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| 1 | Asymmetric dimethylarginine, a biomarker of cardiovascular complications in diabetes mellitus显示文摘Cardiovascular(CV) complications are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis being a common risk factor for prospective crisis of coronary artery diseases and/or cerebral infarction in DM subjects. From another point of view, asymmetric dimethylarginine(ADMA) has been established as an inhibitor of endogenous nitric oxide synthesis and the relationship between ADMA and arteriosclerosis has been reported. In our study with 87 type 2 DM(T2DM) patients, we have examined whether ADMA and other CV risk factors are the useful predictors of DMCV complications. After the measurement of the respective CV risk factors, we have followed the enrolled T2 DM patients for 5 years. We have finally analyzed 77 patients. DMCV complications developed in 15 cases newly within 5 years, and 4 cases recurred. The concentrations of ADMA in plasma were markedly more elevated in 19 DM patients with CV complications than in 58 DM patients without CV complications. Urinary albumin(U-Alb), mean intimal-medial thickness(IMT) and ankle brachial index(ABI) were also higher in patients with CV complications. Multiple regression analyses showed that U-Alb had an influence on the high level of ADMA(standardized β = 6.59, P = 0.00014) independently of age, systolic BP, fibrinogen, mean IMT, plaque score, and ABI. The review indicates what is presently known regarding plasma ADMA that might be a new and meaningful biomarker of CV complications in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Yuzo Yano Taku Tsunoda Takashi Ikawa Toshihiro Matsuo Fumihiro Ochi Yoshiki Kusunoki Masaru Tokuda Tomoyuki Katsuno Tomoya Hamaguchi Jun-ichiro Miyagawa Mitsuyoshi Namba | 2015 | World Journal of Experimental Medicine2015，5，2： | 16 |
| 2 | Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus显示文摘Atherosclerotic involvements are an essential causal element of prospect in diabetes mellitus(DM), with carotid atherosclerosis(CA) being a common risk-factor for prospective crisis of coronary artery diseases(CAD) and/or cerebral infarction(CI) in DM subjects. From another point of view, several reports have supplied augmenting proof that hepatocyte growth factor(HGF) has a physiopathological part in DM involvements. HGF has been a mesenchymal-derived polyphenic factor which modulates development, motion, and morphosis of diverse cells, and has been regarded as a humor intermediator of epithelial-mesenchymal interplays. The serum concentrations of HGF have been elevated in subjects with CAD and CI, especially during the acute phase of both disturbances. In our study with 89 type 2 DM patients, the association between serum concentrationsof HGF and risk-factors for macrovascular complicationsinclusive of CA were examined. The average of serumHGF levels in the subjects was more elevated than thereference interval. The serum HGF concentrations associated positively with both intimal-media thickness(IMT)(r = 0.24, P = 0.0248) and plaque score(r = 0.27, P =0.0126), indicating a relationship between the elevatedHGF concentrations and advancement of CA involvements. Multivariate statistical analysis accentuated thatserum concentrations of HGF would be associated inde-pendently with IMT(standardized = 0.28, P = 0.0499).The review indicates what is presently known regardingserum HGF might be a new and meaningful biomarkerof macroangiopathy in DM subjects. | Hiroyuki Konya Masayuki Miuchi Kahori Satani Satoshi Matsutani Taku Tsunoda Yuzo Yano Tomoyuki Katsuno Tomoya Hamaguchi Jun-Ichiro Miyagawa Mitsuyoshi Namba | 2014 | World Journal of Diabetes2014，5，5： | 5 |
| 3 | Selective removal of low density lipoprotein by plasmapheresis in familial hypercholesterolemia显示文摘 | Yokoyama S Hayashi R Satani M | 1985 | Arteriosclerosis1985，5，： | 1 |
| 4 | A selective removal of LDL by plasmapheresis in familial hypercholesterolemia显示文摘 | Yokoyama S Hayashi R Satani M | 1985 | Arterosclerosis1985，5，6： | 1 |
| 5 | Postoperative analgesia in pefitonectomy for patients with peritoneal surface malignancy显示文摘 | Tomita A Satani M Morimoto A | 2015 | Masui2015，64，2： | 1 |
| 6 | Clinical significance of circulating hepatocyte growth factor, a new risk marker of carotid atherosclerosis in patients with type 2 diabetes显示文摘 | Satani K Konya H Hamaguchi T | 2006 | Diabet Med2006，23，6： | 1 |
| 7 | Myocardial salvage for ST-elevation myocardial infarction with terminal QRS distortion and restoration of brisk epicardial coronary flow 显示文摘 | Nakamura N Gohda M Satani O | 2008 | Heart Vessel2008，24，2： | 1 |
| 8 | Selective removal of LDL by plasmapheresis in familial hypercholesterolemia显示文摘 | Yokoyama S Haaayashi R Satani M | 1985 | Arterosclerosis1985，5，6： | 1 |
| 9 | Colored cosmetic contact lens- es:an unsafe trend in the younger generation显示文摘 | Singh S Satani D Patel A | 2012 | Cornea2012，31，7： | 1 |
| 10 | Myocardial salvage for ST-elevation myocardial infarction with terminal QRS distortion andrestoration of brisk epicardial coronary flow 显示文摘 | Nakamura N Gohda M Satani O | 2009 | Heart Vessels2009，24，2： | 1 |
| 11 | Application of amniotic membrane transplantation in cases of symblepharon 显示文摘 | Patel AP Satani DR Singh S | 2012 | J Indian Med Assoc2012，110，6： | 1 |
| 12 | Therapeutic targeting of the endothlin a receptor in human ovarian carcinoma 显示文摘 | Rosano L Spinella F Satani D | 2003 | Cancer Res2003，63，10： | 1 |
| 13 | Clinical significance of circulating hepatocyte growth factor , a new risk marker of carotid atherosclerosis in patients with Type 2 diabetes 显示文摘 | Satani K Konya H Hamaguchi T | 2006 | Diabet Med2006，23，6： | 1 |
| 14 | Amyioid deposition in primary pulmonary marginal zone B-cell lymphoma of mucosa-associated lymphoid 显示文摘 | Satani T Yokose T Kaburagi T | 2007 | Pathol Int2007，57，11： | 1 |
| 15 | Application of amniotic mem- brane transplantation in cases of symblepharon 显示文摘 | Patel AP Satani DR Singh S | 2012 | J Indian Med Assoc2012，110，6： | 1 |
| 16 | Intra-abdominal bronchogenic cyst with gastric attachment:report of a case显示文摘 | Ubukata H Satani T Motohashi G | | 0，，： | 1 |
| 17 | Effects of gliclazide on platelet aggregation and the plasminogen activator inhibitor type 1 level in patients with type 2 diabetes mellitus显示文摘 | Hiroyuki Konya Yoshikazu Hasegawa Tomoya Hamaguchi Kahori Satani Akiko Umehara Tomoyuki Katsuno Tetsuya Ishikawa Masayuki Miuchi Kousuke Kohri Akira Suehiro Eizo Kakishita Jun-ichiro Miyagawa Mitsuyoshi Namba | 2010 | Metabolism2010，，9： | 1 |
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