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| 1 | The Ghd7 transcription factor represses ARE1 expression to enhance nitrogen utilization and grain yield in rice显示文摘The genetic improvement of nitrogen use efficiency(NUE)of crops is vital for grain productivity and sustainable agriculture.However,the regulatory mechanism of NUE remains largely elusive.Here,we report that the rice Grain number,plant height,and heading date7(Ghd7)gene genetically acts upstream of ABC1 REPRESSOR1(ARE1),a negative regulator of NUE,to positively regulate nitrogen utilization.As a transcriptional repressor,Ghd7 directly binds to two Evening Element-like motifs in the promoter and intron 1 of ARE1,likely in a cooperative manner,to repress its expression.Ghd7 and ARE1 display diurnal expression patterns in an inverse oscillation manner,mirroring a regulatory scheme based on these two loci.Analysis of a panel of 2656 rice varieties suggests that the elite alleles of Ghd7 and ARE1 have undergone diversifying selection during breeding.Moreover,the allelic distribution of Ghd7 and ARE1 is associated with the soil nitrogen deposition rate in East Asia and South Asia.Remarkably,the combination of the Ghd7 and ARE1 elite alleles substantially improves NUE and yield performance under nitrogen-limiting conditions.Collectively,these results define a Ghd7–ARE1-based regulatory mechanism of nitrogen utilization,providing useful targets for genetic improvement of rice NUE. | Qing Wang Qingmei Su Jinqiang Nian Jian Zhang Meng Guo Guojun Dong Jiang Hu Rongsheng Wang Changshuo Wei Guanwen Li Wan Wang Hui-Shan Guo Shaoyang Lin Wenfeng Qian XianzhiXie Qian Qian Fan Chen Jianru Zuo | 2021 | Molecular Plant2021，14，6： | 10 |
| 2 | Expression and function of Delta-like ligand 4 in a rat model of retinopathy of prematurity显示文摘The Delta-like ligand 4/Notch signaling pathway was shown to participate in the process of retinal development and angiogenesis.However,the function of the Delta-like ligand 4/Notch signaling pathway in retinopathy of prematurity requires further study.Retinopathy of prematurity was induced in 5-day-old Sprague-Dawley rats exposed to hyperoxia for 7 days,and then returned to room air.Reverse transcription-PCR and western blot revealed that Delta-like ligand 4 levels decreased at postnatal day 12 and increased at postnatal day 17 in retinopathy of prematurity rats.Flat-mounted adenosine diphosphatase stained retina and hematoxylin-eosin stained retinal tissue slices showed that the clock hour scores and the nuclei counts in retinopathy of prematurity rats were significantly different compared to normal control rats.After retinopathy of prematurity rats were intravitreally injected with Delta-like ligand 4 monoclonal antibody to inhibit the Delta-like ligand 4/Notch signaling pathway,there was a significant increase in the severity of retinal neovascularization (clock hours) in the intravitreally injected eyes.The nuclei count was highly correlated with the clock hour score.These results suggest that Delta-like ligand 4/Notch signaling plays an essential role in the process of physiological and pathological angiogenesis in the retina. | Shaoyang Shi Xun Li You Li Cunwen Pei Hongwei Yang Xiaolong Chen | 2013 | Neural Regeneration Research2013，8，8： | 4 |
| 3 | Enhancing rice grain production by manipulating the naturally evolved cis-regulatory element-containing inverted repeat sequence of OsREM20显示文摘Grain number per panicle(GNP)is an important agronomic trait that contributes to rice grain yield.Despite its importance in rice breeding,the molecular mechanism underlying GNP regulation remains largely unknown.In this study,we identified a previously unrecognized regulatory gene that controls GNP in rice,Oryza sativa REPRODUCTIVE MERISTEM 20(OsREM20),which encodes a B3 domain transcription factor.Through genetic analysis and transgenic validation we found that genetic variation in the CArG box-containing inverted repeat(IR)sequence of the OsREM20 promoter alters its expression level and contributes to GNP variation among rice varieties.Furthermore,we revealed that the IR sequence regulates OsREM20 expression by affecting the direct binding of OsMADS34 to the CArG box within the IR sequence.Interestingly,the divergent pOsREM20IR and pOsREM20ΔIR alleles were found to originate from different Oryza rufipogon accessions,and were independently inherited into the japonica and indica subspecies,respectively,during domestication.Importantly,we demonstrated that IR sequence variations in the OsREM20 promoter can be utilized for germplasm improvement through either genome editing or traditional breeding.Taken together,our study characterizes novel genetic variations responsible for GNP diversity in rice,reveals the underlying molecular mechanism in the regulation of agronomically important gene expression,and provides a promising strategy for improving rice production by manipulating the cis-regulatory element-containing IR sequence. | Xiaowei Wu Yan Liang Hengbin Gao Jiyao Wang Yan Zhao Lekai Hua Yundong Yuan Ahong Wang Xiaohui Zhang Jiafan Liu Jie Zhou Xiangbing Meng Dahan Zhang Shaoyang Lin Xuehui Huang Bin Han Jiayang Li Yonghong Wang | 2021 | Molecular Plant2021，14，6： | 3 |
| 4 | Schisandrol A protects AGEs-induced neuronal cells death by allosterically targeting ATP6V0d1 subunit of V-ATPase显示文摘Diabetes have been shown to cause progressive neuronal injury with pain and numbness via advanced glycation end-products(AGEs)-induced neuronal cell apoptosis;however, the valuable drug targets for diabetic neuropathy have been poorly reported so far. In this study, we discovered a natural small-molecule schisandrol A(SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis. ATP6V0D1, a major subunit of vacuolar-type ATPase(V-ATPase) in lysosome was identified as a crucial cellular target of SolA. Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification.Interestingly, SolA-induced lysosome pH downregulation resulted in a mitochondrial-lysosomal crosstalk by selectively promoting mitochondrial BH3-only protein BIM degradation, thereby preserving mitochondrial homeostasis and neuronal cells survival. Collectively, our findings reveal ATP6V0D1 is a valuable pharmacological target for diabetes-associated neuronal injury via controlling lysosomal acidification, and also provide the first small-molecule template allosterically activating V-ATPase for preventing diabetic neuropathy. | Xiaoqing Zhou Shaoyang Zhao Tingting Liu Lu Yao Meimei Zhao Xiaoming Ye Xiaowen Zhang Qiang Guo Pengfei Tu Kewu Zeng | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 3 |
| 5 | Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase/reductases with converse stereoselectivity显示文摘Fusidic acid is the only fusidane-type antibiotic that has been clinically used. However,biosynthesis of this important molecule in fungi is poorly understood. We have recently elucidated the biosynthesis of fusidane-type antibiotic helvolic acid, which provides us with clues to identify a possible gene cluster for fusidic acid(fus cluster). This gene cluster consists of eight genes, among which six are conserved in the helvolic acid gene cluster except fusC1 and fusB1. Introduction of the two genes into the Aspergillus oryzae NSAR1 expressing the conserved six genes led to the production of fusidic acid. A stepwise introduction of fusC1 and fusB1 revealed that the two genes worked independently without a strict reaction order. Notably, we identified two short-chain dehydrogenase/reductase genes fusC1 and fusC2 in the fus cluster, which showed converse stereoselectivity in 3-ketoreduction. This is the first report on the biosynthesis and heterologous expression of fusidic acid. | Zhiqin Cao Shaoyang Li Jianming Lv Hao Gao Guodong Chen Takayoshi Awakawa Ikuro Abe Xinsheng Yao Dan Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 3 |
| 6 | Improving Low Bitrate Video Coding via Computation Incorporating A Priori Information显示文摘The growing number of mobile users, as well as the diversification in types of services have resulted in increasing demands for wireless network bandwidth in recent years. Although evolving transmission techniques are able to enlarge the network capacity to some degree, they still cannot satisfy the requirements of mobile users. Meanwhile, following Moore's Law, the data processing capabilities of mobile user terminals are continuously improving. In this paper, we explore possible methods of trading strong computational power at wireless terminals for transmission efficiency of communications. Taking the specific scenario of wireless video conversation, we propose a model-based video coding scheme by learning the structures in multimedia contents. Benefiting from both strong computing capability and pre-learned model priors, only low-dimensional parameters need to be transmitted; and the intact multimedia contents can also be reconstructed at the receivers in real-time. Experiment results indicate that, compared to conventional video codecs, the proposed scheme significantly reduces the data rate with the aid of computational capability at wireless terminals. | Tao Xiaoming Dong Linhao Li Shaoyang Li Yang Ge Ning Lu Jianhua | 2015 | China Communications2015，12，9： | 2 |
| 7 | Comprehensive analysis of polarimetric radar cross-section parameters for insect body width and length estimation显示文摘The length and width of insect body are critical parameters for entomological radar species identification. However, the body width is not measurable in entomological radar currently. In this study,the scattering matrices(SM) of 159 insect specimens were measured using an X-band fully polarimetric laboratory rig in a microwave anechoic chamber. The relationships between the polarimetric radar crosssection(RCS) parameters extracted from the SM and the insect body width were studied. It was found that all these parameters have good correlations with the body width and can be used to estimate it. The mopping relationships between the polarimetric RCS parameters and the body width are built, and can be used as empirical formulas for insect body width estimation. In addition, based on these parameters, two new body length estimation methods were proposed. The performance of the proposed body width and length estimation methods when the echo signals were noisy was analyzed. It was found that the parameter that represents the product of the RCSs when the polarization direction is parallel and perpendicular to the insect body axis has the best performance for both the estimation of body width and length. | Weidong LI Cheng HU Rui WANG Shaoyang KONG Fan ZHANG | 2021 | Science China(Information Sciences)2021，64，2： | 2 |
| 8 | Numerical reconstruction of microstructure of graphite anode of lithium-ion battery显示文摘Due to the presence of graphite flake cascades,the real graphite anode of Li-ion battery shows non-isotropic characteristic. The present work developed an ellipsoid-based simulated annealing method and numerically reconstructed the three-dimensional microstructure of a graphite anode. The reconstructed anode is a composite of three clearly distinguished phases: pore(or electrolyte),graphite, and solid additives, well representing the nonisotropic heterogeneous characteristic of real graphite anode. Characterization analysis of the reconstructed electrode gives information such as the connectivity of individual phase, the specific interfacial area between solid and pore phase, and the pore size distribution. The effects of the ellipsoid size on the structural characteristics of graphite anode were particularly studied. As the size of the ellipsoidal particle slightly increases, the average pore diameter increases and as a result the specific interfacial area between the solid and pore phase in the reconstructed area decreases; compared with the equatorial radius, the polar radius of ellipsoidal graphite particles has more significant influence on the characteristics of electrode microstructure. | Shaoyang He Jianbang Zeng Bereket Tsegai Habte Fangming Jiang | 2016 | Science Bulletin2016，61，8： | 2 |
| 9 | GLOBAL ATTRACTIVITY IN THE DISCRETE LASOTA-WAZEWSKA MODEL显示文摘Consider the discrete Lasota Wazewska modelN n+1 -N n =-μN n +pe -rN n-k , n=0,1,2,...(*)where μ∈(0,1),r,p∈(0,∞) and k ∈N.A sufficient condition for all positive solutions of (*) to be attracted to its equilibrium N is obtained.It improves correspondent result obtained by Chen and Yu in 1999. | Li Jingwen Dept. of Math., Shaoyang Teachers College, Hunan 422000. | 2000 | Applied Mathematics(A Journal of Chinese Universities)2000，15，4： | 2 |
| 10 | 金樱子—西瓜混合保健果汁饮料的研究显示文摘以金樱子果和西瓜皮为主要原料,经取汁、调配、过滤、杀菌等加工工序,研制出了混合透明的营养保健型果汁饮料。研究表明,用明胶能有效除去金樱子果汁中的多酚物质,防止了产品的浑浊;适量添加西瓜汁和柠檬酸,能有效地抑制金樱子汁的涩味,提高了产品的适口性并确定了产品的最佳生产配方。 | Yu Yougui Shaoyang Higher Training School\ Shaoyang\ 422004 | 1998 | 饮料工业1998，1，6： | 2 |
| 11 | A search-free near-field source localization method with exact signal model显示文摘Most of the near-field source localization methods are developed with the approximated signal model,because the phases of the received near-field signal are highly non-linear.Nevertheless,the approximated signal model based methods suffer from model mismatch and performance degradation while the exact signal model based estimation methods usually involve parameter searching or multiple decomposition procedures.In this paper,a search-free near-field source localization method is proposed with the exact signal model.Firstly,the approximative estimates of the direction of arrival(DOA)and range are obtained by using the approximated signal model based method through parameter separation and polynomial rooting operations.Then,the approximative estimates are corrected with the exact signal model according to the exact expressions of phase difference in near-field observations.The proposed method avoids spectral searching and parameter pairing and has enhanced estimation performance.Numerical simulations are provided to demonstrate the effectiveness of the proposed method. | PAN Jingjing SINGH Parth Raj MEN Shaoyang | 2021 | Journal of Systems Engineering and Electronics2021，32，4： | 1 |
| 12 | Combination antigene therapy targeting c - myc and c - erbB - 2 in the ovarian cancer COC ( 1 ) cell line显示文摘 | Fei R Shaoyang L | 2002 | GynecolOneol2002，85，1： | 1 |
| 13 | Producing biodiesel from high free fatty acids wastecooking oil assisted by radio frequency heating显示文摘 | Liu Shaoyang Timothy McDonald Wang Yifen | 2010 | Fuel2010，89，10： | 1 |
| 14 | Application of a low pressure economizer for wasteheat recovery from the exhaust flue gas in a 600 MW power plant显示文摘 | Chaojun Wang Boshu He Shaoyang Sun | 2012 | Energy2012，20，： | 1 |
| 15 | TAT-Mediated Protein Transduction of Nogo Extracellular Peptide 1-40 and its Biological Activity显示文摘 | Qiang Wang Xingchun Gou Weilin Jin Lize Xiong Lichao Hou Shaoyang Chen Hui Zhang Xiaoling Zhu Lixian Xu | 2009 | Cellular and Molecular Neurobiology2009，，： | 1 |
| 16 | Combination antigene therapy targeting c-myc and c-erbB(2) in the ovarian cancer COC(1) cell line显示文摘 | Fei R Shaoyang L | 2002 | Gynecol Oncol2002，85，1： | 1 |
| 17 | Channel coordination mechanism with retailer having fairness preference -- An improved quantity discount mechanism显示文摘 | Chuan Ding Kaihong Wang Shaoyang Lai | 2013 | J of Industrial and Management Optimization2013，9，4： | 1 |
| 18 | Combination antigene therapy targeting c-myc and c-erbB-2 in the ovarian cancer COC (1) cell line显示文摘 | Shaoyang L | 2002 | Gynecol Oncol2002，85，： | 1 |
| 19 | Csy4-based vector system enables conditional chimeric gene editing in zebrafish without interrupting embryogenesis显示文摘Dear Editor,Despite diverse transfection approaches, zygote micro-injection remains the most widely used method to deliver the CRISPR/Cas9 system into most model organisms,including zebrafish and non-human primates Oao et aL,2013;Niu et aL,2014). | Jingjing Wang Fei Fei Michael A.Berberoglu Shaoyang Sun Lei Wang Zhiqiang Dong Xu Wang | 2018 | Journal of Molecular Cell Biology2018，10，6： | 1 |
| 20 | Hydrothermal synthesis and photocatalytic property of nano-ZnO显示文摘 | Ding Shiwen Zhang Shaoyang Liu Shujuan | 2002 | Journal of Hebei University2002，22，3： | 1 |
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