiguan Le Chenyuan Wu Dayan Sun Yang Wei Fei Wu Rui Zhang Lingxian Zhu Hui Zhang Shuai jang Xingdong Chen Xiaofeng Wang Yao Zhang Longli Kang Wenyuan Duan Bin Qiao Jiucun Wang Li Jin | 2023 | National Science Review2023，10，5： | 0 |
| 10 | Preparation of Sintered Titanium Anode and Its Electrochemical Properties显示文摘In this paper, the sintered Ti anodes (STA) with Ti suboxide intermediate layers and β-MnO2 activelayers were investigated in detail. At usual industrial current densities, the oxygen evolutionoverpotential on STA is reduced by 350 mV compared with lead anodes. According to the equationobtained experimentally, the service life of STA may be expected to be more than 3 years. After los-ing activity, STA may be recoated with β-MnO2 active layers and used again. The electrocatalyticactivity and the service life of the reused anodes remained almost unchanged. The possible reasonsfor losing activity of STA during the anodic evolution of oxygen were investigated by means of elec-tron probe microanalysis, electron scanning microscope and X-ray diffraction. | Jiangming LU Bangna ZHOU Zhongxing YU Shiguan CHEN+, Shanghai University of Technology, Shanghai 200072, China | 1993 | Journal of Materials Science & Technology1993，9，2： | 0 |
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