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| 1 | Glypican-3 is a prognostic factor and an immunotherapeutic target in hepatocellular carcinoma显示文摘Glypican-3(GPC3)is a cell surface oncofetal proteoglycan that is anchored by glycosylphosphatidylinositol.Whereas GPC3 is abundant in fetal liver,its expression is hardly detectable in adult liver.Importantly,GPC3is overexpressed in hepatocellular carcinoma(HCC),and several immunohistochemical studies reported that overexpression predicts a poorer prognosis for HCC patients.Therefore,GPC3 would serve as a useful molecular marker for HCC diagnosis and also as a target for therapeutic intervention in HCC.Indeed,some immunotherapy protocols targeting GPC3 are under investigations;those include humanized anti-GPC3cytotoxic antibody,peptide vaccine and immunotoxin therapies.When considering the clinical requirements for GPC3-targeting therapy,companion diagnostics to select the appropriate HCC patients are critical,and both immunohistochemical analysis of tissue sections and measurement of serum GPC3 level have been suggested for this purpose.This review summarizes current knowledge regarding the clinical implication of GPC3detection and targeting in the management of patients with HCC. | Yukihiro Haruyama Hiroaki Kataoka | 2016 | World Journal of Gastroenterology2016，22，1： | 35 |
| 2 | Criteria for the diagnosis and severity stratification of acute pancreatitis显示文摘Recent diagnostic and therapeutic progress for severe acute pancreatitis(SAP)remarkably decreased the casemortality rate.To further decrease the mortality rate of SAP,it is important to precisely evaluate the severity at an early stage,and initiate appropriate treatment as early as possible.Research Committee of Intractable Diseases of the Pancreas in Japan developed simpler criteria combining routinely available data with clinical signs.Severity can be evaluated by laboratory examinations or by clinical signs,reducing the defect values of the severity factors.Moreover,the severity criteria considered laboratory/clinical severity scores and contrastenhanced computed tomography(CE-CT)findings as independent risk factors.Thus,CE-CT scans are not necessarily required to evaluate the severity of acute pancreatitis.There was no fatal case in mild AP diagnosed by the CE-CT severity score,whereas case-mortality rate in those with SAP was 14.8%.Case-mortality of SAP that fulfilled both the laboratory/clinical and the CE-CT severity criteria was 30.8%.It is recommended,therefore,to perform CE-CT examination to clarify the prognosis in those patients who were diagnosed as SAP by laboratory/clinical severity criteria.Because the mortality rate of these patients with SAP is high,such patients should be transferred to advanced medical units. | Makoto Otsuki Kazunori Takeda Seiki Matsuno Yasuyuki Kihara Masaru Koizumi Masahiko Hirota Tetsuhide Ito Keisho Kataoka Motoji Kitagawa Kazuo Inui Yoshifumi Takeyama | 2013 | World Journal of Gastroenterology2013，19，35： | 24 |
| 3 | Bleeding after endoscopic submucosal dissection: Risk factors and preventive methods显示文摘Endoscopic submucosal dissection(ESD) has become widely accepted as a standard method of treatment for superficial gastrointestinal neoplasms because it enables en block resection even for large lesions or fibrotic lesions with minimal invasiveness, and decreases the local recurrence rate. Moreover, specimens resected in an en block fashion enable accurate histological assessment. Taking these factors into consideration, ESD seems to be more advantageous than conventional endoscopic mucosal resection(EMR), but the associated risks of perioperative adverse events are higher than in EMR. Bleeding after ESD is the most frequent among these adverse events. Although post-ESD bleeding can be controlled by endoscopic hemostasis in most cases, it may lead to serious conditions including hemorrhagic shock. Even with preventive methods including administration of acid secretion inhibitors and preventive hemostasis, post-ESD bleeding cannot be completely prevented. In addition high-risk cases for post-ESD bleeding, which include cases with the use of antithrombotic agents or which require large resection, are increasing. Although there have been many reports about associated risk factors and methods of preventing post-ESD bleeding, many issues remain unsolved. Therefore, in this review, we have overviewed risk factors and methods of preventing post-ESD bleeding from previous studies. Endoscopists should have sufficient knowledge of these risk factors and preventive methods when performing ESD. | Yosuke Kataoka Yosuke Tsuji Yoshiki Sakaguchi Chihiro Minatsuki Itsuko Asada-Hirayama Keiko Niimi Satoshi Ono Shinya Kodashima Nobutake Yamamichi Mitsuhiro Fujishiro Kazuhiko Koike | 2016 | World Journal of Gastroenterology2016，22，26： | 16 |
| 4 | Lentinan prolonged survival in patients with gastric cancer receiving S-1-based chemotherapy显示文摘AIM:To examine whether administration of lentinan,purifiedβ-1,3-glucan,can prolong survival in advanced gastric cancer patients receiving S-1-based chemotherapy.METHODS:Since 2004,78 patients with metastatic or recurrent gastric cancer have received S-1-based chemotherapy as first-line treatment.Survival,side effects,and the ratio of granulocytes/lymphocytes(G/L ratio)were compared between 2 groups of patients who received chemo-immunotherapy using lentinan and chemotherapy alone.RESULTS:Median overall survival was significantly longer in the former group than in the latter group[689 d(95%CI:431-2339 d)vs 565 d(95%CI:323-662 d),P=0.0406].In addition,the G/L ratio in patients who received lentinan was maintained around or below 2,which was significantly lower than that in patients who received chemotherapy alone(P<0.001).CONCLUSION:Chemo-immunotherapy with lentinan offers a significant advantage over S-1-based chemotherapy alone in terms of survival in patients with advanced gastric cancer. | Kenji Ina Ryuichi Furuta Takae Kataoka Satoshi Kayukawa Takashi Yoshida Takaya Miwa Yoshitaka Yamamura Yuuki Takeuchi | 2011 | World Journal of Clinical Oncology2011，2，10： | 10 |
| 5 | 基本参数法X-射线荧光光谱同时分析镍、钴和铁基合金显示文摘用基本参数法分析了镍、钴和铁基合金,对每种元素在整个含量范围内用单一校准进行了测定,并获得了满意的结果。研究显示,本方法可以采用多通道光谱仪对主次元素进行分析测定。例如,对镍元素来说,在质量分数0%到100%的浓度范围内,准确度达到质量分数0.14%。我们还发现,在铬的分析中,三级激发很显著,对整体强度的贡献率达到2.4%。通过将三级激发考虑进理论强度计算,方法的准确度可由质量分数0.14%提高到0.10%。对灵敏度进行了最小二乘拟合法校准,研究显示二次拟合多项式用单一校准曲线在整个浓度范围内都能给出很好的结果。在多通道光谱仪中,当通道不再适合谱线重叠时,理论强度重叠校正法是有效的手段。 | KATAOKA Yoshiyukki FURUSAWA Eiichi KOHNO Hisayuki ARAI Tomoya MARTIN Al INOUE Hisashi MANTLER Michael | 2009 | 冶金分析2009，29，5： | 9 |
| 6 | Helicobacter pylori infection in subjects negative for high titer serum antibody显示文摘AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori(H. pylori) antibody.METHODS The antibody titers were measured using antigens derived from Japanese individuals. ^(13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness.RESULTS Of the 136 subjects enrolled, 23(17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve(0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10^(-20)) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies(89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate analysis.CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients. | Osamu Toyoshima Toshihiro Nishizawa Masahide Arita Yosuke Kataoka Kosuke Sakitani Shuntaro Yoshida Hiroharu Yamashita Keisuke Hata Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，13： | 9 |
| 7 | Consensus of primary care in acute pancreatitis in Japan显示文摘在日本的尖锐胰腺炎的发生正在增加并且每百万张人口从 187 ~ 347 个盒子。盒子命运是 0.2% 为对温和中等,并且 9.0% 为在在 2003 的日本的严重尖锐胰腺炎。在日本的胰腺炎的专家做了与尖锐胰腺炎在病人的早管理集中于实际方面的这个文件。尖锐胰腺炎和严厉层化的正确诊断应该为尖锐胰腺炎的诊断用标准在所有病人被做并且多,因素得分系统尽早由胰的难处理的疾病的研究委员会求婚了。与尖锐胰腺炎诊断的所有病人应该在医院里被管理。血压监视,脉搏和呼吸率,体温,时时尿的体积,和血氧饱和水平在如此的病人的管理是必要的。早精力旺盛的静脉内的水和具有最前的重要性稳定循环动力学。有鸦片剂的足够的疼痛地势也是重要的。在严重尖锐胰腺炎,在一个早阶段的抗菌素的预防静脉内的管理被推荐。一旦尖锐胰腺炎的诊断被证实,朊酶禁止者的管理应该被开始。如果没有肠塞痛并且胃肠的流血的清楚的症状,从早舞台用非肠道的营养喂的肠内的联合被推荐。有严重尖锐胰腺炎的病人应该尽早被转移到 ICU 执行象朊酶的连续地区性的动脉的注入那样的特殊措施禁止者和抗菌素,和连续牙齿过敏过滤。日本政府为难处理的疾病作为关于措施的研究的工程之一为严重尖锐胰腺炎盖住医疗保健开销。 | Makoto Otsuki Masahiko Hirota Shinju Arata Masaru Koizumi Shigeyuki Kawa Terumi Kamisawa Kazunori Takeda Toshihiko Mayumi Motoji Kitagawa Tetsuhide Ito Kazuo Inui Tooru Shimosegawa Shigeki Tanaka Keisho Kataoka Hiromitsu Saisho Kazuichi Okazaki Yosikazu Kuroda Norio Sawabu Yoshifumi Takeyama | 2006 | World Journal of Gastroenterology2006，12，21： | 9 |
| 8 | X射线荧光分析法测定铁矿石中全铁显示文摘铁矿石中全铁的含量范围通常较宽,因此需要高的分析精确度。尽管熔融制样法已经被普遍用于铁矿石的X射线荧光光谱分析,但作为样品制备的另一种方法,压片法由于简便、快捷的特点,其应用需求同样较大。康普顿散射比法已经被普遍用于岩石等样品中的重金属元素测定,其中荧光X射线与X射线管线发射的康普顿散射X射线的强度比被用作校正。不过,这种方法不能为矿石和精矿中高含量重金属元素的测定提供足够的准确度。本研究建立了一种新的方法,在元素间校正项中,将基本参数法获取的理论α系数用于康普顿散射比校正。本方法可以将铁矿石中全铁含量的测定准确度提高到0.14%(质量分数)。 | KATAOKA Y HOMMA H KOHNO H | 2011 | 冶金分析2011，31，7： | 8 |
| 9 | Usefulness of urinary trypsinogen-2 and trypsinogen activation peptide in acute pancreatitis:A multicenter study in Japan显示文摘BACKGROUND Rapid urinary trypsinogen-2 dipstick test and levels of urinary trypsinogen-2 and trypsinogen activation peptide(TAP) concentration have been reported as prognostic markers for the diagnosis of acute pancreatitis.AIM To reconfirm the validity of all these markers in the diagnosis of acute pancreatitis by undertaking a multi-center study in Japan.METHODS Patients with acute abdominal pain were recruited from 17 medical institutions in Japan from April 2009 to December 2012. Urinary and serum samples were collected twice, at enrollment and on the following day for measuring target markers. The diagnosis and severity assessment of acute pancreatitis were assessed based on prognostic factors and computed tomography(CT) Grade of the Japanese Ministry of Health, Labour, and Welfare criteria.RESULTS A total of 94 patients were enrolled during the study period. The trypsinogen-2 dipstick test was positive in 57 of 78 patients with acute pancreatitis(sensitivity,73.1%) and in 6 of 16 patients with abdominal pain but without any evidence of acute pancreatitis(specificity, 62.5%). The area under the curve(AUC) score of urinary trypsinogen-2 according to prognostic factors was 0.704, which was highest in all parameter. The AUC scores of urinary trypsinogen-2 and TAP according to CT Grade were 0.701 and 0.692, respectively, which shows higher than other pancreatic enzymes. The levels of urinary trypsinogen-2 and TAP were significantly higher in patients with extended extra-pancreatic inflammation as evaluated by CT Grade.CONCLUSION We reconfirmed urinary trypsinogen-2 dipstick test is useful as a marker for the diagnosis of acute pancreatitis. Urinary trypsinogen-2 and TAP may be considered as useful markers to determine extra-pancreatic inflammation in acute pancreatitis. | Hiroaki Yasuda Keisho Kataoka Yoshifumi Takeyama Kazunori Takeda Tetsuhide Ito Toshihiko Mayumi Shuji Isaji Tetsuya Mine Motoji Kitagawa Seiki Kiriyama Junichi Sakagami Atsushi Masamune Kazuo Inui Kenji Hirano Ryukichi Akashi Masamichi Yokoe Yoshio Sogame Kazuichi Okazaki Chie Morioka Yasuyuki Kihara Shigeyuki Kawa Masao Tanaka Akira Andoh Wataru Kimura Isao Nishimori Junji Furuse Isao Yokota Tooru Shimosegawa | 2019 | World Journal of Gastroenterology2019，25，1： | 7 |
| 10 | 日本高灌蓝莓采收最适线锯振动速度(摘选) | Longsheng Fu Hiroshi Okamoto Yoichiro Hoshino Takashi Kataoka Youichi Shibata | 2012 | 农业工程2012，2，2： | 5 |
| 11 | FTY720,Sphingosine 1-Phosphate Receptor Modulator,Ameliorates Experimental Autoimmune Encephalomyelitis by Inhibition of T Cell Infiltration显示文摘FTY720, a sphingosine 1-phosphate receptor modulator, induces a marked decrease in the number of peripheral blood lymphocytes and exerts immunomodulating activity in various experimental allograft and autoimmune disease models. In this study, we evaluated the effect of FTY720 and its active metabolite, (S)-enantiomer of FTY720-phosphate [(S)-FTY720-P] on experimental autoimmune encephalomyelitis (EAE) in rats and mice.Prophylactic administration of FTY720 at 0.1 to 1 mg/kg almost completely prevented the development of EAE,and therapeutic treatment with FTY720 significantly inhibited the progression of EAE and EAE-associated histological change in the spinal cords of LEW rats induced by immunization with myelin basic protein. Consistent with rat EAE, the development of proteolipid protein-induced EAE in SJL/J mice was almost completely prevented and infiltration of CD4+ T cells into spinal cord was decreased by prophylactic treatment with FTY720 and (S)-FTY720-P. When FTY720 or (S)-FTY720-P was given after establishment of EAE in SJL/J mice, the relapse of EAE was markedly inhibited as compared with interferon-β, and the area of demyelination and the infiltration of CD4+ T cells were decreased in spinal cords of EAE mice. Similar therapeutic effect by FTY720 was obtained in myelin oligodendrocyte glycoprotein-induced EAE in C57BL/6 mice. These results indicate that FTY720 exhibits not only a prophylactic but also a therapeutic effect on EAE in rats and mice, and that the effect of FTY720 on EAE appears to be due to a reduction of the infiltration of myelin antigen-specific CD4+ T cells into the inflammation site. | Hirotoshi Kataoka Kunio Sugaharal Kyoko Shimano Koji Teshima Mamoru Koyama Atsyshi Fukunari Kenji Chiba | 2005 | Cellular & Molecular Immunology2005，2，6： | 5 |
| 12 | Role of cortical spreading depression in the pathophysiology of migraine显示文摘A migraine is a recurring neurological disorder characterized by unilateral,intense,and pulsatile headaches.In one-third of migraine patients,the attacks are preceded by a visual aura,such as a slowly-propagating scintillating scotoma.Migraine aura is thought to be a result of the neurovascular phenomenon of cortical spreading depression(SD),a self-propagating wave of depolarization that spreads across the cerebral cortex.Several animal experiments have demonstrated that cortical SD causes intracranial neurogenic inflammation around the meningeal blood vessels,such as plasma protein extravasation and pro-inflammatory peptide release.Cortical SD has also been reported to activate both peripheral and central trigeminal nociceptive pathways.Although several issues remain to be resolved,recent evidence suggests that cortical SD could be the initial trigger of intracranial neurogenic inflammation,which then contributes to migraine headaches via subsequent activation of trigeminal afferents. | Yilong Cui Yosky Kataoka Yasuyoshi Watanabe | 2014 | Neuroscience Bulletin2014，30，5： | 4 |
| 13 | Delayed esophageal perforation occurring with endoscopic submucosal dissection:A report of two cases显示文摘We report two cases of delayed esophageal perforation occurring with endoscopic submucosal dissection. Our cases involved delayed perforation after 10 d in case 1 and after 6 d in case 2. Both cases were related to solid food. We performed subtotal esophagectomy with gastric tube reconstruction of the esophagus via the subcutaneous route anterior to the thoracic wall without conservative treatment because both cases involved chest pain and major leakage of food into the mediastinum. Postoperative complications were a local factor(including suture failure and esophageal stricture) in case 1, and we performed endoscopic balloon dilatation five times for esophageal stricture. There was no intrathoracic and mediastinal infection in either case. Surgical treatment for delayed esophageal perforation can be performed safely and surely if diagnosis and assessment are not delayed. | Yasuhiro Matsuda Naoki Kataoka Tomoyuki Yamaguchi Masafumi Tomita Kazuki Sakamoto Shinichiro Makimoto | 2015 | World Journal of Gastrointestinal Surgery2015，7，7： | 4 |
| 14 | Advances in refractory ulcerative colitis treatment: A new therapeutic target, Annexin A2显示文摘Medical treatment has progressed significantly over the past decade towards achieving and maintaining clinical remission in patients with refractory ulcerative colitis(UC). Proposed mediators of inflammation in UC include pro-inflammatory cytokines such as tumor necrosis factor-α(TNF-α) and interleukin-2, and the cellsurface adhesive molecule integrin α4β7. Conventional therapeutics for active UC include 5-aminosalicylic acid, corticosteroids and purine analogues(azathioprine and 6-mercaptopurine). Patients who fail to respond to conventional therapy are treated with agents such as the calicineurin inhibitors cyclosporine and tacrolimus, the TNF-α inhibitors infliximab or adalimumab, or a neutralizing antibody(vedolizumab) directed against integrin α4β7. These therapeutic agents are of benefit for patients with refractory UC, but are not universally effective. Our recent research on TNF-α shedding demonstrated that inhibition of annexin(ANX) A2 may be a new therapeutic strategy for the prevention of TNF-α shedding during inflammatory bowel disease(IBD) inflammation. In this review, we provide an overview of therapeutic treatments that are effective and currently available for UC patients, as well as some that are likely to be available in the near future. We also propose the potential of ANX A2 as a new molecular target for IBD treatment. | Satoshi Tanida Tsutomu Mizoshita Keiji Ozeki Takahito Katano Hiromi Kataoka Takeshi Kamiya Takashi Joh | 2015 | World Journal of Gastroenterology2015，21，29： | 4 |
| 15 | Clear cell adenocarcinoma of the colon:A case report and review of literature显示文摘A primary clear cell adenocarcinoma of the colon is a rare oncologic entity. We herein report a case of such a tumor of the sigmoid colon in a 71-year-old woman who was successfully treated by an endoscopic polypectomy in our hospital. We also reviewed the published reports regarding cases of primary clear cell tumors in the colon. | Koichi Soga Hideyuki Konishi Natsuko Tatsumi Chika Konishi Keimei Nakano Naoki Wakabayashi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Ken-Ichi Mukaisho Takanori Hattori | 2008 | World Journal of Gastroenterology2008，14，7： | 4 |
| 16 | Perforation associated with endoscopic submucosal dissection for duodenal neoplasm without a papillary portion显示文摘AIM To investigate predictors of perforation after endoscopic resection(ER) for duodenal neoplasms without a papillary portion.METHODS This was a single-center, retrospective, cohort study conducted between April 2003 and September 2014. A total of 54 patients(59 lesions) underwent endoscopic mucosal resection(EMR)(n = 36) and endoscopic submucosal dissection(ESD)(n = 23). Clinical features, outcomes, and predictors of perforation were investigated.RESULTS Cases of perforation occurred in eight(13%) patients(95%CI: 4.7%-22.6%). Three ESD cases required sur-gical management because they could not be repaired by clipping. Delayed perforation occurred in two ESD cases, which required surgical management, although both patients underwent prophylactic clipping. All patients with perforation who required surgery had no postoperative complications and were discharged at anaverage of 13.2 d after ER. Perforation after ER showed a significant association with a tumor size greater than20 mm(P = 0.014) and ESD(P = 0.047).CONCLUSION ESD for duodenal neoplasms exceeding 20 mm may be associated with perforation. ESD alone is not recom-mended for tumor treatment, and LECS should be con-sidered as an alternative. | Yasuhiro Matsuda Kazuki Sakamoto Naoki Kataoka Tomoyuki Yamaguchi Masafumi Tomita Shinichiro Makimoto | 2017 | World Journal of Gastrointestinal Surgery2017，9，7： | 3 |
| 17 | 经皮冠状动脉成形术中的冠状动脉破裂原因分析显示文摘目的:探讨冠状动脉成形术中冠状动脉破裂的可能原因。方法:对所有介入治疗前的靶病变行定性和定量造影分析,并选择在发生冠状动脉破裂前最近一次的血管内超声(IVUS)图像进行分析。结果:在5个心脏介入中心总共1 506例经皮冠状动脉成形术(PCI)患者中,发生冠状动脉破裂15例(1.0%),其中6例与操作导丝相关,1例与单纯球囊扩张相关,8例与支架植入相关。6例与导丝相关的破裂均由亲水涂层或中等硬度导丝所致,靶病变包括3例闭塞、4例偏心和3例分叉病变。与球囊或支架相关冠状动脉破裂包括6例偏心、6例中等至严重钙化病变。有血管内超声分析的5例,其病变偏心率均小于0.4,钙化弓在42~109度。除了单纯球囊破裂病例,在所有支架植入导致的破裂,球囊/管腔比值均超过1.3。所有与导丝相关冠状动脉破裂属于EllisⅡ级,与球囊或支架相关的2例属Ⅱ级,7例属Ⅲ级。结论:导丝相关的冠状动脉破裂常发生在采用亲水涂层或中等硬度导丝对偏心、分叉或闭塞病变进行操作;球囊或支架相关冠状动脉破裂经常与球囊尺寸过大或压力过大有关,常发生在偏心和伴钙化的病变处。 | 邱朝晖 Kataoka Toru 郭新贵 Kobayashi Yoshiki Nishioka Hiroki 张煜 Sakamoto Kazuo Yoshi mura Takayoshi Shi mada Kenei Yoshikawa Junichi | 2010 | 中国临床医学2010，17，4： | 3 |
| 18 | Paradoxical brain embolism followed by percutaneous atrial septal closure: Stroke in a patient's thirties highlighting some issues surrounding brain stroke in an emergency setting显示文摘Brain stroke in patients younger than 40 deprivessociety of its work force. Paradoxical brain embolism(PBE) is sometimes responsible. PBE should never beoverlooked in emergency settings because its recurrencemay be preventable. | Daisuke Matsubara Koichi Kataoka Teppei Matsubara Takaomi Minami Takanori Yamagata | 2017 | World Journal of Emergency Medicine2017，8，4： | 3 |
| 19 | Detection of BCL2-IGHrearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma显示文摘A 59-year-old woman was admitted to our hospital because of recurrent follicular lymphorna (FL). Colonoscopic examination revealed a rectal submucosal tumor (SMT) without any erosions and ulcers. In this patient, it was difficult to distinguish non-Hodgkin's lymphoma (NHL) invasion from other disorders of the colon including carcinoid tumor merely based on endoscopic findings. Histopathologic and immunohistochemical studies on biopsy specimens showed an infiltration of atypical lymphocytes that were positive for CD20 and BCL2 but negative for UCHL-1. Fluorescence in situ hybridization on paraffin-embedded tissue sections (T-FISH) identified a translocation of BCL2 with IGHgene.Based on these findings, the tumor was defined as an invasion of FL. T-FISH method is useful for the detection of a monoclonality of atypical lymphocytes in an SMT of the gastrointestinal tract, and particularly for the detection of chromosomal translocations specific to lymphoma subtypes. | Naohisa Yoshida Kenichi Nomura Yosuke Matsumoto Kazuhiro Nishida Naoki Wakabayashi Hideyuki Konishi Shoji Mitsufuji Keisho Kataoka Takeshi Okanoue Masafumi Taniwaki | 2004 | World Journal of Gastroenterology2004，10，17： | 3 |
| 20 | Effects of blue light on gametophyte development of Laminaria japonica (Laminariales, Phaeophyta)显示文摘Laminaria gametophyte was greatly influenced by light in its growth and development. Using light-emitting diodes (LED) as blue and red light sources, we analyzed the light effect on gametophytes devel- opment of Laminaria japonica Aresch. The gametophytes were obtained from zoospores collected in April, May, July, 2003 and September, 2004. We found that the growth of gametophytes was stimulated by increasing inten- sity of blue light (BL) and red light (RL) illumination, of which BL was obviously stronger than that of RL. The fertilization of gametophytes depended largely on BL, and only sufficient BL illumination could take the repro- ductive effect. In addition, we noticed that there was a significant difference in light responses for gametophytes developed from zoospore collected in different times. For zoospores released in April, under BL1 (73.90 μmol photons/m·s), the unicellular female gametophytes and multi-cellular male gametophytes produced eggs and sperms respectively, and further developed towards sporophytes. However, for gametophytes developed in May, July or September, they became multi-cellular and never formed oogonia or antheridia. It is believed that the Laminaria sporangium maturation stage could affect the gametophytes reaction to BL under laboratory culture conditions. Therefore, cryptochrome- or phototropin-like BL photoreceptors is probably involved in BL-induced development of Laminaria gametophytes. | 史翠娟 KATAOKA Hironao 段德麟 | 2005 | Chinese Journal of Oceanology and Limnology2005，23，3： | 3 |
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