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| 1 | Osteoarthritis:pathogenic signaling pathways and therapeutic targets显示文摘Osteoarthritis(OA)is a chronic degenerative joint disorder that leads to disability and affects more than 500 million population worldwide.OA was believed to be caused by the wearing and tearing of articular cartilage,but it is now more commonly referred to as a chronic whole-joint disorder that is initiated with biochemical and cellular alterations in the synovial joint tissues,which leads to the histological and structural changes of the joint and ends up with the whole tissue dysfunction.Currently,there is no cure for OA,partly due to a lack of comprehensive understanding of the pathological mechanism of the initiation and progression of the disease.Therefore,a better understanding of pathological signaling pathways and key molecules involved in OA pathogenesis is crucial for therapeutic target design and drug development.In this review,we first summarize the epidemiology of OA,including its prevalence,incidence and burdens,and OA risk factors.We then focus on the roles and regulation of the pathological signaling pathways,such as Wnt/β-catenin,NF-κB,focal adhesion,HIFs,TGFβ/ΒΜP and FGF signaling pathways,and key regulators AMPK,mTOR,and RUNX2 in the onset and development of OA.In addition,the roles of factors associated with OA,including MMPs,ADAMTS/ADAMs,and PRG4,are discussed in detail.Finally,we provide updates on the current clinical therapies and clinical trials of biological treatments and drugs for OA.Research advances in basic knowledge of articular cartilage biology and OA pathogenesis will have a significant impact and translational value in developing OA therapeutic strategies. | Qing Yao Xiaohao Wu Chu Tao Weiyuan Gong Mingjue Chen Minghao Qu Yiming Zhong Tailin He Sheng Chen Guozhi Xiao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 11 |
| 2 | New Nodosaurid Dinosaur from the Late Cretaceous of Lishui, Zhejiang Province, China显示文摘nodosaurid 恐龙的一个新类和种:Zhejiangosaurus lishuiensisgen。et sp。nov。此处被树立。它被由至少三真骶的 vertebrae,熔化形成 presacral 杆的 5 尾的背面的 vertebrae,从身体的中间的线的肠骨的长苗条的 preacetabular 过程的宽分叉,和定位在的 fourthtrochanter 组成的骶骨描绘大腿骨中间长度。 | LU Junchang JIN Xingsheng SHENG Yiming LI Yihong WANG Guoping Yoichi AZUMA | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 8 |
| 3 | A Joint Learning Framework for the CCKS-2020 Financial Event Extraction Task显示文摘This paper presents a winning solution for the CCKS-2020 financial event extraction task, where the goal is to identify event types, triggers and arguments in sentences across multiple event types. In this task, we focus on resolving two challenging problems(i.e., low resources and element overlapping) by proposing a joint learning framework, named SaltyFishes. We first formulate the event extraction task as a joint probability model. By sharing parameters in the model across different types, we can learn to adapt to low-resource events based on high-resource events. We further address the element overlapping problems by a mechanism of Conditional Layer Normalization, achieving even better extraction accuracy. The overall approach achieves an F1-score of 87.8% which ranks the first place in the competition. | Jiawei Sheng Qian Li Yiming Hei Shu Guo Bowen Yu Lihong Wang Min He Tingwen Liu Hongbo Xu | 2021 | Data Intelligence2021，3，3： | 4 |
| 4 | Highly Efficient Synthesis of Environmentally Friendly Ag-modified TiO2 Nanoflowers to Enhance Photocatalytic Performance显示文摘Ag-modified TiO2 nanoflowers were prepared using a two-step process. The experimental process is green and free from contamination and can be synthesized directly at room temperature. Compared with pure TiO2, Ag-modified TiO2 enhances the absorption of visible light and effectively promotes the detachment of photoelectron pairs, Ag-TiO2 has a significantly enhanced visible light response activity to photodecomposition of methyl orange(MO). It is shown that the strong interaction between Ag nanoparticles and TiO2 enhances the photocatalytic activity of TiO2 nanoflowers. The self-made open-air reactor was used to test the photocatalytic performance of different samples. The results showed that Ag-modified TiO2 nanoflowers had excellent photodegradation ability. After repeated photodegradation of MO, Ag-modified TiO2 nanoflowers showed good stability. | 李洋 CAI Lun WU Hongbiao HUANG Qilin DU Yiming LIU Shiqiu SHENG Zongqiang CHEN Changzhao | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，6： | 3 |
| 5 | Method of GIL partial discharge localization based on natural neighbour interpolation and ECOC‐MLP‐SVM using optical simulation technology显示文摘Partial discharge(PD)is one of the main causes rendering the deterioration of the insulation state in gas‐insulated transmission line(GIL).Accurate and timely localization of the PD source is essential to ensure the safe and stable operation of the GIL.At present,optical PD detection technology shows advantages in terms of high sensitivity and strong anti‐inter-ference performance.Therefore,an optical PD localization method based on optical simulation fingerprint database is proposed.The introduction of simulation conquers the difficulty of obtaining a PD fingerprint database in field experiments.This method con-structs a simulation fingerprint database by performing PD simulation in a GIL simulation model of the same size as the actual GIL.The natural neighbour interpolation algorithm is applied to expand the simulation fingerprint database to cover all locations in the GIL.The two‐level localization method proposed is to match the PD fingerprint to be tested with the expanded fingerprint database,which can reduce the amount of calculation while main-taining the localization accuracy.The experimental results show that the average localiza-tion error of this method is only 9.7 mm,and the localization time is reduced by about 11 times compared with the normal one‐level localization method. | Yiming Zang Yong Qian Hui Wang Antian Xu Gehao Sheng Xiuchen Jiang | 2021 | High Voltage2021，6，3： | 1 |
| 6 | ANALYSIS OF INTER-LAMINAR STRESSES FOR COMPOSITE LAMINATED PLATE WITH INTERFACIAL DAMAGE显示文摘为有 intra 层和 inter-laminar 接口的损坏效果的合成把压成薄片的盘子的一个组成的模型被介绍。模型基于一般 six-degreesof-freedom 板理论,接口上的排水量的断绝被三个形状函数描绘,它根据解决方案被提出令人满意三个平衡方程。由使用变化原则,三维的非线性的平衡与二个不同损坏模型一起的把压成薄片的盘子的微分方程被导出。就有损坏的一个简单地支持的把压成薄片的盘子而言,然后,一个分析答案用有限差别方法被介绍获得 inter-laminar 压力。 | Yiming Fu Sheng Li Yejie Jiang | 2008 | Acta Mechanica Solida Sinica2008，21，2： | 0 |
| 7 | Nondestructive Phenomic Tools for the Prediction of Heat and Drought Tolerance at Anthesis in Brassica Species显示文摘Oilseed Brassica species are vulnerable to heat and drought stress,especially in the early reproductive stage.We evaluated plant imaging of whole plant and flower tissue,leaf stomatal conductance,leaf and bud temperature,photochemical reflectance index,quantumyield of photosynthesis,and leaf gas exchange for their suitability to detect tolerance to heat(H)and/or drought(D)stress treatments in 12 Brassica genotypes(G).A replicated factorial experiment was set up with 7 d of stress treatment fromthe beginning of anthesis with various levels of three factors H,D,and��.Most phenomics tools detected plant stress as indicated by significant main effects of H,D,and H×D.Whole plant volume was highly correlated with fresh weight changes,suggesting that whole plant imaging may be a useful surrogate for fresh weight in future studies.Vcmax,the maximum carboxylation rate of photosynthesis,increased rapidly on day 1 in H and H+D treatments,and there were significant interactions of G×H and G×D.Vcmax of genotypes on day 1 inHandH+Dtreatments was positively correlated with their harvested seed yield.Vcmax onday 1 andday3were clustered with seed yield in H and H+D treatments as shown in the heatmaps of genotypic correlations.TPU,the rate of triose phosphate use,also showed significant positive genotypic correlations with seed yield in H+D treatments.Flower volume showed significant interactions of G×H and G×D on day 7,and flower volume of genotypes on day 7 inHwas positively correlated with their harvested seed yield.There were few interactions of G×H or G×D for leaf stomatal conductance,leaf and bud temperature,photochemical reflectance index,and quantum yield of photosynthesis.Vcmax,TPU,and volume of flowers are potential nondestructive phenomic traits for heat or combined heat and drought stress tolerance screening in Brassica germplasm. | Sheng Chen Yiming Guo Xavier Sirault Katia Stefanova Renu Saradadevi Neil CTurner Matthew NNelson Robert TFurbank Kadambot HMSiddique Wallace ACowling | 2019 | Plant Phenomics2019，1，1： | 0 |
| 8 | ADHESIVE CONTACT PROBLEM OF AXISYMMETRIC MINIATURE CIRCULAR PLATES WITH CENTRAL RIGID BUMP显示文摘就粘合剂效果和几何非线性而言,在有在一致横向的压力和在里面飞机的行动下面的二个不同中央僵硬肿块的有弹性的底层和一个夹钳的缩小的圆形的盘子之间的粘合剂接触在光线的方向的张力的力量被分析。并且一个分析答案被使用不安方法介绍。有批评负担的表面粘合剂精力的关系联系表面被获得分开。在数字结果,粘合剂精力的效果,在里面飞机批评负担上的张力的力量,僵硬肿块尺寸和接触半径被讨论,并且有在为不同粘合剂精力的中央僵硬肿块和底层之间的差距的批评接触半径的关系被调查。 | Fu Yiming Li Sheng Tian Yanping | 2006 | Acta Mechanica Solida Sinica2006，19，4： | 0 |
| 9 | Bcl-3 promotes Wnt signaling by maintaining the acetylation ofβ-catenin at lysine 49 in colorectal cancer显示文摘Wnt/β-catenin signaling plays a critical role in colorectal cancer(CRC)tumorigenesis and the homeostasis of colorectal cancer stem cells(CSCs),but its molecular mechanism remains unclear.B-cell lymphoma 3(Bcl-3),a member of the IκB family,is overexpressed in CRC and promotes tumorigenicity.Here,we report a novel function of Bcl-3 in maintaining colorectal CSC homeostasis by activating Wnt/β-catenin signaling.Silencing Bcl-3 suppresses the self-renewal capacity of colorectal CSCs and sensitizes CRC cells to chemotherapeutic drugs through a decrease in Wnt/β-catenin signaling.Moreover,our data show that Bcl-3 is a crucial component of Wnt/β-catenin signaling and is essential forβ-catenin transcriptional activity in CRC cells.Interestingly,Wnt3a increases the level and nuclear translocation of Bcl-3,which binds directly toβ-catenin and enhances the acetylation ofβ-catenin at lysine 49(Ac-K49-β-catenin)and transcriptional activity.Bcl-3 depletion decreases the Ac-K49-β-catenin level by increasing the level of histone deacetylase 1 to remove acetyl groups fromβ-catenin,thus interrupting Wnt/β-catenin activity.In CRC clinical specimens,Bcl-3 expression negatively correlates with the overall survival of CRC patients.A significantly positive correlation was found between the expression of Bcl-3 and Ac-K49-β-catenin.Collectively,our data reveal that Bcl-3 plays a crucial role in CRC chemoresistance and colorectal CSC maintenance via its modulation of the Ac-K49-β-catenin,which serves as a promising therapeutic target for CRC. | Xi Chen Chen Wang Yuhang Jiang Qi Wang Yu Tao Haohao Zhang Yongxu Zhao Yiming Hu Cuifeng Li Deji Ye Dandan Liu Wenxia Jiang Eugene Y.Chin Sheng Chen Yongzhong Liu Mingliang Wang Sanhong Liu Xiaoren Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 10 | Low-cost preferential different amine grafted silica spheres adsorbents for DAC CO_(2)removal显示文摘DAC CO_(2)capture is gaining wide attention as one of the most difficult carbon approaches to tackle climate change.In this work,different pore-size silica spheres were grafted using different amine groups such as APTES,APTMS,and Diamine.Herein,all samples based on the wet and dry grafting method were used for CO_(2)adsorption isotherm at room temperature and pressure(298 K and 1 bar).The sample based on the wet grafting(Silica-APTES-W)sample shows the highest CO_(2)uptake 1.67 mmol/g.Also,the adsorption isotherm of the Silica-APTES-W sample was showed a high capacity of CO_(2)1.2 mmol/g at 25℃,which describes the strong physical interaction between CO_(2)and amine.The isosteric adsorption of Silica-APTES-W also confirmed that the physical adsorption was dominant because of low adsorption heat ranging from 23 to 37 k J/mol.Also,the fixed bed experiment was conducted with 2000 ppm CO_(2)that obtains the optimal working capacity 4.5 m L/g with the lowest regeneration temperature 90℃.It was shown that Silica-APTES-W sample was superior performance for DAC CO_(2)capture in practical applications. | Salman Qadir Hongjiu Su Defu Li Yiming Gu Shengsheng Zhao Sheng Wang Shudong Wang | 2022 | Journal of Energy Chemistry2022，，12： | 0 |
| 11 | Roles of focal adhesion proteins in skeleton and diseases显示文摘The skeletal system,which contains bones,joints,tendons,ligaments and other elements,plays a wide variety of roles in body shaping,support and movement,protection of internal organs,production of blood cells and regulation of calcium and phosphate metabolism.The prevalence of skeletal diseases and disorders,such as osteoporosis and bone fracture,osteoarthritis,rheumatoid arthritis,and intervertebral disc degeneration,increases with age,causing pain and loss of mobility and creating a huge social and economic burden globally.Focal adhesions(FAs)are macromolecular assemblies that are composed of the extracellular matrix(ECM),integrins,intracellular cytoskeleton and other proteins,including kindlin,talin,vinculin,paxillin,pinch,Src,focal adhesion kinase(FAK)and integrin-linked protein kinase(ILK)and other proteins.FA acts as a mechanical linkage connecting the ECM and cytoskeleton and plays a key role in mediating cell–environment communications and modulates important processes,such as cell attachment,spreading,migration,differentiation and mechanotransduction,in different cells in skeletal system by impacting distinct outside-in and inside-out signaling pathways.This review aims to integrate the up-to-date knowledge of the roles of FA proteins in the health and disease of skeletal system and focuses on the specific molecular mechanisms and underlying therapeutic targets for skeletal diseases. | Sheng Chen Tailin He Yiming Zhong Mingjue Chen Qing Yao Di Chen Zengwu Shao Guozhi Xiao | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 12 | THE ANALYSIS OF INTERLAMINAR STRESSES FOR COMPOSITE LAMINATED SHALLOW SHELLS WITH INTERFACIAL DAMAGE显示文摘Based on the general six-degrees-of-freedom plate theory towards the accurate stress analysis and nonlinear theory of shallow shells, considering the damage effect of the interlaminar interface and using the variation principle, the three-dimensional non-linear equilibrium differential equations of the laminated shallow shells with interfacial damage are derived. Then, considering a simply supported laminated shallow shell with damage and under normal load, an analytical solution is presented by using finite difference method to obtain the interlaminar stresses. Numerical results show, the stiffness of the shell is weakened, greater absolute values of displacements as well as smaller interlaminar stresses are obtained by interfacial damage. When the interfacial damage is further increased, delamination occurs obviously under normal pulling load and pure shear slip occurs under normal pressure load. The portion of the load undertaken by the two sides of the interface is more different. Different mechanical behaviors are shown in both sides of the interface, and the discontinuation of stresses and displacements takes place in the interface. | Yiming Fu Sheng Li Yiqi Mao | 2011 | Acta Mechanica Solida Sinica2011，24，6： | 0 |
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