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| 1 | Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-blockstyrene) surgical device for the treatment of primary open-angle glaucoma: a review显示文摘Trabeculectomy remains the‘gold standard’intraocular pressure(IOP)-lowering procedure for moderate-to-severe glaucoma;however,this approach is associated with the need for substantial post-operative management.Microinvasive glaucoma surgery(MIGS)procedures aim to reduce the need for intra-and post-operative management and provide a less invasive means of lowering IOP.Generally,MIGS procedures are associated with only modest reductions in IOP and are targeted at patients with mild-to-moderate glaucoma,highlighting an unmet need for a less invasive treatment of advanced and refractory glaucoma.The PRESERFLO®MicroShunt(formerly known as InnFocus MicroShunt)is an 8.5 mm-long(outer diameter 350μm;internal lumen diameter 70μm)glaucoma drainage device made from a highly biocompatible,bioinert material called poly(styrene-block-isobutylene-blockstyrene),or SIBS.The lumen size is sufficiently small that at normal aqueous flow hypotony is avoided,but large enough to avoid being blocked by sloughed cells or pigment.The MicroShunt achieves the desired pressure range in the eye by draining aqueous humor from the anterior chamber to a bleb formed under the conjunctiva and Tenon’s capsule.The device is implanted ab externo with intraoperative Mitomycin C via a minimally invasive(relative to incisional surgery)surgical procedure,enabling precise control of placement without the need for gonioscopy,suture tension control,or suture lysis.The implantation procedure can be performed in combination with cataract surgery or as a standalone procedure.The MicroShunt received ConformitéEuropéenne(CE)marking in 2012 and is intended for the reduction of IOP in eyes of patients with primary open-angle glaucoma in which IOP remains uncontrolled while on maximum tolerated medical therapy and/or in which glaucoma progression warrants surgery.Three clinical studies assessing the long-term safety and efficacy of the MicroShunt have been completed;a Phase 3 multicenter,randomized clinical study comparing the MicroShunt to primary trabeculectomy is underway.In preliminary studies,the MicroShunt effectively reduced IOP and use of glaucoma medications up to 3 years after implantation,with an acceptable safety profile.This article summarizes current literature on the unique properties of the MicroShunt,the preliminary efficacy and safety findings,and discusses its potential use as an alternative to trabeculectomy for glaucoma surgery. | Omar Sadruddin Leonard Pinchuk Raymund Angeles Paul Palmberg | 2019 | Eye and Vision2019，6，1： | 2 |
| 2 | Resveratrol:biologic and therapeutic implications显示文摘 | SADRUDDIN S ARORA R | 2009 | J Cardiometab Syndr2009，4，2： | 1 |
| 3 | Maternal mortality in dif- ferent Pakistani sites : ratios, clinical causes and determinants 显示文摘 | Fikree FF Midhet F Sadruddin S | 1997 | Acta Obstetrica Gvnecologica1997，76，7： | 1 |
| 4 | Resveratrol:biologic and therapeutic implications显示文摘 | Sadruddin S Arora R | | 0，，02： | 1 |
| 5 | Resveratrol: biologic and therapeutic implications显示文摘 | Sadruddin S Arora R | 2009 | J Cardiometab Syndr2009，4，2： | 1 |
| 6 | Community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Haripur district, Pakistan: a cluster randomised trial显示文摘 | Bari A Sadruddin S Khan A | 2011 | Lancet2011，378，9805： | 1 |
| 7 | Community case managementof severe pneumonia with oral amoxicillin in children aged 2-59months in Haripur district,Pakistan : a cluster randomised trial显示文摘 | Bari A Sadruddin S Khan A | 2011 | Lancet2011，378，9805： | 1 |
| 8 | Low rates of treatment failure in children aged 2-59 months treated for severe pneumonia: A multisite pooled analysis显示文摘 | Fox MP Thea DM Sadruddin S | 2013 | Clinical infectious diseases2013，56，7： | 1 |
| 9 | Resveratrol: biologic and therapeutic im- plications显示文摘 | Sadruddin S Arora R | 2009 | J Cardiometab Syndr2009，4，2： | 1 |
| 10 | Low rates of treatment failure in children aged 2-59 months treated for severe pneumonia: amultisite pooled analysis 显示文摘 | Fox M P Thea D M Sadruddin S | 2013 | Clin Infect Dis2013，56，7： | 1 |
| 11 | Community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Haripur district,Pakistan:a cluster randomised trial 显示文摘 | Bail A Sadruddin S Khan A | 2011 | Lancet2011，378，9805： | 1 |
| 12 | Resveratrol:biologic and therapeutic implications显示文摘 | Sadruddin S Arora R | | 0，，02： | 1 |
| 13 | Low Rates of Treatment Failure in Children Aged 2-59 Months Treated for Severe Pneumonia: A Multisite Pooled Analysis 显示文摘 | Fox MP Thea DM Sadruddin S | 2013 | Clinical Infectious Diseases2013，56，7： | 1 |
| 14 | Resveratrol:biologic and therapeutic implications显示文摘 | Sadruddin S Arora R | 2009 | J Cardiometab Syndr2009，4，2： | 1 |
| 15 | Low rates of treatment failure in children aged 2-59 months treated for severe pneumonia:A multisite pooled analysis显示文摘 | Fox MP Thea DM Sadruddin S | 2013 | Clinical infectious diseases2013，56，7： | 1 |
| 16 | Mobile phones in the orthopedic operating room: Microbial colonization and antimicrobial resistance显示文摘BACKGROUND Surgical site infections are a major cause of morbidity and mortality following orthopedic surgery.Recent efforts to identify sources of contamination in the operating rooms have implicated mobile phones.AIM To investigate microbial colonization on the mobile phones of health care professionals in the orthopedic operating room.METHODS We conducted a cross-sectional study involving culture and sensitivity analysis of swabs taken from the mobile phones of orthopedic and anesthesia attendings,residents,technicians and nurses working in the orthopedic operating rooms over a period of two months.Demographic and cell phone related factors were recorded using a questionnaire and the factors associated with contamination were analyzed.RESULTS Ninety-three of 100 mobile phones were contaminated.Species isolated were Coagulase-negative Staphylococcus(62%),Micrococcus(41%)and Bacillus(26%).The risk of contamination was increased with mobile covers and cracked screens and decreased by cell phone cleaning.CONCLUSION Mobile phones belonging to health care workers are frequently contaminated with pathogenic bacteria with the potential of transferring drug resistance to nosocomial pathogens.Studies investigating the relationship to surgical site infections need to be conducted.The concept of'mobile hygiene'involving the change of mobile covers,replacement of cracked screens or even wiping the phone with an alcohol swab could yield the cost-effective balance that contaminated cell phones deserve until they are established as a direct cause of surgical site infections. | Nada Qaisar Qureshi Syed Hamza Mufarrih Seema Irfan Rizwan Haroon Rashid Akbar Jaleel Zubairi Anum Sadruddin Israr Ahmed Shahryar Noordin | 2020 | World Journal of Orthopedics2020，11，5： | 0 |
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