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| 1 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 2 | Strain-Insensitive Hierarchically Structured Stretchable Microstrip Antennas for Robust Wireless Communication显示文摘As the key component of wireless data transmission and powering,stretchable antennas play an indispensable role in flexible/stretchable electronics.However,they often suffer from frequency detuning upon mechanical deformations;thus,their applications are limited to wireless sensing with wireless transmission capabilities remaining elusive.Here,a hierarchically structured stretchable microstrip antenna with meshed patterns arranged in an arched shape showcases tunable resonance frequency upon deformations with improved overall stretchability.The almost unchanged resonance frequency during deformations enables robust on-body wireless communication and RF energy harvesting,whereas the rapid changing resonance frequency with deformations allows for wireless sensing.The proposed stretchable microstrip antenna was demonstrated to communicate wirelessly with a transmitter(input power of−3 dBm)efficiently(i.e.,the receiving power higher than−100 dBm over a distance of 100 m)on human bodies even upon 25%stretching.The flexibility in structural engineering combined with the coupled mechanical-electromagnetic simulations,provides a versatile engineering toolkit to design stretchable microstrip antennas and other potential wireless devices for stretchable electronics. | Jia Zhu Senhao Zhang Ning Yi Chaoyun Song Donghai Qiu Zhihui Hu Bowen Li Chenghao Xing Hongbo Yang Qing Wang Huanyu Cheng | 2021 | Nano-Micro Letters2021，13，8： | 1 |
| 3 | Smart bioadhesives for wound healing and closure显示文摘The high demand for rapid wound healing has spurred the development of multifunctional and smart bioadhesives with strong bioadhesion,antibacterial effect,real-time sensing,wireless communication,and on-demand treatment capabilities.Bioadhesives with bio-inspired structures and chemicals have shown unprecedented adhesion strengths,as well as tunable optical,electrical,and bio-dissolvable properties.Accelerated wound healing has been achieved via directly released antibacterial and growth factors,material or drug-induced host immune responses,and delivery of curative cells.Most recently,the integration of biosensing and treatment modules with wireless units in a closed-loop system yielded smart bioadhesives,allowing real-time sensing of the physiological conditions(e.g.,pH,temperature,uric acid,glucose,and cytokine)with iterative feedback for drastically enhanced,stage-specific wound healing by triggering drug delivery and treatment to avoid infection or prolonged inflammation.Despite rapid advances in the burgeoning field,challenges still exist in the design and fabrication of integrated systems,particularly for chronic wounds,presenting significant opportunities for the future development of next-generation smart materials and systems. | Jia Zhu Honglei Zhou Ethan Michael Gerhard Senhao Zhang Flor Itzel Parra Rodríguez Taisong Pan Hongbo Yang Yuan Lin Jian Yang Huanyu Cheng | 2023 | Bioactive Materials2023，，1： | 0 |
| 4 | 长期磷添加对热带森林土壤磷酸单酯酶与磷酸二酯酶活性比值的影响显示文摘热带森林土壤微生物可以通过改变不同类型的磷酸酶活性来适应低磷的环境。以往的研究认为,低磷环境中土壤微生物更倾向于分解有机磷单酯键而非二酯键。因此,磷酸单酯酶(PME)的活性变化对生态系统磷输入的响应可能更敏感,其与磷酸二酯酶(PDE)活性的比值在磷输入后将显著降低。为了检验土壤微生物在低磷的热带森林中对不同磷酸酶的“投资”策略,我们在鼎湖山3种热带森林进行了长达10年的磷添加实验。与以往的研究不同,本研究发现长期磷添加没有改变原生林与次生林的PME:PDE比值,但显著提高了人工林土壤PME:PDE比值。结果表明,长期磷添加可能减少了凋落物或穿透雨来源的PDE,从而使其土壤PDE活性下降较PME降低更快,因而PME:PDE比值未能降低。 | Taiki Mori Senhao Wang Cong Wang Ji Chen Cheng Peng Mianhai Zheng Juan Huang Faming Wang Zhanfeng Liu Jiangming Mo Wei Zhang | 2023 | Journal of Plant Ecology2023，16，3： | 0 |
| 5 | Anti-clogging ability of the labyrinth emitter and its evaluation method显示文摘Emitter clogging is one of the most serious factors that restrict the drip irrigation system operation and water use efficiency.To scientifically characterize and evaluate emitter clogging risk,a literature review,short-period emitter anti-clogging tests,and CFD(Computational Fluid Dynamics)hydraulic performance tests were conducted.Results showed that the emitter anti-clogging ability is related to its structure,material,and processing technology,not external factors.This was evidenced in the irrigation tests,as with the different water qualities,the same emitters were repeatedly prone to clog or to avoid clogging.A predictive model of structural resistance coefficient(Cs),a quantitative indicator of the emitter anti-clogging ability,whose value ranges between 0 and 1,was utilized.Larger Cs values indicate a lower anti-clogging ability and thus a higher risk of clogging.A good linear relationship between Cs and the relative flow rate was detected,and the Cs relationship with the fluidity index(x)was determined to be a power function.The Cs should be controlled within the range of 0.146-0.461 when designing new emitters to ensure that they have good anti-clogging properties.This research will provide theoretical guidance for the anti-clogging management of drip irrigation systems and for the design of optimal emitter structures. | Wenqian Zhang Zhaoxi Wang Senhao Cheng Aihong Dong Erxin Zhang Wenquan Niu | 2022 | International Journal of Agricultural and Biological Engineering2022，15，6： | 0 |
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