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| 1 | Effect of chondroitin sulfate proteoglycans on neuronal cell adhesion, spreading and neurite growth in culture显示文摘As one major component of extracellular matrix(ECM) in the central nervous system, chondroitin sulfate proteoglycans(CSPGs) have long been known as inhibitors enriched in the glial scar that prevent axon regeneration after injury. Although many studies have shown that CSPGs inhibited neurite outgrowth in vitro using different types of neurons, the mechanism by which CSPGs inhibit axonal growth remains poorly understood. Using cerebellar granule neuron(CGN) culture, in this study, we evaluated the effects of different concentrations of both immobilized and soluble CSPGs on neuronal growth, including cell adhesion, spreading and neurite growth. Neurite length decreased while CSPGs concentration arised, meanwhile, a decrease in cell density accompanied by an increase in cell aggregates formation was observed. Soluble CSPGs also showed an inhibition on neurite outgrowth, but it required a higher concentration to induce cell aggregates formation than coated CSPGs. We also found that growth cone size was significantly reduced on CSPGs and neuronal cell spreading was restrained by CSPGs, attributing to an inhibition on lamellipodial extension. The effect of CSPGs on neuron adhesion was further evidenced by interference reflection microscopy(IRM) which directly demonstrated that both CGNs and cerebral cortical neurons were more loosely adherent to a CSPG substrate. These data demonstrate that CSPGs have an effect on cell adhesion and spreading in addition to neurite outgrowth. | Jingyu Jin Sharada Tilve Zhonghai Huang Libing Zhou Herbert M.Geller Panpan Yu | 2018 | Neural Regeneration Research2018，13，2： | 2 |
| 2 | Rapid synthesis of cerium oxide nanoparticles with superior humidity-sensing performance显示文摘 | Sharada Thakur Pradip Patil | 2013 | Sensors & Actuators: B. Chemical2013，，： | 1 |
| 3 | Effectws of alternative maternal micronutrient supplements on low birth weight in rural Nepal:double blind randomised community trial显示文摘 | Steven C Sharada Ram | 2003 | BMJ2003，326，57： | 1 |
| 4 | In vitro bulblet regeneration from bulb scale explants of Lilium japanicum thunb,Effect of plant growth regulators and culture environment显示文摘 | Maesato K Sharada K and Fukui H | 1994 | Journal of Horticultural Science1994，2，69： | 1 |
| 5 | A model proposed for reducing the false positive alarm rate using the feature of e vent correlation显示文摘 | SHARADA K A HEMANT PRASHANTH | 2012 | International Journal of Advanced Research in Computer Science and Software Engineering2012，，8： | 1 |
| 6 | A problem sol- ving approach to nutrition education and counseling 显示文摘 | Hours P Sharada S Klassen AC | 2006 | Journal of Nutrition Education and Behavior2006，38，4： | 1 |
| 7 | Modelling and simulation of pseudolite-based navigation: A GPS- independent radio navigation system显示文摘 | Tiwary K Behera S K Sharada G | 2010 | Defence Science J2010，60，5： | 1 |
| 8 | Expression of matrix metalloproteinase ( MMP - 2) and extracellular matrix meta - lloproteinases inducer (EMMPRIN) in be - nign and advanced breast cancer tissue samples 显示文摘 | Chandru H Sharada AC Manjunath S | 2007 | Biomed Khim2007，53，4： | 1 |
| 9 | Inhibition of the bacterial enoyl reduetase fab Ⅰ by triclosan:structure-activity analysis of fab Ⅰ inhibition by triclosan analogues显示文摘 | Sharada Sivaraman | 2004 | J Med Chem2004，47，： | 1 |
| 10 | Muhicys tic dysplastic kidney: a retrospective study 显示文摘 | Sharada S Vijayakumar M Nageswaran P | 2014 | Indian Pedi- atr2014，51，8： | 1 |
| 11 | 2, 4-D induced, c-AMP mediated, sclerotial formation in Rhizoctonia solani显示文摘 | Sharada K Lkegami H Hyakumachi M | 1992 | Mycological Research1992，96，： | 1 |
| 12 | Ascorbic acid acts as inhibitory transmitter in the hypothalamus to inhibit stimulated luteinizing hormone-releasing 显示文摘 | Sharada K Wen HY Anna W | 1999 | Proc Natl Acad Sci USA1999，97，： | 1 |
| 13 | Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli by Triclosan 显示文摘 | Sharada Sivaraman Jacque Zwahlen Alasdair F Bell | 2003 | Biochemistry2003，42，： | 1 |
| 14 | Bioterrorism: Challenges and considerations显示文摘 | Prakash N Sharada P Pradeep G | 2010 | J Forensic Dent Sci2010，2，2： | 1 |
| 15 | Inhibitoin of the bacterial enoyl reductase FabI by Triclosan: a structure-reactivity analysis of FabI ingibition by Triclosan analogues 显示文摘 | Sharada Sivaraman | 2004 | Med Chem2004，47，： | 1 |
| 16 | PCR-baseddetection of Colletotrichum acutatum on strawberry 显示文摘 | Sreenivasappasad S Sharada K Brown A E | 1996 | PlantPathology1996，45，： | 1 |
| 17 | Withanolide production by in vitro cultures of Withania somnifera and its association with differentiation 显示文摘 | Sharada M Ahuja A Asuri K | 2007 | Biologia Plantarum2007，51，1： | 1 |
| 18 | PCR-basecl de-tection of Colletotrichum acutatum on strawberry显示文摘 | Sreenivasaprasad S Sharada K Brown A E | 1996 | Plant Patholo- gy1996，45，： | 1 |
| 19 | Domestic violence and Dowry: Evidence from a South Indian Village 显示文摘 | Sharada Srinivasan Arjun S Bedi | 2007 | World Development2007，35，5： | 1 |
| 20 | Cobalamindeficiency presenting as refractory vaso vagal syncope显示文摘 | Sharada K Reddy G Narasimhan C | 2012 | Intern J Cardiol2012，156，1： | 1 |
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