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| 1 | Mixed epithelial endocrine neoplasms of the colon and rectum–An evolution over time:A systematic review显示文摘BACKGROUND Mixed tumors of the colon and rectum,composed of a combination of epithelial and endocrine elements of benign and malignant potential are rare neoplasms.These can occur anywhere in the gastrointestinal tract and are often diagnosed incidentally.Though they have been a well-documented entity in the pancreas,where the exocrine-endocrine mixed tumors have been known for a while,recognition and accurate diagnosis of these tumors in the colon and rectum,to date,remains a challenge.This is further compounded by the different terminologies that have been attributed to these lesions over the years adding to increased confusion and misclassification.Therefore,dedicated literature reviews of these lesions in the colon and rectum are inconsistent and are predominantly limited to case reports and case series of limited case numbers.Though,most of these tumors are high grade and of advanced stage,intermediate and low grade lesions of these mixed tumors are also increasingly been reported.There are no established independent consensus based guidelines for the therapeutic patient management of these unique lesions.AIM To provide a comprehensive targeted literature review of these complex mixed tumors in the colon and rectum that chronicles the evolution over time with summarization of historical perspectives of terminology and to further our understanding regarding their pathogenesis including genomic landscape,clinicoradiological features,pathology,treatment,prognosis,the current status of the management of the primary lesions,their recurrences and metastases.METHODS A comprehensive review of the published English literature was conducted using the search engines PubMed,MEDLINE and GOOGLE scholar.The following search terms[“mixed tumors colon”OR mixed endocrine/neuroendocrine tumor/neoplasm/lesion colon OR adenocarcinoma and endocrine/neuroendocrine tumor colon OR mixed adenocarcinoma and endocrine/neuroendocrine carcinoma colon OR Amphicrine tumors OR Collision tumors]were used.Eligibility criteria were defined and all potential relevant items,including full articles and/or abstracts were independently reviewed,assessed and agreed upon items were selected for in-depth analysis.RESULTS In total 237 full articles/abstracts documents were considered for eligibility of which 45 articles were illegible resulting in a total of 192 articles that were assessed for eligibility of which 139 have been selected for reference in this current review.This seminal manuscript is a one stop article that provides a detailed outlook on the evolution over time with summarization of historical perspectives,nomenclature,clinicoradiological features,pathology,treatment,prognosis and the current status of the management of both the primary lesions,their recurrences and metastases.Gaps in knowledge have also been identified and discussed.An important outcome of this manuscript is the justified proposal for a new,simple,clinically relevant,non-ambiguous terminology for these lesions to be referred to as mixed epithelial endocrine neoplasms(MEENs).CONCLUSION MEEN of the colon and rectum are poorly understood rare entities that encompass an extensive range of heterogeneous tumors with a wide variety of combinations leading to tumors of high,intermediate or low grade malignant potential.This proposed new revised terminology of MEEN will solve the biggest hurdle of confusion and misclassification that plagues these rare unique colorectal neoplasms thus facilitating the future design of multi institutional prospective randomized controlled clinical trials to develop and evaluate newer therapeutic strategies that are recommended for continued improved understanding and personal optimization of clinical management of these unique colorectal neoplasms. | Rani Kanthan Suresh Tharmaradinam Tehmina Asif Shahid Ahmed Selliah C Kanthan | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Fecal Molecular Markers for Colorectal Cancer Screening显示文摘 | Rani Kanthan Jenna-Lynn Senger Selliah Chandra Kanthan Cesare Hassan | 2011 | Gastroenterology Research and Practice2011，，： | 2 |
| 3 | Effective gene suppression using small interfering RNA in hard-to-transfect human T cells 显示文摘 | Yin J Ma Z Selliah N | 2006 | J Immunol Methods2006，312，12： | 1 |
| 4 | Biochemical mechanisms of HIV induced T cell apoptosis显示文摘 | SELLIAH N FINKEL T H | 2001 | Cell Death Differ2001，8，： | 1 |
| 5 | Molecular Events in Primary and Metastatic Colorectal Carcinoma: A Review显示文摘 | Rani Kanthan Jenna-Lynn Senger Selliah Chandra Kanthan Marco Volante | 2012 | Pathology Research International2012，，： | 1 |
| 6 | The HIV-1Vif protein mediates degradation of Vpr and reducesVpr-induced cell cycle arrest显示文摘 | Wang J Shackelford J M Selliah N | 2008 | DNA Cell Biol2008，27，5： | 1 |
| 7 | Molecular Events in Primary and Metastatic Colorectal Carcinoma: A Review显示文摘 | Rani Kanthan Jenna-Lynn Senger Selliah Chandra Kanthan Marco Volante | 2012 | Pathology Research International2012，，： | 1 |
| 8 | Effective gene suppression using small interfering RNA in hard-to-transfect human T cells显示文摘 | Yin J Ma Z Selliah N | 2006 | Immunol Methods2006，312，12： | 1 |
| 9 | TRINETR: an architecture for collaborative intrusion detection and knowledge-based alert evaluation 显示文摘 | YU Jin-qiao REDDY Y V R SELLIAH S | 2005 | Advanced Engineering Inforrnatics2005，19，2： | 1 |
| 10 | The HIV-1 Vif protein mediates degradation of Vpr and reduces Vpr-in duced cell cycle arrest显示文摘 | WANG J SHACKELFORD JM SELLIAH N | 2008 | DNA Cell Biol2008，27，5： | 1 |
| 11 | TRINETR: An architecture for collabora-tive intrusion detection and knowledge - based alert evaluation显示文摘 | J Yu Y Reddy S Selliah | 2005 | Advanced Engineering Informatics2005，，： | 1 |
| 12 | Expression of E1 F-2 on hepatitis C RNA-containing particles released from primary cultured human hepatocytes derived from infected cirrhotic livers 显示文摘 | Ndongo N Selliah S Berthillon P Raymond VA Trpo C Bilodeau M | 2011 | Intervirology2011，54，1： | 1 |
| 13 | Biochemical mechanisms of HIV induced T cell apoptosis显示文摘 | Selliah N Finkel TH | 2001 | Cell Death & Differentiation2001，8，2： | 1 |
| 14 | TRINETR:An architecture for collaborative intrusion detection and knowledge-based alert evaluation显示文摘 | Yu J Reddy Y Selliah S | 2005 | Advanced Engineering Informatics2005，19，： | 1 |
| 15 | Effective gene suppression using small interfering RNA in hard-to transfect human T cells显示文摘 | Yin J Ma Z Selliah N | 2006 | J Immunol Methods2006，312，： | 1 |
| 16 | Disposition kinetics in dogs of diethyldithiocarbamate, a metabolite of disulfiram显示文摘 | John Cobby Michael Mayersohn Sathi Selliah | 1978 | Journal of Pharmacokinetics and Biopharmaceutics1978，，5： | 1 |
| 17 | Survival impact of surgical resection of primary tumor in patients with stage IV colorectal cancer: Results from a large population‐based cohort study显示文摘 | Shahid Ahmed Anne Leis Anthony Fields Selliah Chandra‐Kanthan Kamal Haider Riaz Alvi Bruce Reeder Punam Pahwa | 2014 | Cancer2014，，5： | 1 |
| 18 | Anti-HIV designer T cells progressively eradicate a latently infected cell line by sequentially inducing HIV reactivation then killing the newly gpl20-positive cells显示文摘 | Sahu GK Sango K Selliah N | 2013 | Virology2013，446，12： | 1 |
| 19 | TRINETR:An architecture for collaborative intrusion detection And knowledge-based aler evaluation显示文摘 | Yu J Reddy Y Selliah S | 2005 | Advanced Engineering Informatics2005，19，： | 1 |
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