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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | Abdominal incision: decision or indecision? 显示文摘 | Cahalane M J Shapiro ME Silen W | 1989 | Lancet1989，8630，1： | 1 |
| 3 | Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in nonobese diabetic mice 显示文摘 | Shapiro A M Suarez-Pinzon W L Power R | 2002 | Diabetologia2002，45，2： | 1 |
| 4 | Hoist scheduling for a PCB electroplating facility显示文摘 | SHAPIRO G W NUTTLE H W | 1988 | HE Transactions1988，20，2： | 1 |
| 5 | Increased expression of bioactive chemokines in human cerebromicrovascular endothelial cells and astrocytes subjected to simulated ischemia in vitro显示文摘 | Zhang W D Smith Catherine Shapiro Anthony | 1999 | J Neuroimmunology1999，101，2： | 1 |
| 6 | The effect of section of the medial collateral ligament on force generated in the anterior cruciate ligament 显示文摘 | Shapiro M S Markolf K L Finerman G A M Mitchell P W | 1991 | Journal of Bone and Joint Surgery1991，72，： | 1 |
| 7 | Natural products used for dia- betes 显示文摘 | Shapiro K Gong W C | 2002 | J Am Pharm Assoc2002，42，2： | 1 |
| 8 | Self-healing in modern operating systems显示文摘 | SHAPIRO M W | 2004 | ACM Queue2004，2，9： | 1 |
| 9 | Hoist scheduling for a PCB electroplating facility显示文摘 | Nuttle H W | 1988 | IIE Transactions1988，20，2： | 1 |
| 10 | Homozyagous deletions of the multiple tumor suppressor gene 1 in the progression of human astrocytomas显示文摘 | Shapiro DG Duan W Popovic EA | 1995 | Cancer Res1995，55，1： | 1 |
| 11 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 12 | Improved method for numerical Solution of the general incompressible fluid film lubrication problem显示文摘 | Castelli V Shapiro W | 1967 | ASME Journal of lubrication technology1967，8，： | 1 |
| 13 | Independent effect of depression and anxiety on chronic obstructive pulmonary disease exacerbations and hospitalizations 显示文摘 | Xu W Collet JP Shapiro S | 2008 | Am J Respir Crit Care Med2008，178，9： | 1 |
| 14 | Acute acalculous cholecystitis in the critically ill显示文摘 | SHAPIRO M J LUCHTEFELD W B KURZWEIL S | 1994 | Am Surg1994，60，5： | 1 |
| 15 | Practical Modeling for Resource Management 显示文摘 | Benders P Northrup W Shapiro J | 1981 | Harvard Business Review1981，59，2： | 1 |
| 16 | Clinical safety and tolerability of montelukast, a leukotriene receptor antagonist, in controlled clinical trials in patients aged > or = 6 years 显示文摘 | Storms W Michele TM Knorr B Noonan G Shapiro G Zhang J Shingo S Reiss TF | 2001 | Clin Exp Allergy2001，31，1： | 1 |
| 17 | SARPs: a family of secreted apoptosis-related proteins 显示文摘 | Melkonyan H S Chang W C Shapiro J P | 1997 | Proc Natl Acad Sci USA1997，94，13： | 1 |
| 18 | The physics of ghost imaging 显示文摘 | Shapiro J H Boyd R W | 2012 | Quantum Inf Process2012，，11： | 1 |
| 19 | lmmunohistochemical localization of calcium-binding proteins in the brainstem vestibular nucleiof the jaundiced Gunn rat显示文摘 | Shaia W T Shapiro S M Heller A J | 2002 | Hear Res2002，173，12： | 1 |
| 20 | Factors Affecting Farmers'Hedging Decisions显示文摘 | Brorsen B W | 1988 | North Central Journal of Agricultural Economics1988，10，2： | 1 |
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