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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Using genetic diversity information to establish core collections of Stylosanthes capitata and Stylosanthes macrocephala 显示文摘 | Santos-Garcia M O Toledo-Silva G Sassaki R P | 2012 | Genet Mol Biol2012，35，4： | 1 |
| 3 | Changes in sugar content during cold acclimation and deacclimation of cabbage seedlings显示文摘 | Sassaki H Ichimura K Oda M | 1996 | Annals of Botany1996，78，3： | 1 |
| 4 | Further study of the structure of lentinan,an antitumor polysaccharide from letinus edobes显示文摘 | SASSAKI T TAKUMA M JAKASUKA J | 1976 | Carbohydr Res1976，47，1： | 1 |
| 5 | Low heart rate variabilityis a risk factor for sudden cardiac death in type 2 diabetes显示文摘 | Kataoka M Ito C Sassaki H | | 0，，01： | 1 |
| 6 | Distribution of cyclooxygensse-2 in eutopic and endometrin in endonetriosis and andnomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 7 | Isolation and characterization of microsatellite loci in tropical forage Stylosanthes capitata Vogel 显示文摘 | Santos M O Sassaki R P Chiari L | 2009 | Molecular Ecology Resources2009，9，1： | 1 |
| 8 | 显示文摘 | SASSAKI H NAGURA K ISHINO M | 1995 | J Biol Chem1995，270，21： | 1 |
| 9 | Distribution of cyclooxygenase-2 in eutopic and endometrim in endometriosis and adenomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 10 | Effect of fluori-dated varnish and silver diamine fluoride solution on enamel de- mineralization: pH-eycling study 显示文摘 | Delbem AC Bergamaschi M Sassaki KT | 2006 | J Appl Oral Sci2006，4，2： | 1 |
| 11 | Isolation and characterization of microsatellite loci in tropical forage Stylosanthes capitata Vogel显示文摘 | Santos M O Sassaki R P Chiari L Resende R M S Souza A P | 2009 | Molecular Ecology Resources2009，9，1： | 1 |
| 12 | Involvement of ICAM-1 in the progression of atherosclerosis in apoE-knockout mice显示文摘 | Kitagawa K Matsumoto M Sassaki Tj | 2002 | Atherosclerosis2002，160，2： | 1 |
| 13 | Distribution of cyclooxygenase- 2 in eutopic and endometrin in endonetriosis and andnomyosis 显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
| 14 | Molecular and structural characterization of the biosurfactant produced by Pseudornonas aeraginosa DAUPE 614 显示文摘 | Monteiro S A Sassaki G L de Souza L M | 2007 | Chem Phys Lipids2007，147，： | 1 |
| 15 | Effect of rinsing with water immediately after neutral gel and foam fluoride topical application on enamel remineralization: An in situ study显示文摘 | Delbem ABC Danelon M Sassaki TK | 2010 | Arch Oral Biol2010，55，11： | 1 |
| 16 | In silico evaluation of the Eucalyptus transcriptome显示文摘 | Vicentini R Sassaki F T Gimanes M A | 2005 | Genetics and Molecular Biology2005，28，： | 1 |
| 17 | Isolation and characterization of microsatellite loci in tropical forage Stylosanthes capitata Vogel显示文摘 | Santos M O Sassaki R P Chiari L Resende R M Souza P | 2009 | Molecular Ecology Resources2009，9，： | 1 |
| 18 | Cistemal irrigation therapy with urokinase and ascorbic acid for prevention of vasospasm after aneurismal subarachnoid hemonhage显示文摘 | Sassaki T Kawakami M | 2000 | Surg Neurol2000，53，： | 1 |
| 19 | Iso- lation and characterization of microsatellite loci in tropical forage Stylosanthes capitata Vogel 显示文摘 | Santos M O Sassaki R P Chiari L | 2009 | Molecular Ecology Resources2009，9，1： | 1 |
| 20 | Distribution of cyclooxygenase- 2 in eutopic and endometrin ir endonetriosis and andnomyosis显示文摘 | Ota H Igarashi S Sassaki M | 2001 | Hum Reprod2001，16，3： | 1 |
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