|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 2 | Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke显示文摘Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV. | Adam de Havenon Alicia Bennett Gregory J Stoddard Gordon Smith Lee Chung Steve O’Donnell J Scott McNally David Tirschwell Jennifer J Majersik | 2017 | Stroke & Vascular Neurology2017，2，1： | 6 |
| 3 | Effect of fiber supplementation on the microbiota in critically ill patients显示文摘AIM:To determine tolerance to fiber supplementation of semi-elemental tube feeds in critically ill patients and measure its effect on colonic microbiota and fermentation.METHODS:Thirteen intensive care unit patients receiving jejunal feeding with a semi-elemental diet for predominantly necrotizing pancreatitis were studied.The study was divided into 2 parts:first,short-term (3-9 d)clinical tolerance and colonic fermentation as assessed by fecal short chain fatty acid(SCFA)concentrations and breath hydrogen and methane was measured in response to progressive fiber supplementation increasing from 4 g tid up to normal requirement levels of 8 g tid;second,4 patients with diarrhea were studied for 2-5 wk with maximal supplementation to additionally assess its influence on fecal microbiota quantitated by quantitative polymerase chain reaction (qPCR)of microbial 16S rRNA genes and Human Intestinal Tract Chip(HITChip)microarray analysis.Nearly all patients were receiving antibiotics(10/13)and acid suppressants(11/13)at some stage during the studies.RESULTS:In group 1,tolerance to progressive fiber supplementation was good with breath hydrogen and methane evidence(P=0.008 and P<0.0001,respectively)of increased fermentation with no exacerbation of abdominal symptoms and resolution of diarrhea in 2 of 4 patients.In group 2 before supplementation,fecal microbiota mass and their metabolites,SCFA,were dramatically lower in patients compared to healthy volunteers.From qPCR and HITChip analyses we calculated that there was a 97%reduction in the predominant potential butyrate producers and starch degraders.Following 2-5 wk of fiber supplementation there was a significant increase in fecal SCFA(acetate 28.4±4.1μmol/g to 42.5±3.1μmol/g dry weight,P=0.01;propionate 1.6±0.5 vs 6.22±1.1,P=0.006 and butyrate 2.5±0.6 vs 5.9±1.1,P=0.04)and microbial counts of specific butyrate producers,with resolution of diarrhea in 3 of 4 patients.CONCLUSION:Conventional management of critically ill patients,which includes the use of elemental diets and broad-spectrum antibiotics,was associated with gross suppression of the colonic microbiota and their production of essential colonic fuels,i.e.,SCFA.Our investigations show that fiber supplementation of the feeds has the potential to improve microbiota mass and function,thereby reducing the risks of diarrhea due to dysbiosis. | Stephen JD O'Keefe Junhai Ou James P DeLany Scott Curry Erwin Zoetendal H Rex Gaskins Scott Gunn | 2011 | World Journal of Gastrointestinal Pathophysiology2011，2，6： | 3 |
| 4 | 4号染色体短臂微卫星多态性与鼻咽癌相关性的研究显示文摘鼻咽癌(NPC)是一种多因素复杂疾病。其发病过程涉及EB病毒慢性感染、环境致癌因素及宿主基因之间的相互作用。在这一过程中,那些宿主基因在EB病毒感染及鼻咽癌的发生发展中起了关键作用仍不清楚。本研究的目的是发现与鼻咽癌发生发展中两个关键步骤相关的遗传变异,即EB病毒持续性感染鼻咽部上皮细胞和鼻咽癌的形成。我们在广西梧州市及苍梧县鼻咽癌高发区收集汉族鼻咽癌患者350例、EB病毒壳抗原IgA抗体阳性者(IgA/VCA+)288例和EB病毒壳抗原IgA抗体阴性者(IgA/VCA—)346例。对先前鼻咽癌家系研究显示的鼻咽癌易感区4号染色体短臂(4p15.1~q12)进行了微卫星精细扫描,在18Mb的范围内选择34个微卫星标记,包括319个等位基因,对其进行基因分型。比较分析NPC组和IgA/VCA+组等位基因频率结果显示,9个等位基因与鼻咽癌呈相关,其中5个为易感等位基因(OR=1.51~5.36,P=0.01~0.03),4个为限制性等位基因(OR值为0.3~0.71,P值为0.02~0.045)。比较分析IgA/VCA+组和IgA/VCA-组及比较所有IgA/VCA+者(包括NPC患者)和IgA/VCA-者等位基因频率的结果显示,12个等位基因与EB病毒壳抗原IgA抗体持续存在相关,其中3个在两组比较中均呈显著相关。等位基因D4S3241~136(P=0.004,OR=1.9,95%CI=1.2~3.0)和D4S3347-213(P=0.001,OR=1.6,95%CI=1.2~2.1)可增加EB病毒IgA/VCA抗体形成的危险,为易感基因;而等位基因D4S174.202(P=0.001,OR=0.5,95%CI=0.3~0.7)可限制IgA/VCA抗体的形成。但上述结果经多因素比较校正后,均失去相关性。结果不能确定该区域与非家族性鼻咽癌的形成相关,但本研究却提供了进一步发现鼻咽癌相关基因的研究模式。有关4号染色体短臂与EB病毒慢性持续感染及鼻咽癌的形成仍值得进一步深入研究。 | 郭秀婵 O’BRIEN Stephen J WINKLER Cheryl SCOTT Kevin HUTCHESON Holli DAVID Victor KESSING Bailey 郑裕明 廖建 刘彦 GUY de The 曾毅 | 2006 | 遗传2006，28，7： | 2 |
| 5 | Phase II Pilot Study of Vemurafenib in Patients With Metastatic BRAF -Mutated Colorectal Cancer显示文摘 | Kopetz Scott Desai Jayesh Chan Emily Hecht Joel Randolph O’Dwyer Peter J. Maru Dipen Morris Van Janku Filip Dasari Arvind Chung Woonbook Issa Jean-Pierre J. Gibbs Peter James Brian Powis Garth Nolop Keith B. Bhattacharya Suman Saltz Leonard | 2015 | Journal of Clinical Oncology2015，，34： | 2 |
| 6 | A role of stretch-activated potassium currents in the regulation of uterine smooth muscle contraction显示文摘早熟的出生的率是惊人的并且威胁社会和世界范围的保健系统。早产在超过 50% 盒子导致早熟的出生。Preterm 出生说明婴儿病态和死亡的 three-quarters。在 34 星期怀孕期前熬过出生的孩子经常面对终生的残疾。为劳动正在想要的 preterm 的当前的处理。没有处理被发现了通常有效,任何一个都系统地没在 48 h 以外被评估。preterm 劳动的处理的新途径绝望地被需要。从我们的实验室的最近的研究建议子宫的肌肉是有不同于另外的光滑的肌肉的子宫的松驰的规定的唯一的分隔空间。这里,我们讨论最近的证据机械地激活的 2 毛孔钾隧道, TREK-1,可以贡献在子宫的光滑的肌肉和变体与人的劳动联系了的那 TREK-1 基因发信号的收缩松驰, preterm 劳动可以导致 preterm 劳动和它的可能的预防的更好的理解。 | Iain L O BUXTON Nathanael HEYMAN Yi-ying WU Scott BARNETT Craig ULRICH | 2011 | Acta Pharmacologica Sinica2011，32，6： | 2 |
| 7 | Leukocyte and Bacterial Counts Do Not Correlate With Severity of Symptoms in Men With Chronic Prostatitis: The National Institutes of Health Chronic Prostatitis Cohort Study显示文摘 | Anthony J. Schaeffer Jill S. Knauss J. Richard Landis Kathleen J. Propert Richard B. Alexander Mark S. Litwin J. Curtis Nickel Michael P. O’leary Robert B. Nadler Michel A. Pontari Daniel A. Shoskes Scott I. Zeitlin Jackson E. Fowler Carissa A. Mazurick J | 2002 | The Journal of Urology2002，，3： | 2 |
| 8 | Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals With Type 2 Diabetes and Various Components of the Metabolic Syndrome显示文摘 | Scott Russell O’Brien Richard Fulcher Greg Pardy Chris d’Emden Michael Tse Dana Taskinen Marja-Riitta Ehnholm Christian Keech Anthony | 2009 | Diabetes Care2009，，： | 2 |
| 9 | Specific criteria for selection of alloy compositions for bulk metallic glasses显示文摘 | Senkov O N Scott J M | 2004 | Scripta Materialia2004，50，： | 1 |
| 10 | GOLPH3 modulates mTOR signaling and rapamycin sensitivity in cancer 显示文摘 | Scott KL Kabbarah O Liang MC | 2009 | Nature2009，459，7250： | 1 |
| 11 | Marked improvement of PAC and BAG cloning is achieved using electroelution of pulsed-field gelseperated partial digested of genomic DNA显示文摘 | Scott J S Yuko O Gary W L | 1997 | Nucleic Acids Res1997，25，： | 1 |
| 12 | Random-peptide librar-ies and antigen-fragment libraries for epitope mappingand the development of vaccines and diagnostics显示文摘 | Irving M B Pan O Scott J K | 2001 | Curr Opin Chem Biol2001，5，3： | 1 |
| 13 | Highly stable Pt-Runanoparticles supported on three-dimensional cubic or-dered mesoporous carbon(Pt-Ru/CMK-8)as promisingelectrocatalysts for methanol oxidation显示文摘 | Maiyalagan T Alaje T O Scott K | 2012 | The Journalof Physical Chemistry C2012，116，： | 1 |
| 14 | Pricing stock options in a jump-diffusion model with stochastic volatility and interest rates:applications of Fourier inversion method显示文摘 | Scott L O | 1997 | Math Finance1997，7，4： | 1 |
| 15 | A Phase I Study of the Chinese Herbal Medicine PHY906 as a Modulator of Irinotecan-based Chemotherapy in Patients with Advanced Colorectal Cancer显示文摘 | Shivaani Kummar M. Sitki Copur Michal Rose Scott Wadler Joe Stephenson Mark O’Rourke Wayne Brenckman Robert Tilton Shwu-Huey Liu Zaoli Jiang Tahmun Su Yung-chi Cheng Edward Chu | 2011 | Clinical Colorectal Cancer2011，，2： | 1 |
| 16 | Low temperature mechanical properties of scandium-modified Al-Zn-Mg-Cu alloys显示文摘 | SENKOY O N MIRACLE D B MILMAN Y V SCOTT J M LOTSKO D V SIRKO A I | 2002 | Materials Science Forum2002，，： | 1 |
| 17 | Stem-like cells in bone sarcomas: implications for tumorigenesis显示文摘 | Gibbs C P Kukekov V G Reith J D Tchigrinova O Suslov O N Scott E W | 2005 | Neoplasia2005，7，： | 1 |
| 18 | Frequency of Allogeneic Hematopoietic Cell Transplantation Among Patients With High- or Intermediate-Risk Acute Myeloid Leukemia in First Complete Remission显示文摘 | Raya Mawad Ted A. Gooley Vicky Sandhu Jack Lionberger Bart Scott Brenda M. Sandmaier Paul O’Donnell Pamela S. Becker Stephen Petersdorf Kathleen Shannon Dorcy Paul Hendrie Mohamed L. Sorror Roland B. Walter H. Joachim Deeg Frederick R. Appelbaum Elihu H. | 2013 | Journal of Clinical Oncology2013，，31： | 1 |
| 19 | The regional impact of monetary policy显示文摘 | Scott I O | 1955 | Quarterly Journal of Economics1955，69，2： | 1 |
| 20 | Option pricing when the variance changes randomly: theory,estimation, and an application显示文摘 | Scott L O | 1987 | Journal of Financial and Quantitative Analysis1987，22，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员