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| 1 | Histone deacetylase inhibitor pre-treatment enhances the efficacy of DNA-interacting chemotherapeutic drugs in gastric cancer显示文摘BACKGROUND The prognosis of gastric cancer continues to remain poor,and epigenetic drugs like histone deacetylase inhibitors(HDACi)have been envisaged as potential therapeutic agents.Nevertheless,clinical trials are facing issues with toxicity and efficacy against solid tumors,which may be partly due to the lack of patient stratification for effective treatments.To study the need of patient stratification before HDACi treatment,and the efficacy of pre-treatment of HDACi as a chemotherapeutic drug sensitizer.METHODS The expression activity of class 1 HDACs and histone acetylation was examined in human gastric cancer cells and tissues.The potential combinatorial regime of HDACi and chemotherapy drugs was defined on the basis of observed drug binding assays,chromatin remodeling and cell death.RESULTS In the present study,the data suggest that the differential increase in HDAC activity and the expression of class 1 HDACs are associated with hypoacetylation of histone proteins in tumors compared to normal adjacent mucosa tissue samples of gastric cancer.The data highlights for the first time that pretreatment of HDACi results in an increased amount of DNA-bound drugs associated with enhanced histone acetylation,chromatin relaxation and cell cycle arrest.Fraction-affected plots and combination index-based analysis show that pre-HDACi chemo drug combinatorial regimes,including valproic acid with cisplatin or oxaliplatin and trichostatin A with epirubicin,exhibit synergism with maximum cytotoxic potential due to higher cell death at low combined doses in gastric cancer cell lines.CONCLUSION Expression or activity of class 1 HDACs among gastric cancer patients present an effective approach for patient stratification.Furthermore,HDACi therapy in pretreatment regimes is more effective with chemotherapy drugs,and may aid in predicting individual patient prognosis. | Ramchandra Vigay Amnekar Shafqat Ali Khan Mudasir Rashid Bharat Khade Rahul Thorat Poonam Gera Shailesh V Shrikhande Duane T Smoot Hassan Ashktorab Sanjay Gupta | 2020 | World Journal of Gastroenterology2020，26，6： | 3 |
| 2 | Src kinase activity is essential for osteoclast function 显示文摘 | Miyazaki T Sanjay A Neff L | 2004 | J Bid Chem2004，279，17： | 1 |
| 3 | Novel vinyl ester resin and its urethane derivatives for glass reinforced composites 显示文摘 | Sanjay V P Dipak K R Jatin R T | 1999 | Die Angewandte Makromolekulare Chemie1999，265，1： | 1 |
| 4 | Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti- inflammatory agents 显示文摘 | Selvam C Sanjay M Jachaka R T | 2005 | Bioorg Med Chem Lett2005，15，： | 1 |
| 5 | Src kinase activity is essential for osteoclast function显示文摘 | MIYAZAKI T SANJAY A NEFF L | 2004 | J Biol Chem2004，279，17： | 1 |
| 6 | Src'kinase activity is essential for osteoclast function显示文摘 | Miyazaki T Sanjay A Neff L | 2004 | J Biol Chem2004，279，17： | 1 |
| 7 | Caffeine alters proliferation of neuronal precursors in the adult hippocampus 显示文摘 | Christian T Wentz Sanjay S Magavi | 2009 | Neuropharmacology2009，56，67： | 1 |
| 8 | Bioadhesive microspheres as a controlled drug delivery system显示文摘 | Jaspreet KV Kaustubh T Sanjay G | 2003 | Int J Pharm2003，255，12： | 1 |
| 9 | Retrospective comparison of mesh and sutured repair for adult umbilical hernias显示文摘 | SANJAY P REID T D DAVIES E L | 2005 | Hernia2005，9，3： | 1 |
| 10 | Absorption of carbon dioxide in aqueous piperazinelMDEA显示文摘 | Sanjay B G T R | 2002 | AIChEJournal2002，48，12： | 1 |
| 11 | Unruptured intracranial aneurysms : review of natural history and recommended management strategies 显示文摘 | Panigrahi M Sanjay T Reddy AK | 2002 | Neurol India2002，，： | 1 |
| 12 | Color spaces for transform-based image retrieval 显示文摘 | SANJAY N T SATISHKUMAR L V | 2010 | International Journal of Computer Applications2010，9，12： | 1 |
| 13 | The influence of interracial characteristics between SiCp and Mg/Al metal matrix on wear, coefficient of friction and microhardness显示文摘 | SANJAY K T BRIJ K D | 2001 | Wear2001，247，： | 1 |
| 14 | Absorption of carbon dioxide in aqueous piperazine/methyldiethanolamine 显示文摘 | Sanjay Bishnoi Rochelle Gary T | 2002 | AIChE Journal2002，48，12： | 1 |
| 15 | Bioadhesive microspheres as a controlled drug delivery system显示文摘 | Jaspreet KV Kaustubh T Sanjay G | 2003 | In J Pharm2003，255，1： | 1 |
| 16 | Molar mass and mo{ecularweight distribution determination of UHMWPE synthesized using a living homogeneous catalyst显示文摘 | Saeid T Rob D Sanjay R | 2010 | Macromolecules2010，43，6： | 1 |
| 17 | Diagno- sis of tuberculosis: available technologies, limita- tions, and possibilities显示文摘 | Sanjay K G Tiwari R P Dileep T eta| | 2003 | Joumal of Clinical Labo- ratory Analysis2003，17，5： | 1 |
| 18 | Experimental super- ensemble forecasts of tropical cyclones over the Bay of Bengal 显示文摘 | V1JAYA KUMAR T S V SANJAY J BASU B K | 2007 | Nat Hazards2007，41，3： | 1 |
| 19 | The influence of interfacial characteristics between SiCp and Mg/Al metal matrix on wear, coefficient of friction and microhardness显示文摘 | Sanjay T Dhindaw K Kumar B | 2001 | Wear2001，247，2： | 1 |
| 20 | Unruptured intracranial aneurysms:review of natural history and recommended management strategies显示文摘 | Sanjay T Reddy AK | 2002 | Neurol India2002，50，： | 1 |
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