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| 1 | Functional roles and clinical values of insulin-like growth factor-binding protein-5 in different types of cancers显示文摘Insulin-like growth factor-bindin g proteins (IGFBPs) are critical regulators of the mitogenic activity of insulin-like growth factors (IGFs). IGFBP5, one of these IGFBPs, has special structural features, including a nuclear transport domain, heparin-binding motif, and IGF/extracellular matrix/acid-labile subunit-binding sites. Furthermore, IGFBP5 has several functional effects on carcinogenesis and even normal cell processes, such as cell growth, death, motility, and tissue remodeling. These biological effects are sometimes related with IGF (IGF-dependent effects) and sometimes not (IGF-independent effects). The functional role of IGFBP5 is most likely determined in a cell-type and tissue-type specific manner but also depends on cell context, especially in terms of the diversity of interacting proteins and the potential for nuclear localization. Clinical findings show that IGFBP5 has the potential to be a useful clinical biomarker for predicting response to therapy and clinical outcome of cancer patients. In this review, we summarize the functional diversity and clinical importance of IGFBP5 in different types of cancers. | Gökçe Güllü Sevgi Karabulut Mustafa Akkiprik | 2012 | Chinese Journal of Cancer2012，31，6： | 8 |
| 2 | Thrombospondin-1 expression correlates with angiogenesis in experimental cirrhosis显示文摘AIM:To investigate the significance of Thrombospondin-1 (TSP-1) expression and its relationship with angiogenesis during experimental fibrosis. METHODS:Cirrhosis was induced in male Wistar rats by intraperitoneal administration of diethyl nitrosamine (DEN). The serial sections from liver tissues were stained with anti-CD34 and anti-TSP-1 antibodies before being quantitated by light microscopy. RESULTS:Our results showed that of TSP-1 expression gradually increases according to the severity of fibrosis (GroupⅠvs group Ⅱ, Group Ⅲ and Group Ⅳ;Group Ⅱ vs group Ⅲ and group Ⅳ;group Ⅲ vs group Ⅳ, P < 0.05). Moreover, TSP-1 expression was found to be correlated with angiogenesis (P < 0.05). CONCLUSION:The correlative evidence of the link between TSP-1 and fibrosis or angiogenesis provided by this study suggests that besides its role as a strong promoter of transforming growth factor-β1 (TGF-β1), TSP-1 might have an additional role in liver fibrogenesis by stimulating angiogenesis and this protein could be a potential target to prevent fibrogenesis in chronic inflammatory diseases of the liver. | Gülsüm zlem Elpek Güzide Ayse Gkhan Sevgi Bozova | 2008 | World Journal of Gastroenterology2008，14，14： | 7 |
| 3 | An unusual cause of cholecystitis:Heterotopic pancreatic tissue in the gallbladder显示文摘Gallbladder localization of heterotopic pancreas (HP) is uncommon and very rarely gives rise to symptoms. Herein we report a case of HP found in the gallbladder neck presented with signs and symptoms of cholecystitis. The patient was a 40-year old male, suffering from epigastric pain, abdominal fullness and fever. On physical examination, the right upper abdomen was tender with a positive Murphy’s sign. Ultrasonographic examination showed a hydropic gallbladder without stones and he underwent a cholecystectomy. Pathological examination revealed an intramural nodule (9 mm) in the neck region which is consisted of acini, ducts and islet cells of an aberrant pancreatic tissue. Although HP is encountered rarely in the gallbladder and is found incidentally during pathological studies, this case emphasizes that HP might cause symptoms and present clinically as cholecystitis. For this reason, in patients presenting with symptomatic gallbladder diseases, including cholecystitis without any other pathology, HP should be taken into consideration before it is diagnosed as 'idiopathic’’. | Glsm zlem Elpek Sevgi Bozova Gkben Y■d■r■m Kpesiz Mehmet ■■ | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 4 | Two-way propagation model- ing in waveguides with three-dimensional finite- ele- ment and split-step Fourier-based PE approaehes显示文摘 | APAYDIN G SEVGI L | 2011 | IEEE Antennas and Wireless Propagation Letters2011，10，： | 1 |
| 5 | Numerical Investigations of and Path Loss Predictions for Surface Wave Propagation Over Sea Paths Including Hilly Island显示文摘 | Apaydin G Sevgi L | 2010 | IEEE Trans Antennas Propag2010，58，4： | 1 |
| 6 | The Characterization and dif- ferentiation of higher plants by fourier transform infrared spectros- copy:Fourier-transform infrared micorospectroscory a novel and raid tool for identification of yeasts 显示文摘 | SEVGI T G MUSA D FERIDE S | 2007 | Applied Spectroscopy2007，61，： | 1 |
| 7 | Groundwave propagation at short ranges and accurate source modeling显示文摘 | Apaydm G Sevgi L | 2013 | IEEE Trans An- tennas Propag2013，55，3： | 1 |
| 8 | Numerical investigations of and path loss predictions for surface wave propagation over sea paths including hilly island transitions显示文摘 | Apaydin G Sevgi L | 2010 | IEEE Trans on Antenna and Propagation2010，58，4： | 1 |
| 9 | Plasma-sprayed Bovine Hydroxyapatite Coatings显示文摘 | SEVGI OL OKTAR F N GOLLER G | | 0，，21： | 1 |
| 10 | Radar cross section (RCS) model- ing and simulation: Part II-A novel FDTD-based RCS prediction virtual tool 显示文摘 | Caklr G Caklr M Sevgi L | 2008 | IEEE Antennas and Propagation Magazine2008，50，2： | 1 |
| 11 | Rain water chemistry in Ankara, Turkey显示文摘 | Smara G Tuned Sevgi Ungor | 1996 | Atmospheric Environment1996，30，15： | 1 |
| 12 | A novel split-step parabolic-equation package for surface-wave propagation prediction along multiple mixed irregular terrain paths显示文摘 | Apaydin G Sevgi L | 2010 | IEEEAntennas Propag Mag2010，52，4： | 1 |
| 13 | Calibration of three-dimensional parabolic-equation propagation models with the rectangular waveguide problem显示文摘 | Apaydin G and Sevgi L | 2012 | IEEE Antennas and Propagation Magazine2012，54，6： | 1 |
| 14 | The split-step-fourier and finite-element-based parabolic equation propagation-prediction tools: canonical tests, system- atic comparisons, and calibration显示文摘 | Apaydin G Sevgi L | 2010 | IEEEAntennas and Propagation Magazine2010，52，3： | 1 |
| 15 | C-Jun N-terminal kina- ses (JNKs) and the cytoskeleton-functions beyond neurode- generation 显示文摘 | Mathias G Sevgie E Thomas H | 2004 | International Journal of Developmental Neu- roscience2004，22，7： | 1 |
| 16 | Dimensions of mental health: Life satisfaction, anxiety and depression: A preventive mental health study in Ankara University students population显示文摘 | Sevgi G Temel K Murat B | 2010 | Procedia So- cial and Behavioral Sciences2010，2，： | 1 |
| 17 | Groundwave Propagation at Short Ranges and Accurate Source Modeling l,Testing Ourselves-]显示文摘 | APAYDIN G SEVGI L | 2013 | Antennas and Propagation Magazine IEEE2013，55，3： | 1 |
| 18 | Analysis of the distribution of epiphytic li- chens on Cedrus libani in Elmali research forest (Antalya, Tur- key) 显示文摘 | Cobanoglu G Sevgi O | 2009 | Journal of Environmental Biology2009，30，2： | 1 |
| 19 | Two-way propagation modeling in waveguides with three-dimensional finite-element and split-stepFourier-based PE approaches显示文摘 | APAYDIN G SEVGI L | 2011 | IEEE Antennas and Wireless Propagation Letters2011，10，： | 1 |
| 20 | Dimensions of mental health: Life satisfaction, anxiety and depression: A preventive mental health study in Ankara University students population 显示文摘 | Sevgi G Temel K Murat B | 2010 | Procedia Social and Behavioral Sciences2010，11，2： | 1 |
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