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| 1 | Bitter melon: a panacea for inflammation and cancer显示文摘Nature is a rich source of medicinal plants and their products that are useful for treatment of various diseases and disorders. Momordica charantia, commonly known as bitter melon or bitter gourd, is one of such plants known for its biological activities used in traditional system of medicines. This plant is cultivated in all over the world, including tropical areas of Asia, Amazon, east Africa, and the Caribbean and used as a vegetable as well as folk medicine. All parts of the plant, including the fruit, are commonly consumed and cooked with different vegetables, stir-fried, stuffed or used in small quantities in soups or beans to give a slightly bitter flavor and taste. The plant is reported to possess anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, anti-bacterial, anti-obesity, and immunomodulatory activities. The plant extract inhibits cancer cell growth by inducing apoptosis, cell cycle arrest, autophagy and inhibiting cancer stem cells. The plant is rich in bioactive chemical constituents like cucurbitane type triterpenoids, triterpene glycosides, phenolic acids, flavonoids, essential oils, saponins, fatty acids, and proteins. Some of the isolated compounds(Kuguacin J, Karaviloside XI, Kuguaglycoside C, Momordicoside Q-U, Charantin, α-eleostearic acid) and proteins(α-Momorcharin, RNase MC2, MAP30) possess potent biological activity. In the present review, we are summarizing the anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents. | Prasad R. Dandawate Dharmalingam Subramaniam Subhash B. Padhye Shrikant Anant | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 14 |
| 2 | Effect of drying methods and packaging materials on quality parameters of stored kokum rind显示文摘In this study kokum rind dried by different methods,i.e.open air sun drying,solar drying and the convective hot air drying(60℃)was taken after being packaged in gunny bags,nylon bags and plastic jars for storage study upto nine months.The effect of different drying methods on quality parameters i.e.acidity,pH,TSS,reducing sugar,non-reducing sugar,colour(L,a and b)and calorific value of the stored product were evaluated.The quality parameters were tested at three-month intervals.Among three packaging materials,plastic jar was found best for kokum rind storage upto nine months as compared with nylon and gunny bags.Deterioration occurred as changes in acidity,non-reducing sugar,lightness,redness and calorific value over the storage period from the 0^(th) to the 9^(th) month.However,the TSS and b value increased as storage duration extended. | A.R.Hande Shrikant Baslingappa Swami N.J.Thakor | 2014 | International Journal of Agricultural and Biological Engineering2014，7，4： | 9 |
| 3 | Dynamic role of myofibroblasts in oral lesions显示文摘Fibroblasts are the most abundant cellular components of connective tissue. They possess phenotypical heterogenicity and may be present in the form of smooth muscle cells or myofibroblasts(MFs). MFs are spindle-shaped cells with stress fibres and welldeveloped fibronexus,and they display α-smooth muscle actin immunohistochemically and smoothmuscle myofilaments ultrastructurally. MFs play a crucial role in physiological and pathological processes. Derived from various sources,they play pivotal roles not only by synthesizing and producing extracellular matrix components,such as other connective tissue cells,but also are involved in force production. In the tissue remodelling phase of wound closure,integrinmediated interactions between MFs and type I collagen result in scar tissue formation. The tumour stroma in oral cancer actively recruits various cell types into the tumour mass,where they act as different sources of MFs. This article reviews the importance of MFs and its role in pathological processes such as wound healing,odontogenic cysts and tumours,salivary gland tumours,oral preneoplasia,and oral squamous cell carcinoma. Research oriented on blocking the transdifferentiation of fibroblasts into MFs can facilitate the development of noninvasive therapeutic strategies for the treatment of fibrosis and/or cancer. | Neeta Bagul Anjali Ganjre SN Goryawala Rahul Kathariya Shrikant Dusane | 2015 | World Journal of Clinical Oncology2015，6，6： | 2 |
| 4 | Comparison of artificial neural network (ANN) and response surface methodology (RSM) in fermentation media optimization: Case study of fermentative production of scleroglucan显示文摘 | Kiran M. Desai Shrikant A. Survase Parag S. Saudagar S.S. Lele Rekha S. Singhal | 2008 | Biochemical Engineering Journal2008，，3： | 2 |
| 5 | ICAM - 1 gene expression by glial cells: differential mechanisms of inhibition by interleukin- 10 and interleukin - 6 显示文摘 | Shrikant P Weber E Jilling T | 1995 | J Immunol1995，155，： | 1 |
| 6 | De- velopment and application of triglyceride-based polymers and composites显示文摘 | Shrikant N Khot John John Lascala Erde Can | 2001 | J Appl Polym Sci2001，82，3： | 1 |
| 7 | Tu1249 Environmental Factors Impact the Natural History of Ulcerative Colitis (UC): Indian-Americans With UC Have a Higher Riks for Colectomy Than Asian Indian Counterparts显示文摘 | Saurabh Mukewar Shrikant Mukewar Kaustubh Limaye Rocio Lopez Xianrui Wu Bo Shen | 2012 | Gastroenterology2012，，5： | 1 |
| 8 | Knockdown of RNA Binding Protein Musashi-1 Leads to Tumor Regression In Vivo显示文摘 | Sripathi M. Sureban Randal May Robert J. George Brian K. Dieckgraefe Howard L. McLeod Satish Ramalingam Kumar S. Bishnupuri Gopalan Natarajan Shrikant Anant Courtney W. Houchen | 2008 | Gastroenterology2008，，5： | 1 |
| 9 | Expression of Wilms tumor gene(WT1) in epithelial ovarian cancer显示文摘 | Hylander B Repasky E Shrikant P | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 10 | Cytokine-indnced expression of vascular cell adhesion molecule-1 (VCAM-1) by astrocytes and astrocytoma cell lines显示文摘 | Rosenman SJ Shrikant P Dubb L | 1995 | J Immunol1995，154，4： | 1 |
| 11 | New sheet molding compound resins from soybean oil显示文摘 | LU J Shrikant K Richard W | 2005 | Polymer2005，46，： | 1 |
| 12 | Development and application of triglyceride-based polymer and eomposites显示文摘 | Shrikant N K John J L Erde C | 2001 | J Applid Polymer Sci2001，82，： | 1 |
| 13 | Clavulanic acid: A review显示文摘 | Parag S Saudagar Shrikant A Survase Rekha S Singhal | 2008 | Biotechnology Advances2008，26，： | 1 |
| 14 | Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer显示文摘 | Hylander B Repasky E Shrikant P | 2006 | Gynecol Oncol2006，101，1： | 1 |
| 15 | Novel and validated titrimetric method for determination of selected angiotensin- II -receptor antagonists in pharmaceutical preparations and its comparison with UV spectropho- tometric determination 显示文摘 | SHRIKANT H P MINAKSHI V J | 2012 | J Pharm Anal2012，2，6： | 1 |
| 16 | Water transportation through organic coatings:Correlation between electrochemical impedance measurements,gravimetry,and water vapor permeability显示文摘 | SUBRAHMANYA S SHRIKANT M N MOHAN R V | | 0，，17： | 1 |
| 17 | Leaf disease severity measurement using image processing显示文摘 | Sanjay B Patil Shrikant Dr Bodhe K | | 0，，05： | 1 |
| 18 | Fermentative production of microbial cellulose显示文摘 | CHAWLA PR BAJAJ IB SHRIKANT A | 2009 | Food Teelmol Biotech2009，47，2： | 1 |
| 19 | Steam reforming of model compounds and fast pyrolysis bio-oil on supported nobel metal catalysts显示文摘 | Cyrille Rioche Shrikant Kulkami Meunier Frederic C | 2005 | Applied Catalysis B: Environmental2005，61，： | 1 |
| 20 | Studies in 3,4 diaryl-1,2,5-oxadiazoles and their N oxides: Search for better COX-2 inhibitors显示文摘 | Mange R Y Shrikant T S Devendra S P | 2007 | Acta Pharm2007，57，： | 1 |
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