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| 1 | Consensus statement AIGO/SICCR diagnosis and treatment of chronic constipation and obstructed defecation(Part Ⅱ:Treatment)显示文摘The second part of the Consensus Statement of the Italian Association of Hospital Gastroenterologists and Italian Society of Colo-Rectal Surgery reports on the treatment of chronic constipation and obstructed defecation.There is no evidence that increasing fluid intake and physical activity can relieve the symptoms of chronic constipation.Patients with normal-transit constipation should increase their fibre intake through their diet or with commercial fibre.Osmotic laxatives may be effective in patients who do not respond to fibre supplements.Stimulant laxatives should be reserved for patients who do not respond to osmotic laxatives.Controlled trials have shown that serotoninergic enterokinetic agents,such as prucalopride,and prosecretory agents,such as lubiprostone,are effective in the treatment of patients with chronic constipation.Surgery is sometimes necessary.Total colectomy with ileorectostomy may be considered in patients with slow-transit constipation and inertia coli who are resistant to medical therapy and who do not have defecatory disorders,generalised motility disorders or psychological disorders.Randomised controlled trials have established the efficacy of rehabilitative treatment in dys-synergic defecation.Many surgical procedures may be used to treat obstructed defecation in patients with acquired anatomical defects,but none is considered to be the gold standard.Surgery should be reserved for selected patients with an impaired quality of life.Obstructed defecation is often associated with pelvic organ prolapse.Surgery with the placement of prostheses is replacing fascial surgery in the treatment of pelvic organ prolapse,but the efficacy and safety of such procedures have not yet been established. | Antonio Bove Massimo Bellini Edda Battaglia Renato Bocchini Dario Gambaccini Vincenzo Bove Filippo Pucciani Donato Francesco Altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni | 2012 | World Journal of Gastroenterology2012，18，36： | 33 |
| 2 | Consensus statement AIGO/SICCR:Diagnosis and treatment of chronic constipation and obstructed defecation(partⅠ:Diagnosis)显示文摘Chronic constipation is a common and extremely troublesome disorder that significantly reduces the quality of life,and this fact is consistent with the high rate at which health care is sought for this condition.The aim of this project was to develop a consensus for the diagnosis and treatment of chronic constipation and obstructed defecation.The commission presents its results in a 'Question-Answer' format,including a set of graded recommendations based on a systematic review of the literature and evidence-based medicine.This section represents the consensus for the diagnosis.The history includes information relating to the onset and duration of symptoms and may reveal secondary causes of constipation.The presence of alarm symptoms and risk factors requires investigation.The physical examination should assess the presence of lesions in the anal and perianal region.The evidence does not support the routine use of blood testing and colonoscopy or barium enema for constipation.Various scoring systems are available to quantify the severity of constipation;the Constipation Severity Instrument for constipation and the obstructed defecation syndrome score for obstructed defecation are the most reliable.The Constipation-Related Quality of Life is an excellent tool for evaluating the patient's quality of life.No single test provides a pathophysiological basis for constipation.Colonic transit and anorectal manometry define the pathophysiologic subtypes.Balloon expulsion is a simple screening test for defecatory disorders,but it does not define the mechanisms.Defecography detects structural abnormalities and assesses functional parameters.Magnetic resonance imaging and/or pelvic floor sonography can further complement defecography by providing information on the movement of the pelvic floor and the organs that it supports.All these investigations are indicated to differentiate between slow transit constipation and obstructed defecation because the treatments differ between these conditions. | Antonio Bove Filippo Pucciani Massimo Bellini Edda Battaglia Renato Bocchini Donato Francesco Altomare Giuseppe Dodi Guido Sciaudone Ezio Falletto Vittorio Piloni Dario Gambaccini Vincenzo Bove | 2012 | World Journal of Gastroenterology2012，18，14： | 20 |
| 3 | Stepwise approach and surgery for gallbladder adenomyomatosis: a mini-review显示文摘BACKGROUND: Gallbladder adenomyomatosis (GBA) is a hyperplastic disease affecting the wall of the gallbladder, with some typical features. It has historically been considered a benign condition, nevertheless recent reports highlighted a potential role of GBA in predisposing to malignancies of the gallbladder. DATA SOURCES: We reviewed the literature concerning GBA from its identification until July 2012. Owing to the relative rarity of the disease, studies often are case reports or case series. Thus we herein report a summary of the key-points concerning diagnosis and treatment of GBA, easily applicable in everyday practice, rather than a systematic review. Also, results are integrated with our recent experience. RESULTS: In our experience, we observed a trend toward an increase of GBA during the last years, probably due to enhanced ultrasonographic technical advancements and physician's expertise. GBA has distinctive imaging features. Several recent reports highlight the potential risk of cancer associated with GBA; however the disease is still classified as a benign condition. Although its correlation with malignancy has not been demonstrated, it is prudent to recommend cholecystectomy in some cases. However, in selected asymptomatic patients, a wait-and-see policy is a viable alternative. We propose an algorithm, based on GBA pathological pattern (diffuse, segmental, localized or fundal), suitable for decision-making.CONCLUSIONS: In symptomatic patients and if the diagnosis is doubtful, cholecystectomy is mandatory. Postponing surgery is an option to be offered to asymptomatic patients with low-risk GBA pattern who adhere to scheduled follow-ups. | Gianluca Pellino Guido Sciaudone Giuseppe Candilio Giuseppe Perna Antonio Santoriello Silvestro Canonico Francesco SelvaggiAuthor | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 9 |
| 4 | FGD-PET in the followup of recurrent colorectal cancer显示文摘 | Selvaggi F Cuocolo A Sciaudone G | 2003 | Colorectal Dis2003，5，5： | 1 |
| 5 | Treatment of complex perianal fistulas in Crohn disease:infliximab,surgery or combined approach显示文摘 | Sciaudone G Di Stazio C Limongelli P | | 0，，05： | 1 |
| 6 | Notch 1 impairs osteoblastic cell differentiation 显示文摘 | Sciaudone M Gzzerro E Priest L | 2003 | Endocrinology2003，144，12： | 1 |
| 7 | Rectal diverticulum:a new complication of STARR procedure for obstructed defecation显示文摘 | Sciaudone G Stazio CD Guadagni I | 2008 | Tech Coloproctol2008，12，： | 1 |
| 8 | Inguinal hernia repair in patients with coagulation problems : prevention of postopera- tive bleeding with human fibrin glue显示文摘 | Canonico S Sciaudone G Pacifico F | 1999 | Surgery1999，125，3： | 1 |
| 9 | Quality of life in patients with ileal pouch for ulcerative colitis显示文摘 | Selvaggi F Giuliani A Sciaudone G | 2004 | Chir Ital2004，56，2： | 1 |
| 10 | Effect of surgery on health-related quality of life of patients with locally recurrent rectal cancer显示文摘 | Pellino G Sciaudone G Candilio G | 2015 | Dis Colon Rectum2015，58，8： | 1 |
| 11 | Notch 1 impairs osteohlastic cell differentiation 显示文摘 | Sciaudone M Gazzerro E Priest L | 2003 | Endocrinology2003，144，12： | 1 |
| 12 | Inguinal hernia repair in patients with coagulation problems: prevention of postoperative bleeding with human fibrin glue显示文摘 | Canonico S Sciaudone G Pacifico F | 1999 | Surgery1999，25，3： | 1 |
| 13 | Rectal diver- ticulum: a new complication of STARR procedure for obstructed defecation显示文摘 | Sciaudone G Stazio CD Guadagni I | 2008 | Tech Coloproctol2008，12，： | 1 |
| 14 | Rectal diverticulum:a new complication of STARR procedure for obstructed defecation显示文摘 | Sciaudone G Di Stazio C Guadagni L | 2008 | Tech Coloproctol2008，1，12： | 1 |
| 15 | Inguinal hernia repair in patients with coagulation problems:prevention of postoperative bleeding with human fibrin glue显示文摘 | Canonico S Sciaudone G Pacifico F | | 0，，03： | 1 |
| 16 | FGD-PET in the fol- lowup of recurrent colorectal cancer 显示文摘 | Selvaggi F Cuocolo A Sciaudone G | 2003 | Colorectal Dis2003，5，5： | 1 |
| 17 | Notch 1 impairs osteoblastic cell differentiation显示文摘 | Sciaudone M Gazzerro E Priest L Delany AM Canalis E | | 0，，： | 1 |
| 18 | Disseminated Cryptococcus neoformans infection and Crohn's disease in an immunocompetent patient显示文摘 | Sciaudone G Pellino G Guadagni I | | 0，，： | 1 |
| 19 | Inguinal hernia repair in patients with coagulation problems:prevention of postoperative bleeding with human fibrin glue 显示文摘 | Canonico S Sciaudone G Pacifico F | 1999 | Surgery1999，25，3： | 1 |
| 20 | 为什么南欧和拉美在流行Firefox手机显示文摘新兴市场的移动运营商开始转向Firefox
“我可以告诉你的是,西班牙电信正在力推Firefox” | Brendan Greeley Patricia Laya Oscar Medina Corina Pons Cornelius Rahn Christiana Sciaudone 经雷 | 2014 | 商业周刊(中文版)2014，，14： | 0 |
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