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| 1 | Garden rue inhibits the arachidonic acid pathway, scavenges free radicals, and elevates FRAP: role in inflammation显示文摘AIM:In the present study,the anti-inflammatory and antioxidant activities of the methanol extract of Ruta graveolens leaves(RG-M) were evaluated using various in vivo and in vitro models.METHOD:For anti-inflammatory activity,RG-M was administered by the oral route(p.o.) in a carrageenan–induced paw edema model,and by the intraperitoneal route(i.p.) in an exudative inflammation model.In vitro inhibition of cyclooxygenase and lipoxygenase enzymes was evaluated.In vitro antioxidant activity was also examined.Endogenous antioxidant status was further evaluated by ferric reducing ability of plasma model.RESULTS:RG-M showed maximum inhibition of carrageenan-induced edema(100 mg·kg-1–33.36%; 200 mg·kg-1–45.32% and 400 mg·kg-1–56.28%).In the exudative inflammation model,a significant reduction in leukocyte migration(200 mg·kg-1–54.75% and 400 mg·kg-1–77.97%) and protein exudation(200 mg·kg-1–31.14% and 400 mg·kg-1–49.91%) were observed.RG-M also exhibited inhibition of COX–1(IC50 182.27 μg·mL-1) and COX–2(IC50 190.16 μg·mL-1) as well as 5–LOX(IC50 215.71 μg·mL-1).Antioxidant activity was significant with improved endogenous antioxidant status.CONCLUSION:The results demonstrated the anti-inflammatory and antioxidant activity of RG-M with potent inhibitory effects on the arachidonic acid pathways. | Manjir Sarma Kataki Bibhuti B Kakoti Biman Bhuyan Ananya Rajkumari Prakash Rajak | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 3 |
| 2 | Integration algorithm for modeling the elasto-viscoplastic response of polycrystalline materials显示文摘 | Sarma G B Zacharia T | 1999 | Journal of the Mechanics and Physics of Solids1999，47，： | 2 |
| 3 | Safety of Green Tea Extracts: A Systematic Review by the US Pharmacopeia显示文摘 | Sarma Dandapantula N Barrett Marilyn L Chavez Mary L Gardiner Paula Ko Richard Mahady Gail B Marles Robin J Pellicore Linda S Giancaspro Gabriel I Dog Tieraona Low | 2008 | Drug Safety2008，，6： | 2 |
| 4 | A coupled soil water and nitrogen balance model for flooded rice fields in India显示文摘 | CHOWDARY V M RAO N H SARMA P B S | 2004 | Agriculture Ecosystem & Environment2004，103，3： | 1 |
| 5 | Significance of foamy-oil behavior in primary production of heavy oil 显示文摘 | MAINI B B SARMA H K GEORGE A E | 1993 | JCPT1993，32，6： | 1 |
| 6 | Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study 显示文摘 | Kumarasamy KK Toleman MA Walsh TR Bagaria J Butt F Balakrishnan R Chaudhary U Doumith M Giske CG Irfan S Krishnan P Kumar AV Maharjan S Mushtaq S Noorie T Paterson DL Pearson A Perry C Pike R Rao B Ray U Sarma JB Sharma M Sheridan E Thirunarayan MA Turton J Upadhyay S Warner M Welfare W Livermore DM Woodford N | 2010 | Lancet Infect Dis2010，10，9： | 1 |
| 7 | Photoelectron spectroscopic study of CdS nanocrystallites 显示文摘 | NANDA J KURUVILLA B A SARMA D D | 1999 | Phys Rev B1999，59，： | 1 |
| 8 | The Spectrum of the Corona of Two Graphs显示文摘 | Barik S Pati S Sarma B K | 2007 | SIAM Journal on Discrete Mathematics2007，21，1： | 1 |
| 9 | Clinical and anaesthetic effects of detomidine and ketamine in cats显示文摘 | Sarma B Amresh K Harnam S | 1996 | Indian Vet J1996，73，6： | 1 |
| 10 | On the null-spaces of acyclic and unicyclic singular graphs显示文摘 | NATH M SARMA B K | 2007 | Linear Algebra and its Application2007，427，： | 1 |
| 11 | Fractional flow reserve:a review:invasive imaging显示文摘 | De Bruyne B Sarma J | 2008 | Heart2008，94，7： | 1 |
| 12 | 查看详情显示文摘 | Singha B Sarma A Chutia J | | 0，，： | 1 |
| 13 | Extraction of Iron(Ill) at Macro-level Concentrations Using TBP, MIBK and Their Mixtures 显示文摘 | Reddy B R Sarma P V R B | 1996 | Hydrometallurgy1996，41，3： | 1 |
| 14 | A coupled soil water and nitrogen balance model for flooded rice fields in India 显示文摘 | Chowdary V M Rao N H Sarma P B S | 2004 | Agriculture Ecosystems and Environment2004，103，： | 1 |
| 15 | Development of Erysiphe pisi( Powdery mildew)on normal and albino mutants of pea(Pisum sativum L) 显示文摘 | SINGH U P PRITHIVIRAL B SARMA B K | 2000 | Joumal of Phytopathology2000，148，： | 1 |
| 16 | Hepatic toxicity in South Indian patients during treatment of tuberculosis with short-course regimens containing isoniazid,rifampicin and pyrazinamide显示文摘 | Parthasarathy R Sarma GR Janardhanam B | 1986 | Tubercle1986，67，2： | 1 |
| 17 | Reduction of α,β-unsaturated carbonyl compounds by palladium(11) and nickel(11) complexes having nitrogen-containing ligands显示文摘 | JANA P P SARMA R BARUAH J B | 2008 | Journal of Molecular Catalysis A Chemical2008，289，12： | 1 |
| 18 | Frequency of occurrence of mangrove fungi from the east coast of India显示文摘 | SARMA V V HYDE K D VITTAL B P R | 2001 | Hydrobiologia2001，455，： | 1 |
| 19 | Modeling the kinetics and microstructural evolution during static recrystallization-Monte Carlo simulation of recrystallization 显示文摘 | Radhakrishnan B Sarma G B Zacharia T | 1998 | Acta M aterialia1998，46，12： | 1 |
| 20 | Impact of atmospheric and physical forcings on biogeochemical cycling of dissolved oxygen and nutrients in the coastal Bay of Bengal显示文摘 | Sarma V Sridevi B Maneesha K | 2013 | Journal of Oceanography2013，69，2： | 1 |
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