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| 1 | A matched-pair analysis of laparoscopic versus open pancreaticoduodenectomy: oncological outcomes using Leeds Pathology Protocol显示文摘BACKGROUND: Laparoscopic pancreaticoduodenectomy(LPD)is a safe procedure. Oncological safety of LPD is still a matter for debate. This study aimed to compare the oncological outcomes,in terms of adequacy of resection and recurrence rate following LPD and open pancreaticoduodenectomy(OPD).METHODS: Between November 2005 and April 2009, 12LPDs(9 ampullary and 3 distal common bile duct tumors)were performed. A cohort of 12 OPDs were matched for age,gender, body mass index(BMI) and American Society of Anesthesiologists(ASA) score and tumor site.RESULTS: Mean tumor size LPD vs OPD(19.8 vs 19.2 mm,P=0.870). R0 resection was achieved in 9 LPD vs 8 OPD(P=1.000). The mean number of metastatic lymph nodes and total number resected for LPD vs OPD were 1.1 vs 2.1(P=0.140)and 20.7 vs 18.5(P=0.534) respectively. Clavien complications grade I/II(5 vs 8), III/IV(2 vs 6) and pancreatic leak(2 vs 1)were statistically not significant(LPD vs OPD). The mean high dependency unit(HDU) stay was longer in OPD(3.7 vs 1.4 days,P<0.001). There were 2 recurrences each in LPD and OPD(logrank,P=0.983). Overall mortality for LPD vs OPD was 3 vs 6(log-rank, P=0.283) and recurrence-related mortality was 2 vs 1.There was one death within 30 days in the OPD group secondary to severe sepsis and none in the LPD group.CONCLUSIONS: Compared to open procedure, LPD achieved a similar rate of R0 resection, lymph node harvest and longterm recurrence for tumors less than 2 cm. Though technically challenging, LPD is safe and does not compromise oncological outcome. | Abdul R Hakeem Caroline S Verbeke Alison Cairns Amer Aldouri Andrew M Smith Krishna V Menon | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，4： | 24 |
| 2 | Bone mineral density and disorders of mineral metabolism in chronic liver disease显示文摘AIM:To estimate the prevalence and identify the risk factors for metabolic bone disease in patients with cirrhosis.METHODS:The study was performed on 72 Indian patients with cirrhosis(63 male, 9 female;aged < 50 years).Etiology of cirrhosis was alcoholism(n = 37), hepatitis B(n = 25) and hepatitis C(n = 10).Twenty-three patients belonged to Child class A, while 39 were in class B and 10 in class C.Secondary causes for metabolic bone disease and osteoporosis were ruled out.Sunlight exposure, physical activity and dietary constituents were calculated.Complete metabolic profiles were derived, and bone mineral density(BMD) was measured using dual energy X ray absorptiometry.Low BMD was defined as a Z score below-2.RESULTS:Low BMD was found in 68% of patients.Lumbar spine was the most frequently and severely affected site.Risk factors for low BMD included low physical activity, decreased sunlight exposure, and low lean body mass.Calcium intake was adequate, with unfavorable calcium:protein ratio and calcium:phosphorus ratio.Vitamin D deficiency was highly prevalent(92%).There was a high incidence of hypogonadism(41%).Serum estradiol level was elevated significantly in patients with normal BMD.Insulin-like growth factor(IGF) 1 and IGF binding protein 3 levels were below the age-related normal range in both groups.IGF-1 was signiflcantly lower in patients with low BMD.Serum osteocalcin level was low(68%) and urinary deoxypyridinoline to creatinine ratio was high(79%), which demonstrated low bone formation with high resorption.CONCLUSION:Patients with cirrhosis have low BMD.Contributory factors are reduced physical activity, low lean body mass, vitamin D def iciency and hypogonadism and low IGF-1 level. | Joe George Hosahithlu K Ganesh Shrikrishna Acharya Tushar R Bandgar Vyankatesh Shivane Anjana Karvat Shobna J Bhatia Samir Shah Padmavathy S Menon Nalini Shah | 2009 | World Journal of Gastroenterology2009，15，28： | 15 |
| 3 | Gender differences in cardiac function during early remodeling after acute myocardial infarction in mice显示文摘 | CAVASIN M A TAO Z MENON S | 2004 | Life Sei2004，75，18： | 1 |
| 4 | The BuddChiari syndrome显示文摘 | Menon K V Shah V Kamath P S | 2004 | N Engl J Med2004，350，6： | 1 |
| 5 | (31 Integrins expression in adult rat ventricular myocytes and itsrole in the regulation of beta-adrenergic receptor-stimulated ap-optosis显示文摘 | Communal C Singh M Menon B Xie Z Colucci W S Singh K | 2003 | J Cell Biochem2003，89，： | 1 |
| 6 | Parkinson's disease, depression, and quality-of-life显示文摘 | Menon B Nayar R Kumar S | 2015 | Indian J Psychol Med2015，37，2： | 1 |
| 7 | Effect of subgrid models on the computed interscale energy transfer in isotropie turbulence 显示文摘 | MENON S YEUNG P KIM W | 1996 | Computer and Fluids1996，25，2： | 1 |
| 8 | Integrated Guidance and Control of Moving-mass Actuated Kinetic Warheads显示文摘 | Menon K P Sweriduk D G Ohlmeyer E J Malyevac S D | 2004 | Journal of Guidance Control and Dynamics January-February 20042004，27，1： | 1 |
| 9 | Intrinsic signal changes accompanying sensory stimulation: functional brain mapping using MRI显示文摘 | Tank D Menon R | 1992 | Proc Natl Acad Sci USA1992，89，13： | 1 |
| 10 | Th late open artery hopothesis-a decade late显示文摘 | Buller C Menon V | 2001 | Am Heart J2001，142，3： | 1 |
| 11 | The cop9 signalosome inhibits p27(kipl) degradation and impedes g1-s phase progression vis deneddylation of scf cull显示文摘 | Yang X Menon S Lykke-Andersen K | 2002 | Curr Biol2002，12，： | 1 |
| 12 | A comparison of scalar PDF turbulent combustion models 显示文摘 | G M Goldin S Menon | 1998 | Combustion and Flame1998，113，： | 1 |
| 13 | Structure of Premixed Turbulent Flames in the Thin-Reaction-Zone Regime 显示文摘 | Sankaran V Menon S | 2000 | Proceedings of the Combustion Institute2000，，28： | 1 |
| 14 | Gain-scheduled nonlinear control of Utube steam generator water level 显示文摘 | MENON S K PORLOS A- G | 1992 | Nuclear Science Engineering1992，111，： | 1 |
| 15 | Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes 显示文摘 | Fortunato S Menon R Lombardi S | 1999 | Obstetrics and Gynecology1999，94，3： | 1 |
| 16 | Intrinsic signal changes accompanying sensory stimulation:functional brain mapping using MRI显示文摘 | Ogawa S Tank D Menon R | 1992 | Proc Natl Acad Sci USA1992，89，7： | 1 |
| 17 | Establishing a human chorionic gonadotropin cutoff to guide methotrexate treatment of ectopic pregnancy: u systematic review 显示文摘 | Menon S Colins J Barnhart KT | 2007 | Fertil Steril2007，87，： | 1 |
| 18 | The late artery hypothesis-a decade late显示文摘 | Sadananjan S Buller C Menon V | 2001 | Am Heart J2001，142，2： | 1 |
| 19 | Synthesis and study of binuclear calix arene Schiff base Co(II)complexes as catalyst in the presence of PhIO for the catalytic oxidation of olefin显示文摘 | PATEL R V PANCHAL J G MENON S K | 2010 | J Incl Phenom Macrocycl Chem2010，67，12： | 1 |
| 20 | Making innovation happen in organizations : Individual creativity mechanisms, organization creativity mechanisms or both? 显示文摘 | Bharadwaj S Menon A | 2000 | Journal of Production Innovation Management2000，17，： | 1 |
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