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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 超临界连续GAS过程制备对苯二酚超细颗粒显示文摘建立了一套连续的气体抗溶剂实验装置。以对苯二酚 -丙酮 -二氧化碳物系为研究对象 ,利用超临界流体抗溶剂过程制备了对苯二酚超细颗粒并将其结果与文献进行了比较 ,从而验证了装置的可靠性。同时 ,对不同的溶液浓度和溶液流量对结晶颗粒形貌与尺寸的影响进行了研究。结果表明 ,溶液流量增大颗粒粒径减小 ,而溶液浓度增大颗粒粒径增加 ;溶液流量较大时 ( 1 2 .0 0 L/min) ,产品颗粒为菱形晶体 ,溶液流量较小时 ( 2 .0 0 L/min) ,产品颗粒为棒状晶体 ; | Serge R Bitemo 洪镭 刘昆 高勇 | 2001 | 华东理工大学学报(自然科学版)2001，27，4： | 8 |
| 3 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 4 | Intensified chemotherapy with ACVBP plus rituximab versus standard CHOP plus rituximab for the treatment of diffuse large B-cell lymphoma (LNH03-2B): an open-label randomised phase 3 trial显示文摘 | Christian Récher Bertrand Coiffier Corinne Haioun Thierry Jo Molina Christophe Fermé Olivier Casasnovas Catherine Thiéblemont André Bosly Guy Laurent Franck Morschhauser Hervé Ghesquières Fabrice Jardin Serge Bologna Christophe Fruchart Bernadette Corront | 2011 | 2011 (9806)2011，，9806： | 2 |
| 5 | Innate immune reaction in response to seizures:implications for the neuropathology associated with epilepsy显示文摘 | Nicolas PT Serge R | 2004 | Neurobio Disease2004，16，： | 1 |
| 6 | The CAS-OB Process inthe Steelshop of Fos-Sur-Mer-Conception and First OperatingReslts 显示文摘 | Serge A Pierre G Jean P R | 1989 | MPT1989，12，6： | 1 |
| 7 | Bioavailability of naproxen sodium and its relationship to clinical analgesic effects 显示文摘 | Sevelius H Runkel R Serge E | 1980 | Br J Clin Pharmacol1980，10，3： | 1 |
| 8 | Spectral elec- tromyography assessment of back muscles in patients with low back pain undergoing rehabilitation 显示文摘 | Serge H R Carlo J D Mark E B S | 1995 | Spine1995，20，1： | 1 |
| 9 | Simulating climate change impacts on fire frequency and vegetation dynamics in a Mediterranean-type ecosystem 显示文摘 | FLORENT M SERGE R RICHARD J | 2002 | Global Change Biology2002，8，： | 1 |
| 10 | Toll-like receptor TLR-2 and TLR-4 regulate infammation, gliosis and myelin sparing after spinal cord injury显示文摘 | Kristina A K Wenmin L Serge R | 2007 | J Neurochem2007，102，1： | 1 |
| 11 | Purification and biochemical characterization of the hydantoin hydrolyzing enzyme from Agrobacerium species A hydantoinase with no 5,6-dihydropyrimidine amidohydrolase activity显示文摘 | Patrick C | 1993 | Biochem1993，213，： | 1 |
| 12 | Passive transfer of streptococcus-induced antibodies reproduces behavioral disturbances in a mouse model of pediatric autoimmune neu- ropsychiatric disorders associated with streptococcal infee tion显示文摘 | Yaddanapudi K Hornig M Serge R | 2010 | Molecular Psychiatry2010，15，7： | 1 |
| 13 | Evaluation of the ulnopalmar arterial arches with pulse oximetry and plethysmography: Comparison with the Allen’s test in 1010 patients显示文摘 | Gérald R Barbeau Fran?ois Arsenault Louise Dugas Serge Simard Marie Mai Larivière | 2004 | American Heart Journal2004，，3： | 1 |
| 14 | Electroenzymatic polypyrrole-intercalator sensor for the determination of west nile virus c DNA显示文摘 | SERGE C IONESCU R E SEBASTIEN H | 2006 | Analytical Chemistry2006，78，19： | 1 |
| 15 | Influence of the sol-gel synthesis on the formation of spinel MgAl2O4 显示文摘 | Julien P Mireille R P Serge V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 16 | Simulating climate change impacts on fire frequency and vegetation dynamics in a Mediterranean - type ecosystem显示文摘 | Florent M Serge R Richard J | 2002 | Global Change Biology2002，8，5： | 1 |
| 17 | A Reverse Logistics Decisions Concep- tual Framework 显示文摘 | Serge L Diane R Walid A K | 2011 | Computers & Industrial Engineering2011，61，3： | 1 |
| 18 | Multi-site evaluation of IKONOS data for classification of tropical coral reef environments显示文摘 | Serge Andréfou?t Philip Kramer Damaris Torres-Pulliza Karen E Joyce Eric J Hochberg Rodrigo Garza-Pérez Peter J Mumby Bernhard Riegl Hiroya Yamano William H White Mayalen Zubia John C Brock Stuart R Phinn Abdulla Naseer Bruce G Hatcher Frank E Muller-Karg | 2003 | Remote Sensing of Environment2003，，1： | 1 |
| 19 | Influence of the sol gel synthesis on the formation of spinel MgAl2 O4 显示文摘 | JULIEN P MIREILLE R P SERGE V | 1998 | Mater Res Bull1998，33，11： | 1 |
| 20 | Global magnitude of visual impairment caused by uncorrected refractive errors in 2004 显示文摘 | SERGE R DONATELLA P SILVIO PM | 2008 | Bull World Health Organ2008，86，1： | 1 |
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