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| 1 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 2 | Male breast cancer显示文摘 | GOMEZ RAPOSO C ZAMBRANA TfiVAR F SERENO MOYA-NO M | 2010 | Cancer Treat Rev2010，36，6： | 1 |
| 3 | Cortical Surface -based analysis Ⅰ: segmentation and surface reconstruction 显示文摘 | A Dale B Fischl M Sereno | | Neuroimage0，9，： | 1 |
| 4 | Reduction of soil water spatial density using scaled semivariograms and simulated annealing 显示文摘 | Ferreyra R A Apeztegufa H P Sereno R | 2002 | Geodema2002，110，： | 1 |
| 5 | A New Method to Close the Gastrotomy by Using a Cardiac Septal Occluder: Long-term Survival Study in a Porcine Model显示文摘 | Perretta S Sereno S Forgione A | 2007 | Gastrointest Endosc2007，66，4： | 1 |
| 6 | Modelling shrinkage during convective drying of food materials: a review显示文摘 | Mayor L Sereno A M | 2004 | Journal of Food Engineer- ing2004，61，3： | 1 |
| 7 | Phylogeny of the bird-hipped dinosaurs (Order Ornithischia) 显示文摘 | Sereno P C | 1986 | National Geographic Society Research1986，，2： | 1 |
| 8 | Modeling shrinkage during convective drying of food materials: a review 显示文摘 | MAYOR L SERENO AM | 2004 | Journal of Food Engineering2004，，61： | 1 |
| 9 | Micro- structural changes during osmotic dehydration of parenehymatie pumpkin tissue 显示文摘 | MAYOR L PISSARRA J SERENO A M | 2008 | Journal Food Engineering2008，85，3： | 1 |
| 10 | Mapping of contralateral space in retinotopic coordinates by a parietal cotlical area in humans显示文摘 | Sereno MI Pitzalis S Martinez A | 2001 | Scienee2001，294，5545： | 1 |
| 11 | Fine Grained Software Degradation Models for Optimal Software Rejuvenation Policies Performance Evaluation显示文摘 | A Bobbio M Sereno C Anglano | 2001 | Performance Evaluation2001，46，： | 1 |
| 12 | in vivo efficiency evaluation of a phage cocktail in controlling severe colibacillosis in confined conditions and experimental poultry houses显示文摘 | OLIVEIRA A SERENO R AZEREDO J | 2010 | Veterinary Microbiology2010，146，34： | 1 |
| 13 | Diagnostic andtherapeutie guideline for acute eonfusional syndrome 显示文摘 | Tejeiro Mortinez J Gomez Sereno B | 2002 | Rev Clin Esp2002，202，5： | 1 |
| 14 | Chemother-apy-induced peripheral neuropathy:clinical features,diagnosis,prevention and treatment strategies显示文摘 | Gutierrez-Gutierrez G Sereno M Miralles A | 2010 | Clin Transl Oncol2010，12，2： | 1 |
| 15 | Modelling shrinkage duringconvective drying of food materials:a review显示文摘 | Mayor L Sereno A M | 2004 | Journalof Food Engineering2004，61，3： | 1 |
| 16 | Inhibition of bladder tumour growth by sirolimus in an experimental carcinogenesis model显示文摘 | BelmiroParada FlávioReis ArnaldoFigueiredo PedroNunes EditeTeixeira‐Lemos PatríciaGarrido JoséSereno RuiPinto Maria F.X.Cunha PaulaNeto PauloSantos IsabelVelada AlfredoMota FredericoTeixeira | 2010 | BJU International2010，，1： | 1 |
| 17 | Borders of multiple visual areas in humans revealed by functional magnetic resonance imaging显示文摘 | SERENO M 1 HAWKEN M J SHAPLEY R | 1995 | Science1995，268，： | 1 |
| 18 | Early evolution of avian flight and perching:new evidence from the Lower Cretaceous of China显示文摘 | Sereno P C Rao Cheng-gang | 1992 | Science1992，255，5046： | 1 |
| 19 | Expression profile as predictor of relapse after adjuvant treatment in gastric cancer显示文摘 | Sereno M De Castro J Cejas P | | 0，，02： | 1 |
| 20 | Analysis of retinotopic maps in extrastriate cortex显示文摘 | Sereno MI McDonald CT Allman JM | 1994 | Cereb Cortex1994，4，6： | 1 |
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