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| 1 | nvasive Spartina and reduced sediments: Shanghai’s dangerous silver bullet显示文摘Aims This synthesis paper is developed to provide a summary of ecological,socioeconomic challenges facing the estuarine wetlands within the Yangtze River delta.Methods We combined literature review of the estuarine wetlands and ground measurements of sedimentation,vegetation,and carbon fluxes to illustrate the foreseeable crises in managing these wetlands that play a critical role in Shanghai’s urban development.Where the Yangtze River meets the Pacific Ocean,4.153108 mg/year of suspended sediments are deposited along mainland and island shorelines of the 40000 km2 delta-resulting in an average growth rate of land outwards 64 m/year since 1951.However,completion of the Three Gorges Dam in 2003,and earlier dam projects,reduced the rates of sedimentation and growth of the islands.To meet the increasing demands for lands and agriculture,policymakers have attempted to enlarge the islands by diking coastal areas and introducing Spartina alterniflora-a grass native to tidal salt marshes of the southeastern USA but exotic to China.Spartina is one of the 16 greatest invasive species listed by the State Environmental Protection Administration of China.Successful plantations and rapid spread of this species have increased the production and fertility of the coast,but at the cost of native ecosystems.We outline the social,economic,and ecological controversies related to this land management strategy in the context of global warming.Important findings Combinations of these changes,including sea level rise,and alterations to storm patterns and long-shore currents,with the continued spread of Spartina,human population growth,and river flow and sediment reduction will make current management untenable. | Jiquan Chen Bin Zhao Wenwei Ren Sari C.Saunders Zhijun Ma Bo Li Yiqi Luo Jiakuan Chen | 2008 | Journal of Plant Ecology2008，1，2： | 2 |
| 2 | Regulation of average 24h human plasma leptin level;The influence of exercise and physiological changes in energy balance显示文摘 | Van Aggel-Leijssen DPC van Baak MA Tenenbaum R Campfield LA and Saris WHM | 1999 | Int J Obes1999，23，： | 1 |
| 3 | Hepddin hound to α2-maeroglobulin reduces ferroportin-1 expression and en- hances its activity at reducing serum iron levels显示文摘 | Huang ML Austin CJ Sari MA | 2013 | J Biol Chem2013，288，25： | 1 |
| 4 | Outcome of the IASO 1st Stock Conference and consensus statement 显示文摘 | Saris WH Blair SN van Baak MA | 2003 | Obes Rev2003，4，： | 1 |
| 5 | Funct-ional importance of angiotensin-converting enzyme -dependent in situ angiotensin Ⅱ generation in the human forearm显示文摘 | van Dijk MA Kroon I | 2000 | Hypertension2000，35，3： | 1 |
| 6 | Multiple structural and functional abnormalities in the P450 aromatase expressing transgenic male mice are ameliorated by a P450 aromatase inhibitor显示文摘 | Xiangdong Li Leena Strauss Sari Ma | 2004 | Am J Pathol2004，164，3： | 1 |
| 7 | Functional importance of angiotensin converting enzyme-dependent in situ angiotensin Ⅱ generation in the human forearm 显示文摘 | SARIS JJ VAN DIJK MA KROON I | 2000 | Hypertensin2000，35，1： | 1 |
| 8 | Studies on the expression and metabolic capabilities of human liver cytochrome P450 Ⅲ A5 (HLp3)显示文摘 | Wrighton SA Brian WR Sari MA | 1990 | Mol Pharmacol1990，38，2： | 1 |
| 9 | Studies on the expression and metabolic capabilities of human liver cytochrome P4503A5(HLp3)显示文摘 | Wrighton SA Brian WR Sari MA | 1990 | Mol Pharmacol1990，38，2： | 1 |
| 10 | Studies on the expression and metabolic capabilities of human liver cytochrome P450m A5(HLP3)显示文摘 | Wrighton SA Brian WR Sari MA | 1990 | Mol Pharmacol1990，38，2： | 1 |
| 11 | Functional importance o{ angiotensin converting enzyme--dependent in situ angiotensin K generation in the human forearm 显示文摘 | Saris JJ Van Dijk MA Kroon I | 2000 | Hypertension2000，35，1： | 1 |
| 12 | Studies on the expression and metabolic capabilities of human liver cytochrome P450 Ⅲ A5(HLp3) 显示文摘 | Wrighton SA Brian WR Sari MA | 1990 | Mol Pharmacol1990，38，2： | 1 |
| 13 | Expression of human cytochrome P450 enzymes in yeast and bacteria and relevance to studies on catalytic specificity显示文摘 | Guengerich FP Gillam EM Ohmori S Sandhu P Brian WR Sari MA | 1993 | To- xicology1993，82，13： | 1 |
| 14 | Treatment of ankylosing spon-dylitis显示文摘 | Sari I Oztlirk MA Akkog N | 2015 | Turk J Med Sci2015，45，2： | 1 |
| 15 | Outcome of the IASO 1st stock conference and consensus statement显示文摘 | Saris WH Blair SN Van Baak MA | 2003 | Obes Rev2003，4，： | 1 |
| 16 | Studies on the ex- pression and metabolic capabilities of human liver cyto- chrome P450Ⅲ A5 ( HLp3 ) 显示文摘 | Wrighton SA Brian WR Sari MA | 1990 | Mol Pharmacol1990，38，2： | 1 |
| 17 | Mierocystic urothelial carcinoma of the urinary bladder metastatic to the penis显示文摘 | Sari A Uyaroglu MA Ermete M | 2007 | Pathol Oncol Res2007，13，2： | 1 |
| 18 | Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine显示文摘 | Mazier C Jaouen M Sari MA | 2004 | Bioorg Med Chem Lett2004，14，21： | 1 |
| 19 | Functional importance of angiotensin converting enzyme-dependent in situ angiotensin Ⅰ generation in the human forearm显示文摘 | Saris JJ Van Dijk MA Kroon Ⅰ | 2000 | Hypertension2000，35，1： | 1 |
| 20 | An Investigation of Regional Variations in the Biaxial Mechanical Properties of Porcine Mitral Valve显示文摘Objective Mitral valve(MV)plays an importance role in regulating blood flow from left atrium to left ventricle and preventing backflow to left atrium.Mitral Valve consist of four important parts;anterior leaflet,posterior leaflet,chordae tendineae,and papillary muscles,which all work in harmony.The material properties alteration on the leaflet causes MV malfunction,and leading to valve diseases such as regurgitation and stenosis.The alteration may be caused by several factors such as calcification,genetic disorders,and infection,which usually have an influence to the mechanical properties,and thus affecting the mechanical behavior of MV.In consequence,some of the patients need MV replacement or repair to restore the normal function of MV.The important point for succeeding such a medical treatment depends on the technique,design,and material used in the treatment shall help rebuild the normal mechanical environment and behavior of MV.Therefore,the mechanical and materials characteristics of MV become a magnetism to explore.In this study,we present an integrated experimental and mathematical constitutive study base in collagen distribution aiming at the mechanical property differences in various region on MV.Methods and materials Both the size and composition of porcine valves are similar to human’s,so the porcine heart valve is often being used in experimental research.Mitral valve was isolated from fresh eight porcine hearts(250-500 gr),and perfused in PBS solution to maintain moist.Anterior and posterior leaflets were separated and dissected into 4 part(two 8~*8 mm rough zone and two clear zone samples)and 2 part(8~*8 mm belly and edge of the clear zone)respectively.Tracking markers(glass bean)were stickled on specimen with superglue(cyanoacrylate adhesive).Then,the specimen was mounted onto biaxial tester machine(CeIIScale,Biotester),and the tests are run by force control.During mechanical test,the specimen is immersed into PBS solution in physiological temperature(37℃).Every test procedure contains 8 preconditioning cycles and 8 loading cycles.The mechanical behavior was determined from the relationship between first Piola-Kirchoff stress and stretch.Constitutive model was reconstructed and material parameters were fitted from biaxial tensile result.Histological analyses were performed in the specimen before and after test.First,a piece of the specimen was cut and immersed in fixation solution(4%paraformaldehyde),then it was dehydrated in graded alcohol solution,and next embedding in paraffin wax block.Paraffin block was then cut and stained with VVG and Picro-sirius red.The collagen fibril orientation was observed from those histological results.Results The experimental results of the clear zone of MV’s first Piola-Kirchhoff stress and stretch curve are similar to those of the recent study from others,while result of the rough zone shows a different trend.This can be explained by differences in collagen distribution between clear zone and rough zone of MV.Our result thus allows for a refinement of computational models for more accurately predicting MV condition,where tissue heterogeneity plays an important role in the MV function. | Candra Ratna Sari Shenda Chen Yang Lei Hao Gao Guixue Wang Xingsuang Ma | 2019 | 医用生物力学2019，34，A01： | 0 |
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