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| 1 | Circulating adhesion molecules in patients with virus-related chronic diseases of the liver显示文摘AIM: In the inflammatory state, intercellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) play a key role in promoting migration of immunological cells from the circulation to target site.Aim of our study was to investigate soluble forms of these molecules in patients with virus-related chronic liver diseases, to assess their behavior in different pathologies and correlation with severity of liver damage.METHODS: Circulating ICAM-1 and VCAM-1 were assayed by EIA commercial kits (R&D System Co.,Abington, UK) in 23 patients with chronic active hepatitis (CH), 50 subjects affected by liver cirrhosis (LC) and 15 healthy controls comparable for sex and age. In patients, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were also detected by autoanalyzer.RESULTS: LC patients had significantly higher ICAM-1 values than CH patients (38.56±7.4 ng/mL vs 20.89±6.42 ng/mL; P<0.001) and these ones had significantly higher values than controls (12.92±1.08 ng/mL; P<0.001). In CH group, ICAM-1 levels were significantly related to inflammatory activity (P= 0.041) and ALT values (r= 0.77;P<0.05). VCAM-1 values were significantly increased only in LC patients (P<0.001) and related to severity of liver impairment.CONCLUSION: These findings suggest that the determination of serum ICAM-1 can be considered as an additional useful marker of hepatocellular necrosis and inflammatory activity in chronic hepatitis, while serum VCAM-1 is an indicator of liver fibrogenesis and severity of disease in cirrhosis. | Cosimo Marcello Bruno Claudio Sciacca Danila Cilio Gaetano Bertino Anna Elisa Marchese Gaetana Politi Lucia Chinnici | 2005 | World Journal of Gastroenterology2005，11，29： | 19 |
| 2 | 多民族人群中卵圆孔未闭与缺血性卒中的发生风险显示文摘目的:拟评价北曼哈顿多民族的前瞻性队列中卵圆孔未闭(PFO)引起缺血性卒中的风险。背景:PFO被认为与缺血性卒中风险增加相关,证据主要来自病例对照研究。在普通人群中,实际的PFO相关性卒中风险仍不明确。方法:研究对象为来自北曼哈顿研究(NOMAS)中1100例年龄〉39岁(平均68.7±10.0岁)的无卒中受试者,利用造影剂注射经胸二维超声心动图检查评估基线时的PFO。同时记录房间隔动脉瘤(ASA)。受试者接受每年随访。在校正已知的卒中危险因素后,评价PFO/ASA相关的卒中风险。 | Di Tullio M.R. Sacco R.L. Sciacca R.R. 韩瑞娟 | 2007 | 世界核心医学期刊文摘(心脏病学分册)2007，3，7： | 11 |
| 3 | 未经治疗脑动静脉畸形患者出血的预测因素显示文摘Background: Intracranial hemorrhage is a serious possible complication in patients with brain arteriovenous malformation (AVM). Several morphologic factors associated with hemorrhagic AVM presentation have been established, but their relevance for the risk of subsequent AVM hemorrhage remains unclear. Methods: The authors analyzed follow-up data on 622 consecutive patients from the prospective Columbia AVM database, limited to the period between initial AVM diagnosis and the start of treatment (i.e., any endovascular, surgical, or radiation therapy). Univariate and multivariate logistic regression and Cox proportional hazard models were applied to analyze the effect of patient age, gender, AVM size, anatomic location, venous drainage pattern, and associated arterial aneurysms on the risk of intracranial hemorrhage at initial presentation and during follow-up. Results: The mean pretreatment follow-up was 829 days (median: 102 days), during which 39 (6%) patients experienced AVM hemorrhage. Increasing age (hazard ratio [HR] 1.05, 95%CI 1.03 to 1.08), initial hemorrhagic AVM presentation (HR 5.38, 95%CI 2.64 to 10.96), deep brain location (HR 3.25, 95%CI 1.30 to 8.16), and exclusive deep venous drainage (HR 3.25, 95%CI 1.01 to 5.67) were independent predictors of subsequent hemorrhage. Annual hemorrhage rates on follow-up ranged from 0.9%for patients without hemorrhagic AVM presentation, deep AVM location, or deep venous drainage to as high as 34.4%for those harboring all three risk factors. Conclusions: Hemorrhagic arteriovenous malformation (AVM) presentation, increasing age, deep brain location, and exclusive deep venous drainage appear to be independent predictors for AVM hemorrhage during natural history follow-up. The risk of spontaneous hemorrhage may be low in AVMs without these risk factors. | Stapf C. Mast H. Sciacca R. R. 邱伟庆(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 8 |
| 4 | Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease显示文摘 | Sunder Mudaliar Robert R. Henry Arun J. Sanyal Linda Morrow Hanns-Ulrich Marschall Mark Kipnes Luciano Adorini Cathi I. Sciacca Paul Clopton Erin Castelloe Paul Dillon Mark Pruzanski David Shapiro | 2013 | Gastroenterology2013，，： | 7 |
| 5 | Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies显示文摘AIM To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal adenoma.METHODS Pub Med and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein(CRP), interleukin-6(IL-6), and tumor necrosis factor-alpha(TNF-a) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios(ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of heterogeneity.RESULTS A total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary(OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, P heterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma(OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, P heterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-a and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00(95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19(95%CI: 0.92-1.55).CONCLUSION Summary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated. | Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso | 2017 | World Journal of Gastroenterology2017，23，10： | 5 |
| 6 | Effect of Medical Treatment in Stroke Patients With Patent Foramen Ovale: Patent Foramen Ovale in Cryptogenic Stroke Study显示文摘 | Shunichi Homma Ralph L. Sacco Marco R. Di Tullio Robert R. Sciacca J. P. Mohr | 2002 | Circulation: Journal of the American Heart Association2002，，： | 2 |
| 7 | Deter- mination of left ventricular mass by real-time three-dimension- al echocardiography: in vitro validation 显示文摘 | TAKUMA S CABRERIZA S E SCIACCA R | 2000 | Eehocardio- graphy2000，17，7： | 1 |
| 8 | The role of insulin receptors and IGF-I receptors in cancer and other diseases 显示文摘 | Frasca F Pandini G Sciacca L | 2008 | Arch Physiol Biochem2008，114，1： | 1 |
| 9 | Infalmma- tory cytokines in acute ischemic stroke 显示文摘 | Tuttolomondo A Di Raimondo D bi Sciacca R | 2008 | Curr Pharm Desh2008，14，33： | 1 |
| 10 | Advanced SCADA concepts显示文摘 | Sciacca S C Block W R | 1995 | IEEE Computer Applications in Power1995，8，1： | 1 |
| 11 | Measurement of the hot earrier damage profile in LDMOS devices stressed at high drain voltage 显示文摘 | Uorso D Aurite S Sciacca E | 2007 | Mieroelectronics Reliability2007，47，45： | 1 |
| 12 | The epidemiol- ogy of brain Arteriovenous Malformations显示文摘 | Berman M F Sciacca R R Pile-Spellman J | 2000 | Neurosurgery2000，47，2： | 1 |
| 13 | Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes:relationship with TOAST subtype, outcome and infarct site显示文摘 | Tuttolomondo A Di Sciacca R Di Raimondo D | 2009 | J Neuroimmunol2009，215，： | 1 |
| 14 | Insulin receptor isoform A and insulin-like growth factor Ⅱ as additional treatment targets in human osteosarcoma显示文摘 | Avnet S Sciacca L Salerno M | 2009 | Cancer Res2009，69，6： | 1 |
| 15 | The role of insulin receptors and IGF- I receptors in cancer and other di- seases显示文摘 | Frasca F Pandini G Sciacca L | 2008 | Arch Physiol Biochem2008，114，1： | 1 |
| 16 | Inflammatory cytokines in acute ischemic stroke显示文摘 | Tuttolam ondo A Raim ondo D Sciacca R | 2008 | Curr Pham Des2008，14，33： | 1 |
| 17 | Diabetes and cancer显示文摘 | Vigneri P Frasca F Sciacca L | 2009 | Endocr Relat Cancer2009，16，4： | 1 |
| 18 | Tumor lysis syndrome in elderly显示文摘 | Pumo V Sciacca D Malaguarnera M | 2007 | Crit Rev Oncol Hematol2007，64，1： | 1 |
| 19 | Determinants of left ventricular thrombus formation after primary percutaneous coronary intervention for anterior wall myocardial infarction显示文摘 | Rabbani L E Waksmonski C Iqbal S N Stant J Sciacca R Apfelbaum M | 2008 | J Thromb Thrombolysis2008，25，： | 1 |
| 20 | Determination of left ventricular mass by real-time three-dimensional echocardiography: In vitro validation显示文摘 | TAKUMA S CABRERIZA SE SCIACCA R | 2000 | Echocardiography2000，17，： | 1 |
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