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| 1 | Pyogenic liver abscess:An audit of 10 years’experience显示文摘AIM:To describe our own experience with pyogenic liver abscesses over the past 10 years and investigate the risk factors associated with failure of initial percutaneous therapy.METHODS:A retrospective study of records of 63 PLA patients presenting between 1998 and 2008 to Australian tertiary referral centre,were reviewed.Amoebic and hydatid abscesses were excluded.Demographic,clinical,radiological,and microbiological characteristics,as well as surgical/radiological interventions,were recorded.RESULTS:Sixty-three patients(42 males,21 females) aged 65(±14) years[mean±(SD) ]had prodromal symptoms for a median(interquartile range;IQR) of 7(5-14) d.Only 59%of patients were febrile at presentation;however,the serum C-reactive protein was elevated in all 47 in whom it was measured.Liver function tests were non-specifically abnormal.67%of patients had a solitary abscess,while 32%had>3 abscesses with a median(IQR) diameter of 6.3(4-9) cm.Causative organisms were:Streptococcus milleri 25%,Klebsiella pneumoniae 21%,and Escherichia coli 16%.A presumptive cryptogenic cause was most common (34%).Four patients died in this series:one from sepsis,two from advanced cancer,and one from acute myocardial infarction.The initial procedure was radiological aspiration±drainage in 54 and surgery in two patients.17%underwent surgical management during their hospitalization.Serum hypoalbuminaemia[mean (95%CI) :32(29-35) g/L vs 28(25-31) g/L,P=0.045] on presentation was found to be the only factor related to failure of initial percutaneous therapy on univariate analysis.CONCLUSION:PLA is a diagnostic challenge,because the presentation of this condition is non-specific.Intravenous antibiotics and radiological drainage in the first instance allows resolution of most PLAs;However,a small proportion of patients still require surgical drainage. | Tony CY Pang Thomas Fung Jaswinder Samra Thomas J Hugh Ross C Smith | 2011 | World Journal of Gastroenterology2011，17，12： | 46 |
| 2 | One hundred and seventy-eight consecutive pancreatoduodenectomies without mortality:role of the multidisciplinary approach显示文摘BACKGROUND:Pancreatoduodenectomy offers the only chance of cure for patients with periampullary cancers.This,however,is a major undertaking in most patients and is associated with a significant morbidity and mortality.A multidisciplinary approach to the workup and follow-up of patients undergoing pancreatoduodenectomy was initiated at our institution to improve the diagnosis,resection rate,mortality and morbidity.We undertook the study to assess the effect of this approach on diagnosis,resection rates and short-term outcomes such as morbidity and mortality.METHODS:A prospective database of patients presenting with periampullary cancers to a single surgeon between April 2004 and April 2010 was reviewed.All cases were discussed at a multidisciplinary meeting comprising surgeons,gastroenterologists,radiologists,oncologists,radiation oncologists,pathologists and nursing staff.A standardized investigation and management algorithm was followed.Complications were graded according to the Clavien-Dindo classification.RESULTS:A total of 295 patients with a periampullary lesion were discussed and 178 underwent pancreatoduodenectomy (resection rate 60%).Sixty-one patients (34%) required either a vascular or an additional organ resection.Eighty-nine patients experienced complications,of which the commonest was blood transfusion (12%).Thirty-four patients (19%) had major complications,i.e.grade 3 or above.There was no in-hospital,30-day or 60-day mortality.CONCLUSIONS:Pancreatoduodenectomy can safely be performed in high-volume centers with very low mortality.The surgeon's role should be careful patient selection,intensive preoperative investigations,use of a team approach,and an unbiased discussion at a multidisciplinary meeting to optimize the outcome in these patients. | Jaswinder S Samra Raul Alvarado Bachmann Julian Choi Anthony Gill Michael Neale Vikram Puttaswamy Cameron Bell Ian Norton Sarah Cho Steven Blome Ritchie Maher Sivakumar Gananadha Thomas J Hugh | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 8 |
| 3 | Ampullary cancer of intestinal origin and duodenal cancer-A logical clinical and therapeutic subgroup in periampullary cancer显示文摘Periampullary cancers include pancreatic, ampullary, biliary and duodenal cancers. At presentation, the majority of periampullary tumours have grown to involve the pancreas, bile duct, ampulla and duodenum. This can result in difficulty in defining the primary site of origin in all but the smallest tumors due to anatomical proximity and architectural distortion. This has led to variation in the reported proportions of resected periampullary cancers. Pancreatic cancer is the most common cancer resected with a pancreaticoduodenectomy followed by ampullary(16%-50%), bile duct(5%-39%), and duodenal cancer(3%-17%). Patients with resected duodenal and ampullary cancers have a better reported median survival(29-47 mo and 22-54 mo) compared to pancreatic cancer(13-19 mo). The poorer survival with pancreatic cancer relates to differences in tumour characteristics such as a higher incidence of nodal, neural and vascular invasion. While small ampullary cancers can present early with biliary obstruction, pancreatic cancers need to reach a certain size before biliary obstruction ensues. This larger size at presentation contributes to a higher incidence of resection margin involvement in pancreatic cancer. Ampullary cancers can be subdivided into intestinal or pancreatobiliary subtype cancers with histomolecular staining. This avoids relying on histomorphology alone, as even some poorly differentiated cancers preserve the histomolecular profile of their mucosa of origin. Histomolecular profiling is superior to anatomic location in prognosticating survival. Ampullary cancers of intestinal subtype and duodenal cancers are similar in their intestinal origin and form a logical clinical and therapeutic subgroup of periampullary cancers. They respond to 5-FU based chemotherapeutic regimens such as capecitabine-oxaliplatin. Unlike pancreatic cancers, KRAS mutation occurs in only approximately a third of ampullary and duodenal cancers. Future clinical trials should group ampullary cancers of intestinal origin and duodenal cancers together given their similarities and their response to fluoropyrimidine therapy in combination with oxaliplatin. The addition of anti-epidermal growth factor receptor therapy in this group warrants study. | Manju D Chandrasegaram Anthony J Gill Jas Samra Tim Price John Chen Jonathan Fawcett Neil D Merrett | 2017 | World Journal of Gastrointestinal Oncology2017，9，10： | 4 |
| 4 | Evaluation of use of a new Chromogenic agar in detection of urinary tract pathogens显示文摘 | Samra Z Heifetz M Talmor J | 1998 | J Clin Microbiol1998，36，4： | 1 |
| 5 | Impact of Personal Values and Innovativeness on Hedonic and U- tilitarian Aspects of Web Use: An Empirical Study among United States Teenagers 显示文摘 | Hartman J B Samra Y M | 2008 | In- ternational Journal of Management2008，25，1： | 1 |
| 6 | Prioritizing erosion-prone areas in hills using remote sensing and GIS-a case study of the Sukhna Lake catchment, Northern India显示文摘 | SHRIMALI S S AGGARWAL S P SAMRA J S | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，1： | 1 |
| 7 | Effect of soil sodicity on the growth of four cultivars of grape显示文摘 | SAMRA J S | 1986 | Indian J Hort1986，43，12： | 1 |
| 8 | Evaluation of CHROMagar KPC for rapid detection of Carbapenem-resistant Enterobacteriaceae显示文摘 | Samra Z Bahar J Madar-Shapiro L | 2008 | J Clin Microbiol2008，46，9： | 1 |
| 9 | Evaluation of CHROM agar KPC for rapid detection of earbapenem-resistant enterobacteriaceae显示文摘 | Samra Z Bahar J Madar-Shapiro L et a1 | | 0，，09： | 1 |
| 10 | Prioritizing erosion-prone areas in hills using remote sensing and GIS--A case study of the Sukhna Lake catchment, Northern India 显示文摘 | Shrimali S S Aggarwal S P Samra J S | 2001 | International Journal of Applied Earth Observation and Geoinformation2001，3，1： | 1 |
| 11 | Effect of cranberry juice on eradication of Helicobacter pylori in patients treated with antibiotics and a proton pump inhibitor显示文摘 | Shmuely H Yahav J Samra Z | 2007 | Mol Nutr Food Res2007，51，： | 1 |
| 12 | Optimal detection of Staphylococcus au-reus from clinical specimens using a new chromogenic medium显示文摘 | Samra Z Ofir 0 Bahar J | 2004 | Diagn Microbiol Infect Dis2004，49，4： | 1 |
| 13 | Pyogenic liver abscess: An audit of 10 years' experience显示文摘 | PANG TCY FUNG T SAMRA J | 2011 | World Journal of Gas- troenterology: WJG2011，17，12： | 1 |
| 14 | Impaired postprandial tissue regulation of blood flow in insulin resistance: a determinant of cardiovascular risk? 显示文摘 | Summers L K Samra J S Frayn K N | 1999 | Atherosclerosis1999，147，： | 1 |
| 15 | Upstream tissue inhibitor of metalloproteinases-1 (TIMP- 1) element-1, a novel and essential regulatory DNA motif in the human TIMP-1 gene promoter, directly interacts with a 30-kDa nuclear protein 显示文摘 | TRIM J E SAMRA S K ARTHUR M J | 2000 | J Biol Chem2000，275，： | 1 |
| 16 | The early fall in levels of S-100 beta in traumatic brain injury显示文摘 | Jackson R G Samra G S Radcliffe J | 2000 | Clin Chem Lab Med2000，38，： | 1 |
| 17 | The early fall in levels of S100 beta in traumatic brain injury显示文摘 | Jackson RG Samra GS Radcliffe J | 2000 | Clin Chem Lab Med2000，38，11： | 1 |
| 18 | Differential suppression of priA2: :kan phenotypes in Escherichia coli K-12 by mutations in priA, lexA, and dnaC 显示文摘 | Sandier S J Samra H S Clark A J | 1996 | Genetics1996，143，1： | 1 |
| 19 | Low flow and high flow responses to converting natural grassland into bluegum (Eucalyptus globulus) in Nilgiris watersheds of South India显示文摘 | Sikka A K Samra J S Sharda V N | 2003 | Journal of Hydrology2003，270，12： | 1 |
| 20 | Annual risk assessment for overload security 显示文摘 | DAI Y MCCALLEY J D ABI- SAMRA N | 2001 | IEEE Transactions on Power Systems2001，16，4： | 1 |
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