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| 1 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 6 |
| 2 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 1 |
| 3 | Characterization of polyploid wheat genomic diversity using a high-density 90 000 single nucleotide polymorphism array 显示文摘 | Wang SC Debbie W Kerrie F Alexandra A Shiaoman C Bevan EH Marco M Silvio S Sara GM Luigi C Anna MM Alex W Stuart S Gary B Ralf W Joerg P International Wheat Genome Sequencing Consortium Morten L Diane M Rudi A Rudy D Gina BG Abraham K Alina RA Catherine F Jerome S Michele M Curtis P Luo MC Jan DMM Jorge D Martin G Roberto T Cindy L Ivan M Colin C Keith JE Matthew H Eduard A | 2014 | Plant Biotechnol J2014，12，： | 1 |
| 4 | Apolipoprotein E polymorphism influences orthotopic liver transplantation outcomes in patients with hepatitis C virus-induced liver cirrhosis显示文摘BACKGROUND Hepatitis C virus(HCV)infection is responsible for a chronic liver inflammation,which may cause end-stage liver disease and hepatocellular carcinoma.Apolipoprotein E(protein:ApoE,gene:APOE),a key player in cholesterol metabolism,is mainly synthesized in the liver and APOE polymorphisms may influence HCV-induced liver damage.AIM To determine whether APOE alleles affect outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation(OLT).METHODS This was a cohort study in which 179 patients,both genders and aged 34-70 years,were included before or after(up to 10 years follow-up)OLT.Liver injury severity was assessed using different criteria,including METAVIR and models for endstage liver disease.APOE polymorphisms were analyzed by quantitative real-time polymerase chain reaction.RESULTS The APOE3 allele was the most common(67.3%).In inflammation severity of biopsies from 89 OLT explants and 2 patients in pre-transplant,the degree of severe inflammation(A3F4,0.0%)was significantly less frequent than in patients with minimal and moderate degree of inflammation(≤A2F4,16.2%)P=0.048,in patients carrying the APOE4 allele when compared to non-APOE4.In addition,a significant difference was also found(≤A2F4,64.4%vs A3F4,0.0%;P=0.043)and(A1F4,57.4%vs A3F4,0.0%;P=0.024)in APOE4 patients when compared to APOE3 carriers.The fibrosis degree of the liver graft in 8 of 91 patients and the lack of the E4 allele was associated with more moderate fibrosis(F2)(P=0.006).CONCLUSION Our results suggest that the E4 allele protects against progression of liver fibrosis and degree of inflammation in HCV-infected patients. | José Carlos Rodrigues Nascimento Lianna C Pereira Juliana Magalhães C Rêgo Ronaldo P Dias Paulo Goberlânio B Silva Silvio Alencar C Sobrinho Gustavo R Coelho Ivelise Regina C Brasil Edmilson F Oliveira-Filho James S Owen Pierluigi Toniutto Reinaldo B Oriá | 2021 | World Journal of Gastroenterology2021，27，11： | 1 |
| 5 | Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxmia显示文摘 | Harbrecht B G Silvio M D Demetris A J | 1994 | Hepatology1994，20，： | 1 |
| 6 | Combined Treatment of Major Depression in Patients With Borderline Personality Dis- order:A Comparis-on With Pharmacotherapy显示文摘 | Silvio Bellino MD Monica Zizza Ph B | 2006 | Can J Psy- chiatry2006，51，： | 1 |
| 7 | Ipilimumab and Nivolumab induced steroid-refractory colitis treated with infliximab: A case report显示文摘BACKGROUND A variety of immune-modulating drugs are becoming increasingly used for various cancers. Despite increasing indications and improved efficacy, they are often associated with a wide variety of immune mediated adverse events including colitis that may be refractory to conventional therapy. Although these drugs are being more commonly used by Hematologists and Oncologists, there are still many gastroenterologists who are not familiar with the incidence and natural history of gastrointestinal immune-mediated side effects, as well as the role of infliximab in the management of this condition.CASE SUMMARY We report a case of a 63-year-old male with a history of metastatic renal cell carcinoma who presented to our hospital with severe diarrhea. The patient had received his third combination infusion of the anti-CTLA-4 monoclonal antibody Ipilimumab and the immune checkpoint inhibitor Nivolumab and developed severe watery non-bloody diarrhea the same day. He presented to the hospital where he was found to be severely dehydrated and in acute renal failure. An extensive workup was negative for infectious etiologies and he was initiated on high dose intravenous steroids. However, he continued to worsen. A colonoscopy was performed and revealed no endoscopic evidence of inflammation. Random biopsies for histology were obtained which showed mild colitis, and were negative for Cytomegalovirus and Herpes Simplex Virus. He was diagnosed with severe steroid-refractory colitis induced by Ipilimumab and Nivolumab and was initiated on Infliximab. He responded promptly to it and his diarrhea resolved the next day with progressive resolution of his renal impairment. On follow up his gastrointestinal side symptoms did not recur.CONCLUSION Given the increasing use of immune therapy in a variety of cancers, it is important for gastroenterologists to be familiar with their gastrointestinal side effects and comfortable with their management, including prescribing infliximab. | Ammar B Nassri Valery Muenyi Ahmad AlKhasawneh Bruno De Souza Ribeiro James S Scolapio Miguel Malespin Silvio W de Melo Jr | 2019 | World Journal of Gastrointestinal Pharmacology and Therapeutics2019，10，1： | 1 |
| 8 | Automatic road extraction from aerial images by pmbabilistic contour tracking显示文摘 | Manuele B Silvio D Gianni V | 2003 | IEEE Image Processing2003，3，9： | 1 |
| 9 | Powertransmission network design by greedy randomized adaptivepath relinking 显示文摘 | HAROLDO FJ SILVIO B MAURICIOGCR | 2005 | IEEE Trans on Power Systems2005，20，1： | 1 |
| 10 | Relationships of age at onset with clinical features and cognitive functions in a sample of schizophrenia patients显示文摘 | Silvio B Paola R Luca P | 2004 | J Clin Psychiatry2004，65，： | 1 |
| 11 | Scientific principles and clinical implications of perioperative glucose regulation and control显示文摘 | Shamsuddin A Paul G B Silvio E I | 2010 | Anesth Analg2010，11，2： | 1 |
| 12 | A greedy randomized adaptive search procedure for transmission expansion planning显示文摘 | Silvio B Gerson C de O Joao L de A | 2001 | IEEE Transaction on Power Systems2001，16，2： | 1 |
| 13 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 1 |
| 14 | Variability of left ventricular electromechanieal activation during right ventrieular pacing: impli- cations for the selection of the optimal pacing site显示文摘 | Pastore G Silvio A Enrico B | 2010 | Pacing Clin Electrophysiol2010，33，5： | 1 |
| 15 | American Association of Clinical Endocrinologists and American Diabetes Association Consensus Statement on Inpatient Glycemic Control显示文摘 | Moghissi Etie S Korytkowski Mary T DiNardo Monica Einhorn Daniel Hellman Richard Hirsch Irl B Inzucchi Silvio E Ismail-Beigi Faramarz Kirkman M Sue Umpierrez Guillermo E | 2009 | Diabetes Care2009，，6： | 1 |
| 16 | Tumor necrosis factor-α regulates in vivo nitric oxide synthesis and induces liver injury during endotoxmia显示文摘 | Harbrecht B G Silvio M D Demetris A J Curran R D | | 0，，： | 1 |
| 17 | Mycophenolate mofetil versus AZAthioprine for prevention of acute rejection in renal transplantation (MYSS): a randomised trial显示文摘 | Giuseppe R Mariadomenica L Eliana G Maria G Borislav DD Bogdan EI Giulia G Donato D Maurizio S Silvio S Umberto V Giuseppe S Georges M Stefano F Paolo R Vito S Jean-Louis B Norberto P Piero R | 2004 | Lancet2004，364，7： | 1 |
| 18 | High-relaxivity contrast agents for magnetic resonance imaging based on multisite interactions between a β-cyclodextrin oligomer and suitably functionalized Gd ( Ⅲ ) chelates 显示文摘 | SILVIO A MAURO B FRANCO F | 2001 | Chemistry A European J2001，24，： | 1 |
| 19 | Body fat is the main predictor of fibrinogen levels in healthy non-obese men显示文摘 | MARIO B O SILVIO RASPO FABIO MORRA | 2004 | Metabolism2004，8，： | 1 |
| 20 | Acid Hydrolysis of Eucalyptus grandis chips for microbial production of xylitol显示文摘 | Silvio S Silva Maria G A Felipe Felipe Joao B A | 1998 | Process Biochemistry1998，33，1： | 1 |
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