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| 1 | Two-dimensional Pd-based nanomaterials for bioapplications显示文摘Noble metal nanomaterials have been extensively explored in cancer diagnostic and therapeutic applications owing to their unique physical and chemical properties, such as facile synthesis, straightforward surface functionalization, strong photothermal effect, and excellent biocompatibility. Herein, we summarize the recent development of two-dimensional(2D) Pd-based nanomaterials and their applications in cancer diagnosis and therapy. Different synthetic strategies for Pd nanosheets and the related nanostructures, including Pd@Au, Pd@Ag nanoplates and mesocrystalline Pd nanocorolla, are first discussed.Together with their unique properties, the potential bioapplications of these 2D Pd nanomaterials are then demonstrated. With strong absorption in near-infrared(NIR) region, these nanomaterials have great potentials in cancer photothermal therapy(PTT). They also readily act as contrast agents in photoacoustic(PA) imaging or X-ray computed tomography(CT) to achieve image-guided cancer therapy. Moreover,significant efforts have been devoted to studying the combination of PTT and other treatment modalities(e.g., chemotherapy or photodynamic therapy) based on Pd nanomaterials. The remarkable synergistic or collaborative effects to achieve better therapeutic efficacy are discussed as well. Additionally, the biosafety of 2D Pd-based nanomaterials in vitro and in vivo was evaluated. Finally, challenges for the applications of Pd-based nanomaterials in cancer diagnosis and therapy, and future research prospects are highlighted. | Xiaolan Chen Saige Shi Jingping wei Mei Chen Nanfeng Zheng | 2017 | Science Bulletin2017，62，8： | 4 |
| 2 | How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?显示文摘P-glycoprotein(ABCB1),multidrug resistance protein-1(ABCC1)and breast cancer resistance protein(ABCG2)belong to the ATP-binding cassette(ABC)superfamily of proteins that play an important physiological role in protection of the body from toxic xenobiotics and endogenous metabolites.Beyond this,these transporters determine the toxicity profile of many drugs,and confer multidrug resistance(MDR)in cancer cells associated with a poor treatment outcome of cancer patients.It has long been hypothesized that inhibition of ABC drug efflux transporters will increase drug accumulation and thereby overcome MDR,but until now no approved inhibitor of these transporters is available in the clinic.In this review we present molecular strategies to overcome this type of drug resistance and discuss for each of these strategies their promising value or indicate underlying reasons for their limited success. | Adrian C.Jaramillo Farah Al Saig Jacqueline Cloos Gerrit Jansen Godefridus J.Peters | 2018 | Cancer Drug Resistance2018，1，1： | 3 |
| 3 | Effect of glutathione on in vivo biodistribution and clearance of surface-modified small Pd nanosheets显示文摘Plasmonic Pd nanosheets have been emerging as promising materials for application in near-infrared(NIR) photothermal therapy(PTT) of cancer. However, animal in mice studies indicated that the original synthesized poly(vinylpyrrolidone)(PVP)-protected small Pd nanosheets(Pd-PVP) and some further surface-modified small Pd nanosheets such as Pd-PEG(SH) easily accumulated in reticuloendothelial system(RES) organs(liver, spleen, etc.) and were difficult to be cleared from these organs quickly. In the work, we surprisingly found that glutathione(GSH) could promote the clearance of surface-modified small Pd nanosheets(e.g. Pd-PVP, Pd-PEG(SH) and Pd-GSH) from the RES organs efficiently. The effects of GSH on the biodistribution and clearance of different surface-modified Pd nanosheets were investigated. Our results indicated that these surface-modified Pd nanosheets with or without GSH added caused no morbidity at target primary organs, and GSH can promote the clearance of different surface-modified Pd nanosheets in the order of Pd-PVP≈Pd-PEG(SH)>Pd-GSH. This study suggests that glutathione could be an attractive reagent for promoting nanomaterials eliminated from the reticuloendothelial systems(RES). | Yizhuan Huang Xiaolan Chen Saige Shi Mei Chen Shaoheng Tang Shiguang Mo Jingping Wei Nanfeng Zheng | 2015 | Science China Chemistry2015，58，11： | 3 |
| 4 | Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wolbachia显示文摘 | Moreira LA Saig E Turley AP | | 0，，12： | 1 |
| 5 | Systemic and Local hormone therapy for endometrial hyperplasia and early adenocarcinoma 显示文摘 | Hubbs JL Saig RM Abaid LN | 2013 | Obstet Gynecol2013，121，6： | 1 |
| 6 | microRNA expression profile in stage III colorectal cancer: CirculatingmiR-18a and miR-29a as promising biomarkers显示文摘 | Anna Brunet Vega Carles Pericay Irene Moya Anna Ferrer Emma Dotor Aleydis Pisa àlex Casalots Xavier Serra-Aracil Joan-Carles Oliva Anna Ruiz Eugeni Saigí | 2013 | Oncology Reports2013，，1： | 1 |
| 7 | Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wol- bachia显示文摘 | Moreira LA Saig E Turley AP | 2009 | PLoS Negl Trop Dis2009，3，12： | 1 |
| 8 | Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wolbachia显示文摘 | Moreira LA Saig E Turley AP | 2009 | PLoS Negl Trop Dis2009，3，12： | 1 |
| 9 | When does search openness really matter? A contingency study of health-care innovation projects显示文摘 | Saige T O Barrett M I Dopson S | 2013 | Journal of Product Innovation Management2013，30，4： | 1 |
| 10 | Sparse solution of under- determined systems of linear equations by stagewise orthogo- nal matching pursuit 显示文摘 | Donoho D L Saig Y Drori I | 2012 | IEEE Transactions on Information Theory2012，58，2： | 1 |
| 11 | A pediatrician-friendly review of three common behavioral health screeners in pediatric practice: Findings and recommendations显示文摘Behavioral health concerns are surging in pediatric practices.Fortunately,integrated behavioral/medical health clinics are growing and child psychiatrists/psychologists are increasingly embedded in these care settings to help shoulder the clinical load.Routine screening of behavioral health problems in primary care facilities enables early identification and treatment.However,deciding on sound,efficient,and scalable screening measures is sometimes arduous.Accordingly,this article presents a clinician-friendly review of three common instruments useful in screening pediatric behavioral health concerns including anxiety,depression,and conduct problems.Psychometric findings and clinical applications of the Pediatric Symptom Checklist-17(PSC-17),the Patient Health Questionnaire-9(PHQ-9),and the Screen for Child Anxiety Related Emotional Disorders(SCARED)are delineated.Finally,clinical implications and recommendations for practicing pediatricians and child psychiatrists are offered. | Sandra Trafalis Courtney Giannini Jeremy Joves Saige Portera Hannah Toyama Anika Mehta Krista Basile Robert D.Friedberg | 2021 | Pediatric Investigation2021，5，1： | 1 |
| 12 | Systemic and local hormone therapy for endometrial hyperplasia and early adenocarcinoma 显示文摘 | Huhbs JL Saig RM Abaid LN | 2013 | Obstet Gyneco12013，121，6： | 1 |
| 13 | microRNA expression profile in stage III colorectal cancer: CirculatingmiR-18a and miR-29a as promising biomarkers显示文摘 | Anna Brunet Vega Carles Pericay Irene Moya Anna Ferrer Emma Dotor Aleydis Pisa àlex Casalots Xavier Serra-Aracil Joan-Carles Oliva Anna Ruiz Eugeni Saigí | 2013 | Oncology Reports2013，，1： | 1 |
| 14 | Amphibian-derived peptide homodimer OA-GL17d promotes skin wound regeneration through the miR-663a/TGF-β1/Smad axis显示文摘Background:Amphibian-derived peptides exhibit considerable potential in the discovery and development of new therapeutic interventions for clinically challenging chronic skin wounds.MicroRNAs(miRNAs)are also considered promising targets for the development of effective therapies against skin wounds.However,further research in this field is anticipated.This study aims to identify and provide a new peptide drug candidate,as well as to explore the underlying miRNA mechanisms and possible miRNA drug target for skin wound healing.Methods:A combination of Edman degradation,mass spectrometry and cDNA cloning were adopted to determine the amino acid sequence of a peptide thatwas fractionated from the secretion of Odorrana andersonii frog skin using gel-filtration and reversed-phase high-performance liquid chromatography.The toxicity of the peptide was evaluated by Calcein-AM/propidium iodide(PI)double staining against human keratinocytes(HaCaT cells),hemolytic activity against mice blood cells and acute toxicity against mice.The stability of the peptide in plasma was also evaluated.The prohealing potency of the peptide was determined by MTS,scratch healing and a Transwell experiment against HaCaT cells,full-thickness injury wounds and scald wounds in the dorsal skin of mice.miRNA transcriptome sequencing analysis,enzyme-linked immunosorbent assay,real-time polymerase chain reaction and western blotting were performed to explore the molecular mechanisms.Results:A novel peptide homodimer(named OA-GL17d)that contains a disulfide bond between the 16th cysteine residue of the peptide monomer and the sequence‘GLFKWHPRCGEEQSMWT’was identified.Analysis showed that OA-GL17d exhibited no hemolytic activity or acute toxicity,but effectively promoted keratinocyte proliferation and migration and strongly stimulated the repair of full-thickness injury wounds and scald wounds in the dorsal skin of mice.Mechanistically,OA-GL17d decreased the level of miR-663a to increase the level of transforming growth factor-β1(TGF-β1)and activate the subsequent TGF-β1/Smad signaling pathway,thereby resulting in accelerated skin wound re-epithelialization and granular tissue formation.Conclusions:Our results suggest that OA-GL17d is a new peptide drug candidate for skin wound repair.This study emphasizes the importance of exogenous peptides as molecular probes for exploring competing endogenous RNA mechanisms and indicates that miR-663a may be an effective target for promoting skin repair. | Yue Zhang Ying Wang Lin Zeng Yixiang Liu Huiling Sun Shanshan Li Siyu Wang Longjun Shu Naixin Liu Saige Yin Junsong Wang Dan Ni Yutong Wu Ying Yang Li He Buliang Meng Xinwang Yang | 2022 | Burns & Trauma2022，10，1： | 0 |
| 15 | Knowledge Graph Embedding Based on Adaptive Negative Sampling显示文摘Knowledge graph embedding aims at embedding entities and relations in a knowledge graph into a continuous, dense, low-dimensional and realvalued vector space. Among various embedding models appeared in recent years, translation-based models such as TransE, TransH and TransR achieve state-of-the-art performance. However, in these models, negative triples used for training phase are generated by replacing each positive entity in positive triples with negative entities from the entity set with the same probability;as a result, a large number of invalid negative triples will be generated and used in the training process. In this paper, a method named adaptive negative sampling (ANS) is proposed to generate valid negative triples. In this method, it first divided all the entities into a number of groups which consist of similar entities by some clustering algorithms such as K-Means. Then, corresponding to each positive triple, the head entity was replaced by a negative entity from the cluster in which the head entity was located and the tail entity was replaced in a similar approach. As a result, it generated a set of high-quality negative triples which benefit for improving the effectiveness of embedding models. The ANS method was combined with the TransE model and the resulted model was named as TransE-ANS. Experimental results show that TransE-ANS achieves significant improvement in the link prediction task. | Saige Qin Guanjun Rao Chenzhong Bin Liang Chang Tianlong Gu Wen Xuan | 2019 | 国际计算机前沿大会会议论文集2019，，1： | 0 |
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