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| 1 | Efficacy and safety of treatment of hepatitis C virus infection in renal transplant recipients显示文摘AIM: To assess the efficacy and safety of combinedpegylated interferon and ribavirin therapy in hepatitis C virus (HCV) infection in renal transplant recipients. METHODS: This is a retrospective chart review of post renal transplant patients who were positive for anti-HCV and HCV-RNA, and who have received treatment with combination of pegylated interferon and ribavirin between October 2003 and December 2008. Only patients with stable graft function and absence of evidence of cirrhosis and who received the therapy for continuous 48 wk were included. Nineteen patients (13 male and 6 female) were identified and included. The patient's complete blood count, liver and kidney prof ile, and cal- culated glomerular f iltration rate (GFR) were monitored every 6-8 wk while on treatment. HCV-RNA was tested at 12 wk for early virological response, at 48 wk for end of treatment response (ETR), and then retested at 24, and 48 wk after completion of therapy for sustained virological response (SVR). Liver biopsies were obtained before treatment from all patients and graft kidney biopsies were performed as required. RESULTS: Of the entire cohort, 9 patients (47.4%) showed an ETR and 8 had SVR (42.1%). Of the 8 patients with abnormal alanine aminotransferase (ALT) levels at baseline, 78.9% had their ALT normalized (including the virological non responders). ALT was normal in all responders at the end of therapy and at 24 wk post therapy (100%). Only one patient (5.3%) developed an increase in creatinine and decline in GFR from baseline towards the end of treatment. This patient's kidney biopsy revealed borderline rejection. There was no impact on response by HCV-genotype, initial HCV RNA load, age or sex of the patient or duration post transplant before commencement of therapy. All patients tolerated treatment in the same way as non-transplant with no unusual or increased occurrence of side effects. CONCLUSION: The combination of pegylated interferon and ribavirin is effective in suppressing HCV-RNA,with a low risk of graft rejection or failure in HCV infected renal transplant recipients. | Abdulrahman A Aljumah Mohamed A Saeed Ahmed I Al Flaiw Ibrahim H Al Traif Abduljaleel M Al Alwan Salem H Al Qurashi Ghormallah A Al Ghamdi Fayez F Al Hejaili Mohammed A Al Balwi Abdulla A Al Sayyari | 2012 | World Journal of Gastroenterology2012，18，1： | 2 |
| 2 | Vapour treatments with methyl salicy-late or methyl jasmonate alleviated chilling injury and enhancedantioxidant potential during postharvest storage of pomegranates显示文摘 | SAYYARI M BABALAR M KALANTARI S GUILLEN F SERRANO M VALERO D | 2011 | Food Chemistry2011，124，3： | 1 |
| 3 | Effect of salicylic acid treatment on reducing chilling injury in stored pomegranates 显示文摘 | Sayyari M Babalar M Kalantari S | 2009 | Postharvest Biology and Technology2009，53，3： | 1 |
| 4 | Effect of salicylic acid treatment on reducing chilling injury in stored pomegranates显示文摘 | SAYYARI M BABALAR M KALANTARI S | 2009 | Postharvest Biol Techno2009，53，： | 1 |
| 5 | Effect of salicylic acid treatment on reducing chillinginjury in stored pomegra-nates显示文摘 | SAYYARI M BABALAR M KALANTARI S | 2009 | Postharvest BiologyandTechnology2009，53，3： | 1 |
| 6 | Vapour treatments with methyl salicylate or methyl jasmonate alleviated chilling injury and enhanced antioxidant po- tential during postharvest storage of pomegranates 显示文摘 | Sayyari M Babalar M Kalantari S | 2011 | Food Chemisty2011，124，3： | 1 |
| 7 | Role of heat treatment, calcium chloride and potassium permanganate on storage life and fruit firmness of Golden Delicious apple (Malus domestica Borkh)显示文摘 | Sayyari M Rahemi M | 2003 | Journal of Science and Technology of Agriculture and Natural Resources2003，6，4： | 1 |
| 8 | Prestorage oxalic acid treatment maintained visual quality, bioactive compounds, and antioxidant potential of pomegranate after long-term storage at 2 ℃ 显示文摘 | Sayyari M Valero D Babalar M | 2010 | Journal of Agricultural and Food Chemistry2010，58，11： | 1 |
| 9 | Acetyl salicylic acid alleviates chilling injury and maintains nutritive and bioactive compounds and antioxidant activity during postharvest storage of pomegranates显示文摘 | Sayyari M Castillo S Valero D | 2011 | Postharvest Biology and Technology2011，60，2： | 1 |
| 10 | Effect of salicylic acid treatment on reducing chilling injury in stored pomeg-ranates显示文摘 | SAYYARI M BABALAR M KALANTARI S | | 0，，03： | 1 |
| 11 | Effect of salicylic acid treatment on reducing chilling injury in stored pomegranates显示文摘 | SAYYARI M BABALAR M KALANTARI S | | 0，，03： | 1 |
| 12 | Effect of salicylic acid treatment on reducing chilling injury in stored pomegranates显示文摘 | SAYYARI M BABALAR M KALANTARI S | 2009 | Postharvest Biol Technol2009，53，3： | 1 |
| 13 | Effect of salicylic acid treat- ment on reducing chilling injury in stored pomegranates显示文摘 | Sayyari M Babalar M Kalantari S | 2009 | Postharvest Biol Technol2009，53，3： | 1 |
| 14 | Vapour treat- ments with methyl salicylate or methyl jasmonate alleviated chilling injury and enhanced antioxidant potential during postharvest storage of pomegranates显示文摘 | SAYYARI M BABALAR M KALANTARI S | 2011 | Food Chem2011，124，3： | 1 |
| 15 | Effect of salicylic acid treatment on reducing chilling injury in stored pomegranates显示文摘 | Sayyari M Babalar M Kalantari S | 2009 | Postharvest Biology and Technology2009，53，： | 1 |
| 16 | Effect of salicylic acid treatment on reducing chillinginjury in stored pomegra-nates显示文摘 | SAYYARI M BABALAR M KALANTARI S | 2009 | Postharvest BiologyandTechnology2009，53，3： | 1 |
| 17 | Prestorage oxalic acid treatment maintained visual quality,bioaetive compounds,and antioxidant potential of pomegranate after long-term storage at 2~C 显示文摘 | Sayyari M Valero D Babalar M | 2010 | Journal of Agricultural and Food Chemistry2010，58，11： | 1 |
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