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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | 睾丸活检:临床操作及其诠释显示文摘睾丸活检许多年来被认为是不明病因男性不育和无精症诊断的基础。近来,男性不育指南都限定诊断性睾丸活检只能用于梗阻性无精子症(睾丸体积正常,生殖激素正常)的鉴别诊断。现今,睾丸活检取精技术与胞浆内单精子显微注射(ICSI)联用于非梗阻性无精子症患者的取精过程中。此外,睾丸活检还可以应用于有睾丸恶性肿瘤风险的患者的取精治疗中。研究一些不育男性后发现,不育患者患原位睾丸癌的风险越来越高,尤其是曾有隐睾症、睾丸恶性肿瘤病史,或患睾丸萎缩的患者。睾丸超声异常,比如睾丸微石症,实质内呈弥散分布,软细胞组织不均、睾丸组织损伤等,进一步增加了这些患者原位癌的发病率。准确的组织学分类,正确的组织处理和固定,样品准备和评估是必须的。同时,推荐使用标准的睾丸活检方法。另外,通过免疫组织化学法检测睾丸组织的肿瘤恶化程度是不可缺少的技术支持。本综述主要描述了睾丸活检用于男性不育临床诊断和治疗措施的最新进展。 | Gert R Dohle Saad Elzanaty Niels J van Casteren | 2012 | Asian Journal of Andrology2012，14，1： | 13 |
| 3 | Drug eluting biliary stents to decrease stent failure rates:Areview of the literature显示文摘Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy. | Joseph Shatzel Jisoo Kim Kartik Sampath Sharjeel Syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，2： | 6 |
| 4 | Critical analysis of feeding jejunostomy following resection of upper gastrointestinal malignancies显示文摘AIM To assess nutritional recovery,particularly regarding feeding jejunostomy tube(FJT)utilization,following upper gastrointestinal resection for malignancy. METHODS A retrospective review was performed of a prospectively-maintained database of adult patients who underwent esophagectomy or gastrectomy(subtotal or total)for cancer with curative intent,from January 2001 to June 2014. Patient demographics,the approach to esophagectomy,the extent of gastrectomy,FJT placement and utilization at discharge,administration of parenteral nutrition(PN),and complications were evaluated. All patients were followed for at least ninety days or until death.RESULTS The 287 patients underwent upper GI resection,comprised of 182 esophagectomy(n=107 transhiatal,58.7%; n=56 Ivor-Lewis,30.7%)and 105 gastrectomy [n=63 subtotal(SG),60.0%; n=42 total(TG),40.0%]. 181 of 182 esophagectomy patients underwent FJT,compared with 47 of 105 gastrectomy patients(99.5% vs 44.8%,P < 0.0001),of whom most had undergone TG(n=39,92.9% vs n=8 SG,12.9%,P < 0.0001). Median length of stay was similar between esophagectomy and gastrectomy groups(14.7 d vs 17.1 d,P=0.076). Upon discharge,87 esophagectomy patients(48.1%)were taking enteral feeds,with 53(29.3%)fully and 34(18.8%)partially dependent. Meanwhile,20 of 39 TG patients(51.3%)were either fully(n=3,7.7%)or partially(n=17,43.6%)dependent on tube feeds,compared with 5 of 8 SG patients(10.6%),all of whom were partially dependent. Gastrectomy patients were significantly less likely to be fully dependent on tube feeds at discharge compared to esophagectomy patients(6.4% vs 29.3%,P=0.0006). PN was administered despite FJT placement more often following gastrectomy than esophagectomy(n=11,23.4% vs n=7,3.9%,P=0.0001). FJT-specific complications requiring reoperation within 30 d of resection occurred more commonly in the gastrectomy group(n=6),all after TG,compared to 1 esophagectomy patient(12.8% vs 0.6%,P=0.0003). Six of 7 patients(85.7%)who experienced tube-related complications required PN.CONCLUSION Nutritional recovery following esophagectomy and gastrectomy is distinct. Operations are associated with unique complication profiles. Nutritional supplementation alternative to jejunostomy should be considered in particular scenarios. | Andrew M Blakely Saad Ajmal Rachel E Sargent Thomas T Ng Thomas J Miner | 2017 | World Journal of Gastrointestinal Surgery2017，9，2： | 4 |
| 5 | A clinician's guide to salvage therapy for persistent Helicohacter pylori infection显示文摘 | Luther J Chey WD Saad RJ | 2011 | Hosp Praet2011，39，1： | 1 |
| 6 | Dense Subgraph Extraction with application to community detection显示文摘 | Chen J Saad Y | 2012 | IEEE Transactions on Knowledge and Da- ta Engineering2012，24，： | 1 |
| 7 | Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents显示文摘 | Gungor N Saad R Janosky J | 2004 | Pediatr2004，144，1： | 1 |
| 8 | A comparison of magnesium sulfate and nimodipine for the prevention of eclampsia显示文摘 | Belfort MA Anthony J Saade GR | 2003 | N Engl J Med2003，348，： | 1 |
| 9 | Hemisection as an alterna-tive treatment for decayed multirooted terminal abutment: a case report 显示文摘 | Saad MN Moreno J Crawford C | 2009 | J Can Dent Assoc2009，75，5： | 1 |
| 10 | Linear mixed-effects modeling approach to FMRI group analysis显示文摘 | Chen G Saad Z S Britton J C | 2013 | Neurolmage2013，73，： | 1 |
| 11 | Essential oils from Moroccanplants as potential chemosensitisers restoring antibiotic activity inresistant Gram-negative bacteria显示文摘 | Fadli M Chevalier J Saad A | 2011 | Int J Antimicrob Agents2011，38，4： | 1 |
| 12 | Classification of molten pool modes in variable polaa~ity plasma arc welding based on acoustic signature 显示文摘 | Saad E Wang H J Kovacevic R | 2006 | Journal of Materials Processing Technology2006，174，1： | 1 |
| 13 | Mapping convex and normal fuzzy sets显示文摘 | Jean J Saade | 1996 | Fuzzy Sets and Systems1996，，81： | 1 |
| 14 | Ten-year review of groin laparoseopy in 1001 pediatric patients with clinical unilateral inguinal hernia: an improved technique with transhernia multiple-channel scope显示文摘 | Saad S Mansson J Saad A | 2011 | J Pediatr Surg2011，46，5： | 1 |
| 15 | Clinical significance of cytologic diagnosis of atypical squamous cells, cannot exclude high grade, in perimenopausal and postmenopausal women 显示文摘 | Saad RS Dabbs D J Kordunsky L | 2006 | Am J Clin Pathol2006，126，： | 1 |
| 16 | Lymphatic vessel density as prognostic marker in esophageal ade- nocarcinoma显示文摘 | SAAD R S LINDNER J L LIU Y | 2009 | Am J Clin Pathol2009，131，： | 1 |
| 17 | Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance显示文摘 | ARAKI E MIRALPEIX M | 1992 | J Clin Invest1992，90，5： | 1 |
| 18 | Which is the best method of sterilization of tumour bone for reimplantation?A biomechanical and histopathological study显示文摘 | Singh VA Nagalingam J Saad M | 2010 | Biomed Eng Online2010，9，： | 1 |
| 19 | Commercial quality of pot chrysanthemum,cultivar Puritan,irrigated at different substrate water tension in a greenhouse显示文摘 | De Farias M F Saad J C C Boas R L V | 2003 | Irrigation2003，8，2： | 1 |
| 20 | Ordering fuzzy sets over the real line: an approach based on decision making under uncertainty 显示文摘 | Saade J Schwarzlander H | 1992 | Fuzzy Sets and Systems1992，，50： | 1 |
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