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| 1 | The alphal-microglobulin/bikunin gene: characterization in mouse and evolution显示文摘 | Lindqvist A Rouest P Salier JP | 1999 | Gene1999，234，2： | 1 |
| 2 | Inter-alpha-trypsin inhibitor: emergence of a family within the Kunitz-type protease inhibitor superfamily 显示文摘 | Salier J P | 1990 | Trends Biochem Sci1990，15，11： | 1 |
| 3 | High-order Harmonic-generation cutoff显示文摘 | Lewenstein M Salieres P | 1993 | Phys Rev A1993，48，： | 1 |
| 4 | Feynman’s path-in-tegral approach for intense-laser-atom interactions显示文摘 | SALIERES P CARRE B DEROFF L L | 2001 | Science2001，292，5518： | 1 |
| 5 | Mouse alpha-l-microglobulin/bikunin precursor :cDNA analysis, gene evolution and physical assignment of the gene next to the orosomucoid locus 显示文摘 | Chan P Salier J P | 1993 | Biochim Biophys Acta1993，1174，2： | 1 |
| 6 | The inter-alpha-inhibitor family:from structure to regulation显示文摘 | Salier JP Rouet P Raguenez G | | 0，，1： | 1 |
| 7 | The inter-alpha-inhibitor family: From structure to regulation显示文摘 | Salier JP Rouet P Raguenez G | 1996 | Biochem J1996，315，： | 1 |
| 8 | Genome-wide differences in hepatitis C-vs alcoholism-associated hepatocellular carcinoma显示文摘AIM:To look at a comprehensive picture of etiology- dependent gene abnormalities in hepatocellular carcinoma in Western Europe. METHODS:With a liver-oriented microarray,transcript levels were compared in nodules and cirrhosis from a training set of patients with hepatocellular carcinoma (alcoholism,12;hepatitis C,10)and 5 controls.Loose or tight selection of informative transcripts with an abnormal abundance was statistically valid and the tightly selected transcripts were next quantified by qRTPCR in the nodules from our training set(12+10) and a test set(6+7). RESULTS:A selection of 475 transcripts pointed to significant gene over-representation on chromosome 8 (alcoholism)or-2(hepatitis C)and ontology indicated a predominant inflammatory response(alcoholism)or changes in cell cycle regulation,transcription factors and interferon responsiveness(hepatitis C).A stringent selection of 23 transcripts whose differences betweenetiologies were significant in nodules but not in cirrhotic tissue indicated that the above dysregulations take place in tumor but not in the surrounding cirrhosis.These 23 transcripts separated our test set according to etiologies. The inflammation-associated transcripts pointed to limited alterations of free iron metabolism in alcoholic vs hepatitis C tumors. CONCLUSION:Etiology-specific abnormalities(chromo- some preference;differences in transcriptomes and related functions)have been identified in hepatocellular carcinoma driven by alcoholism or hepatitis C.This may open novel avenues for differential therapies in this disease. | Céline Derambure Cédric Coulouarn Frédérique Caillot Romain Daveau Martine Hiron Michel Scotte Arnaud Franois Celia Duclos Odile Goria Marie Gueudin Catherine Cavard Benoit Terris Maryvonne Daveau Jean-Philippe Salier | 2008 | World Journal of Gastroenterology2008，14，11： | 1 |
| 9 | Coherence con-trol of high-order harmonics显示文摘 | SALIERES P L’HUILLIER A LEWENSTEIN M | 1995 | Physics Review Letters1995，74，19： | 1 |
| 10 | Chromosomal location, exon/intron organization and evolution of lipocalin genes显示文摘 | Salier J P | 2000 | Biochimica et Biophysica Acta2000，1482，： | 1 |
| 11 | Transient and etiology-related transcription regulation in cirrhosis prior to hepatocellular carcinoma occurrence显示文摘AIM:To search for transcription dysregulation that could(1) differentiate hepatocellular carcinoma(HCC)-free from HCC-related cirrhosis(2) differentiate HCC-free cirrhosis related to HCV from that related to alcohol intake.METHODS:Using microarray analysis,we compared transcript levels in HCC-free cirrhosis(alcoholism:7;hepatitis C:7),HCC-associated cirrhosis(alcoholism:10;hepatitis C:10) and eight control livers.The identified transcripts were validated by qRT-PCR in an independent cohort of 45 samples(20 HCC-free cirrhosis;15 HCC-associated cirrhosis and 10 control livers).We also confirmed our results by immunohistochemistry.transcripts which differentiated between alcoholic-related cirrhosis,HCV-related cirrhosis and control livers.They mainly corresponded to down-regulation.Dysregulation of Signal Transduction and Activator of Transcription-3(STAT-3) was found along with related changes in STAT-3 targets which occurred in an etiology-dependent fashion in HCC-free cirrhosis.In contrast,in HCC,such transcription dysregulations were not observed.CONCLUSION:We report that transcriptional dysregulations exist in HCC-free cirrhosis,are transiently observed prior to detectable HCC onset and may be appear like markers from cirrhosis to HCC transition. | Frédérique Caillot Céline Derambure Paulette Bioulac-Sage Arnaud Franois Michel Scotte Odile Goria Martine Hiron Maryvonne Daveau Jean-Philippe Salier | 2009 | World Journal of Gastroenterology2009，15，3： | 1 |
| 12 | Chromosomal location,exon/intron organization and evolution of lipocalin genes显示文摘 | Jean-Philippe Salier | 2000 | Biochimica et Biophysica Acta2000，1482，： | 1 |
| 13 | The inter-alpha in-hibitor family : from structure to regulation 显示文摘 | Salier JP Rouet P Raguenez G | 1996 | BiochemicalJournal1996，，： | 1 |
| 14 | Cost, fair value and depreciation reserves显示文摘 | EARL A SALIERS | 1930 | The American Economic Review1930，10，2： | 1 |
| 15 | Feynman' s path- integral approach for intense-laser-atom interactions 显示文摘 | SALIERES P CARRE B DEROFF L L | 2001 | Science2001，292，5518： | 1 |
| 16 | The inter-alpha-inhibitor family: from structure to regulation 显示文摘 | Salier JP Rouet P Raguenez G | 1996 | Biochem J1996，315，1： | 1 |
| 17 | Chromosomal location, exon/intron organization and evolution of lipocalin genes显示文摘 | Salier Jean Philippe | 2000 | Biochimica et Biophysica Acta2000，1482，： | 1 |
| 18 | Chromosomal location,exon/intron organization and evolution of lipocalin genes显示文摘 | Salier J P | 2000 | Biochim Biophys Acta2000，1482，12： | 1 |
| 19 | The liver-specific human alpha(1)-microglobulin/bikunin precursor (AMBP) is capable of self-association显示文摘 | Tyagi S Salier JP Lal SK | 2002 | Arch Biochem Biophys2002，399，1： | 1 |
| 20 | Feynman' s Path Integral Approach for Intense-Laser-Atom Interactions 显示文摘 | CARRE B SALIERE P DEROFF L L | | Science0，，： | 1 |
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