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| 1 | A novel heterodimeric cytokine consisting of IL-17 and IL-17F regulates inflammatory responses显示文摘CD4+ 助手 T (TH ) 房间在免疫反应起关键作用。最近 TH 房间,称为的 TH (IL-17 ) , TH17 或煽动性的 TH (THi ) 的一个新奇子集,作为织物的批评调停人被识别了发炎。这些房间生产 IL-17 (也叫的 IL-17A ) andIL-17F,分享类似的规定的二很相应的 cytokines。这里,我们报导在 293T 房间, IL-17 和 IL-17F 的 whenoverexpressed 形成不仅 homodimers 而且 heterodimers,我们作为 IL-17A/F 说出它。充分区分的老鼠 THi 房间自然地也也分泌 IL-17A/F asIL-17 和 IL-17F 人二聚的 cytokines。在作为与人相比导致 IL-6 和 KC (CXCL1 ) 的力量的重组体 IL-17A/F 蛋白质展览中介层次二聚的 cytokines。IL-6 和 KC 表示的 IL-17A/F 规定依赖于 IL-17RA 和 TRAF6。因此, IL-17A/F cytokine 代表 T 房间调整煽动性的回答并且可以为治疗各种各样的调停免疫者的疾病用作一个新奇目标的另一机制。 | Seon Hee Chang | 2007 | Cell Research2007，17，5： | 48 |
| 2 | IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation显示文摘 | Juan Peng Xuexian O Yang Seon Hee Chang Jiong Yang Chen Dong | 2010 | Cell Research2010，20，1： | 31 |
| 3 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 4 | Expression and regulation of IL-22 in the IL-17.producing CD4+T lymphocytes显示文摘IL-22 是在工作对感染支持纸巾的天生的免疫的 IL-10 家庭的新奇 cytokine。尽管 CD4+ 助手 T 淋巴细胞(TH ) 作为 IL-22 的来源被发现,这 cytokine 的规定糟糕被理解。这里,我们证明 IL-22 被也做 IL-17 的 TH 房间的一个新奇子集在 mRNA 和蛋白质层次表示。IL-22 和 IL-17 被发现被即时 PCR 以及 ELISA 分析被 TGFbeta 和 IL-6 并列地在 TH 区别期间调整。然而, IL-22 不调整 TH 区别;外长的 IL-22 或一个 IL-22 对手没在 TH 区别上有效果。这些数据表明 IL-17-producing T 房间表示的新奇 cytokine,并且建议在组织发炎和自体免疫的疾病表明小径的 IL-22 和 IL-17 的相互作用和协同作用。 | Yeonseok Chung Xuexian Yang Seon Hee Chang Li Ma Qiang Tian Chen Dong | 2006 | Cell Research2006，16，11： | 20 |
| 5 | Prevalence of clonorchiasis in patients with gastrointestinal disease: A Korean nationwide multicenter survey显示文摘AIM: To investigate prevalence of Clonorchis sinensis in patients with gastrointestinal symptoms, and the relation of the infection to hepatobiliary diseases in 26 hospitals in Korea.METHODS: Consecutive patients who had been admitted to the Division of Gastroenterology with gastrointestinal symptoms were enrolled from March to April 2005. Of those who had been diagnosed with clonorchiasis, epidemiology and correlation between infection and hepatobiliary diseases were surveyed by questionnaire.RESULTS: Of 3080 patients with gastrointestinal diseases, 396 (12.9%) had clonorchiasis and 1140 patients (37.2%) had a history of eating raw freshwater fish. Of those with a history of raw freshwater fish ingestion, 238 (20.9%) patients had clonorchiasis. Cholangiocarcinoma was more prevalent in C. sinensis-infected patients than non-infected patients [34/396 (8.6%) vs 145/2684 (5.4%), P = 0.015]. Cholangiocarcinoma and clonorchiasis showed statistically significant positive cross-relation (P = 0.008). Choledocholithiasis, cholecystolithiasis, cholangitis, hepatocellular carcinoma, and biliary pancreatitis did not correlate with clonorchiasis.CONCLUSION: Infection rate of clonorchiasis was still high in patients with gastrointestinal diseases in Korea, and has not decreased very much during the last two decades. Cholangiocarcinoma was related to clonorchiasis, which suggested an etiological role for the parasite. | Ho Gak Kim Jimin Han Myung-Hwan Kim Kyu Hyun Cho Im Hee Shin Gwang Ha Kim Jae Seon Kim Jin Bong Kim Tae Nyeun Kim Tae Hyeon Kim Tae Hyo Kim Jae Woo Kim Ji Kon Ryu Young-Soo Moon Jong Ho Moon Sung Jae Park Chan Guk Park Sung-Jo Bang Chang Heon Yang Kyo-Sang Yoo Byung Moo Yoo Kyu Taek Lee Dong Ki Lee Byung Seok Lee Sang Soo Lee Seung Ok Lee Woo Jin Lee Chang Min Cho Young-Eun Joo Gab Jin Cheon Young Woo Choi Jae Bok Chung Yong Bum Yoon | 2009 | World Journal of Gastroenterology2009，15，1： | 15 |
| 6 | Assessment of scoring systems for acute-on-chronic liver failure at predicting short-term mortality in patients with alcoholic hepatitis显示文摘AIM To assess the performance of proposed scores specific for acute-on-chronic liver failure in predicting shortterm mortality among patients with alcoholic hepatitis.METHODS We retrospectively collected data from 264 patients with clinically diagnosed alcoholic hepatitis from January to December 2013 at 21 academic hospitals in Korea. The performance for predicting short-term mortality was calculated for Chronic Liver FailureSequential Organ Failure Assessment(CLIF-SOFA), CLIF Consortium Organ Failure score(CLIF-C OFs), Maddrey'sdiscriminant function(DF), age, bilirubin, international normalized ratio and creatinine score(ABIC), Glasgow Alcoholic Hepatitis Score(GAHS), model for end-stage liver disease(MELD), and MELD-Na.RESULTS Of 264 patients, 32(12%) patients died within 28 d. The area under receiver operating characteristic curve of CLIF-SOFA, CLIF-C OFs, DF, ABIC, GAHS, MELD, and MELD-Na was 0.86(0.81-0.90), 0.89(0.84-0.92), 0.79(0.74-0.84), 0.78(0.72-0.83), 0.81(0.76-0.86), 0.83(0.78-0.88), and 0.83(0.78-0.88), respectively, for 28-d mortality. The performance of CLIF-SOFA had no statistically significant differences for 28-d mortality. The performance of CLIF-C OFs was superior to that of DF, ABIC, and GAHS, while comparable to that of MELD and MELD-Na in predicting 28-d mortality. A CLIF-SOFA score of 8 had 78.1% sensitivity and 79.7% specificity, and CLIF-C OFs of 10 had 68.8% sensitivity and 91.4% specificity for predicting 28-d mortality.CONCLUSION CLIF-SOFA and CLIF-C OF scores performed well, with comparable predictive ability for short-term mortality compared to the commonly used scoring systems in patients with alcoholic hepatitis. | Hee Yeon Kim Chang Wook Kim Tae Yeob Kim Do Seon Song Dong Hyun Sinn Eileen L Yoon Young Kul Jung Ki Tae Suk Sang Soo Lee Chang Hyeong Lee Tae Hun Kim Jeong Han Kim Hyung Joon Yim Sung Eun Kim Soon Koo Baik Byung Seok Lee Jae Young Jang Young Seok Kim Sang Gyune Kim Jin Mo Yang Joo Hyun Sohn Heon Ju Lee Seung Ha Park Eun Hee Choi Dong Joon Kim Korean Acute-on-Chronic Liver Failure Study Group | 2016 | World Journal of Gastroenterology2016，22，41： | 5 |
| 7 | Effect of ultra high pressure processing on immuno-modulatory activities of the fruits of Rubus coreanus Miquel显示文摘 | Yong Chang Seo Woon Yong Choi Ji Seon Kim Chang Soon Yoon Hye Won Lim Jeong Sub Cho Ju hee Ahn Hyeon Yong Lee | 2011 | Innovative Food Science and Emerging Technologies2011，，3： | 1 |
| 8 | Prediction of cognitive dysfunction and patients’ outcome following valvular heart surgery and the role of cerebral oximetry显示文摘 | Seong Wook Hong Jae Kwang Shim Yong Seon Choi Dae Hee Kim Byung Chul Chang Young Lan Kwak | 2008 | European Journal of Cardio-Thoracic Surgery2008，，4： | 1 |
| 9 | Transcription of Il17 and Il17f Is Controlled by Conserved Noncoding Sequence 2显示文摘 | Xiaohu Wang Yibing Zhang Xuexian O. Yang Roza I. Nurieva Seon Hee Chang Sandra S. Ojeda Hong S. Kang Kimberly S. Schluns Jianfang Gui Anton M. Jetten Chen Dong | 2012 | Immunity2012，，： | 1 |
| 10 | Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma显示文摘 | Jin C. Kim Kum H. Koo Seon A. Roh Yong K. Cho Hee C. Kim Chang S. Yu Ho J. Kim Jung S. Kim Moon K. Cho | 2003 | International Journal of Colorectal Disease2003，，3： | 1 |
| 11 | A Co-Operative Study: Clinical Characteristics of 334 Korean Patients with Moyamoya Disease Treated at Neurosurgical Institutes (1976–1994)显示文摘 | Dae Hee Han O-Ki Kwon Bark Jang Byun Byung Yeon Choi Chang Wha Choi Joong Uhn Choi Seon Gil Choi Jong Oung Doh Jong Woo Han Shin Jung Sung Don Kang Dae Jo Kim Hyoung-Ihl Kim Hyung Dong Kim Moon Chul Kim Sang Chul Kim Soo Chun Kim Youn Kim Byung Duk Kwun B | 2000 | Acta Neurochirurgica2000，，11： | 1 |
| 12 | T helper 17 cells play a critical pathogenic role in lung cancer 显示文摘 | Seon Hee Chang Seyedeh Golsar Mirabolfathinejad Harshadadevi Katta | 2014 | Proceedings of the National Academy of Sciences of the United States of America2014，111，15： | 1 |
| 13 | Helicobacter pylori Might Induce TGF ‐β1‐Mediated EMT by Means of cagE显示文摘 | Hyun Chang Nayoung Kim Ji Hyun Park Ryoung Hee Nam Yoon Jeong Choi Seon Mee Park Yoon Jin Choi Hyuk Yoon Cheol Min Shin Dong Ho Lee | 2015 | Helicobacter2015，，6： | 1 |
| 14 | Influence of anemia on tumor response to preoperative chemoradiotherapy for locally advanced rectal cancer显示文摘 | Seong Dae Lee Ji Won Park Kui Seon Park Seok-Byung Lim Hee Jin Chang Dae Yong Kim Seung-Yong Jeong Hyo Seong Choi Jae Hwan Oh | 2009 | International Journal of Colorectal Disease2009，，12： | 1 |
| 15 | Comparison of the methods for tumor response assessment in patients with hepatocellular carcinoma undergoing transarterial chemoembolization显示文摘 | Eun Suk Jung Ji Hoon Kim Eileen L. Yoon Hyun Jung Lee Soon Jae Lee Sang Jun Suh Beom Jae Lee Yeon Seok Seo Hyung Joon Yim Tae-Seok Seo Chang Hee Lee Jong Eun Yeon Jong-Jae Park Jae Seon Kim Young Tae Bak Kwan Soo Byun | 2013 | Journal of Hepatology2013，，6： | 1 |
| 16 | Methylation of the hMLH1 and hMSH2 promoter in early-onset sporadic colorectal carcinomas with microsatellite instability显示文摘 | Hee C. Kim Chang N. Kim Chang S. Yu Seon A. Roh Jin C. Kim | 2003 | International Journal of Colorectal Disease2003，，3： | 1 |
| 17 | Comparative study between doxorubicin-eluting beads and conventional transarterial chemoembolization for treatment of hepatocellular carcinoma显示文摘 | Myeong Jun Song Ho Jong Chun Do Seon Song Hee Yeon Kim Sun Hong Yoo Chung-Hwa Park Si Hyun Bae Jong Young Choi U Im Chang Jin Mo Yang Hae Giu Lee Seung Kew Yoon | 2012 | Journal of Hepatology2012，，6： | 1 |
| 18 | Effect of ginsam, a vinegar extract from Panax ginseng, on body weight and glucose homeostasis in an obese insulin-resistant rat model显示文摘 | Soo Lim Ji Won Yoon Sung Hee Choi Bong Jun Cho Jun Tae Kim Ha Soon Chang Ho Seon Park Kyong Soo Park Hong Kyu Lee Young-Bum Kim Hak Chul Jang | 2009 | Metabolism2009，，1： | 1 |
| 19 | MAP kinase phosphatase 1 is necessary for T cell activation and function显示文摘 | Zhang Yong-liang Joseph Reynolds Seon Hee Chang | | 0，，： | 1 |
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