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| 1 | A metabonomic investigation on the biochemical perturbation in liver failure patients caused by hepatitis b virus显示文摘 | Yu, K Sheng, GP Sheng, JF Chen, YM Xu, W Liu, XL Cao, HC Qu, HB Cheng, YY Li, LJ | 2007 | 中国生物学文摘2007，21，11： | 25 |
| 2 | CIPK9: a calcium sensor-interacting protein kinase required for low-potassium tolerance in Arabidopsis显示文摘钾是为在植物的很多个细胞的过程的主要宏营养素必需品之一。在土壤的低钾水平为庄稼生产代表一个限制因子。最近的研究识别了涉及钾获得的钾运输 ers,并且他们中的一些为在低钾条件下面的钾营养是批评的。然而,很少在涉及低钾发信号和回答的分子的部件上被理解。我们这里在 Arabidopsis 作为低钾反应的一个批评管理者报导 calcineurin 象 B 一样交往蛋白质的 proteinkinase (CIPK9 ) 的鉴定。CIPK9 基因对不能生活的压力条件应答,并且它的抄本由钾剥夺在根和射击是可诱导的。CIPK9 功能的混乱使变异的植物变为过分敏感到低钾媒介。进一步的分析显示那 K (+) 举起和内容没在变异的植物被影响,暗示在钾利用的规定的 CIPK9 或察觉到过程。 | Girdhar K Pandey Yong Hwa Cheongx Beom-Gi Kim John J Grant Legong Li Sheng Luan | 2007 | Cell Research2007，17，5： | 23 |
| 3 | Yes相关蛋白通过肿瘤坏死因子受体相关因子6控制内皮活化和血管炎症显示文摘继发于异常的内皮激活的微血管炎症和内皮功能障碍在败血症和器官衰竭的病理生理学中起关键作用。抑制内皮细胞过度活化的内在信号传导机制尚未完全明了。该研究旨在确定Yes相关蛋白(Yes-associated protein,YAP)(Hippo通路的主要转录共激活剂)在调节内皮活化和血管炎症的强度和程度中的中心作用。 | 刘青 叶鹏 Lv Y Kim K Sheng Y Cho J Qain Z Zhao YY Hu G Pan D Malik AB | 2018 | 中华高血压杂志2018，26，8： | 20 |
| 4 | Repeatability and Reproducibility of Quantitative Assessment of the Retinal Microvasculature Using Optical Coherence Tomography Angiography Based on Optical Microangiography显示文摘Objective The aim of this study was to determine the repeatability and reproducibility of optical coherence tomography angiography(OCTA) based on optical microangiography(OMAG) measurements of macular vessels in normal eyes. Methods In this prospective cohort study, 40 eyes of 40 healthy volunteers underwent repeated OCTA(Cirrus HD-OCT 5000 angiography system, Carl Zeiss Meditec, Inc.) scans on two separate visit days. On each visit day, the eyes were scanned three times. The following parameters were used to quantitatively describe the OCTA images of the superficial vascular network: vessel area density(VAD), vessel skeleton density(VSD), vessel diameter index(VDI), vessel perimeter index(VPI), vessel complexity index(VCI), flux, and foveal avascular zone(FAZ). Coefficient of variation(CV) and intraclass correlation coefficient(ICC) were calculated for evaluating intravisit and intervisit repeatability, as well as interobserver reproducibility. Results The measurements showed high repeatability [CVs ≤ 4.2%(intravisit) and ≤ 4.6%(intervisit)] and interobserver reproducibility(ICCs ≥ 0.923) for all parameters. Conclusion This study demonstrated good repeatability and reproducibility of OCTA based on OMAG for the measurement of superficial vessel parameters in normal eyes. | ZHAO Qi YANG Wen Li WANG Xiao Na Ruikang K Wang YOU Qi Sheng CHU Zhong Di XIN Chen ZHANG Meng Yu LI Dong Jun WANG Zi Yang CHEN Wei LI Yi Feng CUI Rui SHEN Lin WEI Wen Bin | 2018 | Biomedical and Environmental Sciences2018，31，6： | 8 |
| 5 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 6 | Overall optimization of Rankine cycle system for waste heat recovery of heavy-duty vehicle diesel engines considering the cooling power consumption显示文摘The Rankine cycle system for waste heat recovery of heavy-duty vehicle diesel engines has been regarded as a promising technique to reduce fuel consumption. Its heat dissipation in the condensation process, however, should be taken away in time, which is an energy-consuming process. A fan-assisted auxiliary water-cooling system is employed in this paper. Results at 1300 r/min and 50% load indicate that the cooling pump and cooling fan together consume 7.66% of the recovered power. What's worse for the heavy load, cooling accessories may deplete of all the recovered power of the Rankine cycle system. Afterwards, effects of the condensing pressure and water feeding temperature are investigated, based on which a cooling power consumption model is established. Finally, an overall efficiency optimization is conducted to balance the electric power generation and cooling power consumption, taking condensing pressure, pressure ratio and exhaust bypass valve as major variables. The research suggests that the priority is to increase condensing pressure and open exhaust bypass valve appropriately at high speed and heavy load to reduce the cooling power consumption, while at low speed and light load, a lower condensing pressure is favored and the exhaust bypass valve should be closed making the waste heat recovered as much as possible. Within the sub-critical region, a larger pressure ratio yields higher overall efficiency improvement at medium-low speed and load. But the effects taper off at high speed and heavy load. For a given vehicular heavy-duty diesel engine, the overall efficiency can be improved by 3.37% at 1300 r/min and 25% load using a Rankine cycle system to recover exhaust energy. The improvement becomes smaller as engine speed and load become higher. | YANG Can XIE Hui ZHOU Sheng K | 2016 | Science China(Technological Sciences)2016，59，2： | 4 |
| 7 | Nanosized gold clusters formation in selected areas of soda-lime silicate glass 显示文摘 | SHENG J KADONO K YAZAWA T | 2003 | J Non-Cryst Solids2003，324，： | 2 |
| 8 | An active ingredient of cat's claw water extracts identification and efficacy of quinic acid 显示文摘 | Sheng Y Akesson C Holmgren K | 2005 | J Ethnopharmacol2005，96，3： | 1 |
| 9 | A resource-based theory of strategic alliances显示文摘 | DAS T K TENG Bing Sheng | 2000 | Journal of Management2000，26，1： | 1 |
| 10 | Molecular characterization and immune analysis of a defense from freshwater pearl mussel, Hyriopsis schlegelii显示文摘 | Peng K Wang J H Sheng J Q | 2012 | Aquaculture2012，，： | 1 |
| 11 | Use of a classroom response system to enhance classroom interactivity显示文摘 | Siau K Sheng H Nah F.F.H | | 0，，03： | 1 |
| 12 | Ultrahigh-rate supercapacitors based on eletrochemically reduced graphene oxide for ac line- filtering显示文摘 | Sheng K Sun Y Li C | 2012 | Scientific reports2012，2，： | 1 |
| 13 | Fast and accurate IGBT model for PSpice显示文摘 | SHENG K FINNEY S J WILLIAMS B W | 1996 | Electronics Letters1996，32，25： | 1 |
| 14 | Assessment of tobacco heating system 2.4 on osteogenic differentiation of mesenchymal stem cells and primary human osteoblasts compared to conventional cigarettes显示文摘BACKGROUND Cigarette smoking(CS)is the most common method of consuming tobacco.Deleterious effects on bone integrity,increased incidence of fractures,and delayed fracture healing are all associated with CS.Over 150 of the 6500 molecular species contained in cigarette smoke and identified as toxic compounds are inhaled by CS and,via the bloodstream,reach the skeletal system.New technologies designed to develop a reduced-risk alternative for smokers are based on electronic nicotine delivery systems,such as e-cigarettes and tobacco heating systems(THS).THS are designed to heat tobacco instead of burning it,thereby reducing the levels of harmful toxic compounds released.AIM To examine the effects of THS on osteoprogenitor cell viability and function compared to conventional CS.METHODS Human immortalized mesenchymal stem cells(n=3)and primary human preosteoblasts isolated from cancellous bone samples from BG Unfall Klinik Tübingen(n=5)were osteogenically differentiated in vitro with aqueous extracts generated from either the THS 2.4“IQOS”or conventional“Marlboro”cigarettes for up to 21 d.Cell viability was analyzed using resazurin conversion assay(mitochondrial activity)and calcein-AM staining(esterase activity).Osteogenic differentiation and bone cell function were evaluated using alkaline phosphatase(AP)activity,while matrix formation was analyzed through alizarin red staining.Primary cilia structure was examined by acetylatedα-tubulin immunofluorescent staining.Free radical production was evaluated with 2’,7’-dichlorofluoresceindiacetate assay.RESULTS Our data clearly show that THS is significantly less toxic to bone cells than CS when analyzed by mitochondrial and esterase activity(P<0.001).No significant differences in cytotoxicity between the diverse flavors of THS were observed.Harmful effects from THS on bone cell function were observed only at very high,non-physiological concentrations.In contrast,extracts from conventional cigarettes significantly reduced the AP activity(by two-fold)and matrix mineralization(four-fold)at low concentrations.Additionally,morphologic analysis of primary cilia revealed no significant changes in the length of the organelle involved in osteogenesis of osteoprogenitor cells,nor in the number of ciliated cells following THS treatment.Assessment of free radical production demonstrated that THS induced significantly less oxidative stress than conventional CS in osteoprogenitor cells.CONCLUSIONTHS was significantly less harmful to osteoprogenitor cells during osteogenesisthan conventional CS. Additional studies are required to confirm whether THS isa better alternative for smokers to improve delays in bone healing followingfracture. | Romina H Aspera-Werz Sabrina Ehnert Monja Müller Sheng Zhu Tao Chen Weidong Weng Johann Jacoby Andreas K Nussler | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 15 | Computation of scattering from anisotropically coated bodies using con- formal FDTD 显示文摘 | ZHENG H X SHENG X Q YUNG E K N | 2002 | Progress In Electromagnetics Re- search2002，35，： | 1 |
| 16 | Oxy-fuel combustion technology for coalfired power generation 显示文摘 | BUHRE B J P ELLIOIT L K SHENG C D | 2005 | Progress in Energy and Combustion Science2005，31，4： | 1 |
| 17 | Effect of additives in electrolyte on characteristic of ceramic coatings formed by micro-are oxidation显示文摘 | Wang Y K Sheng L Xiang R E | 1999 | Surface Engineering1999，15，2： | 1 |
| 18 | Oxy-fuelcombustion technology for coal-fired power genera-tion显示文摘 | Buhre B J P Elliott L K Sheng C D | 2005 | Progress in Energy and Combustion Science2005，31，4： | 1 |
| 19 | Oxy-fuel combustion technology for coal-fired power generation显示文摘 | BUHRE B J P ELLIOTT L K SHENG C D GUPTA R P WALL T F | 2005 | Prog Energy Combust2005，31，4： | 1 |
| 20 | Graphene hydrogels deposited in nickel foams for high-rate electrochemical capacitors 显示文摘 | Chen J Sheng K Luo P | 2012 | Advanced Materials2012，24，33： | 1 |
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